Belumosudil (mesylate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belumosudil (mesylate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belumosudil (mesylate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.078349
UBC ubiquitin C 0.0420212
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0418897
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0418056
FAM13A family with sequence similarity 13, member A 0.0310043
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0290167
SDC4 syndecan 4 0.0277986
DSPP dentin sialophosphoprotein 0.0259745
RPL4 ribosomal protein L4 0.0254295
TPM3 tropomyosin 3 0.0254059
MAP1B microtubule-associated protein 1B 0.025359
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0245751
IGFBP3 insulin-like growth factor binding protein 3 0.0242139
ADAM9 ADAM metallopeptidase domain 9 0.0229703
UBA6 ubiquitin-like modifier activating enzyme 6 0.0222603
FTH1 ferritin, heavy polypeptide 1 0.0215761
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0213053
ELL2 elongation factor, RNA polymerase II, 2 0.020933
H1-0 H1.0 linker histone 0.0202257
MSN moesin 0.0197361
TSC22D2 TSC22 domain family, member 2 0.0193923
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0193562
MYO5B myosin VB 0.0192583
AHNAK AHNAK nucleoprotein 0.0190617
GRB10 growth factor receptor-bound protein 10 0.0184077
TMF1 TATA element modulatory factor 1 0.0169337
DTNA dystrobrevin, alpha 0.0167982
FNDC3B fibronectin type III domain containing 3B 0.0164656
ARRDC3 arrestin domain containing 3 0.0162007
DSG2 desmoglein 2 0.0158976
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0155901
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0155328
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.014532
ERRFI1 ERBB receptor feedback inhibitor 1 0.0134917
YTHDC1 YTH domain containing 1 0.0134602
MEF2A myocyte enhancer factor 2A 0.0130665
MYO10 myosin X 0.0127848
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0127132
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0122867
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0122583
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.012124
MACC1 metastasis associated in colon cancer 1 0.0117345
ANXA1 annexin A1 0.0116769
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.011574
TXNIP thioredoxin interacting protein 0.0115581
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0114683
FXR1 fragile X mental retardation, autosomal homolog 1 0.011372
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0113196
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0108891
HMGN2 high mobility group nucleosomal binding domain 2 0.0108106
USP3 ubiquitin specific peptidase 3 0.0107901
CCNL1 cyclin L1 0.0106381
PDIA4 protein disulfide isomerase family A, member 4 0.0102481
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0100213
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.00997422
NDRG1 N-myc downstream regulated 1 0.00995868
TRIO trio Rho guanine nucleotide exchange factor 0.00986598
SRRM1 serine/arginine repetitive matrix 1 0.00986487
IRF6 interferon regulatory factor 6 0.00970868
SGMS2 sphingomyelin synthase 2 0.00965501
GARS1 glycyl-tRNA synthetase 1 0.00965444
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.00960836
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00930344
VGLL3 vestigial-like family member 3 0.00924999
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.00922727
RYBP RING1 and YY1 binding protein 0.00922395
CANX calnexin 0.00921891
SNX9 sorting nexin 9 0.00920049
DUSP10 dual specificity phosphatase 10 0.00918822
MCTP2 multiple C2 domains, transmembrane 2 0.00900636
PDIA3 protein disulfide isomerase family A, member 3 0.00899117
RAP2B RAP2B, member of RAS oncogene family 0.00896667
RTN4 reticulon 4 0.00879646
RAD23B RAD23 homolog B (S. cerevisiae) 0.00877517
ANO6 anoctamin 6 0.00865312
ARL5B ADP-ribosylation factor-like 5B 0.00851442
ATP13A3 ATPase type 13A3 0.00850022
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.00844203
LNPEP leucyl/cystinyl aminopeptidase 0.00841503
IL6ST interleukin 6 signal transducer 0.00838482
MIER1 mesoderm induction early response 1, transcriptional regulator 0.00837931
FHIT fragile histidine triad 0.00825436
APLP2 amyloid beta (A4) precursor-like protein 2 0.00824216
WDR36 WD repeat domain 36 0.00819109
RBM33 RNA binding motif protein 33 0.00812277
ZNF292 zinc finger protein 292 0.00811436
RNF145 ring finger protein 145 0.00811195
NAMPT nicotinamide phosphoribosyltransferase 0.00810146
RIOK3 RIO kinase 3 0.00806251
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.00797139
FNBP1L formin binding protein 1-like 0.00794782
ANKRD28 ankyrin repeat domain 28 0.00792765
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.00790198
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0078038
STEAP4 STEAP family member 4 0.00776689
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.00771036
KDM1A lysine (K)-specific demethylase 1A 0.00767841
COPA coatomer protein complex, subunit alpha 0.00766515
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.00745582
PCM1 pericentriolar material 1 0.00743233

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.261826
FTL ferritin, light polypeptide -0.201802
TMSB10 thymosin beta 10 -0.160303
RPL35A ribosomal protein L35a -0.141721
ACTG1 actin gamma 1 -0.134814
TPT1 tumor protein, translationally-controlled 1 -0.112705
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.108466
RPLP1 ribosomal protein, large, P1 -0.0749588
RPS29 ribosomal protein S29 -0.0658648
RPL34 ribosomal protein L34 -0.0641768
EIF1 eukaryotic translation initiation factor 1 -0.0561293
RPL23 ribosomal protein L23 -0.0551022
ISG15 ISG15 ubiquitin-like modifier -0.0548252
RPLP2 ribosomal protein, large, P2 -0.0536359
HLA-B major histocompatibility complex, class I, B -0.0524879
RPS13 ribosomal protein S13 -0.0522877
RPL31 ribosomal protein L31 -0.0517949
S100A6 S100 calcium binding protein A6 -0.0515427
S100A10 S100 calcium binding protein A10 -0.0513561
RPS23 ribosomal protein S23 -0.0488479
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0442012
RPS24 ribosomal protein S24 -0.043794
EXT1 exostosin glycosyltransferase 1 -0.0429483
RPL9 ribosomal protein L9 -0.04216
RPS8 ribosomal protein S8 -0.0419906
RPS25 ribosomal protein S25 -0.0416126
LIMCH1 LIM and calponin homology domains 1 -0.0410814
IFI27 interferon, alpha-inducible protein 27 -0.0410211
POTEF POTE ankyrin domain family, member F -0.0386222
HLA-A major histocompatibility complex, class I, A -0.0380981
RPS19 ribosomal protein S19 -0.0377131
ASPH aspartate beta-hydroxylase -0.037376
RPL37A ribosomal protein L37a -0.0369184
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0361852
WSB1 WD repeat and SOCS box containing 1 -0.0359551
RPL38 ribosomal protein L38 -0.0359039
IFI6 interferon, alpha-inducible protein 6 -0.0354427
SLC38A1 solute carrier family 38, member 1 -0.0353047
LPP LIM domain containing preferred translocation partner in lipoma -0.035205
TM4SF1 transmembrane 4 L six family member 1 -0.0351372
KPNB1 karyopherin (importin) beta 1 -0.0346729
VIM vimentin -0.0342124
IFITM3 interferon induced transmembrane protein 3 -0.0341203
TPM4 tropomyosin 4 -0.0341188
VCL vinculin -0.0335316
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0332982
IFITM1 interferon induced transmembrane protein 1 -0.0332487
RPL11 ribosomal protein L11 -0.0330452
RPS3 ribosomal protein S3 -0.0329197
CD63 CD63 molecule -0.0327023
C15ORF48 chromosome 15 open reading frame 48 -0.0321745
S100A9 S100 calcium binding protein A9 -0.0319293
RPS16 ribosomal protein S16 -0.0315627
RPL27A ribosomal protein L27a -0.031539
RPL36A ribosomal protein L36a -0.0309494
PKM pyruvate kinase, muscle -0.030916
RPL37 ribosomal protein L37 -0.0308121
RPS14 ribosomal protein S14 -0.0304609
RPL15 ribosomal protein L15 -0.0303932
RPS27A ribosomal protein S27a -0.029952
ENO2 enolase 2 (gamma, neuronal) -0.0299046
CAVIN1 caveolae associated protein 1 -0.0295153
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0289214
GNAS GNAS complex locus -0.0288245
RPS10 ribosomal protein S10 -0.0280902
CCND1 cyclin D1 -0.0280367
RPS21 ribosomal protein S21 -0.0279746
FBXO32 F-box protein 32 -0.0278811
LMNA lamin A/C -0.0276539
RPL8 ribosomal protein L8 -0.027616
SACK1A scaffolding CK1 anchoring protein A -0.0275433
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0275158
RPL28 ribosomal protein L28 -0.0272375
HLA-E major histocompatibility complex, class I, E -0.0272024
LAMB3 laminin, beta 3 -0.0263977
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0261955
RPL7A ribosomal protein L7a -0.0260547
RPS27 ribosomal protein S27 -0.0260021
ANXA2 annexin A2 -0.0259346
PGK1 phosphoglycerate kinase 1 -0.0258874
HSPB1 heat shock 27kDa protein 1 -0.0255073
RPS17 ribosomal protein S17 -0.0252612
ALCAM activated leukocyte cell adhesion molecule -0.024743
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0244795
TMSB4X thymosin beta 4, X-linked -0.0243694
RACK1 receptor for activated C kinase 1 -0.0235544
EPCAM epithelial cell adhesion molecule -0.0233714
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.023256
KRT7 keratin 7, type II -0.0229742
MCL1 myeloid cell leukemia 1 -0.0228727
MYO1E myosin IE -0.0227635
ARID4B AT rich interactive domain 4B (RBP1-like) -0.022253
RBM47 RNA binding motif protein 47 -0.0221199
CALR calreticulin -0.0221117
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0220025
RPL19 ribosomal protein L19 -0.0219684
WASF2 WAS protein family, member 2 -0.0218116
IFIH1 interferon induced with helicase C domain 1 -0.0217666
NPC2 Niemann-Pick disease, type C2 -0.0213951
CTSB cathepsin B -0.021139