| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil (mesylate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.291438 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0988535 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0985857 |
| OSMR | oncostatin M receptor | 0.0895326 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.076283 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.072609 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0711302 |
| PDE10A | phosphodiesterase 10A | 0.0702926 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0684387 |
| VCL | vinculin | 0.0646882 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0588751 |
| MCL1 | myeloid cell leukemia 1 | 0.0574062 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0533634 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0512864 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0510907 |
| RPL4 | ribosomal protein L4 | 0.0467513 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0456891 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0448186 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0445648 |
| HMGA2 | high mobility group AT-hook 2 | 0.043701 |
| VMP1 | vacuole membrane protein 1 | 0.0436545 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0432966 |
| EGR1 | early growth response 1 | 0.0427024 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0421781 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0407361 |
| YBX3 | Y box binding protein 3 | 0.0405862 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0402364 |
| INTS6 | integrator complex subunit 6 | 0.0391422 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0388263 |
| AHNAK | AHNAK nucleoprotein | 0.0387721 |
| FMNL2 | formin-like 2 | 0.0383944 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0382301 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0381459 |
| AEBP2 | AE binding protein 2 | 0.0369819 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0367399 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0362638 |
| PDLIM5 | PDZ and LIM domain 5 | 0.035524 |
| ATXN1 | ataxin 1 | 0.0351213 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0350504 |
| RNF213 | ring finger protein 213 | 0.0343149 |
| WWOX | WW domain containing oxidoreductase | 0.0341778 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0338143 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0325715 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0321468 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0321308 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0319998 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0319922 |
| H1-0 | H1.0 linker histone | 0.0319695 |
| UBC | ubiquitin C | 0.0316157 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0312581 |
| SMAD3 | SMAD family member 3 | 0.0312497 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0303767 |
| ATP11A | ATPase, class VI, type 11A | 0.0302534 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0302459 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0292855 |
| STC1 | stanniocalcin 1 | 0.0290687 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0287452 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0282027 |
| ATG7 | autophagy related 7 | 0.0281905 |
| VCP | valosin containing protein | 0.0276008 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0273984 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0263982 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0259673 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0256014 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0255041 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0254073 |
| GRAMD1B | GRAM domain containing 1B | 0.0251908 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0250579 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0248154 |
| ACTG1 | actin gamma 1 | 0.0245114 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0240913 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0240294 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0237518 |
| HDAC4 | histone deacetylase 4 | 0.0233925 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0233467 |
| HOMER1 | homer scaffolding protein 1 | 0.022537 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0224647 |
| SVIL | supervillin | 0.0222111 |
| BMP5 | bone morphogenetic protein 5 | 0.0219346 |
| EXOC4 | exocyst complex component 4 | 0.0219132 |
| DENND5B | DENN/MADD domain containing 5B | 0.0218349 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0217488 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.0216343 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0214944 |
| TPM4 | tropomyosin 4 | 0.0211944 |
| DIAPH2 | diaphanous-related formin 2 | 0.0210571 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0210527 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0209199 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0205236 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | 0.0203788 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0202151 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0200959 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0200486 |
| JUN | jun proto-oncogene | 0.0200206 |
| NEK10 | NIMA-related kinase 10 | 0.0192148 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | 0.0191615 |
| PLSCR1 | phospholipid scramblase 1 | 0.0188672 |
| MAP7 | microtubule-associated protein 7 | 0.0185758 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0183928 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0182964 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | -0.226806 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0935347 |
| TXNRD1 | thioredoxin reductase 1 | -0.0852036 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0765211 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0711792 |
| XPO1 | exportin 1 | -0.0700808 |
| RTN4 | reticulon 4 | -0.0699386 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0646186 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0635604 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0605849 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.057043 |
| PHIP | pleckstrin homology domain interacting protein | -0.0562277 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0561216 |
| BBX | bobby sox homolog (Drosophila) | -0.0551024 |
| TPI1 | triosephosphate isomerase 1 | -0.0539563 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0515697 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0513673 |
| GOLGA4 | golgin A4 | -0.0506043 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0483974 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0476292 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0468145 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0462361 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0461209 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0452375 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0450256 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0443063 |
| PTMA | prothymosin, alpha | -0.0431108 |
| KIF5B | kinesin family member 5B | -0.043093 |
| RPL37A | ribosomal protein L37a | -0.0425128 |
| PCBP2 | poly(rC) binding protein 2 | -0.0421606 |
| OGA | O-GlcNAcase | -0.0419835 |
| RPS12 | ribosomal protein S12 | -0.0416884 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0406096 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0404255 |
| MKI67 | marker of proliferation Ki-67 | -0.0404236 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0400298 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0400279 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0393447 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.038618 |
| ZNF292 | zinc finger protein 292 | -0.0386065 |
| RPS29 | ribosomal protein S29 | -0.0385491 |
| PPME1 | protein phosphatase methylesterase 1 | -0.0384153 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0375858 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0365611 |
| RPL12 | ribosomal protein L12 | -0.036388 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0357708 |
| CEP192 | centrosomal protein 192kDa | -0.0357412 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0356038 |
| CLTC | clathrin, heavy chain (Hc) | -0.0354135 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0353998 |
| PCNX1 | pecanex 1 | -0.0352553 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0348733 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0334963 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0334414 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0334062 |
| CENPF | centromere protein F, 350/400kDa | -0.0332616 |
| SEPTIN7 | septin 7 | -0.0330756 |
| TMSB10 | thymosin beta 10 | -0.0325252 |
| SRPK1 | SRSF protein kinase 1 | -0.0324503 |
| RPL26 | ribosomal protein L26 | -0.0322906 |
| RPS3 | ribosomal protein S3 | -0.0322657 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.031338 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0312354 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0309723 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0308886 |
| RPS2 | ribosomal protein S2 | -0.0307771 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0303518 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0303395 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -0.0300376 |
| SET | SET nuclear proto-oncogene | -0.0296283 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0296242 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0295932 |
| WDR45B | WD repeat domain 45B | -0.0294595 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0290556 |
| ZFR | zinc finger RNA binding protein | -0.0289589 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.0289026 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0288585 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0285896 |
| CANX | calnexin | -0.0284959 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0282786 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0281955 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.028114 |
| PCM1 | pericentriolar material 1 | -0.0281096 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0277855 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0277766 |
| SRPK2 | SRSF protein kinase 2 | -0.0276724 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0276353 |
| RPL38 | ribosomal protein L38 | -0.0275595 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0274681 |
| CCND2 | cyclin D2 | -0.0273467 |
| RPS27A | ribosomal protein S27a | -0.0270545 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0270226 |
| PFDN2 | prefoldin subunit 2 | -0.0269739 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0269165 |
| DENR | density-regulated protein | -0.0268588 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.02682 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0267203 |
| CTTNBP2NL | CTTNBP2 N-terminal like | -0.0266432 |
| RECQL | RecQ helicase-like | -0.0265227 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0264783 |
