| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil (mesylate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.316798 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.293203 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0730006 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0727695 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0586783 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.057137 |
| EFNA5 | ephrin-A5 | 0.0552786 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0539494 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0530126 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0517544 |
| RNF213 | ring finger protein 213 | 0.0492142 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0483572 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0467798 |
| MYO1E | myosin IE | 0.0419179 |
| LMO7 | LIM domain 7 | 0.0416039 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0407465 |
| UBC | ubiquitin C | 0.0397661 |
| GRAMD1B | GRAM domain containing 1B | 0.0396117 |
| INTS6 | integrator complex subunit 6 | 0.0395884 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0392565 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0391728 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0387492 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0376452 |
| EGR1 | early growth response 1 | 0.0374883 |
| S100A10 | S100 calcium binding protein A10 | 0.0372292 |
| AHNAK | AHNAK nucleoprotein | 0.036868 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.036622 |
| ENO1 | enolase 1, (alpha) | 0.0364485 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0361296 |
| H1-0 | H1.0 linker histone | 0.0353094 |
| MT2A | metallothionein 2A | 0.034784 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0346606 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.034252 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0336751 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0336469 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0319543 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0315779 |
| STC1 | stanniocalcin 1 | 0.0305299 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0285039 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.028056 |
| SMYD3 | SET and MYND domain containing 3 | 0.0277679 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0273531 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0273086 |
| RPL4 | ribosomal protein L4 | 0.0268856 |
| MYOF | myoferlin | 0.026876 |
| SP100 | SP100 nuclear antigen | 0.0262052 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0258795 |
| RAD51B | RAD51 paralog B | 0.0251574 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0251243 |
| AREG | amphiregulin | 0.0247999 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0246629 |
| ANGPTL4 | angiopoietin-like 4 | 0.0246099 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0238228 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0237881 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0236028 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0234015 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0227283 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0224679 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0223012 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0222075 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0213923 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.021323 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0212736 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0210322 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0205169 |
| HOMER1 | homer scaffolding protein 1 | 0.0201917 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0197989 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0197434 |
| B2M | beta-2-microglobulin | 0.0196314 |
| FOXP1 | forkhead box P1 | 0.0196136 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0194479 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0193775 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0189628 |
| CMIP | c-Maf inducing protein | 0.0188952 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0186668 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.0184319 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0175175 |
| SCEL | sciellin | 0.0174639 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0170687 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.016983 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0168997 |
| MT1X | metallothionein 1X | 0.0168914 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0165531 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0164155 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0164052 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0162781 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0162034 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.016126 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0158565 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.015799 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0156022 |
| MYO1D | myosin ID | 0.0154804 |
| PTMA | prothymosin, alpha | 0.0153778 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0152481 |
| TMSB10 | thymosin beta 10 | 0.0151691 |
| CAV2 | caveolin 2 | 0.0151302 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0149295 |
| SIK3 | SIK family kinase 3 | 0.0148985 |
| SVIL | supervillin | 0.0148723 |
| MX1 | MX dynamin-like GTPase 1 | 0.0146394 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.173246 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.141184 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.12342 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.123402 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0722397 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0721787 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0674547 |
| NDRG1 | N-myc downstream regulated 1 | -0.0636098 |
| CES1 | carboxylesterase 1 | -0.0633022 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0627692 |
| SPAG9 | sperm associated antigen 9 | -0.0624701 |
| TMEM165 | transmembrane protein 165 | -0.0610948 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0602778 |
| TOP1 | topoisomerase (DNA) I | -0.0578832 |
| ASPH | aspartate beta-hydroxylase | -0.0557928 |
| RBM39 | RNA binding motif protein 39 | -0.054734 |
| USP34 | ubiquitin specific peptidase 34 | -0.0544769 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0539269 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0535273 |
| HYOU1 | hypoxia up-regulated 1 | -0.051731 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.051537 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0505123 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0500649 |
| CANX | calnexin | -0.0499205 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0492256 |
| S100P | S100 calcium binding protein P | -0.0480061 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0476471 |
| LAMC2 | laminin, gamma 2 | -0.0476219 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0469506 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0468704 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0468508 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0467364 |
| HDLBP | high density lipoprotein binding protein | -0.0461061 |
| PAPOLA | poly(A) polymerase alpha | -0.0459047 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0457611 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0456787 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0451484 |
| NGLY1 | N-glycanase 1 | -0.0448632 |
| FAM13A | family with sequence similarity 13, member A | -0.044408 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0439431 |
| OGA | O-GlcNAcase | -0.0432892 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.042067 |
| SUCO | SUN domain containing ossification factor | -0.0419207 |
| UVRAG | UV radiation resistance associated | -0.041733 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0411243 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0410484 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0406312 |
| RUNX1 | runt-related transcription factor 1 | -0.0405693 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | -0.0400254 |
| GOLGA4 | golgin A4 | -0.0399948 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0399237 |
| ARRDC3 | arrestin domain containing 3 | -0.0398762 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0396034 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0388578 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0387551 |
| WDR45B | WD repeat domain 45B | -0.0385948 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0385905 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0382459 |
| HELZ | helicase with zinc finger | -0.0371414 |
| TES | testin LIM domain protein | -0.0366989 |
| MATR3 | matrin 3 | -0.0363955 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0363846 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0361593 |
| PGK1 | phosphoglycerate kinase 1 | -0.0361447 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0357679 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0357353 |
| JMJD1C | jumonji domain containing 1C | -0.0356355 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0349763 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0348688 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0345651 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0343958 |
| NUP58 | nucleoporin 58 | -0.0342252 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0339923 |
| ARGLU1 | arginine and glutamate rich 1 | -0.0338008 |
| SRP54 | signal recognition particle 54kDa | -0.0336992 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0336985 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0334865 |
| SETD5 | SET domain containing 5 | -0.03327 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0330776 |
| MKI67 | marker of proliferation Ki-67 | -0.0329846 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0329436 |
| RTN4 | reticulon 4 | -0.0329244 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0328918 |
| ATP13A3 | ATPase type 13A3 | -0.0325991 |
| RPS3 | ribosomal protein S3 | -0.0321005 |
| NCKAP1 | NCK-associated protein 1 | -0.0318576 |
| NPTN | neuroplastin | -0.0318444 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0318306 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0315911 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.03117 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -0.0308964 |
| GIGYF2 | GRB10 interacting GYF protein 2 | -0.0307102 |
| CLTC | clathrin, heavy chain (Hc) | -0.0306404 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0306266 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0303232 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0300671 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | -0.0300567 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0299458 |
| PCBP2 | poly(rC) binding protein 2 | -0.0297071 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0297016 |
