Belumosudil (mesylate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belumosudil (mesylate) perturbation in HCT15 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Belumosudil (mesylate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0942379
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.079656
GOLGA4 golgin A4 0.0478717
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0393273
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0338787
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0321449
RPL4 ribosomal protein L4 0.0304691
RUNX1 runt-related transcription factor 1 0.0291021
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0280936
SEC24A SEC24 family member A 0.0261483
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0259875
LRRC23 leucine rich repeat containing 23 0.0255377
CEMIP2 cell migration inducing hyaluronidase 2 0.0251476
INTS6 integrator complex subunit 6 0.024796
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0235382
TMF1 TATA element modulatory factor 1 0.0234976
ZNF638 zinc finger protein 638 0.0232036
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0228616
AKAP9 A kinase (PRKA) anchor protein 9 0.0226409
COG6 component of oligomeric golgi complex 6 0.0212024
PDIA4 protein disulfide isomerase family A, member 4 0.021193
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.0203527
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0202018
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0198266
SEC24D SEC24 family member D 0.0198116
ZSWIM6 zinc finger, SWIM-type containing 6 0.019162
RAB7A RAB7A, member RAS oncogene family 0.0189135
KDM4C lysine (K)-specific demethylase 4C 0.018699
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0183907
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0182189
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0181508
BRD2 bromodomain containing 2 0.018119
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0181094
CALU calumenin 0.0181023
SEC31A SEC31 homolog A (S. cerevisiae) 0.0177082
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0176434
MON2 MON2 homolog (S. cerevisiae) 0.0174693
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0166891
ARFGEF3 ARFGEF family member 3 0.0162496
BHLHE40 basic helix-loop-helix family, member e40 0.0160161
RPS2 ribosomal protein S2 0.0159936
IFIH1 interferon induced with helicase C domain 1 0.0159315
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0152061
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0150928
PCBP2 poly(rC) binding protein 2 0.0149072
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0148334
SCARB1 scavenger receptor class B, member 1 0.0148093
PHF3 PHD finger protein 3 0.0147975
HELZ helicase with zinc finger 0.0143519
GTF2B general transcription factor IIB 0.0143428
RNMT RNA (guanine-7-) methyltransferase 0.0142974
RNF24 ring finger protein 24 0.0142119
SRP54 signal recognition particle 54kDa 0.0140754
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0137392
CCDC186 coiled-coil domain containing 186 0.0137111
APLP2 amyloid beta (A4) precursor-like protein 2 0.0134687
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0133489
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.0133299
ATF3 activating transcription factor 3 0.0132069
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0131508
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0130643
KIAA1217 KIAA1217 0.0129712
HOMER1 homer scaffolding protein 1 0.0128695
TTC3 tetratricopeptide repeat domain 3 0.0128203
UGDH UDP-glucose 6-dehydrogenase 0.0126039
SON SON DNA binding protein 0.0123496
SUCO SUN domain containing ossification factor 0.0122701
EFNB2 ephrin-B2 0.0121993
RPL3 ribosomal protein L3 0.0121768
YEATS2 YEATS domain containing 2 0.0121193
IFRD1 interferon-related developmental regulator 1 0.0120173
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.0119958
HSPH1 heat shock 105kDa/110kDa protein 1 0.0119024
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0117477
FNIP1 folliculin interacting protein 1 0.0117281
SGMS2 sphingomyelin synthase 2 0.0117043
AFMID arylformamidase 0.0116987
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0116848
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0116323
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0115904
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0115866
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0115672
ELP2 elongator acetyltransferase complex subunit 2 0.0114855
RAB1A RAB1A, member RAS oncogene family 0.0114197
POU2F2 POU class 2 homeobox 2 0.0113853
TMEM14B transmembrane protein 14B 0.0111877
KDM3B lysine (K)-specific demethylase 3B 0.0111593
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0111559
INTS4 integrator complex subunit 4 0.0111461
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.011138
INSIG2 insulin induced gene 2 0.0111235
NBAS neuroblastoma amplified sequence 0.0108457
FBXO32 F-box protein 32 0.0108453
ADARB1 adenosine deaminase, RNA-specific, B1 0.0107998
UBC ubiquitin C 0.0106813
CCNG2 cyclin G2 0.010625
SDC4 syndecan 4 0.0105826
GOLGB1 golgin B1 0.0105679
KAZN kazrin, periplakin interacting protein 0.0105441
KMT2E lysine (K)-specific methyltransferase 2E 0.0104878

decreased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 -0.283801
TMSB10 thymosin beta 10 -0.152575
PTMA prothymosin, alpha -0.139013
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.112775
AHNAK AHNAK nucleoprotein -0.0968413
TPT1 tumor protein, translationally-controlled 1 -0.0910249
MKI67 marker of proliferation Ki-67 -0.0793826
TPM4 tropomyosin 4 -0.0772195
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0658231
NDRG1 N-myc downstream regulated 1 -0.0588321
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0586771
SERINC5 serine incorporator 5 -0.0569098
KRT18 keratin 18, type I -0.0555443
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0536102
ENO1 enolase 1, (alpha) -0.0519224
MT2A metallothionein 2A -0.0509209
RAD51B RAD51 paralog B -0.0497211
RPS8 ribosomal protein S8 -0.0469872
ACTG1 actin gamma 1 -0.0463056
LDHA lactate dehydrogenase A -0.0456713
CENPF centromere protein F, 350/400kDa -0.0453838
RPL35A ribosomal protein L35a -0.044783
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0435239
RPS6 ribosomal protein S6 -0.0424382
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0423224
PGK1 phosphoglycerate kinase 1 -0.0421863
RPS12 ribosomal protein S12 -0.0412624
KRT8 keratin 8, type II -0.04076
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0402006
PKM pyruvate kinase, muscle -0.0399009
RPLP1 ribosomal protein, large, P1 -0.0395498
MSI2 musashi RNA-binding protein 2 -0.0394225
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0360868
MED13L mediator complex subunit 13-like -0.0360475
HMGB2 high mobility group box 2 -0.0360226
RPLP2 ribosomal protein, large, P2 -0.0353597
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0348804
DIAPH3 diaphanous-related formin 3 -0.0343035
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0342142
SLC38A2 solute carrier family 38, member 2 -0.0337008
DLG1 discs, large homolog 1 (Drosophila) -0.033699
POTEF POTE ankyrin domain family, member F -0.033411
S100A10 S100 calcium binding protein A10 -0.0333329
MACF1 microtubule-actin crosslinking factor 1 -0.0332706
VCL vinculin -0.033216
TUBB4B tubulin, beta 4B class IVb -0.0330173
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0326345
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0324956
RPS3 ribosomal protein S3 -0.0322049
ACTN4 actinin, alpha 4 -0.0315893
TPI1 triosephosphate isomerase 1 -0.0308954
TENM3 teneurin transmembrane protein 3 -0.0308118
TUBB tubulin, beta class I -0.0306437
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0304262
HMGA2 high mobility group AT-hook 2 -0.029749
CADPS Ca++-dependent secretion activator -0.0296673
KPNB1 karyopherin (importin) beta 1 -0.0289264
EPCAM epithelial cell adhesion molecule -0.0286381
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0283197
EZR ezrin -0.0281654
RPS13 ribosomal protein S13 -0.0276828
RPL37A ribosomal protein L37a -0.0272445
SPIDR scaffolding protein involved in DNA repair -0.0272226
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.026905
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0266865
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0266484
SMC4 structural maintenance of chromosomes 4 -0.0265916
TUBA1B tubulin, alpha 1b -0.0265889
BCL2L1 BCL2-like 1 -0.0265035
RPS25 ribosomal protein S25 -0.025867
ITGB4 integrin, beta 4 -0.0258547
RPL34 ribosomal protein L34 -0.0258094
RPL36 ribosomal protein L36 -0.0253067
DOCK1 dedicator of cytokinesis 1 -0.025147
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0247483
RPL35 ribosomal protein L35 -0.0246552
HLA-B major histocompatibility complex, class I, B -0.0243267
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.024262
FHIT fragile histidine triad -0.0241362
SLC38A1 solute carrier family 38, member 1 -0.0240587
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.024037
EGFR epidermal growth factor receptor -0.0239819
HMGB1 high mobility group box 1 -0.0237686
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0237187
KRT19 keratin 19, type I -0.0235285
CCND1 cyclin D1 -0.0235283
RPS29 ribosomal protein S29 -0.023341
FAF1 Fas (TNFRSF6) associated factor 1 -0.0232852
RPL36A ribosomal protein L36a -0.0232238
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0231746
RPL19 ribosomal protein L19 -0.0231704
RPL12 ribosomal protein L12 -0.0230667
EIF1 eukaryotic translation initiation factor 1 -0.0230174
FLNB filamin B, beta -0.0229902
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0229678
S100A9 S100 calcium binding protein A9 -0.0229609
CUX1 cut-like homeobox 1 -0.0228827
WWOX WW domain containing oxidoreductase -0.0228783
LPP LIM domain containing preferred translocation partner in lipoma -0.0226418
RPL31 ribosomal protein L31 -0.0224916