Belumosudil (mesylate)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belumosudil (mesylate) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

101 genes differentially expressed following the Belumosudil (mesylate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.198759
EGFR epidermal growth factor receptor 0.153892
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.134599
LAMA4 laminin, alpha 4 0.114952
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.114571
DSCAM Down syndrome cell adhesion molecule 0.0985486
EHBP1 EH domain binding protein 1 0.094877
AHNAK AHNAK nucleoprotein 0.0902727
NDRG1 N-myc downstream regulated 1 0.087311
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0718501
ANKRD11 ankyrin repeat domain 11 0.0668745
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0592741
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0537418
GPC6 glypican 6 0.0484919
TBC1D22A TBC1 domain family, member 22A 0.0474827
AKAP12 A kinase (PRKA) anchor protein 12 0.045218
SLTM SAFB-like, transcription modulator 0.0424167
ENO1 enolase 1, (alpha) 0.0401165
ZSWIM6 zinc finger, SWIM-type containing 6 0.0360957
TPT1 tumor protein, translationally-controlled 1 0.0327905
EFNA5 ephrin-A5 0.0294173
PRKCA protein kinase C, alpha 0.0278206
PTK2 protein tyrosine kinase 2 0.0275084
BIRC6 baculoviral IAP repeat containing 6 0.0263876
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0245954
MYO1E myosin IE 0.0238417
ERRFI1 ERBB receptor feedback inhibitor 1 0.0195817
USP34 ubiquitin specific peptidase 34 0.0168036
SLC38A2 solute carrier family 38, member 2 0.0146627
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0123611
ZFAND3 zinc finger, AN1-type domain 3 0.0112527
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0106795
ANKRD17 ankyrin repeat domain 17 0.00863298
PGK1 phosphoglycerate kinase 1 0.00690689
FN1 fibronectin 1 0.00655886
LDHA lactate dehydrogenase A 0.00573574
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0041945
FNDC3B fibronectin type III domain containing 3B 0.00273877
SBF2 SET binding factor 2 0.00129975
NAP1L1 nucleosome assembly protein 1-like 1 3.40362E-4

decreased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor -0.104354
VIM vimentin -0.0911078
RPS8 ribosomal protein S8 -0.0808571
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0806732
TMSB10 thymosin beta 10 -0.0718957
B2M beta-2-microglobulin -0.0714621
RPL19 ribosomal protein L19 -0.0689655
NKD1 naked cuticle homolog 1 (Drosophila) -0.067139
MT2A metallothionein 2A -0.0623446
LMO7 LIM domain 7 -0.0577357
TPM4 tropomyosin 4 -0.0564134
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0544519
JARID2 jumonji, AT rich interactive domain 2 -0.0541925
MAML2 mastermind-like 2 (Drosophila) -0.0502565
COL5A2 collagen, type V, alpha 2 -0.0482366
NAV2 neuron navigator 2 -0.0476812
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0405733
RPS12 ribosomal protein S12 -0.0401637
CD44 CD44 molecule (Indian blood group) -0.0389196
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0386893
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0382251
RPLP1 ribosomal protein, large, P1 -0.0376041
RPS16 ribosomal protein S16 -0.0374588
RPLP2 ribosomal protein, large, P2 -0.0371606
RPS3 ribosomal protein S3 -0.0360723
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0353864
GMDS GDP-mannose 4,6-dehydratase -0.0331827
SNX9 sorting nexin 9 -0.0330786
RUNX1 runt-related transcription factor 1 -0.0321918
COL6A3 collagen, type VI, alpha 3 -0.0312438
RIGI RNA sensor RIG-I -0.0310395
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0302866
CARD16 caspase recruitment domain family, member 16 -0.0302818
MACF1 microtubule-actin crosslinking factor 1 -0.0289711
ITGA6 integrin, alpha 6 -0.0280113
ZBTB20 zinc finger and BTB domain containing 20 -0.0270643
PTMA prothymosin, alpha -0.0269514
WASF2 WAS protein family, member 2 -0.0269277
EZR ezrin -0.0262439
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0256324
SPATA13 spermatogenesis associated 13 -0.0254902
MYO6 myosin VI -0.0252574
STAG2 stromal antigen 2 -0.0216913
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0214598
SRRM2 serine/arginine repetitive matrix 2 -0.0183687
DST dystonin -0.0139353
TAS2R14 taste receptor, type 2, member 14 -0.0138504
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.012925
EXT1 exostosin glycosyltransferase 1 -0.00971565
LAMB3 laminin, beta 3 -0.00965804
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.00898281
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.00845483
RBM25 RNA binding motif protein 25 -0.00836917
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.00825373
FTL ferritin, light polypeptide -0.00795127
RPL26 ribosomal protein L26 -0.00741515
JMJD1C jumonji domain containing 1C -0.00566408
RNF213 ring finger protein 213 -0.00544169
ASPH aspartate beta-hydroxylase -0.00416699
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.00206124
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.00128624