Belumosudil (mesylate)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belumosudil (mesylate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belumosudil (mesylate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 0.0586933
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0569639
ZSWIM6 zinc finger, SWIM-type containing 6 0.0443641
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0332951
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0315142
SMAD3 SMAD family member 3 0.0295285
SAMD4A sterile alpha motif domain containing 4A 0.0224558
SVIL supervillin 0.0210161
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0207475
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0200516
TLE4 transducin-like enhancer of split 4 0.0197735
FMNL2 formin-like 2 0.018766
MYO5B myosin VB 0.0186676
LPP LIM domain containing preferred translocation partner in lipoma 0.0186264
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0184427
HDAC9 histone deacetylase 9 0.0181056
ARHGAP26 Rho GTPase activating protein 26 0.017792
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0165678
TRIO trio Rho guanine nucleotide exchange factor 0.0156937
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0155237
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0154647
AHNAK AHNAK nucleoprotein 0.0151842
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0147825
JARID2 jumonji, AT rich interactive domain 2 0.0145148
NAV2 neuron navigator 2 0.0142943
GRB10 growth factor receptor-bound protein 10 0.0141283
PCLO piccolo presynaptic cytomatrix protein 0.0140537
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.013702
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0133325
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.013209
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.013177
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0131457
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0129667
SQSTM1 sequestosome 1 0.0127976
SIK3 SIK family kinase 3 0.0126225
SHB Src homology 2 domain containing adaptor protein B 0.0124026
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0124001
ETV6 ets variant 6 0.0123654
SMOC1 SPARC related modular calcium binding 1 0.0121528
AEBP2 AE binding protein 2 0.0120746
MAST4 microtubule associated serine/threonine kinase family member 4 0.0117368
ATXN1 ataxin 1 0.0117081
HOMER1 homer scaffolding protein 1 0.0116334
CEMIP2 cell migration inducing hyaluronidase 2 0.0115731
EXT1 exostosin glycosyltransferase 1 0.0114998
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0114765
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0113959
HMGA2 high mobility group AT-hook 2 0.0113858
TJP1 tight junction protein 1 0.0112732
ATF3 activating transcription factor 3 0.0111914
DOCK1 dedicator of cytokinesis 1 0.0111633
UBC ubiquitin C 0.0111315
CTBP2 C-terminal binding protein 2 0.0111215
PRELID2 PRELI domain containing 2 0.0111096
RIGI RNA sensor RIG-I 0.0108715
APLP2 amyloid beta (A4) precursor-like protein 2 0.0105671
TRAPPC9 trafficking protein particle complex 9 0.0105307
RPL4 ribosomal protein L4 0.0104228
SP100 SP100 nuclear antigen 0.0103829
SDC4 syndecan 4 0.010373
LRRC23 leucine rich repeat containing 23 0.0102999
ANKRD33B ankyrin repeat domain 33B 0.0102694
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.0100186
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.00998328
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.00992563
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.00981769
HSPA8 heat shock 70kDa protein 8 0.009805
BTBD9 BTB (POZ) domain containing 9 0.00977744
IFI44L interferon-induced protein 44-like 0.00976041
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0097115
LRMDA leucine rich melanocyte differentiation associated 0.00968907
SGMS2 sphingomyelin synthase 2 0.00962419
ZNF638 zinc finger protein 638 0.00953268
FER fer (fps/fes related) tyrosine kinase 0.00949409
SENP5 SUMO1/sentrin specific peptidase 5 0.00943013
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.00927287
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.00923912
EIF4A2 eukaryotic translation initiation factor 4A2 0.00923758
HSPH1 heat shock 105kDa/110kDa protein 1 0.00920715
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.00907574
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.00903821
LYST lysosomal trafficking regulator 0.00901044
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.00898929
ZC3H12C zinc finger CCCH-type containing 12C 0.00897975
RNF213 ring finger protein 213 0.00877137
H2AC6 H2A clustered histone 6 0.00875196
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.00871282
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.00867072
HPCAL1 hippocalcin-like 1 0.00852722
NABP1 nucleic acid binding protein 1 0.00850938
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.00848717
PTPRG protein tyrosine phosphatase, receptor type, G 0.00847362
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.00845608
DST dystonin 0.0082593
DENND1A DENN/MADD domain containing 1A 0.00823181
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.00821476
PRKCA protein kinase C, alpha 0.00820071
H1-0 H1.0 linker histone 0.00819985
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.00819359
KDM4B lysine (K)-specific demethylase 4B 0.00812402

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.18089
TMSB10 thymosin beta 10 -0.112352
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.104773
TPT1 tumor protein, translationally-controlled 1 -0.0990274
PTMA prothymosin, alpha -0.0961723
TMSB4X thymosin beta 4, X-linked -0.0828931
HMGA1 high mobility group AT-hook 1 -0.0813083
KRT19 keratin 19, type I -0.0760337
RPL35A ribosomal protein L35a -0.0725165
F3 coagulation factor III (thromboplastin, tissue factor) -0.0686962
LAMB3 laminin, beta 3 -0.0676885
MUC4 mucin 4, cell surface associated -0.0633207
ANXA2 annexin A2 -0.0602018
LAMA4 laminin, alpha 4 -0.0565411
LDHA lactate dehydrogenase A -0.0563827
B2M beta-2-microglobulin -0.0555992
NPEPPS aminopeptidase puromycin sensitive -0.0504682
KRT7 keratin 7, type II -0.0504393
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0495131
EZR ezrin -0.048604
EIF1 eukaryotic translation initiation factor 1 -0.0466249
KRT18 keratin 18, type I -0.0465338
TPM4 tropomyosin 4 -0.0462415
S100A6 S100 calcium binding protein A6 -0.0458927
HLA-B major histocompatibility complex, class I, B -0.0443345
MT2A metallothionein 2A -0.0438898
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0434721
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0408196
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0408175
DLG1 discs, large homolog 1 (Drosophila) -0.0408098
LY6E lymphocyte antigen 6 complex, locus E -0.0403252
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0399147
IFI27 interferon, alpha-inducible protein 27 -0.038681
TPI1 triosephosphate isomerase 1 -0.0386324
UGCG UDP-glucose ceramide glucosyltransferase -0.0377585
NDRG1 N-myc downstream regulated 1 -0.0373065
IGFBP3 insulin-like growth factor binding protein 3 -0.0369361
RPS6 ribosomal protein S6 -0.036598
RPL23 ribosomal protein L23 -0.0349724
TM4SF1 transmembrane 4 L six family member 1 -0.0341343
RPLP1 ribosomal protein, large, P1 -0.0337034
RPS13 ribosomal protein S13 -0.0336825
RPS19 ribosomal protein S19 -0.0335803
FTH1 ferritin, heavy polypeptide 1 -0.0335614
FTL ferritin, light polypeptide -0.0333151
POTEF POTE ankyrin domain family, member F -0.0331179
TMEM123 transmembrane protein 123 -0.032884
RIOK3 RIO kinase 3 -0.0328504
EMP1 epithelial membrane protein 1 -0.0325283
RPS21 ribosomal protein S21 -0.0313469
KRT17 keratin 17, type I -0.030714
PGK1 phosphoglycerate kinase 1 -0.0304271
S100A10 S100 calcium binding protein A10 -0.0303749
CANX calnexin -0.0299671
KRT8 keratin 8, type II -0.0298399
HLA-A major histocompatibility complex, class I, A -0.029342
RPL12 ribosomal protein L12 -0.0292631
RPL19 ribosomal protein L19 -0.0291444
ANLN anillin, actin binding protein -0.0289742
EGR1 early growth response 1 -0.0286441
C6ORF132 chromosome 6 open reading frame 132 -0.0283997
CD2AP CD2-associated protein -0.0283026
ACTG1 actin gamma 1 -0.0274797
CAV1 caveolin 1, caveolae protein, 22kDa -0.0271293
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0270063
KPNB1 karyopherin (importin) beta 1 -0.0259371
PLAT plasminogen activator, tissue -0.0256113
RPS24 ribosomal protein S24 -0.0255368
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0252495
LOC112694756 uncharaterized LOC112694756 -0.0251951
C3 complement component 3 -0.0249012
RPL8 ribosomal protein L8 -0.024775
RPS5 ribosomal protein S5 -0.02462
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0245702
RPS14 ribosomal protein S14 -0.0242943
MYOF myoferlin -0.0242589
RACK1 receptor for activated C kinase 1 -0.0242224
MKI67 marker of proliferation Ki-67 -0.0239831
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0239103
HLA-C major histocompatibility complex, class I, C -0.0238927
ASPH aspartate beta-hydroxylase -0.0237994
SMC4 structural maintenance of chromosomes 4 -0.0236852
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0236676
WFDC2 WAP four-disulfide core domain 2 -0.0236432
RPL37 ribosomal protein L37 -0.0235933
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0235452
ZFP36L1 ZFP36 ring finger protein-like 1 -0.02336
PLAU plasminogen activator, urokinase -0.0232293
RPL31 ribosomal protein L31 -0.0232271
IFITM1 interferon induced transmembrane protein 1 -0.0230675
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0229994
RAB6A RAB6A, member RAS oncogene family -0.0229122
RPL34 ribosomal protein L34 -0.0227934
RPS29 ribosomal protein S29 -0.0227313
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0224326
TXNRD1 thioredoxin reductase 1 -0.022428
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0222575
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0221509
RBM25 RNA binding motif protein 25 -0.0221304
DSG2 desmoglein 2 -0.0217931