| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil (mesylate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0831477 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0758545 |
| FNDC3B | fibronectin type III domain containing 3B | 0.068135 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0668461 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0567085 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0562658 |
| CDH13 | cadherin 13 | 0.0490368 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0422059 |
| GOLGB1 | golgin B1 | 0.0388032 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0357592 |
| AHNAK | AHNAK nucleoprotein | 0.0341734 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0323817 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0322207 |
| GLIS3 | GLIS family zinc finger 3 | 0.0300494 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0248659 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.024711 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0237822 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0232819 |
| SDC2 | syndecan 2 | 0.0226943 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0225974 |
| EGFR | epidermal growth factor receptor | 0.0225696 |
| FBN1 | fibrillin 1 | 0.0225 |
| FNIP1 | folliculin interacting protein 1 | 0.0223395 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0210036 |
| ATXN1 | ataxin 1 | 0.0205901 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0197451 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0196537 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0195258 |
| INHBA | inhibin, beta A | 0.0190705 |
| CALD1 | caldesmon 1 | 0.0190106 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0189011 |
| NAV1 | neuron navigator 1 | 0.0184648 |
| COL5A1 | collagen, type V, alpha 1 | 0.0178811 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0174751 |
| H1-0 | H1.0 linker histone | 0.0174667 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0174038 |
| MLF1 | myeloid leukemia factor 1 | 0.0168756 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0168716 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0167228 |
| DST | dystonin | 0.0166091 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0163134 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0162904 |
| PDE10A | phosphodiesterase 10A | 0.0158487 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0158126 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0155611 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0155054 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0154988 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0154154 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0150388 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0146686 |
| FOXP1 | forkhead box P1 | 0.0146195 |
| PRELID2 | PRELI domain containing 2 | 0.0146004 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0144992 |
| CNTN5 | contactin 5 | 0.0143894 |
| CDK13 | cyclin-dependent kinase 13 | 0.014302 |
| RUNX1 | runt-related transcription factor 1 | 0.0142751 |
| HDAC9 | histone deacetylase 9 | 0.0141751 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0139675 |
| UBC | ubiquitin C | 0.0139223 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0137171 |
| COL3A1 | collagen, type III, alpha 1 | 0.0136772 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0136038 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0135397 |
| FAM107B | family with sequence similarity 107, member B | 0.0135359 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0134959 |
| RPL4 | ribosomal protein L4 | 0.0133244 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0131054 |
| SETBP1 | SET binding protein 1 | 0.0130995 |
| FAM219A | family with sequence similarity 219, member A | 0.0130758 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.013057 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0129022 |
| RND3 | Rho family GTPase 3 | 0.0128701 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0126697 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.012632 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0125818 |
| PTK2 | protein tyrosine kinase 2 | 0.0124928 |
| PPP3CC | protein phosphatase 3, catalytic subunit, gamma isozyme | 0.0123191 |
| VCAN | versican | 0.012289 |
| SVIL | supervillin | 0.0120529 |
| MYO1E | myosin IE | 0.0120281 |
| NEK10 | NIMA-related kinase 10 | 0.0117859 |
| PRKCA | protein kinase C, alpha | 0.0117809 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0117277 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0116343 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0116232 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0115438 |
| SEC24D | SEC24 family member D | 0.0114525 |
| INTS6 | integrator complex subunit 6 | 0.0114488 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0114309 |
| CUX1 | cut-like homeobox 1 | 0.0112356 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0111469 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0109876 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | 0.0109154 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0107679 |
| HM13 | histocompatibility (minor) 13 | 0.0105673 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0105624 |
| RRBP1 | ribosome binding protein 1 | 0.0105017 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0102925 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0102141 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0101949 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.183368 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.154189 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.151212 |
| MT2A | metallothionein 2A | -0.12986 |
| VIM | vimentin | -0.127572 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.122447 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.10571 |
| TMSB10 | thymosin beta 10 | -0.0895572 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0759253 |
| NDRG1 | N-myc downstream regulated 1 | -0.0722987 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0705219 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0564994 |
| B2M | beta-2-microglobulin | -0.0558824 |
| FTL | ferritin, light polypeptide | -0.0516847 |
| COL1A1 | collagen, type I, alpha 1 | -0.0447254 |
| PTMA | prothymosin, alpha | -0.0429976 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0404361 |
| HLA-B | major histocompatibility complex, class I, B | -0.0377514 |
| RPL35A | ribosomal protein L35a | -0.0347893 |
| LDHA | lactate dehydrogenase A | -0.0335379 |
| PKM | pyruvate kinase, muscle | -0.0332673 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0330601 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.031067 |
| CALR | calreticulin | -0.0309163 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0308269 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0307007 |
| ATP13A3 | ATPase type 13A3 | -0.0304172 |
| RTN4 | reticulon 4 | -0.0277602 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0269732 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0260463 |
| HLA-A | major histocompatibility complex, class I, A | -0.0253908 |
| PFN1 | profilin 1 | -0.0253082 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0252672 |
| TPM4 | tropomyosin 4 | -0.0249097 |
| HMGA1 | high mobility group AT-hook 1 | -0.0248583 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0247789 |
| ANXA2 | annexin A2 | -0.0237876 |
| RPS6 | ribosomal protein S6 | -0.023398 |
| RPS19 | ribosomal protein S19 | -0.0229081 |
| YBX1 | Y box binding protein 1 | -0.0219487 |
| RPL11 | ribosomal protein L11 | -0.0218396 |
| USP3 | ubiquitin specific peptidase 3 | -0.0217893 |
| RPL28 | ribosomal protein L28 | -0.0213595 |
| RPS12 | ribosomal protein S12 | -0.0212063 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0211711 |
| RPLP2 | ribosomal protein, large, P2 | -0.0209 |
| RPL19 | ribosomal protein L19 | -0.020799 |
| MT1X | metallothionein 1X | -0.0205767 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0205705 |
| WASF2 | WAS protein family, member 2 | -0.0201352 |
| POTEF | POTE ankyrin domain family, member F | -0.0199299 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0197342 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.01972 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0196994 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0196884 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0195207 |
| ZNF292 | zinc finger protein 292 | -0.0191453 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0190734 |
| RPLP1 | ribosomal protein, large, P1 | -0.0189693 |
| MAP1B | microtubule-associated protein 1B | -0.0186087 |
| RPL8 | ribosomal protein L8 | -0.0185807 |
| STC1 | stanniocalcin 1 | -0.0184902 |
| ECE1 | endothelin converting enzyme 1 | -0.0182009 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0181371 |
| PGK1 | phosphoglycerate kinase 1 | -0.0178333 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0177457 |
| RPL37A | ribosomal protein L37a | -0.0176162 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0175343 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0174834 |
| TAPBP | TAP binding protein (tapasin) | -0.0174504 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0173747 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0173643 |
| RPL36 | ribosomal protein L36 | -0.0168447 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0166565 |
| TPI1 | triosephosphate isomerase 1 | -0.0166203 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0164834 |
| FOSL1 | FOS-like antigen 1 | -0.0164353 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0164182 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0162413 |
| RPS11 | ribosomal protein S11 | -0.0161567 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0157635 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0155081 |
| S100A9 | S100 calcium binding protein A9 | -0.0153622 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0152625 |
| SEPTIN7 | septin 7 | -0.0151193 |
| EGR1 | early growth response 1 | -0.0149346 |
| CTSB | cathepsin B | -0.0149054 |
| POSTN | periostin, osteoblast specific factor | -0.0147724 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0147571 |
| RPL12 | ribosomal protein L12 | -0.0147389 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0147289 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0146751 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0145304 |
| SQLE | squalene epoxidase | -0.0144452 |
| RACK1 | receptor for activated C kinase 1 | -0.0142897 |
| RPL23 | ribosomal protein L23 | -0.0142019 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0141628 |
| SPAG9 | sperm associated antigen 9 | -0.013906 |
| RPS13 | ribosomal protein S13 | -0.0138526 |
| PCBP2 | poly(rC) binding protein 2 | -0.013826 |
