| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil (mesylate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.145082 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.110813 |
| PTMA | prothymosin, alpha | 0.0768048 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0687034 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0474164 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0430688 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0428094 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0399486 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0371444 |
| MYO1E | myosin IE | 0.0337365 |
| FTL | ferritin, light polypeptide | 0.0320758 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0294184 |
| SVIL | supervillin | 0.0293509 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0287288 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0271721 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0263476 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0256692 |
| LMO7 | LIM domain 7 | 0.0222163 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0219947 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0218998 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0217004 |
| RPS8 | ribosomal protein S8 | 0.0215742 |
| EGFR | epidermal growth factor receptor | 0.0213461 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.020895 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0207254 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0198749 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0197091 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0195501 |
| MT2A | metallothionein 2A | 0.0194198 |
| UBC | ubiquitin C | 0.0193394 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.0183322 |
| RPL21 | ribosomal protein L21 | 0.0181786 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0180532 |
| POTEF | POTE ankyrin domain family, member F | 0.0178241 |
| TUBA1B | tubulin, alpha 1b | 0.0175226 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0173288 |
| CRY1 | cryptochrome circadian clock 1 | 0.0170859 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0170135 |
| PFN1 | profilin 1 | 0.0168969 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0166133 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0157139 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0151098 |
| MT1X | metallothionein 1X | 0.0147822 |
| WHRN | whirlin | 0.0145136 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0142787 |
| LMNA | lamin A/C | 0.0141396 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0137591 |
| BMP4 | bone morphogenetic protein 4 | 0.0136612 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0136103 |
| SIK3 | SIK family kinase 3 | 0.0135242 |
| RPL18 | ribosomal protein L18 | 0.013521 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.013492 |
| RPS6 | ribosomal protein S6 | 0.0128977 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.0126252 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0122666 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0121615 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0121027 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.0118678 |
| SGMS2 | sphingomyelin synthase 2 | 0.0118469 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0117644 |
| ANXA1 | annexin A1 | 0.0117023 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0116485 |
| PCDH9 | protocadherin 9 | 0.0115993 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0115761 |
| TMC5 | transmembrane channel-like 5 | 0.0112298 |
| RPL4 | ribosomal protein L4 | 0.0112294 |
| EPHB2 | EPH receptor B2 | 0.0109423 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0108904 |
| PRDX2 | peroxiredoxin 2 | 0.0106883 |
| HMGB1 | high mobility group box 1 | 0.0106032 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0104137 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.010348 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.010321 |
| TOM1L2 | target of myb1-like 2 (chicken) | 0.0102388 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0102123 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.0101034 |
| RNF217 | ring finger protein 217 | 0.0100656 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.00998976 |
| VCAN | versican | 0.009798 |
| JUN | jun proto-oncogene | 0.00971711 |
| CENPF | centromere protein F, 350/400kDa | 0.00966639 |
| DSTN | destrin (actin depolymerizing factor) | 0.00965644 |
| CLOCK | clock circadian regulator | 0.00963993 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | 0.00961916 |
| HDGF | hepatoma-derived growth factor | 0.00957999 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.00957371 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.00945206 |
| DIAPH1 | diaphanous-related formin 1 | 0.00930749 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0092989 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.00926603 |
| SPATA13 | spermatogenesis associated 13 | 0.00922291 |
| EMP1 | epithelial membrane protein 1 | 0.00920688 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00918597 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.00914897 |
| B2M | beta-2-microglobulin | 0.00909114 |
| RORA | RAR-related orphan receptor A | 0.00908522 |
| S100A6 | S100 calcium binding protein A6 | 0.00908109 |
| GREB1L | growth regulation by estrogen in breast cancer-like | 0.00903197 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.00896427 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.00893741 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.270356 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.151736 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.108656 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0892851 |
| NDRG1 | N-myc downstream regulated 1 | -0.0749125 |
| ANXA2 | annexin A2 | -0.0737563 |
| RNF43 | ring finger protein 43 | -0.0715196 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0697182 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0691335 |
| GOLGA4 | golgin A4 | -0.0643161 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0608624 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0540818 |
| EREG | epiregulin | -0.0540059 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0525921 |
| FAM13A | family with sequence similarity 13, member A | -0.0513006 |
| TNS4 | tensin 4 | -0.0502097 |
| S100P | S100 calcium binding protein P | -0.0500341 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0471835 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0460498 |
| OGA | O-GlcNAcase | -0.0458496 |
| RBM39 | RNA binding motif protein 39 | -0.0455952 |
| FAT1 | FAT atypical cadherin 1 | -0.0446214 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0441184 |
| GPHN | gephyrin | -0.0422319 |
| CANX | calnexin | -0.0421598 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0420061 |
| GDF15 | growth differentiation factor 15 | -0.0419656 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0418886 |
| FLNB | filamin B, beta | -0.0418519 |
| PRSS3 | protease, serine, 3 | -0.0417264 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0417255 |
| HDLBP | high density lipoprotein binding protein | -0.0415803 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0414478 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0405936 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.040409 |
| MED13L | mediator complex subunit 13-like | -0.0397848 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0395713 |
| AGR2 | anterior gradient 2 | -0.0392631 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0385373 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0383375 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0373311 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0360628 |
| CADPS | Ca++-dependent secretion activator | -0.035503 |
| CALR | calreticulin | -0.0348988 |
| COG5 | component of oligomeric golgi complex 5 | -0.0344542 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0341395 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0329909 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0327181 |
| ACTN4 | actinin, alpha 4 | -0.0322513 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0321551 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0319107 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0316112 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0313486 |
| ONECUT3 | one cut homeobox 3 | -0.0310376 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0310001 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0309608 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0308333 |
| PRELID2 | PRELI domain containing 2 | -0.0308169 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0306833 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0305523 |
| DERA | deoxyribose-phosphate aldolase (putative) | -0.0304569 |
| PUM2 | pumilio RNA-binding family member 2 | -0.030416 |
| PGK1 | phosphoglycerate kinase 1 | -0.0304023 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0301589 |
| USP3 | ubiquitin specific peptidase 3 | -0.029474 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0291356 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0289905 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0289903 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0287995 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0287811 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0284919 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0283608 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0282111 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | -0.0280209 |
| NF1 | neurofibromin 1 | -0.0276963 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0274964 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0273232 |
| NFIA | nuclear factor I/A | -0.0270476 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.027039 |
| ATXN1 | ataxin 1 | -0.0270274 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0269706 |
| TMSB10 | thymosin beta 10 | -0.0268231 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0264533 |
| RNF145 | ring finger protein 145 | -0.0262434 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0262022 |
| KRT8 | keratin 8, type II | -0.0259612 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0259579 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0256235 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0254824 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0254287 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0253884 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0253486 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0252152 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0252063 |
| TFRC | transferrin receptor | -0.0250877 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0250597 |
| ITGB4 | integrin, beta 4 | -0.024988 |
| NBAS | neuroblastoma amplified sequence | -0.0249458 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0248399 |
| LDHA | lactate dehydrogenase A | -0.0248125 |
