| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Belumosudil (mesylate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0964436 |
| IGF1R | insulin-like growth factor 1 receptor | 0.078227 |
| MYOF | myoferlin | 0.0745532 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0699584 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0688831 |
| EGFR | epidermal growth factor receptor | 0.0623007 |
| HDAC9 | histone deacetylase 9 | 0.060927 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0599036 |
| EZR | ezrin | 0.0546923 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0517841 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0495558 |
| RPL4 | ribosomal protein L4 | 0.04912 |
| PDE10A | phosphodiesterase 10A | 0.048981 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0487081 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0478056 |
| NAV1 | neuron navigator 1 | 0.0471977 |
| PARD3 | par-3 family cell polarity regulator | 0.0454731 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0454074 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0452475 |
| ZNF217 | zinc finger protein 217 | 0.0450525 |
| SLC12A6 | solute carrier family 12 (potassium/chloride transporter), member 6 | 0.0449807 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0448817 |
| CAB39 | calcium binding protein 39 | 0.0448696 |
| MYO1E | myosin IE | 0.043513 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0433372 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0431257 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0424185 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0423252 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0415841 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0414915 |
| ATXN1 | ataxin 1 | 0.0406276 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.0404414 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.039995 |
| LMO7 | LIM domain 7 | 0.0390194 |
| DST | dystonin | 0.03885 |
| CMIP | c-Maf inducing protein | 0.0384538 |
| PHIP | pleckstrin homology domain interacting protein | 0.0383377 |
| LAMC2 | laminin, gamma 2 | 0.0381509 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | 0.03775 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0377165 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0377119 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0373766 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0371529 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0370493 |
| GLG1 | golgi glycoprotein 1 | 0.0369077 |
| ATG5 | autophagy related 5 | 0.0368847 |
| AHNAK | AHNAK nucleoprotein | 0.036602 |
| ATOSA | atos homolog A | 0.0365312 |
| ZNF292 | zinc finger protein 292 | 0.0360317 |
| KIAA1217 | KIAA1217 | 0.0357341 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0354246 |
| DIAPH1 | diaphanous-related formin 1 | 0.0354069 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0352454 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0351881 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0350806 |
| ZNF638 | zinc finger protein 638 | 0.0348797 |
| RNF213 | ring finger protein 213 | 0.0348731 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.034447 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0340859 |
| STK4 | serine/threonine kinase 4 | 0.0338691 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 0.0338572 |
| RTN4 | reticulon 4 | 0.0336271 |
| SLMAP | sarcolemma associated protein | 0.0332329 |
| ERBIN | erbb2 interacting protein | 0.0329111 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0328999 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0328586 |
| VEGFA | vascular endothelial growth factor A | 0.0319782 |
| YTHDC1 | YTH domain containing 1 | 0.0317957 |
| PATJ | PATJ crumbs cell polarity complex component | 0.031754 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0316393 |
| OXSR1 | oxidative stress responsive 1 | 0.0314487 |
| TJP1 | tight junction protein 1 | 0.0313538 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.03118 |
| CTBP2 | C-terminal binding protein 2 | 0.0310541 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0308386 |
| NEBL | nebulette | 0.0305402 |
| PRKCA | protein kinase C, alpha | 0.0304202 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0302408 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0297833 |
| RSF1 | remodeling and spacing factor 1 | 0.0296521 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0295971 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0293778 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0292677 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0288037 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0288001 |
| WDR26 | WD repeat domain 26 | 0.0284618 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0283008 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0282893 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0280911 |
| ANO6 | anoctamin 6 | 0.0280017 |
| CDK13 | cyclin-dependent kinase 13 | 0.027765 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0277233 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0271419 |
| PDE8A | phosphodiesterase 8A | 0.0271325 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.027084 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0267003 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0265194 |
| FOXO1 | forkhead box O1 | 0.0262687 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0261406 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0260568 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.151384 |
| FTL | ferritin, light polypeptide | -0.122854 |
| TMSB10 | thymosin beta 10 | -0.113502 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.1073 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.100976 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0953533 |
| PTMA | prothymosin, alpha | -0.0949831 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0948061 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0939712 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0920411 |
| KRT17 | keratin 17, type I | -0.0898547 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0869493 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0747215 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0737897 |
| NPTN | neuroplastin | -0.0736985 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0718125 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0693554 |
| B2M | beta-2-microglobulin | -0.0678037 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0671932 |
| SRPK2 | SRSF protein kinase 2 | -0.064561 |
| RPL35A | ribosomal protein L35a | -0.0641292 |
| ASPH | aspartate beta-hydroxylase | -0.0616211 |
| DICER1 | dicer 1, ribonuclease type III | -0.0600417 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0595469 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.057533 |
| RPS19 | ribosomal protein S19 | -0.0563059 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.053641 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0535465 |
| H3-3B | H3.3 histone B | -0.0533354 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0508554 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0502684 |
| CSTB | cystatin B (stefin B) | -0.0499185 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0498894 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0498001 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0492222 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0491115 |
| ACVR1 | activin A receptor, type I | -0.0486663 |
| VIM | vimentin | -0.0484077 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0477457 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0465186 |
| OGA | O-GlcNAcase | -0.0458916 |
| RAB8B | RAB8B, member RAS oncogene family | -0.043925 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0438642 |
| MXD1 | MAX dimerization protein 1 | -0.0436497 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0434773 |
| GOLGA4 | golgin A4 | -0.0428583 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.04196 |
| AFAP1 | actin filament associated protein 1 | -0.0408774 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | -0.0408582 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0406509 |
| WASF2 | WAS protein family, member 2 | -0.0399686 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0393106 |
| RPL31 | ribosomal protein L31 | -0.0389786 |
| CLTC | clathrin, heavy chain (Hc) | -0.0388411 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0386321 |
| TXNRD1 | thioredoxin reductase 1 | -0.0382702 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0380994 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0379773 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0375247 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0372006 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0369407 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0367977 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0364793 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.036234 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.036071 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0359532 |
| S100A6 | S100 calcium binding protein A6 | -0.035321 |
| S100A9 | S100 calcium binding protein A9 | -0.0349877 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0349552 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0342941 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0339449 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0336115 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0331751 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.032865 |
| CANX | calnexin | -0.0327728 |
| UBC | ubiquitin C | -0.0325249 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0319114 |
| PCBP2 | poly(rC) binding protein 2 | -0.0311957 |
| CDK6 | cyclin-dependent kinase 6 | -0.030918 |
| MTDH | metadherin | -0.0308205 |
| RPLP2 | ribosomal protein, large, P2 | -0.0308169 |
| NPAS2 | neuronal PAS domain protein 2 | -0.030713 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.030647 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0302638 |
| PKM | pyruvate kinase, muscle | -0.0301871 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.030178 |
| RPS29 | ribosomal protein S29 | -0.0296718 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0294853 |
| CD2AP | CD2-associated protein | -0.0292978 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0290487 |
| RNF149 | ring finger protein 149 | -0.0281455 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0280998 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0279189 |
| RPL7A | ribosomal protein L7a | -0.0275731 |
| SDCBP | syndecan binding protein (syntenin) | -0.0275175 |
| DENND4C | DENN/MADD domain containing 4C | -0.0272711 |
| GNAS | GNAS complex locus | -0.0267829 |
| RPL23 | ribosomal protein L23 | -0.0264779 |
| RPL12 | ribosomal protein L12 | -0.0261351 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0260291 |
