Belumosudil (mesylate)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belumosudil (mesylate) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belumosudil (mesylate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.120876
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0660317
NDRG1 N-myc downstream regulated 1 0.0350359
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0307848
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.030063
RPL4 ribosomal protein L4 0.029476
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0291403
TPM3 tropomyosin 3 0.0286923
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0275729
UBC ubiquitin C 0.0261178
ZNF292 zinc finger protein 292 0.0254594
BHLHE40 basic helix-loop-helix family, member e40 0.0243905
GRB10 growth factor receptor-bound protein 10 0.024366
HSPH1 heat shock 105kDa/110kDa protein 1 0.0243605
VEGFA vascular endothelial growth factor A 0.023704
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0228691
MCTP1 multiple C2 domains, transmembrane 1 0.0224578
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0221672
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0209562
MSN moesin 0.0203082
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0194471
KDM4C lysine (K)-specific demethylase 4C 0.0190127
RPL3 ribosomal protein L3 0.0183373
RUNX1 runt-related transcription factor 1 0.0175181
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0175119
INHBA inhibin, beta A 0.0167644
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0167368
FAM13A family with sequence similarity 13, member A 0.0166179
DUSP10 dual specificity phosphatase 10 0.0164684
MAP2K1 mitogen-activated protein kinase kinase 1 0.0160832
LCOR ligand dependent nuclear receptor corepressor 0.0155663
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0154581
ZSWIM6 zinc finger, SWIM-type containing 6 0.0151517
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0150083
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0149835
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0147806
ADAM17 ADAM metallopeptidase domain 17 0.0147555
AKAP13 A kinase (PRKA) anchor protein 13 0.0145623
UGCG UDP-glucose ceramide glucosyltransferase 0.0144239
APLP2 amyloid beta (A4) precursor-like protein 2 0.0142599
EGFR epidermal growth factor receptor 0.0141417
RNPS1 RNA binding protein S1, serine-rich domain 0.0140793
RPS18 ribosomal protein S18 0.0139364
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0138231
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0137519
TRIM25 tripartite motif containing 25 0.0133545
CREB5 cAMP responsive element binding protein 5 0.0133319
SP100 SP100 nuclear antigen 0.0132989
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0131794
EIF5 eukaryotic translation initiation factor 5 0.0131543
ABHD3 abhydrolase domain containing 3 0.013073
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0127698
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0126332
GLS2 glutaminase 2 (liver, mitochondrial) 0.012544
ALKBH5 AlkB family member 5, RNA demethylase 0.0124603
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0122133
MEIS2 Meis homeobox 2 0.0121676
IRAK2 interleukin-1 receptor-associated kinase 2 0.0120594
FNDC3B fibronectin type III domain containing 3B 0.0119383
DIDO1 death inducer-obliterator 1 0.0119257
SOBP sine oculis binding protein homolog (Drosophila) 0.0118482
UNC13B unc-13 homolog B (C. elegans) 0.0117111
ATXN1 ataxin 1 0.0117032
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0116684
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0116512
USPL1 ubiquitin specific peptidase like 1 0.0116052
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.0115697
KDM2A lysine (K)-specific demethylase 2A 0.0115555
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0115546
WAC WW domain containing adaptor with coiled-coil 0.0115363
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0114879
ELAVL3 ELAV like neuron-specific RNA binding protein 3 0.0114778
CCNY cyclin Y 0.0114729
TSC22D2 TSC22 domain family, member 2 0.0114033
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0113986
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0113044
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0112956
FAM219A family with sequence similarity 219, member A 0.0112319
CERT1 ceramide transporter 1 0.0112241
SSBP2 single-stranded DNA binding protein 2 0.0112104
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0111559
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0110429
POTEF POTE ankyrin domain family, member F 0.0109572
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0109165
EIF4B eukaryotic translation initiation factor 4B 0.0107886
SEC31A SEC31 homolog A (S. cerevisiae) 0.0107127
BRD2 bromodomain containing 2 0.0106772
ZNF451 zinc finger protein 451 0.0105513
MBIP MAP3K12 binding inhibitory protein 1 0.0104967
SREBF2 sterol regulatory element binding transcription factor 2 0.0104445
SEC24A SEC24 family member A 0.0104102
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0103405
ASPH aspartate beta-hydroxylase 0.0102704
ELOVL5 ELOVL fatty acid elongase 5 0.0101755
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 0.0100921
PFKP phosphofructokinase, platelet 0.0100167
MBNL2 muscleblind-like splicing regulator 2 0.00996988
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa 0.00990853
AP1M1 adaptor-related protein complex 1, mu 1 subunit 0.00989608
SRRM2 serine/arginine repetitive matrix 2 0.00987965

decreased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 -0.168094
PDE10A phosphodiesterase 10A -0.154698
PTMA prothymosin, alpha -0.0931318
SMYD3 SET and MYND domain containing 3 -0.0844184
RIMS2 regulating synaptic membrane exocytosis 2 -0.0758956
PDE4B phosphodiesterase 4B, cAMP-specific -0.0739667
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0738693
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0737961
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0681444
CALCA calcitonin-related polypeptide alpha -0.066445
PEG10 paternally expressed 10 -0.0636906
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0631792
CENPF centromere protein F, 350/400kDa -0.0612336
IFI6 interferon, alpha-inducible protein 6 -0.0596716
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.058068
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0567396
MT2A metallothionein 2A -0.0553941
NCOR1 nuclear receptor corepressor 1 -0.0551785
NRG1 neuregulin 1 -0.0548827
SNTG1 syntrophin, gamma 1 -0.0547416
AOPEP aminopeptidase O (putative) -0.0539788
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0536864
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0535954
RIT2 Ras-like without CAAX 2 -0.0528931
PCSK1 proprotein convertase subtilisin/kexin type 1 -0.0522215
ADGRL2 adhesion G protein-coupled receptor L2 -0.0520597
RPL26 ribosomal protein L26 -0.0512056
MKI67 marker of proliferation Ki-67 -0.0503241
TENM1 teneurin transmembrane protein 1 -0.049598
SYT1 synaptotagmin I -0.0487809
FGF14 fibroblast growth factor 14 -0.0476112
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0469147
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0453133
TXNRD1 thioredoxin reductase 1 -0.0445894
RPL38 ribosomal protein L38 -0.0443399
TENT5A terminal nucleotidyltransferase 5A -0.0442274
CNKSR3 CNKSR family member 3 -0.0429939
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0422196
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0407378
RPS3 ribosomal protein S3 -0.0406829
RPL37A ribosomal protein L37a -0.0401039
FOXC1 forkhead box C1 -0.0399402
FTL ferritin, light polypeptide -0.0396377
RPS21 ribosomal protein S21 -0.0383292
EGR1 early growth response 1 -0.0373352
TPT1 tumor protein, translationally-controlled 1 -0.0371902
RAD21 RAD21 homolog (S. pombe) -0.036991
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -0.0369842
ACTG1 actin gamma 1 -0.036849
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0366728
NIPBL Nipped-B homolog (Drosophila) -0.0364803
WSB1 WD repeat and SOCS box containing 1 -0.0358296
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0355738
RPL23 ribosomal protein L23 -0.0353748
PEX5L peroxisomal biogenesis factor 5-like -0.034633
MIS18BP1 MIS18 binding protein 1 -0.0342223
RPL37 ribosomal protein L37 -0.0340654
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0339882
RPL11 ribosomal protein L11 -0.0338776
GPC5 glypican 5 -0.033846
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -0.0335372
RPS8 ribosomal protein S8 -0.0334556
ZNF804A zinc finger protein 804A -0.0334175
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0333681
SASH1 SAM and SH3 domain containing 1 -0.0319287
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0316872
S100A9 S100 calcium binding protein A9 -0.0314515
RPH3AL rabphilin 3A-like (without C2 domains) -0.0313962
NAV2 neuron navigator 2 -0.0309263
PTCHD4 patched domain containing 4 -0.0307312
CANX calnexin -0.0305468
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0304845
NBEA neurobeachin -0.0301661
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0301391
TMSB4X thymosin beta 4, X-linked -0.0299716
DNAH5 dynein, axonemal, heavy chain 5 -0.0297123
GDAP1 ganglioside induced differentiation associated protein 1 -0.0296739
RPL8 ribosomal protein L8 -0.0295843
STXBP5L syntaxin binding protein 5-like -0.0290923
GARS1 glycyl-tRNA synthetase 1 -0.029056
TCF12 transcription factor 12 -0.0289009
PGK1 phosphoglycerate kinase 1 -0.0288245
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -0.0286848
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0286829
TUBB tubulin, beta class I -0.0286196
IGFBP5 insulin-like growth factor binding protein 5 -0.0285931
MAP1B microtubule-associated protein 1B -0.0280822
RPS6 ribosomal protein S6 -0.0280004
RPLP1 ribosomal protein, large, P1 -0.027829
SMC4 structural maintenance of chromosomes 4 -0.0275188
EIF5B eukaryotic translation initiation factor 5B -0.0274225
PHF14 PHD finger protein 14 -0.0268822
KCTD8 potassium channel tetramerization domain containing 8 -0.0266748
IGF1R insulin-like growth factor 1 receptor -0.0264768
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -0.0258915
RBM25 RNA binding motif protein 25 -0.0258211
TMSB10 thymosin beta 10 -0.0258008
EIF1 eukaryotic translation initiation factor 1 -0.0255924
PELI2 pellino E3 ubiquitin protein ligase family member 2 -0.0255889
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0255287