| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil (mesylate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.483314 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.104859 |
| SVIL | supervillin | 0.0892355 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.069175 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0666048 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.055939 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.055795 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0467222 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.045241 |
| H1-0 | H1.0 linker histone | 0.0416017 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0397469 |
| PDGFB | platelet-derived growth factor beta polypeptide | 0.0387474 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0375319 |
| CP | ceruloplasmin (ferroxidase) | 0.0355847 |
| CRY1 | cryptochrome circadian clock 1 | 0.0336998 |
| SDC4 | syndecan 4 | 0.0322696 |
| APOA1 | apolipoprotein A-I | 0.031707 |
| AHSG | alpha-2-HS-glycoprotein | 0.0306032 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0301871 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0300147 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0296979 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0294031 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0293069 |
| FAM13A | family with sequence similarity 13, member A | 0.0289726 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0276096 |
| JMJD1C | jumonji domain containing 1C | 0.0271854 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0271138 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0263164 |
| TMEM181 | transmembrane protein 181 | 0.0262874 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0262591 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0261788 |
| FTL | ferritin, light polypeptide | 0.0260305 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0254271 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0253965 |
| KYNU | kynureninase | 0.0250317 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0245393 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0242965 |
| CPE | carboxypeptidase E | 0.0242067 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 0.0232265 |
| NDRG1 | N-myc downstream regulated 1 | 0.0232083 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0230602 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0230062 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0225517 |
| ASPH | aspartate beta-hydroxylase | 0.0225171 |
| GPC3 | glypican 3 | 0.0224621 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0224343 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0221618 |
| FOXP1 | forkhead box P1 | 0.0221141 |
| DUSP6 | dual specificity phosphatase 6 | 0.0219744 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0219466 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0217963 |
| JAK1 | Janus kinase 1 | 0.0216258 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0215004 |
| FBXO42 | F-box protein 42 | 0.0214757 |
| FAM107B | family with sequence similarity 107, member B | 0.0213877 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0213704 |
| ZNF292 | zinc finger protein 292 | 0.0211763 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0206942 |
| RPL23 | ribosomal protein L23 | 0.0206364 |
| RPLP1 | ribosomal protein, large, P1 | 0.0205565 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.0203778 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0201807 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0201056 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0200961 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0199448 |
| RUNX1 | runt-related transcription factor 1 | 0.0197297 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0193135 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0190128 |
| KIF21A | kinesin family member 21A | 0.0186192 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0184831 |
| RYBP | RING1 and YY1 binding protein | 0.0184159 |
| GNAS | GNAS complex locus | 0.0183088 |
| RPL32 | ribosomal protein L32 | 0.0182331 |
| ARFGEF3 | ARFGEF family member 3 | 0.0182215 |
| S100A9 | S100 calcium binding protein A9 | 0.0178343 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0176503 |
| PER2 | period circadian clock 2 | 0.0175776 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.0175619 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0175496 |
| ENO1 | enolase 1, (alpha) | 0.0174541 |
| PRELID2 | PRELI domain containing 2 | 0.0171258 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0171062 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0170863 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0168401 |
| MFHAS1 | malignant fibrous histiocytoma amplified sequence 1 | 0.0166475 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0165018 |
| PLXDC2 | plexin domain containing 2 | 0.0163777 |
| RPS4X | ribosomal protein S4, X-linked | 0.0163074 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0162624 |
| SIK3 | SIK family kinase 3 | 0.0162529 |
| STK17A | serine/threonine kinase 17a | 0.0161499 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0160934 |
| GK | glycerol kinase | 0.0160675 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0160227 |
| FMNL2 | formin-like 2 | 0.015902 |
| SPATA13 | spermatogenesis associated 13 | 0.015835 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0157143 |
| MTSS1 | metastasis suppressor 1 | 0.0156859 |
| TLE4 | transducin-like enhancer of split 4 | 0.0155623 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0155542 |
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | -0.112439 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0802768 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0766593 |
| FN1 | fibronectin 1 | -0.0714319 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0709916 |
| TMSB10 | thymosin beta 10 | -0.0545873 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0519611 |
| APOA2 | apolipoprotein A-II | -0.0517168 |
| A2M | alpha-2-macroglobulin | -0.050684 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0462815 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.04503 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0433006 |
| C3 | complement component 3 | -0.0429928 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.040435 |
| TPM4 | tropomyosin 4 | -0.036789 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0351716 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0344009 |
| TRIM26 | tripartite motif containing 26 | -0.0307304 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0295406 |
| BCL2L1 | BCL2-like 1 | -0.0282711 |
| ITGAV | integrin, alpha V | -0.026629 |
| HMGA1 | high mobility group AT-hook 1 | -0.0265638 |
| RPL37A | ribosomal protein L37a | -0.0265623 |
| VCL | vinculin | -0.0260218 |
| ACTG1 | actin gamma 1 | -0.0259698 |
| EHBP1 | EH domain binding protein 1 | -0.0256559 |
| RPS12 | ribosomal protein S12 | -0.0254072 |
| MAP1B | microtubule-associated protein 1B | -0.0247926 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0245237 |
| RBM39 | RNA binding motif protein 39 | -0.0239376 |
| DSPP | dentin sialophosphoprotein | -0.0237562 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0236913 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0234706 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.023431 |
| ZNF644 | zinc finger protein 644 | -0.0230484 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0226336 |
| THOC2 | THO complex 2 | -0.0219787 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0217461 |
| TMEM123 | transmembrane protein 123 | -0.021684 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0215248 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0214589 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0214302 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0212698 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0210159 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0209663 |
| AFDN | afadin, adherens junction formation factor | -0.0208562 |
| ANKRD11 | ankyrin repeat domain 11 | -0.02019 |
| PTCHD4 | patched domain containing 4 | -0.0198954 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0198941 |
| POTEF | POTE ankyrin domain family, member F | -0.0194687 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0191243 |
| RPS29 | ribosomal protein S29 | -0.0188329 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.018663 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.018578 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0182592 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0179966 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0178306 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0175736 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | -0.0174975 |
| RPL9 | ribosomal protein L9 | -0.0173045 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0171276 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0171015 |
| BRD2 | bromodomain containing 2 | -0.0170247 |
| RBPMS | RNA binding protein with multiple splicing | -0.0169896 |
| FAT1 | FAT atypical cadherin 1 | -0.0168774 |
| CANX | calnexin | -0.0168623 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0168365 |
| CDR2 | cerebellar degeneration-related protein 2, 62kDa | -0.0165415 |
| CFB | complement factor B | -0.0164468 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0162886 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0161422 |
| NHSL1 | NHS-like 1 | -0.0161142 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | -0.0159478 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0159245 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0156721 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0155693 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0154702 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0154345 |
| ACTN4 | actinin, alpha 4 | -0.0153599 |
| FILIP1L | filamin A interacting protein 1-like | -0.0150956 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | -0.014785 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0147647 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0146723 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0146525 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0146248 |
| ZFHX3 | zinc finger homeobox 3 | -0.0145447 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0144929 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0144289 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0142407 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.014201 |
| S100P | S100 calcium binding protein P | -0.014117 |
| GLG1 | golgi glycoprotein 1 | -0.0139637 |
| ITGB5 | integrin, beta 5 | -0.013926 |
| SYNJ2 | synaptojanin 2 | -0.0137015 |
| VMP1 | vacuole membrane protein 1 | -0.0136911 |
| EGR1 | early growth response 1 | -0.0136812 |
| PHF14 | PHD finger protein 14 | -0.0135848 |
| MT2A | metallothionein 2A | -0.0134744 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0134351 |
| DNAJC10 | DnaJ (Hsp40) homolog, subfamily C, member 10 | -0.0133119 |
