Belumosudil (mesylate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belumosudil (mesylate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belumosudil (mesylate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.0453612
JMJD1C jumonji domain containing 1C 0.034451
RUNX1 runt-related transcription factor 1 0.0279469
ZEB1 zinc finger E-box binding homeobox 1 0.0274251
RPL4 ribosomal protein L4 0.0272918
C2CD2 C2 calcium-dependent domain containing 2 0.0268329
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0247522
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0246645
AGO2 argonaute RISC catalytic component 2 0.0235094
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0217533
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0211342
SGMS2 sphingomyelin synthase 2 0.0211066
CORO1C coronin, actin binding protein, 1C 0.021088
ELL2 elongation factor, RNA polymerase II, 2 0.0205942
MAPK8 mitogen-activated protein kinase 8 0.0191391
BHLHE40 basic helix-loop-helix family, member e40 0.0188612
ATP13A3 ATPase type 13A3 0.0187374
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0186645
RAD21 RAD21 homolog (S. pombe) 0.0184689
MCTP1 multiple C2 domains, transmembrane 1 0.0184406
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.01836
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0178362
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0177593
SPRED2 sprouty-related, EVH1 domain containing 2 0.017448
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0173628
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0171812
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.017084
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0166465
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0161404
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.015663
EXT1 exostosin glycosyltransferase 1 0.0152919
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0150926
TEX10 testis expressed 10 0.0146628
NIPBL Nipped-B homolog (Drosophila) 0.0142203
CDK17 cyclin-dependent kinase 17 0.0140831
RASA2 RAS p21 protein activator 2 0.013867
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0134426
TM4SF19 transmembrane 4 L six family member 19 0.0130844
AKAP12 A kinase (PRKA) anchor protein 12 0.0130409
ENO1 enolase 1, (alpha) 0.012972
TXNRD1 thioredoxin reductase 1 0.0127215
ACTG1 actin gamma 1 0.0126088
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.012551
CRY1 cryptochrome circadian clock 1 0.012367
H1-4 H1.4 linker histone, cluster member 0.0122676
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0122443
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0120427
PUM1 pumilio RNA-binding family member 1 0.0119478
CAPRIN2 caprin family member 2 0.0117709
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0117264
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0115253
PUM2 pumilio RNA-binding family member 2 0.0115235
RCOR1 REST corepressor 1 0.0115221
PTK2 protein tyrosine kinase 2 0.0115178
ZFAND3 zinc finger, AN1-type domain 3 0.0115106
ARFGEF3 ARFGEF family member 3 0.0114399
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0114276
KDM3A lysine (K)-specific demethylase 3A 0.0113325
MKI67 marker of proliferation Ki-67 0.0112955
NF1 neurofibromin 1 0.011236
UBC ubiquitin C 0.0110538
OGA O-GlcNAcase 0.0108709
H1-0 H1.0 linker histone 0.0107981
ANO6 anoctamin 6 0.0107761
ATAD2 ATPase family, AAA domain containing 2 0.0107757
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0106209
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0106186
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0105865
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0103183
CHD7 chromodomain helicase DNA binding protein 7 0.0102757
USP3 ubiquitin specific peptidase 3 0.0102661
USP9X ubiquitin specific peptidase 9, X-linked 0.0102426
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.010241
ZBTB43 zinc finger and BTB domain containing 43 0.01024
BRWD3 bromodomain and WD repeat domain containing 3 0.0100793
BLZF1 basic leucine zipper nuclear factor 1 0.00990685
SPAG9 sperm associated antigen 9 0.00973189
CYRIB CYFIP related Rac1 interactor B 0.00967123
JUN jun proto-oncogene 0.00955609
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.009321
CLTC clathrin, heavy chain (Hc) 0.00930278
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.00913752
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.00911913
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.00898896
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 0.00894692
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.00888497
TJP1 tight junction protein 1 0.00887821
PDS5A PDS5 cohesin associated factor A 0.00887046
PALM2AKAP2 PALM2 and AKAP2 fusion 0.00878894
IQGAP1 IQ motif containing GTPase activating protein 1 0.00874171
BIRC2 baculoviral IAP repeat containing 2 0.00873097
SMC5 structural maintenance of chromosomes 5 0.0086869
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.00863827
ZC3H11A zinc finger CCCH-type containing 11A 0.00862721
ERBIN erbb2 interacting protein 0.00860156
KLF6 Kruppel-like factor 6 0.00851178
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.00849679
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.00848045
RPL6 ribosomal protein L6 0.00847017
KLF10 Kruppel-like factor 10 0.00845566

decreased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.131183
RPS6 ribosomal protein S6 -0.0958225
RPS3 ribosomal protein S3 -0.0615585
RPL37A ribosomal protein L37a -0.0608519
RPS12 ribosomal protein S12 -0.0549463
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0549295
RPS8 ribosomal protein S8 -0.0531147
RPL12 ribosomal protein L12 -0.0510949
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.051073
RPL7A ribosomal protein L7a -0.0506099
ZNF438 zinc finger protein 438 -0.0485919
MT2A metallothionein 2A -0.0475048
RPLP2 ribosomal protein, large, P2 -0.0467636
RPL8 ribosomal protein L8 -0.0465749
RPL35A ribosomal protein L35a -0.0460956
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0445878
NAV3 neuron navigator 3 -0.0435956
RPL9 ribosomal protein L9 -0.0424643
HMGA1 high mobility group AT-hook 1 -0.0418277
RPS19 ribosomal protein S19 -0.0394618
RPL7 ribosomal protein L7 -0.038064
RPL23 ribosomal protein L23 -0.0378294
FTL ferritin, light polypeptide -0.0375088
RPS25 ribosomal protein S25 -0.0368153
TPT1 tumor protein, translationally-controlled 1 -0.0364695
RPS29 ribosomal protein S29 -0.0361662
RACK1 receptor for activated C kinase 1 -0.0356277
RPLP1 ribosomal protein, large, P1 -0.0345552
RPL11 ribosomal protein L11 -0.0340547
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.033938
TMSB10 thymosin beta 10 -0.0336315
RPS13 ribosomal protein S13 -0.0322323
TTR transthyretin -0.0320042
RPL30 ribosomal protein L30 -0.031911
RPS23 ribosomal protein S23 -0.0289251
RPS17 ribosomal protein S17 -0.0280681
RPL26 ribosomal protein L26 -0.0273599
EEF2 eukaryotic translation elongation factor 2 -0.0273579
EGR1 early growth response 1 -0.0271386
RPL13A ribosomal protein L13a -0.0270455
RPL31 ribosomal protein L31 -0.0270181
RPL28 ribosomal protein L28 -0.026818
RPL36 ribosomal protein L36 -0.0264075
RPS20 ribosomal protein S20 -0.0254154
EEF1G eukaryotic translation elongation factor 1 gamma -0.0252992
FRMD6 FERM domain containing 6 -0.0250853
SLC38A2 solute carrier family 38, member 2 -0.0249433
RPLP0 ribosomal protein, large, P0 -0.0246787
RPL37 ribosomal protein L37 -0.0245897
RPL5 ribosomal protein L5 -0.0245594
P4HB prolyl 4-hydroxylase, beta polypeptide -0.02414
NAP1L1 nucleosome assembly protein 1-like 1 -0.0239676
GLRX glutaredoxin (thioltransferase) -0.0238576
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0233726
RPS10 ribosomal protein S10 -0.0229643
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0226592
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0224199
RPS27A ribosomal protein S27a -0.0223078
RPL19 ribosomal protein L19 -0.0220634
RPS5 ribosomal protein S5 -0.0216165
ASPH aspartate beta-hydroxylase -0.0215342
RPL34 ribosomal protein L34 -0.0214555
NABP1 nucleic acid binding protein 1 -0.0213606
RPS14 ribosomal protein S14 -0.0213531
DGKI diacylglycerol kinase, iota -0.0212288
EIF1 eukaryotic translation initiation factor 1 -0.0211487
BNC2 basonuclin 2 -0.0210284
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0208749
RPS15 ribosomal protein S15 -0.0202168
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0201326
RPS16 ribosomal protein S16 -0.0194184
MTDH metadherin -0.0193708
HMGA2 high mobility group AT-hook 2 -0.0193644
HDAC9 histone deacetylase 9 -0.0192906
RPS11 ribosomal protein S11 -0.0192643
PKM pyruvate kinase, muscle -0.0184802
TPM4 tropomyosin 4 -0.0180119
LDHB lactate dehydrogenase B -0.0178407
PFN1 profilin 1 -0.0177166
RPS21 ribosomal protein S21 -0.0176492
RPL10A ribosomal protein L10a -0.0176488
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0174667
POTEF POTE ankyrin domain family, member F -0.0174663
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0173841
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0172669
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0171867
IFI16 interferon, gamma-inducible protein 16 -0.0162719
PDIA3 protein disulfide isomerase family A, member 3 -0.0160459
S100A2 S100 calcium binding protein A2 -0.0159726
RPL35 ribosomal protein L35 -0.0158995
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0158004
RPL18 ribosomal protein L18 -0.0155124
EXOC4 exocyst complex component 4 -0.0153509
RPL38 ribosomal protein L38 -0.0153478
RPL15 ribosomal protein L15 -0.0152954
RPS27 ribosomal protein S27 -0.0152282
RPL27 ribosomal protein L27 -0.0151463
AKAP9 A kinase (PRKA) anchor protein 9 -0.0149537
PCNX4 pecanex 4 -0.0149291
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0148124