| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil (mesylate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0556325 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0540875 |
| TMEM178B | transmembrane protein 178B | 0.0495493 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0492608 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0461007 |
| HDAC9 | histone deacetylase 9 | 0.0442227 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0429997 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0406002 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0383948 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0383655 |
| SVIL | supervillin | 0.036361 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0356951 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0346637 |
| FNIP1 | folliculin interacting protein 1 | 0.0346579 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0333914 |
| EML5 | echinoderm microtubule associated protein like 5 | 0.0324905 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.031992 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0297817 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0297793 |
| SMAD3 | SMAD family member 3 | 0.0288197 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0263892 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0262841 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0261816 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0254218 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0254021 |
| LOXL2 | lysyl oxidase-like 2 | 0.0252296 |
| RUNX1 | runt-related transcription factor 1 | 0.0250842 |
| SP100 | SP100 nuclear antigen | 0.0247055 |
| IFI44L | interferon-induced protein 44-like | 0.0237328 |
| HMGA2 | high mobility group AT-hook 2 | 0.0232112 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0230078 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0229974 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0228591 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0224315 |
| GOLGB1 | golgin B1 | 0.0218745 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0216459 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0216457 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0216037 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0213334 |
| FAM20C | family with sequence similarity 20, member C | 0.0212335 |
| FAT1 | FAT atypical cadherin 1 | 0.0208322 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0205107 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0203668 |
| NAV2 | neuron navigator 2 | 0.0196713 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0189196 |
| LYST | lysosomal trafficking regulator | 0.0189009 |
| NRP1 | neuropilin 1 | 0.018562 |
| INTS6 | integrator complex subunit 6 | 0.0184254 |
| FHIT | fragile histidine triad | 0.0183626 |
| COLEC10 | collectin sub-family member 10 (C-type lectin) | 0.018315 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0181033 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0179702 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0175665 |
| ZNF638 | zinc finger protein 638 | 0.0175511 |
| KIAA1217 | KIAA1217 | 0.0174791 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0174651 |
| COL1A2 | collagen, type I, alpha 2 | 0.0173913 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0173683 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0172518 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0171412 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0170103 |
| BPTF | bromodomain PHD finger transcription factor | 0.0166075 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0164254 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | 0.0162444 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.016214 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0160617 |
| MTSS1 | metastasis suppressor 1 | 0.0159915 |
| COL5A1 | collagen, type V, alpha 1 | 0.0159162 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0158345 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0158019 |
| DST | dystonin | 0.015784 |
| RPL4 | ribosomal protein L4 | 0.0157166 |
| NAV1 | neuron navigator 1 | 0.0156633 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0156372 |
| HLA-E | major histocompatibility complex, class I, E | 0.0155557 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0152483 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0149955 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0148979 |
| HPCAL1 | hippocalcin-like 1 | 0.0148859 |
| MMP12 | matrix metallopeptidase 12 | 0.014724 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0143291 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0142631 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0141427 |
| NOTCH2 | notch 2 | 0.0141343 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0141052 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.0140482 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0139768 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0139564 |
| TLE4 | transducin-like enhancer of split 4 | 0.0138694 |
| COL5A3 | collagen, type V, alpha 3 | 0.0138155 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0137665 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0137456 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0134528 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0133297 |
| MYO1E | myosin IE | 0.0133278 |
| SUMF1 | sulfatase modifying factor 1 | 0.0131796 |
| SH3PXD2B | SH3 and PX domains 2B | 0.0131127 |
| ANO6 | anoctamin 6 | 0.0130988 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0130754 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0128677 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.28253 |
| FN1 | fibronectin 1 | -0.184773 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.123139 |
| MT2A | metallothionein 2A | -0.111482 |
| TMSB10 | thymosin beta 10 | -0.106061 |
| FTL | ferritin, light polypeptide | -0.0887242 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0848598 |
| PTMA | prothymosin, alpha | -0.0777099 |
| HLA-B | major histocompatibility complex, class I, B | -0.0776258 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0737025 |
| NDRG1 | N-myc downstream regulated 1 | -0.0714551 |
| PGK1 | phosphoglycerate kinase 1 | -0.059291 |
| POTEF | POTE ankyrin domain family, member F | -0.0566621 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0542186 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0505879 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0504919 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0498636 |
| COL1A1 | collagen, type I, alpha 1 | -0.0471845 |
| RPL35A | ribosomal protein L35a | -0.0428098 |
| RTN4 | reticulon 4 | -0.0412637 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0408775 |
| TPM4 | tropomyosin 4 | -0.0407163 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0403148 |
| RPLP1 | ribosomal protein, large, P1 | -0.0395426 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0394217 |
| ENO1 | enolase 1, (alpha) | -0.0382462 |
| CENPF | centromere protein F, 350/400kDa | -0.0369054 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0360684 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0358906 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0347257 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.034697 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0346479 |
| B2M | beta-2-microglobulin | -0.033159 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0329215 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0327636 |
| GNAS | GNAS complex locus | -0.0327568 |
| RPL37A | ribosomal protein L37a | -0.0324837 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0321017 |
| RPS8 | ribosomal protein S8 | -0.0312909 |
| PKM | pyruvate kinase, muscle | -0.0308647 |
| MAP1B | microtubule-associated protein 1B | -0.0301837 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0299648 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0297399 |
| RPS21 | ribosomal protein S21 | -0.0295488 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.028997 |
| TPX2 | TPX2, microtubule-associated | -0.0289607 |
| RBM39 | RNA binding motif protein 39 | -0.0286127 |
| LDHA | lactate dehydrogenase A | -0.0284533 |
| RPS6 | ribosomal protein S6 | -0.0283536 |
| SEPTIN7 | septin 7 | -0.0281797 |
| HLA-C | major histocompatibility complex, class I, C | -0.0278754 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.02761 |
| IER3 | immediate early response 3 | -0.0273265 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0270276 |
| ACTG1 | actin gamma 1 | -0.0269613 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0268233 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0266172 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0264587 |
| ANLN | anillin, actin binding protein | -0.0263934 |
| MKI67 | marker of proliferation Ki-67 | -0.0263629 |
| RPS13 | ribosomal protein S13 | -0.0262511 |
| RPLP2 | ribosomal protein, large, P2 | -0.0261491 |
| RPS19 | ribosomal protein S19 | -0.0261329 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.025662 |
| RPL12 | ribosomal protein L12 | -0.0255735 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.025363 |
| IL1B | interleukin 1, beta | -0.0249856 |
| KIF5B | kinesin family member 5B | -0.0245129 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0244316 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0240673 |
| DSTN | destrin (actin depolymerizing factor) | -0.0239051 |
| RPS12 | ribosomal protein S12 | -0.0238689 |
| TNNC1 | troponin C type 1 (slow) | -0.0236888 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0230727 |
| S100A10 | S100 calcium binding protein A10 | -0.0229233 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0228463 |
| HMGB2 | high mobility group box 2 | -0.0226581 |
| DIAPH3 | diaphanous-related formin 3 | -0.0226155 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0224907 |
| S100A11 | S100 calcium binding protein A11 | -0.0224408 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0222675 |
| FAM162A | family with sequence similarity 162, member A | -0.0220412 |
| SETD5 | SET domain containing 5 | -0.0218481 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0217495 |
| RRBP1 | ribosome binding protein 1 | -0.0214979 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.0214457 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0214425 |
| CANX | calnexin | -0.021439 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0213554 |
| RPL28 | ribosomal protein L28 | -0.0212029 |
| RPL11 | ribosomal protein L11 | -0.0211006 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0210568 |
| CTSB | cathepsin B | -0.0210245 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0205851 |
| RACK1 | receptor for activated C kinase 1 | -0.0203888 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0203458 |
| YBX1 | Y box binding protein 1 | -0.020278 |
| RPL36 | ribosomal protein L36 | -0.0202096 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0201828 |
| S100A6 | S100 calcium binding protein A6 | -0.0200216 |
