Belumosudil (mesylate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belumosudil (mesylate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belumosudil (mesylate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0969245
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0779661
HDAC9 histone deacetylase 9 0.0762354
SRRM2 serine/arginine repetitive matrix 2 0.0525378
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0515508
PKM pyruvate kinase, muscle 0.0486108
PDGFC platelet derived growth factor C 0.0472392
POTEF POTE ankyrin domain family, member F 0.0388064
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0380522
UBC ubiquitin C 0.0368074
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0361911
ZNF608 zinc finger protein 608 0.0337458
FLNB filamin B, beta 0.0336103
RPL4 ribosomal protein L4 0.0333086
EML4 echinoderm microtubule associated protein like 4 0.0325286
DSCAM Down syndrome cell adhesion molecule 0.0314985
YAP1 Yes-associated protein 1 0.0312501
ANKRD12 ankyrin repeat domain 12 0.0300457
EZR ezrin 0.0296875
CSF1 colony stimulating factor 1 (macrophage) 0.0294059
RPL3 ribosomal protein L3 0.0291507
BCLAF1 BCL2-associated transcription factor 1 0.0285592
ANXA1 annexin A1 0.0272503
H1-4 H1.4 linker histone, cluster member 0.0267895
GLS2 glutaminase 2 (liver, mitochondrial) 0.0260195
BRD2 bromodomain containing 2 0.0259312
TJP1 tight junction protein 1 0.0257668
CHD1 chromodomain helicase DNA binding protein 1 0.0255237
IQGAP1 IQ motif containing GTPase activating protein 1 0.0244433
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0241242
RHOA ras homolog family member A 0.023926
GOLGA4 golgin A4 0.0236326
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0235618
LATS2 large tumor suppressor kinase 2 0.0234813
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0231698
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0221229
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0221046
RPL21 ribosomal protein L21 0.0218717
ARHGAP25 Rho GTPase activating protein 25 0.0216569
SIK3 SIK family kinase 3 0.0210979
TPM3 tropomyosin 3 0.0208112
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0205427
RAB7A RAB7A, member RAS oncogene family 0.0204426
SON SON DNA binding protein 0.0201647
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0201123
MED13 mediator complex subunit 13 0.0197462
OSBPL8 oxysterol binding protein-like 8 0.0193691
TPD52 tumor protein D52 0.0192602
KIF5C kinesin family member 5C 0.0191746
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0190112
TACC2 transforming, acidic coiled-coil containing protein 2 0.0189111
TRIP12 thyroid hormone receptor interactor 12 0.0188831
FER1L6 fer-1-like family member 6 0.0185504
SGMS2 sphingomyelin synthase 2 0.0185187
BRD4 bromodomain containing 4 0.0182415
ADAM9 ADAM metallopeptidase domain 9 0.0181912
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.017738
ECT2 epithelial cell transforming 2 0.0176955
DSTN destrin (actin depolymerizing factor) 0.017645
HSPH1 heat shock 105kDa/110kDa protein 1 0.0174618
TMF1 TATA element modulatory factor 1 0.0173062
CRY1 cryptochrome circadian clock 1 0.0172084
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0170324
ZNF451 zinc finger protein 451 0.0169852
TM9SF4 transmembrane 9 superfamily protein member 4 0.0169385
TASOR2 transcription activation suppressor family member 2 0.0169237
SBF2 SET binding factor 2 0.0169143
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0167544
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0167237
MYADM myeloid-associated differentiation marker 0.0166259
GOLGB1 golgin B1 0.0166141
TSC22D2 TSC22 domain family, member 2 0.0164035
YTHDC1 YTH domain containing 1 0.0163853
SEC24A SEC24 family member A 0.0163386
USP47 ubiquitin specific peptidase 47 0.0162035
ATP9B ATPase, class II, type 9B 0.0161012
DIAPH1 diaphanous-related formin 1 0.0160408
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0160336
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0159162
PRPF4B pre-mRNA processing factor 4B 0.0159129
RIOK3 RIO kinase 3 0.0157195
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0157108
NUP58 nucleoporin 58 0.0155323
TBK1 TANK-binding kinase 1 0.0154133
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.0153233
ZBTB38 zinc finger and BTB domain containing 38 0.0151707
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0151674
MYOF myoferlin 0.0151111
SENP6 SUMO1/sentrin specific peptidase 6 0.0149925
DUSP6 dual specificity phosphatase 6 0.0148946
CCDC88A coiled-coil domain containing 88A 0.0147187
MACF1 microtubule-actin crosslinking factor 1 0.0147086
SFSWAP splicing factor, suppressor of white-apricot family 0.0145512
SUCO SUN domain containing ossification factor 0.0144462
CD2AP CD2-associated protein 0.0143392
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.014264
TRIM24 tripartite motif containing 24 0.0141686
FXR1 fragile X mental retardation, autosomal homolog 1 0.014061
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0139934
LCOR ligand dependent nuclear receptor corepressor 0.0139861

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.149177
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.143075
TPT1 tumor protein, translationally-controlled 1 -0.12684
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.117232
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.105889
CPED1 cadherin-like and PC-esterase domain containing 1 -0.105303
BMP10 bone morphogenetic protein 10 -0.100197
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.100136
VCL vinculin -0.0971418
TMSB4X thymosin beta 4, X-linked -0.0888882
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0884862
RPL35A ribosomal protein L35a -0.0810596
RPL37A ribosomal protein L37a -0.0698477
RPL31 ribosomal protein L31 -0.0684293
PDE4B phosphodiesterase 4B, cAMP-specific -0.0665532
RPS13 ribosomal protein S13 -0.0663786
CAMKMT calmodulin-lysine N-methyltransferase -0.0648505
RPL12 ribosomal protein L12 -0.0648138
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0639129
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0635672
S100A6 S100 calcium binding protein A6 -0.0625201
PTMA prothymosin, alpha -0.0584291
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0580344
RPLP1 ribosomal protein, large, P1 -0.0526989
RPS23 ribosomal protein S23 -0.052598
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0523269
ACTG1 actin gamma 1 -0.0520159
RPS25 ribosomal protein S25 -0.0517707
PRELID2 PRELI domain containing 2 -0.0513767
RPL11 ribosomal protein L11 -0.0510288
WSB1 WD repeat and SOCS box containing 1 -0.0497471
ZEB1 zinc finger E-box binding homeobox 1 -0.0470591
PGK1 phosphoglycerate kinase 1 -0.046629
PNISR PNN-interacting serine/arginine-rich protein -0.0456927
RPL36 ribosomal protein L36 -0.045096
STAT1 signal transducer and activator of transcription 1, 91kDa -0.044347
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0438135
RPL7A ribosomal protein L7a -0.0437512
RPS3 ribosomal protein S3 -0.0434327
RPS12 ribosomal protein S12 -0.0431459
LOC112694756 uncharaterized LOC112694756 -0.0428316
RPLP2 ribosomal protein, large, P2 -0.0425994
GARS1 glycyl-tRNA synthetase 1 -0.0424619
RPL9 ribosomal protein L9 -0.0420898
NFIA nuclear factor I/A -0.0420765
RPS19 ribosomal protein S19 -0.0405905
RPL26 ribosomal protein L26 -0.0395746
CCND1 cyclin D1 -0.0395385
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0393022
RPS24 ribosomal protein S24 -0.0391543
RPL23 ribosomal protein L23 -0.038719
HDLBP high density lipoprotein binding protein -0.0377097
RPL34 ribosomal protein L34 -0.0375746
RPS8 ribosomal protein S8 -0.036979
NAP1L1 nucleosome assembly protein 1-like 1 -0.036415
RPLP0 ribosomal protein, large, P0 -0.0358319
ANK2 ankyrin 2, neuronal -0.0350746
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0344884
DENND1A DENN/MADD domain containing 1A -0.0341189
SSBP2 single-stranded DNA binding protein 2 -0.0331482
SQSTM1 sequestosome 1 -0.0328416
RPL19 ribosomal protein L19 -0.0322069
RPS27A ribosomal protein S27a -0.0319014
SMYD3 SET and MYND domain containing 3 -0.0317538
RPL38 ribosomal protein L38 -0.0312419
RPL13A ribosomal protein L13a -0.0312384
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0312171
RPS29 ribosomal protein S29 -0.0307031
LARS1 leucyl-tRNA synthetase 1 -0.0306631
RPS21 ribosomal protein S21 -0.0297726
EEF2 eukaryotic translation elongation factor 2 -0.0296707
FOXP1 forkhead box P1 -0.0296341
RPS27 ribosomal protein S27 -0.0292817
NEBL nebulette -0.0292378
S100A4 S100 calcium binding protein A4 -0.0292301
CANX calnexin -0.0286041
INTS6 integrator complex subunit 6 -0.0282683
PDE10A phosphodiesterase 10A -0.0280577
RPL36A ribosomal protein L36a -0.0277561
NPAS2 neuronal PAS domain protein 2 -0.027255
RPL27A ribosomal protein L27a -0.0272525
PDE7B phosphodiesterase 7B -0.0270989
RBM39 RNA binding motif protein 39 -0.026955
HSPA8 heat shock 70kDa protein 8 -0.0269499
RPL28 ribosomal protein L28 -0.0267777
RPS11 ribosomal protein S11 -0.0265657
EBNA1BP2 EBNA1 binding protein 2 -0.0261409
RPS16 ribosomal protein S16 -0.0260101
FKBP10 FK506 binding protein 10, 65 kDa -0.0258948
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0257673
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0257167
ARL4C ADP-ribosylation factor-like 4C -0.0253674
RPS5 ribosomal protein S5 -0.0252979
NBEA neurobeachin -0.0251558
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0250799
LARP1 La ribonucleoprotein domain family, member 1 -0.0248866
FTL ferritin, light polypeptide -0.0248186
ANKRD11 ankyrin repeat domain 11 -0.0247348
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0247073
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0246013