| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil (mesylate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.116746 |
| GRAMD1B | GRAM domain containing 1B | 0.0683182 |
| MYOF | myoferlin | 0.0681582 |
| TXNRD1 | thioredoxin reductase 1 | 0.0672935 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0670256 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0620851 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0606468 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0605164 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0566313 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0564158 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0481064 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0466391 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0431009 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0406255 |
| CENPF | centromere protein F, 350/400kDa | 0.0402446 |
| EZR | ezrin | 0.0402309 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0401179 |
| MT2A | metallothionein 2A | 0.0369407 |
| EFNA5 | ephrin-A5 | 0.0344857 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0329953 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0326233 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0317322 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0312175 |
| FLNB | filamin B, beta | 0.0306183 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0299762 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0295895 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0295739 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0294353 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0288174 |
| PM20D1 | peptidase M20 domain containing 1 | 0.028802 |
| RGS2 | regulator of G-protein signaling 2 | 0.0268101 |
| MKI67 | marker of proliferation Ki-67 | 0.0263188 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0240571 |
| PTGR1 | prostaglandin reductase 1 | 0.0238003 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0237938 |
| FAM13A | family with sequence similarity 13, member A | 0.0237316 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0234055 |
| YBX3 | Y box binding protein 3 | 0.0231468 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.022922 |
| MT1X | metallothionein 1X | 0.0228215 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0225371 |
| PRDX1 | peroxiredoxin 1 | 0.022376 |
| INHBA | inhibin, beta A | 0.0223751 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0219886 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0218644 |
| KYNU | kynureninase | 0.021681 |
| ANXA1 | annexin A1 | 0.0213598 |
| ZNF292 | zinc finger protein 292 | 0.0208979 |
| AHNAK | AHNAK nucleoprotein | 0.0205595 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.0202545 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0200554 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0199642 |
| TPM3 | tropomyosin 3 | 0.0198316 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0194597 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0193542 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0191186 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0187118 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0182983 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0182557 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0182317 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0180921 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0174344 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0173251 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0172755 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0172289 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0171636 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0170336 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0170227 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0169788 |
| CCDC88A | coiled-coil domain containing 88A | 0.0169133 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0166398 |
| RPL4 | ribosomal protein L4 | 0.016565 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0165201 |
| SGO2 | shugoshin 2 | 0.0165166 |
| RNF145 | ring finger protein 145 | 0.0164271 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0163667 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.016346 |
| RAI1 | retinoic acid induced 1 | 0.0162519 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0162123 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0161115 |
| RNF24 | ring finger protein 24 | 0.0159675 |
| XPO1 | exportin 1 | 0.0159479 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0159198 |
| MATR3 | matrin 3 | 0.0159097 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.015895 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0158742 |
| HELZ | helicase with zinc finger | 0.0153425 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0153371 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0153367 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0150685 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0150554 |
| RPS4X | ribosomal protein S4, X-linked | 0.0150332 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0149306 |
| PYGL | phosphorylase, glycogen, liver | 0.014875 |
| DISP1 | dispatched homolog 1 (Drosophila) | 0.0146976 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0146835 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0146157 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0145725 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0145318 |
| MALT1 | MALT1 paracaspase | 0.0143898 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH13 | cadherin 13 | -0.0871291 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0843431 |
| RPL37A | ribosomal protein L37a | -0.0770807 |
| FN1 | fibronectin 1 | -0.0731673 |
| RPS12 | ribosomal protein S12 | -0.0667944 |
| RPL31 | ribosomal protein L31 | -0.0594287 |
| DST | dystonin | -0.0521143 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0516347 |
| COL5A2 | collagen, type V, alpha 2 | -0.0490106 |
| VCL | vinculin | -0.0481691 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0478722 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0467498 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0445134 |
| RPS23 | ribosomal protein S23 | -0.044055 |
| VIM | vimentin | -0.0438674 |
| RPL9 | ribosomal protein L9 | -0.0425619 |
| RPS29 | ribosomal protein S29 | -0.0417201 |
| RPS3 | ribosomal protein S3 | -0.0408442 |
| HLA-B | major histocompatibility complex, class I, B | -0.039144 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0386592 |
| RPS27A | ribosomal protein S27a | -0.0386095 |
| RPL35A | ribosomal protein L35a | -0.0385479 |
| RPS6 | ribosomal protein S6 | -0.0376743 |
| MCL1 | myeloid cell leukemia 1 | -0.0367603 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0355516 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0354224 |
| RPS27 | ribosomal protein S27 | -0.0317957 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0315253 |
| RPS13 | ribosomal protein S13 | -0.0314142 |
| RPL38 | ribosomal protein L38 | -0.0303243 |
| RPL26 | ribosomal protein L26 | -0.0299759 |
| RPS25 | ribosomal protein S25 | -0.0294193 |
| RPL36A | ribosomal protein L36a | -0.0294076 |
| RPS19 | ribosomal protein S19 | -0.0288157 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0282561 |
| RPS8 | ribosomal protein S8 | -0.028102 |
| RPS17 | ribosomal protein S17 | -0.0278836 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0277677 |
| HLA-A | major histocompatibility complex, class I, A | -0.0272197 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0266663 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0264339 |
| RPLP2 | ribosomal protein, large, P2 | -0.0255807 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0253787 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.025348 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0251296 |
| INTS6 | integrator complex subunit 6 | -0.0247572 |
| NIBAN1 | niban apoptosis regulator 1 | -0.0246147 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0238818 |
| RPL11 | ribosomal protein L11 | -0.0232662 |
| RPS10 | ribosomal protein S10 | -0.0232392 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0230651 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0227126 |
| RPL37 | ribosomal protein L37 | -0.0224573 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0218634 |
| SMYD3 | SET and MYND domain containing 3 | -0.0215337 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0214871 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0214654 |
| RTN1 | reticulon 1 | -0.0214472 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0212323 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0205668 |
| RPS11 | ribosomal protein S11 | -0.0205619 |
| AEBP2 | AE binding protein 2 | -0.0201349 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0197397 |
| RPS14 | ribosomal protein S14 | -0.0192729 |
| RPS24 | ribosomal protein S24 | -0.0192324 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.019184 |
| GDA | guanine deaminase | -0.0187997 |
| RPLP1 | ribosomal protein, large, P1 | -0.0187014 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0186972 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0186266 |
| MYPN | myopalladin | -0.018467 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0180309 |
| STEAP1B | STEAP family member 1B | -0.0180016 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0179969 |
| NTN4 | netrin 4 | -0.0176701 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0173297 |
| COL4A6 | collagen, type IV, alpha 6 | -0.017214 |
| RPL7A | ribosomal protein L7a | -0.0169657 |
| RPL36 | ribosomal protein L36 | -0.0169386 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0168309 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0164808 |
| CREB5 | cAMP responsive element binding protein 5 | -0.016472 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0163997 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0160148 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0158598 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0154394 |
| RAD51B | RAD51 paralog B | -0.0153253 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0150974 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0150927 |
| TPM4 | tropomyosin 4 | -0.0150468 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.014871 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0148059 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0147775 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0145865 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0145305 |
| PCNX4 | pecanex 4 | -0.0145194 |
| SFTPA2 | surfactant protein A2 | -0.0143697 |
| CUX1 | cut-like homeobox 1 | -0.0141963 |
| PAPPA2 | pappalysin 2 | -0.0136739 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0136004 |
