Belumosudil (mesylate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belumosudil (mesylate) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belumosudil (mesylate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL4 ribosomal protein L4 0.0945083
LMO7 LIM domain 7 0.0823321
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0666219
KLF5 Kruppel-like factor 5 (intestinal) 0.0564447
PTPRB protein tyrosine phosphatase, receptor type, B 0.0410899
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0393768
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0355353
DSPP dentin sialophosphoprotein 0.0311614
AHNAK AHNAK nucleoprotein 0.030206
INTS6 integrator complex subunit 6 0.029447
EXT1 exostosin glycosyltransferase 1 0.0292477
UBC ubiquitin C 0.028846
SP100 SP100 nuclear antigen 0.0285583
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.028223
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0273442
ZSWIM6 zinc finger, SWIM-type containing 6 0.0267937
GOLGB1 golgin B1 0.0259211
PDE4D phosphodiesterase 4D, cAMP-specific 0.0251465
MYO1E myosin IE 0.0249383
CATSPERB catsper channel auxiliary subunit beta 0.0238781
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0235496
HSPA8 heat shock 70kDa protein 8 0.0230708
LPP LIM domain containing preferred translocation partner in lipoma 0.0227384
CANX calnexin 0.0223381
LOC105378220 macrophage receptor MARCO-like 0.0217857
SQSTM1 sequestosome 1 0.0214885
BACE2 beta-site APP-cleaving enzyme 2 0.0212838
TAS2R14 taste receptor, type 2, member 14 0.0212587
HDLBP high density lipoprotein binding protein 0.0209886
XAF1 XIAP associated factor 1 0.0208321
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0206328
PDLIM5 PDZ and LIM domain 5 0.0203275
SPON1 spondin 1, extracellular matrix protein 0.0193325
EXOC4 exocyst complex component 4 0.0190821
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0179813
CCSER1 coiled-coil serine-rich protein 1 0.0176279
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0174548
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0169888
AEBP2 AE binding protein 2 0.0167141
LRRC23 leucine rich repeat containing 23 0.0166256
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0165226
SERINC5 serine incorporator 5 0.016482
EGFR epidermal growth factor receptor 0.0161766
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0159555
DSG2 desmoglein 2 0.0157417
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0156523
LARP1B La ribonucleoprotein domain family, member 1B 0.0155188
POF1B premature ovarian failure, 1B 0.0151845
SMAD3 SMAD family member 3 0.01502
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0148924
CADPS2 Ca++-dependent secretion activator 2 0.0146086
GOLGA3 golgin A3 0.0144063
LAMB3 laminin, beta 3 0.0143439
CEMIP cell migration inducing protein, hyaluronan binding 0.0139371
MTAP methylthioadenosine phosphorylase 0.0138449
MPRIP myosin phosphatase Rho interacting protein 0.0138297
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.01378
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0137247
ANKLE2 ankyrin repeat and LEM domain containing 2 0.0132326
RPL14 ribosomal protein L14 0.0132309
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0131618
TMED3 transmembrane emp24 protein transport domain containing 3 0.0131557
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0129385
CUX1 cut-like homeobox 1 0.0128452
MYO5B myosin VB 0.0127254
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0126306
ASPH aspartate beta-hydroxylase 0.0125948
DMGDH dimethylglycine dehydrogenase 0.0123602
OSBPL8 oxysterol binding protein-like 8 0.0123138
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0122872
LGALS12 lectin, galactoside-binding, soluble, 12 0.0122233
RPS18 ribosomal protein S18 0.0121156
RPL6 ribosomal protein L6 0.0118748
NCOA7 nuclear receptor coactivator 7 0.0118648
FNIP1 folliculin interacting protein 1 0.0118375
HSPH1 heat shock 105kDa/110kDa protein 1 0.0116785
VCP valosin containing protein 0.0116729
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0116716
PDIA4 protein disulfide isomerase family A, member 4 0.0116482
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0115815
RSL1D1 ribosomal L1 domain containing 1 0.0114727
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.011427
SAMD4A sterile alpha motif domain containing 4A 0.0112764
IGF1R insulin-like growth factor 1 receptor 0.0112519
FBXL17 F-box and leucine-rich repeat protein 17 0.0112295
OSBPL10 oxysterol binding protein-like 10 0.0112237
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0112203
NABP1 nucleic acid binding protein 1 0.0110241
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0109017
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0108198
H1-0 H1.0 linker histone 0.0108094
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.0108032
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.01058
DMXL1 Dmx-like 1 0.0105715
BZW1 basic leucine zipper and W2 domains 1 0.0105091
EIF4A2 eukaryotic translation initiation factor 4A2 0.0104645
TRAPPC9 trafficking protein particle complex 9 0.010403
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0101918
CFAP44 cilia and flagella associated protein 44 0.0101102
RBBP6 retinoblastoma binding protein 6 0.0101083

decreased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.148947
TMSB10 thymosin beta 10 -0.145792
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.145604
RPLP1 ribosomal protein, large, P1 -0.139933
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.136747
RPS6 ribosomal protein S6 -0.134074
RPL35A ribosomal protein L35a -0.0989347
PTMA prothymosin, alpha -0.098198
RPS19 ribosomal protein S19 -0.0979733
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0913745
RPL23 ribosomal protein L23 -0.0772848
RPLP0 ribosomal protein, large, P0 -0.075741
RPLP2 ribosomal protein, large, P2 -0.0621172
CALB1 calbindin 1, 28kDa -0.0599324
RPL34 ribosomal protein L34 -0.0580653
PKM pyruvate kinase, muscle -0.0559039
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0557556
PCBP2 poly(rC) binding protein 2 -0.0521148
RPS14 ribosomal protein S14 -0.0515422
RPS23 ribosomal protein S23 -0.0476577
EEF2 eukaryotic translation elongation factor 2 -0.0473713
ITGA6 integrin, alpha 6 -0.0469581
RPS13 ribosomal protein S13 -0.045978
GOLGA4 golgin A4 -0.045901
RPL11 ribosomal protein L11 -0.044196
RPL31 ribosomal protein L31 -0.0418492
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0414646
RPS8 ribosomal protein S8 -0.0409657
ACTG1 actin gamma 1 -0.0404173
EGR1 early growth response 1 -0.0394482
RPS25 ribosomal protein S25 -0.0394245
CLDN4 claudin 4 -0.0392251
RPL27A ribosomal protein L27a -0.0389754
TXNRD1 thioredoxin reductase 1 -0.0386773
RPL36 ribosomal protein L36 -0.038418
RPS16 ribosomal protein S16 -0.0382521
RPL9 ribosomal protein L9 -0.0381603
RPS21 ribosomal protein S21 -0.0381076
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0373961
RPL12 ribosomal protein L12 -0.0365707
RNF145 ring finger protein 145 -0.0364305
PLAC8 placenta-specific 8 -0.0359354
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0354917
RPS17 ribosomal protein S17 -0.0354198
S100A10 S100 calcium binding protein A10 -0.0353009
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0350794
RPL28 ribosomal protein L28 -0.0347234
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0346956
UBE2H ubiquitin-conjugating enzyme E2H -0.0333612
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0331688
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0331686
GDF15 growth differentiation factor 15 -0.0328066
POTEF POTE ankyrin domain family, member F -0.032782
HMGA1 high mobility group AT-hook 1 -0.0327654
RPS11 ribosomal protein S11 -0.0327485
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0324014
RPS27 ribosomal protein S27 -0.0321372
RPL8 ribosomal protein L8 -0.032113
PDIA3 protein disulfide isomerase family A, member 3 -0.0315311
RPL5 ribosomal protein L5 -0.0310113
ITGB4 integrin, beta 4 -0.0308391
RPS5 ribosomal protein S5 -0.0308018
HLA-B major histocompatibility complex, class I, B -0.0303685
RPS29 ribosomal protein S29 -0.030277
RPS20 ribosomal protein S20 -0.0300788
RPL19 ribosomal protein L19 -0.030012
S100A6 S100 calcium binding protein A6 -0.0299389
ACTN4 actinin, alpha 4 -0.0294789
EZR ezrin -0.0290733
RPL35 ribosomal protein L35 -0.029002
SETD5 SET domain containing 5 -0.0288994
PTBP3 polypyrimidine tract binding protein 3 -0.0287581
RBM39 RNA binding motif protein 39 -0.0284293
RPL32 ribosomal protein L32 -0.0284155
RAP1B RAP1B, member of RAS oncogene family -0.0281406
RPS3 ribosomal protein S3 -0.0280394
EIF1 eukaryotic translation initiation factor 1 -0.0279284
TPT1 tumor protein, translationally-controlled 1 -0.0276979
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0276758
F3 coagulation factor III (thromboplastin, tissue factor) -0.0274492
PFN1 profilin 1 -0.0273501
KTN1 kinectin 1 (kinesin receptor) -0.0266947
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0265062
PRRC2C proline-rich coiled-coil 2C -0.0264674
CBX3 chromobox homolog 3 -0.0262904
PPARG peroxisome proliferator-activated receptor gamma -0.0261456
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0259597
RPL37 ribosomal protein L37 -0.0258951
RPL18 ribosomal protein L18 -0.0258114
C6ORF132 chromosome 6 open reading frame 132 -0.0257908
RPL21 ribosomal protein L21 -0.0255786
AKAP9 A kinase (PRKA) anchor protein 9 -0.0254015
MT2A metallothionein 2A -0.0253183
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0252209
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0249353
SMC4 structural maintenance of chromosomes 4 -0.0249075
RPL36A ribosomal protein L36a -0.0248626
MATR3 matrin 3 -0.0248569
PERP PERP, TP53 apoptosis effector -0.0247511
GARS1 glycyl-tRNA synthetase 1 -0.0247346