| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil (mesylate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.206814 |
| FNDC3B | fibronectin type III domain containing 3B | 0.131914 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.126055 |
| NLGN1 | neuroligin 1 | 0.106479 |
| NRG3 | neuregulin 3 | 0.0793884 |
| DST | dystonin | 0.0644567 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0617354 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0588777 |
| NOTCH2 | notch 2 | 0.0558289 |
| MSN | moesin | 0.0530392 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0516168 |
| CENPF | centromere protein F, 350/400kDa | 0.0507172 |
| PHF21A | PHD finger protein 21A | 0.0502851 |
| CFAP20DC | CFAP20 domain containing | 0.0486995 |
| ENO1 | enolase 1, (alpha) | 0.04683 |
| TPM3 | tropomyosin 3 | 0.0460149 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0457093 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0450122 |
| SMAD3 | SMAD family member 3 | 0.0428839 |
| PKM | pyruvate kinase, muscle | 0.0428501 |
| PTK2 | protein tyrosine kinase 2 | 0.0424092 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.042379 |
| FLNB | filamin B, beta | 0.0421794 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0410089 |
| ANGPTL4 | angiopoietin-like 4 | 0.0403746 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0382636 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0382057 |
| MSI2 | musashi RNA-binding protein 2 | 0.0372158 |
| NAV2 | neuron navigator 2 | 0.0358808 |
| BBX | bobby sox homolog (Drosophila) | 0.035118 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0348112 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0340624 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0339207 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0322539 |
| CDK6 | cyclin-dependent kinase 6 | 0.0314748 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0312576 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0310187 |
| POTEF | POTE ankyrin domain family, member F | 0.0302851 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0299134 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0290399 |
| ATXN1 | ataxin 1 | 0.0288427 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0282437 |
| SOX10 | SRY (sex determining region Y)-box 10 | 0.0282292 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.0279515 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0279147 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0273941 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | 0.0272054 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0267273 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0265654 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0262193 |
| FMNL2 | formin-like 2 | 0.0261106 |
| WWOX | WW domain containing oxidoreductase | 0.0259218 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0256387 |
| LSAMP | limbic system-associated membrane protein | 0.0249791 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0248014 |
| TOB2 | transducer of ERBB2, 2 | 0.0246772 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0240194 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0237299 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0233369 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0232005 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0228844 |
| CD44 | CD44 molecule (Indian blood group) | 0.022884 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0228123 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0220832 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0220571 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0219468 |
| TMEM51 | transmembrane protein 51 | 0.0215778 |
| RPL3 | ribosomal protein L3 | 0.0215718 |
| NAV1 | neuron navigator 1 | 0.0215698 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0213519 |
| VEGFA | vascular endothelial growth factor A | 0.0212559 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0210689 |
| NRP2 | neuropilin 2 | 0.0210417 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0209417 |
| AUTS2 | autism susceptibility candidate 2 | 0.0209171 |
| MMP12 | matrix metallopeptidase 12 | 0.020888 |
| FAM120A | family with sequence similarity 120A | 0.020852 |
| B2M | beta-2-microglobulin | 0.0205666 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.020565 |
| FAM219A | family with sequence similarity 219, member A | 0.0200945 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.020052 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0200409 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.0200013 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0198807 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0196835 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0196003 |
| RAD51B | RAD51 paralog B | 0.0195433 |
| ACLY | ATP citrate lyase | 0.0194553 |
| FAM13A | family with sequence similarity 13, member A | 0.0194014 |
| RUNX1 | runt-related transcription factor 1 | 0.0193889 |
| PCBP2 | poly(rC) binding protein 2 | 0.0192245 |
| AHNAK | AHNAK nucleoprotein | 0.0191732 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0190774 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0190402 |
| SETD5 | SET domain containing 5 | 0.0190281 |
| TNS1 | tensin 1 | 0.0190243 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0190156 |
| KIF5C | kinesin family member 5C | 0.0188953 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0188222 |
| BRD2 | bromodomain containing 2 | 0.0187648 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.306426 |
| FN1 | fibronectin 1 | -0.210859 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.144648 |
| FMN1 | formin 1 | -0.131744 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.11796 |
| VIM | vimentin | -0.103212 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0767158 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0725873 |
| RPS3 | ribosomal protein S3 | -0.0679798 |
| MT2A | metallothionein 2A | -0.0663455 |
| PGK1 | phosphoglycerate kinase 1 | -0.0594328 |
| CANX | calnexin | -0.0568305 |
| GOLGA4 | golgin A4 | -0.053079 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0507196 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0501894 |
| TXNRD1 | thioredoxin reductase 1 | -0.0497603 |
| RPL35A | ribosomal protein L35a | -0.0473483 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0470244 |
| TMSB10 | thymosin beta 10 | -0.0462675 |
| FTL | ferritin, light polypeptide | -0.0447942 |
| SQSTM1 | sequestosome 1 | -0.0441051 |
| RPLP1 | ribosomal protein, large, P1 | -0.0440349 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0411299 |
| RACK1 | receptor for activated C kinase 1 | -0.0396272 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0391525 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0367179 |
| PMEL | premelanosome protein | -0.0366592 |
| HDLBP | high density lipoprotein binding protein | -0.0364689 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0353923 |
| HDAC9 | histone deacetylase 9 | -0.0353409 |
| RPL38 | ribosomal protein L38 | -0.0334021 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0331094 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0323307 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0323204 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0320937 |
| NF1 | neurofibromin 1 | -0.0310293 |
| RPL11 | ribosomal protein L11 | -0.0301577 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0300608 |
| SFTPA2 | surfactant protein A2 | -0.0297018 |
| ERBIN | erbb2 interacting protein | -0.0295126 |
| ACTG1 | actin gamma 1 | -0.0292774 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0284205 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0283654 |
| RAB7A | RAB7A, member RAS oncogene family | -0.028274 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0273016 |
| RPL12 | ribosomal protein L12 | -0.0271786 |
| CLTC | clathrin, heavy chain (Hc) | -0.0269076 |
| SPAG9 | sperm associated antigen 9 | -0.0265082 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0264166 |
| TP63 | tumor protein p63 | -0.0264139 |
| GPATCH8 | G patch domain containing 8 | -0.0262985 |
| CALR | calreticulin | -0.0259584 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0257835 |
| ABI1 | abl-interactor 1 | -0.0257346 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0255996 |
| RPL34 | ribosomal protein L34 | -0.0255073 |
| RBM39 | RNA binding motif protein 39 | -0.025473 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0251255 |
| EP300 | E1A binding protein p300 | -0.0251092 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0250255 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0248985 |
| ANK2 | ankyrin 2, neuronal | -0.0248946 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0247885 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.02474 |
| FNIP1 | folliculin interacting protein 1 | -0.0242676 |
| ARF1 | ADP-ribosylation factor 1 | -0.0241808 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0241129 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.0240468 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0239759 |
| COG5 | component of oligomeric golgi complex 5 | -0.0238568 |
| KAZN | kazrin, periplakin interacting protein | -0.0235672 |
| RPS23 | ribosomal protein S23 | -0.0234151 |
| ATF4 | activating transcription factor 4 | -0.0232559 |
| CLINT1 | clathrin interactor 1 | -0.0231664 |
| RPL23 | ribosomal protein L23 | -0.0231404 |
| ANXA2 | annexin A2 | -0.02304 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0229879 |
| TNPO1 | transportin 1 | -0.0227546 |
| CD63 | CD63 molecule | -0.0226811 |
| FBXW11 | F-box and WD repeat domain containing 11 | -0.0224154 |
| NKTR | natural killer cell triggering receptor | -0.0222081 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0220242 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0218298 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0218285 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0217385 |
| SMYD3 | SET and MYND domain containing 3 | -0.0216366 |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 | -0.021478 |
| STK4 | serine/threonine kinase 4 | -0.0213779 |
| DMXL1 | Dmx-like 1 | -0.0211877 |
| RPL28 | ribosomal protein L28 | -0.0211504 |
| RPS29 | ribosomal protein S29 | -0.0210899 |
| TSC22D2 | TSC22 domain family, member 2 | -0.021009 |
| RPL36A | ribosomal protein L36a | -0.0209619 |
| PUM2 | pumilio RNA-binding family member 2 | -0.020946 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0206464 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.020631 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0205394 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0205326 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0203217 |
| RPL32 | ribosomal protein L32 | -0.020314 |
