Belumosudil (mesylate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belumosudil (mesylate) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belumosudil (mesylate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.0904989
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0783439
NALF1 NALCN channel auxiliary factor 1 0.0627621
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0509566
EXT1 exostosin glycosyltransferase 1 0.0473859
ASPH aspartate beta-hydroxylase 0.0470947
FNDC3B fibronectin type III domain containing 3B 0.0465834
KYNU kynureninase 0.0412648
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0393391
AHNAK AHNAK nucleoprotein 0.039107
DST dystonin 0.0362986
PDE4D phosphodiesterase 4D, cAMP-specific 0.0341917
ZSWIM6 zinc finger, SWIM-type containing 6 0.0296758
AKAP12 A kinase (PRKA) anchor protein 12 0.029294
CALD1 caldesmon 1 0.0274569
MACF1 microtubule-actin crosslinking factor 1 0.026373
BBS9 Bardet-Biedl syndrome 9 0.0260151
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0250268
NAV1 neuron navigator 1 0.0245737
HDAC9 histone deacetylase 9 0.0244346
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0240448
ANO6 anoctamin 6 0.0233664
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0224089
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0223849
IL6ST interleukin 6 signal transducer 0.022052
ZBTB20 zinc finger and BTB domain containing 20 0.0219501
STC1 stanniocalcin 1 0.0217434
MBD5 methyl-CpG binding domain protein 5 0.0217294
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0214773
LAMB1 laminin, beta 1 0.02107
TRIO trio Rho guanine nucleotide exchange factor 0.020538
UBC ubiquitin C 0.0202481
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0192664
OSMR oncostatin M receptor 0.0188809
SEC24D SEC24 family member D 0.0187124
VEGFC vascular endothelial growth factor C 0.0184498
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0178956
MYLK myosin light chain kinase 0.0178656
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0177584
ANKRD11 ankyrin repeat domain 11 0.0175395
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0172265
SDC4 syndecan 4 0.0171888
CDK13 cyclin-dependent kinase 13 0.0171354
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.0170971
CDK6 cyclin-dependent kinase 6 0.017067
SMAD3 SMAD family member 3 0.0170298
LPP LIM domain containing preferred translocation partner in lipoma 0.0169766
PTK2 protein tyrosine kinase 2 0.0164969
STK17A serine/threonine kinase 17a 0.0164686
ARHGAP24 Rho GTPase activating protein 24 0.0164481
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0164129
CANX calnexin 0.0162504
IGFBP5 insulin-like growth factor binding protein 5 0.0162422
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0162107
PRELID2 PRELI domain containing 2 0.0159477
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0158381
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0157046
PTCHD4 patched domain containing 4 0.0155964
SETBP1 SET binding protein 1 0.0154663
MCTP2 multiple C2 domains, transmembrane 2 0.0154656
DOCK5 dedicator of cytokinesis 5 0.0153741
TAS2R14 taste receptor, type 2, member 14 0.0152545
TRIP12 thyroid hormone receptor interactor 12 0.0150747
PHF3 PHD finger protein 3 0.0148099
VCL vinculin 0.0145348
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0145228
FAM114A1 family with sequence similarity 114, member A1 0.0145155
ATXN1 ataxin 1 0.0143577
NF1 neurofibromin 1 0.0141839
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0141105
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0139392
COL12A1 collagen, type XII, alpha 1 0.0137504
FNIP1 folliculin interacting protein 1 0.0136811
FBXL17 F-box and leucine-rich repeat protein 17 0.013656
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0136287
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.0133546
SBF2 SET binding factor 2 0.0132766
EHBP1 EH domain binding protein 1 0.0132383
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0131973
FSTL1 follistatin-like 1 0.0131491
TENM3 teneurin transmembrane protein 3 0.0130384
NAV3 neuron navigator 3 0.012962
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0128837
ZEB1 zinc finger E-box binding homeobox 1 0.0128345
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0128172
CALN1 calneuron 1 0.0127734
ARB2A ARB2 cotranscriptional regulator A 0.0127617
PTPRG protein tyrosine phosphatase, receptor type, G 0.0126989
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0125934
GLS2 glutaminase 2 (liver, mitochondrial) 0.0125855
KCTD16 potassium channel tetramerization domain containing 16 0.0125671
TCF12 transcription factor 12 0.0125572
MYSM1 Myb-like, SWIRM and MPN domains 1 0.0125012
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0124694
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0124677
DOCK1 dedicator of cytokinesis 1 0.0124287
RPL4 ribosomal protein L4 0.01237
FAM219A family with sequence similarity 219, member A 0.0123325
TPM3 tropomyosin 3 0.0122686
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0122305

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.171912
TMSB10 thymosin beta 10 -0.14338
FTL ferritin, light polypeptide -0.129681
VIM vimentin -0.108005
IGFBP3 insulin-like growth factor binding protein 3 -0.0869458
RPL37A ribosomal protein L37a -0.0707732
MT2A metallothionein 2A -0.0699103
HLA-B major histocompatibility complex, class I, B -0.0692763
RPL35A ribosomal protein L35a -0.0645615
B2M beta-2-microglobulin -0.0639273
PTMA prothymosin, alpha -0.0580541
RPS6 ribosomal protein S6 -0.05183
TPT1 tumor protein, translationally-controlled 1 -0.048526
RPS8 ribosomal protein S8 -0.0464864
RPLP1 ribosomal protein, large, P1 -0.0455237
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0447828
NDRG1 N-myc downstream regulated 1 -0.0429032
RPLP2 ribosomal protein, large, P2 -0.0388266
RPL31 ribosomal protein L31 -0.0374315
RPL23 ribosomal protein L23 -0.037289
RPS13 ribosomal protein S13 -0.0366935
WSB1 WD repeat and SOCS box containing 1 -0.0364614
RPL28 ribosomal protein L28 -0.0362654
ENO2 enolase 2 (gamma, neuronal) -0.0351157
TPM4 tropomyosin 4 -0.0348235
RPS19 ribosomal protein S19 -0.034667
PKM pyruvate kinase, muscle -0.0342232
CALR calreticulin -0.0340584
RPL9 ribosomal protein L9 -0.0340096
RPS12 ribosomal protein S12 -0.0338208
EIF1 eukaryotic translation initiation factor 1 -0.0332409
RPS23 ribosomal protein S23 -0.0321879
IGF2 insulin-like growth factor 2 -0.03151
HLA-A major histocompatibility complex, class I, A -0.0313627
HILPDA hypoxia inducible lipid droplet-associated -0.0307054
FN1 fibronectin 1 -0.0298102
RPS25 ribosomal protein S25 -0.0297645
ACTG1 actin gamma 1 -0.0296905
RPS11 ribosomal protein S11 -0.0291254
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0290104
RPS3 ribosomal protein S3 -0.0275954
GRB10 growth factor receptor-bound protein 10 -0.027416
HMGA1 high mobility group AT-hook 1 -0.0272779
RPS14 ribosomal protein S14 -0.027253
RPS29 ribosomal protein S29 -0.026874
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0266724
RPL12 ribosomal protein L12 -0.0264727
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0262517
RPL19 ribosomal protein L19 -0.0257772
RPS27 ribosomal protein S27 -0.0243931
POTEF POTE ankyrin domain family, member F -0.0243218
S100A6 S100 calcium binding protein A6 -0.0241718
RPL34 ribosomal protein L34 -0.0241078
RPL11 ribosomal protein L11 -0.0238131
RPS20 ribosomal protein S20 -0.0237409
RACK1 receptor for activated C kinase 1 -0.0234192
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0234132
RPL27A ribosomal protein L27a -0.0229625
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0228154
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0226555
RPS17 ribosomal protein S17 -0.0221132
PDIA3 protein disulfide isomerase family A, member 3 -0.0220747
RPS27A ribosomal protein S27a -0.0219329
RPL37 ribosomal protein L37 -0.0218477
S100A9 S100 calcium binding protein A9 -0.0214582
ADM adrenomedullin -0.0212569
ISG15 ISG15 ubiquitin-like modifier -0.021222
RPL36 ribosomal protein L36 -0.020927
KPNB1 karyopherin (importin) beta 1 -0.0206656
TPI1 triosephosphate isomerase 1 -0.0203495
RPS16 ribosomal protein S16 -0.0201809
FTH1 ferritin, heavy polypeptide 1 -0.0200942
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0199927
GNAS GNAS complex locus -0.0198671
RPS21 ribosomal protein S21 -0.0193645
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0193524
RPS24 ribosomal protein S24 -0.0187268
S100A10 S100 calcium binding protein A10 -0.0185588
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.018513
TGFBI transforming growth factor, beta-induced, 68kDa -0.018463
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.018309
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.017736
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0177116
RPL36A ribosomal protein L36a -0.0173145
RPL26 ribosomal protein L26 -0.0172758
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0170853
RPL13A ribosomal protein L13a -0.0170236
WARS1 tryptophanyl-tRNA synthetase 1 -0.0166905
FOSL1 FOS-like antigen 1 -0.0165654
RPS15 ribosomal protein S15 -0.016494
RPS10 ribosomal protein S10 -0.016131
SEPTIN9 septin 9 -0.0160016
HIP1 huntingtin interacting protein 1 -0.0159973
HLA-C major histocompatibility complex, class I, C -0.0156011
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0153791
LOC112694756 uncharaterized LOC112694756 -0.0151991
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0148476
SEC61G Sec61 gamma subunit -0.0148364
RTN4 reticulon 4 -0.0148298
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0148228