Belumosudil (mesylate)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belumosudil (mesylate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belumosudil (mesylate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0404001
FNDC3B fibronectin type III domain containing 3B 0.0352416
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0345476
RPL4 ribosomal protein L4 0.031043
TRIO trio Rho guanine nucleotide exchange factor 0.030919
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0294956
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0287616
MACF1 microtubule-actin crosslinking factor 1 0.0282411
PM20D1 peptidase M20 domain containing 1 0.0281253
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.027673
FMNL2 formin-like 2 0.0264626
ZFAND3 zinc finger, AN1-type domain 3 0.0260852
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0257316
ZSWIM6 zinc finger, SWIM-type containing 6 0.0257184
UBC ubiquitin C 0.0256026
WAC WW domain containing adaptor with coiled-coil 0.0254836
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.024074
PTK2 protein tyrosine kinase 2 0.0236697
RICTOR RPTOR independent companion of MTOR, complex 2 0.0235232
PUM2 pumilio RNA-binding family member 2 0.0227001
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0223032
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0222013
SAMD4A sterile alpha motif domain containing 4A 0.020753
BIRC6 baculoviral IAP repeat containing 6 0.0206113
AHNAK AHNAK nucleoprotein 0.0199712
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0199365
KYNU kynureninase 0.0198161
DSCAM Down syndrome cell adhesion molecule 0.0193347
SMOC1 SPARC related modular calcium binding 1 0.0192728
RBM39 RNA binding motif protein 39 0.0192676
APP amyloid beta (A4) precursor protein 0.0189836
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0189045
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0184701
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0183029
PUM1 pumilio RNA-binding family member 1 0.0181939
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0175557
RNF145 ring finger protein 145 0.0174231
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0174158
RAB1A RAB1A, member RAS oncogene family 0.0173992
SDC4 syndecan 4 0.0173047
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.017264
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0168231
ELL2 elongation factor, RNA polymerase II, 2 0.0167936
RUNX1 runt-related transcription factor 1 0.0167417
TPD52 tumor protein D52 0.0164034
NOP58 NOP58 ribonucleoprotein 0.0162529
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0162527
SOD2 superoxide dismutase 2, mitochondrial 0.016111
CYTH1 cytohesin 1 0.0159448
KDM3A lysine (K)-specific demethylase 3A 0.0158567
NEK7 NIMA-related kinase 7 0.0155545
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0154547
SLMAP sarcolemma associated protein 0.0152799
SIK3 SIK family kinase 3 0.0148606
BHLHE40 basic helix-loop-helix family, member e40 0.0148454
NIPBL Nipped-B homolog (Drosophila) 0.0147322
RLF rearranged L-myc fusion 0.0146433
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0144065
AKAP13 A kinase (PRKA) anchor protein 13 0.0142767
PHF3 PHD finger protein 3 0.014156
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0141222
FAM107B family with sequence similarity 107, member B 0.014095
HELZ helicase with zinc finger 0.0140641
KIF13A kinesin family member 13A 0.0137926
CDC73 cell division cycle 73 0.0135962
TRA2A transformer 2 alpha homolog (Drosophila) 0.0135524
TOP1 topoisomerase (DNA) I 0.0134359
SVIL supervillin 0.0134254
COPA coatomer protein complex, subunit alpha 0.0133452
PARD3 par-3 family cell polarity regulator 0.0131752
YTHDC1 YTH domain containing 1 0.0130796
LPP LIM domain containing preferred translocation partner in lipoma 0.0130019
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0129287
ANO6 anoctamin 6 0.0128315
RSRC2 arginine/serine-rich coiled-coil 2 0.0128278
MYOF myoferlin 0.0128143
NCKAP1 NCK-associated protein 1 0.0128084
IFRD1 interferon-related developmental regulator 1 0.0127433
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0126152
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0124364
MT1X metallothionein 1X 0.0122967
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0120392
MED13 mediator complex subunit 13 0.0119523
RYK receptor-like tyrosine kinase 0.0119169
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0116321
PTPRM protein tyrosine phosphatase, receptor type, M 0.0115434
JMJD1C jumonji domain containing 1C 0.0115191
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0113874
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0113801
EXOC6B exocyst complex component 6B 0.0112924
CHD1 chromodomain helicase DNA binding protein 1 0.0112821
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0110874
ERBIN erbb2 interacting protein 0.0110768
NUP153 nucleoporin 153kDa 0.0110724
ANKHD1 ankyrin repeat and KH domain containing 1 0.0110306
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0110013
FBXL20 F-box and leucine-rich repeat protein 20 0.010999
ZNF292 zinc finger protein 292 0.0109747
PAPOLA poly(A) polymerase alpha 0.0109406
RBM6 RNA binding motif protein 6 0.0109276

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.156399
MT2A metallothionein 2A -0.149696
VIM vimentin -0.136091
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.122683
IGF2 insulin-like growth factor 2 -0.0727324
FTL ferritin, light polypeptide -0.0665242
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0657086
GRAMD1B GRAM domain containing 1B -0.0632367
ACTG1 actin gamma 1 -0.0512289
TXNRD1 thioredoxin reductase 1 -0.0458618
EGR1 early growth response 1 -0.0375865
TPM4 tropomyosin 4 -0.035346
POTEF POTE ankyrin domain family, member F -0.0351423
RPL35A ribosomal protein L35a -0.0350033
RPS21 ribosomal protein S21 -0.0341225
RPLP1 ribosomal protein, large, P1 -0.0338028
THSD4 thrombospondin, type I, domain containing 4 -0.0329901
S100A6 S100 calcium binding protein A6 -0.0328231
RPL23 ribosomal protein L23 -0.0326757
PTMA prothymosin, alpha -0.0299376
RPS29 ribosomal protein S29 -0.029799
EIF1 eukaryotic translation initiation factor 1 -0.029623
HMGA1 high mobility group AT-hook 1 -0.0289008
TFPI2 tissue factor pathway inhibitor 2 -0.0287015
TPT1 tumor protein, translationally-controlled 1 -0.0286494
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0281912
MCL1 myeloid cell leukemia 1 -0.0278577
PFN1 profilin 1 -0.0276017
RPS19 ribosomal protein S19 -0.0265659
RPL37A ribosomal protein L37a -0.0261573
RPL36 ribosomal protein L36 -0.0254798
TM4SF1 transmembrane 4 L six family member 1 -0.0246879
PKM pyruvate kinase, muscle -0.0244667
LDHA lactate dehydrogenase A -0.0242577
RPL19 ribosomal protein L19 -0.0241629
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0240651
TOP2A topoisomerase (DNA) II alpha 170kDa -0.023715
RPL31 ribosomal protein L31 -0.0227329
S100A11 S100 calcium binding protein A11 -0.0215165
SLC38A2 solute carrier family 38, member 2 -0.0212659
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0212204
IGFBP4 insulin-like growth factor binding protein 4 -0.0204349
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0204022
RPS23 ribosomal protein S23 -0.0196164
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0187098
RPL7 ribosomal protein L7 -0.0185127
RPL11 ribosomal protein L11 -0.018389
RPL9 ribosomal protein L9 -0.0182695
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0181454
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0179278
TPI1 triosephosphate isomerase 1 -0.0178756
C15ORF48 chromosome 15 open reading frame 48 -0.0178462
CMIP c-Maf inducing protein -0.0174487
MAP1B microtubule-associated protein 1B -0.016989
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0166515
KPNB1 karyopherin (importin) beta 1 -0.0162612
RPS27A ribosomal protein S27a -0.016157
RPS25 ribosomal protein S25 -0.0158953
RPS12 ribosomal protein S12 -0.0157506
SERF2 small EDRK-rich factor 2 -0.0152873
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0152241
EEF2 eukaryotic translation elongation factor 2 -0.0152143
PRDX1 peroxiredoxin 1 -0.0151504
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0151051
IL6 interleukin 6 -0.0148637
LGALS1 lectin, galactoside-binding, soluble, 1 -0.014711
TAGLN2 transgelin 2 -0.0146105
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0144946
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0143731
PYGL phosphorylase, glycogen, liver -0.0143543
RPL37 ribosomal protein L37 -0.0142845
RPS14 ribosomal protein S14 -0.0142556
RPS17 ribosomal protein S17 -0.0141838
RPLP2 ribosomal protein, large, P2 -0.0140883
STC2 stanniocalcin 2 -0.0138299
LOC112694756 uncharaterized LOC112694756 -0.0136797
RAD51B RAD51 paralog B -0.0135812
BICC1 BicC family RNA binding protein 1 -0.0135577
ATP5F1E ATP synthase F1 subunit epsilon -0.0135059
RPS3 ribosomal protein S3 -0.0135047
ATP5F1B ATP synthase F1 subunit beta -0.0133331
FTH1 ferritin, heavy polypeptide 1 -0.0132551
RPS24 ribosomal protein S24 -0.0132417
MYL12B myosin, light chain 12B, regulatory -0.0131915
RPS15 ribosomal protein S15 -0.0131383
ACTN1 actinin, alpha 1 -0.0131352
RPS11 ribosomal protein S11 -0.013116
DEK DEK proto-oncogene -0.0130557
RAN RAN, member RAS oncogene family -0.0130078
CBX3 chromobox homolog 3 -0.0129936
RPL8 ribosomal protein L8 -0.0129914
CENPF centromere protein F, 350/400kDa -0.0129516
TUBB tubulin, beta class I -0.0128548
RACK1 receptor for activated C kinase 1 -0.0127765
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0127415
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0124814
RPL36A ribosomal protein L36a -0.0124265
NNMT nicotinamide N-methyltransferase -0.01235
SRGN serglycin -0.0123088
PFDN2 prefoldin subunit 2 -0.0122678