| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil (mesylate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SOD2 | superoxide dismutase 2, mitochondrial | 0.11575 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0962391 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0899564 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0574345 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0519978 |
| FNDC3B | fibronectin type III domain containing 3B | 0.051633 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0506756 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0501728 |
| UBC | ubiquitin C | 0.0489901 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0458945 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0454975 |
| ENO1 | enolase 1, (alpha) | 0.0444803 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0436472 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0413533 |
| PLIN2 | perilipin 2 | 0.0386441 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0384382 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0380851 |
| BICC1 | BicC family RNA binding protein 1 | 0.0375621 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0361957 |
| ARRDC3 | arrestin domain containing 3 | 0.0359811 |
| MKI67 | marker of proliferation Ki-67 | 0.0350836 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0344043 |
| RPL4 | ribosomal protein L4 | 0.0336735 |
| RND3 | Rho family GTPase 3 | 0.0332643 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0331882 |
| HLA-E | major histocompatibility complex, class I, E | 0.0318304 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0316994 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0316531 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0313913 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0309303 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0308245 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0298282 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0297823 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0293993 |
| MSN | moesin | 0.0290892 |
| KYNU | kynureninase | 0.0289282 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0289061 |
| EGR1 | early growth response 1 | 0.0286544 |
| JMJD1C | jumonji domain containing 1C | 0.0285784 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0285044 |
| CDCP1 | CUB domain containing protein 1 | 0.028224 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0277635 |
| RPS2 | ribosomal protein S2 | 0.0277343 |
| MX1 | MX dynamin-like GTPase 1 | 0.0276211 |
| ZNF292 | zinc finger protein 292 | 0.0257524 |
| TXNIP | thioredoxin interacting protein | 0.0257087 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0255568 |
| CENPF | centromere protein F, 350/400kDa | 0.0252983 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.02472 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0246319 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0241796 |
| CALD1 | caldesmon 1 | 0.0241679 |
| PLPP3 | phospholipid phosphatase 3 | 0.0237208 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0235186 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.023486 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0232687 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0231211 |
| SYAP1 | synapse associated protein 1 | 0.0227798 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0225075 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0222968 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0222894 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0222669 |
| TMF1 | TATA element modulatory factor 1 | 0.0221039 |
| OSMR | oncostatin M receptor | 0.0217728 |
| TAPBP | TAP binding protein (tapasin) | 0.021697 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0213588 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0210642 |
| B2M | beta-2-microglobulin | 0.0207787 |
| CCNL1 | cyclin L1 | 0.0207393 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0206633 |
| SNX3 | sorting nexin 3 | 0.0206249 |
| DUSP5 | dual specificity phosphatase 5 | 0.0203593 |
| AHR | aryl hydrocarbon receptor | 0.020315 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0201034 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0200543 |
| STC1 | stanniocalcin 1 | 0.0200215 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.019981 |
| TPM3 | tropomyosin 3 | 0.019695 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0196916 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0196097 |
| YBX3 | Y box binding protein 3 | 0.0192102 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.0191245 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0191185 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0187228 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0186912 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0186274 |
| FOXP1 | forkhead box P1 | 0.01862 |
| VEGFA | vascular endothelial growth factor A | 0.018436 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0184211 |
| ATF3 | activating transcription factor 3 | 0.0183343 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0182392 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0181125 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0178569 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0176675 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0173962 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0171939 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.017138 |
| IRF1 | interferon regulatory factor 1 | 0.0170635 |
| ANLN | anillin, actin binding protein | 0.0168162 |
| RPL21 | ribosomal protein L21 | 0.0168076 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FRMD4A | FERM domain containing 4A | -0.197255 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.18002 |
| VIM | vimentin | -0.168497 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.123256 |
| HMGA2 | high mobility group AT-hook 2 | -0.117738 |
| GLIS3 | GLIS family zinc finger 3 | -0.117634 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.114453 |
| COL6A3 | collagen, type VI, alpha 3 | -0.110566 |
| FN1 | fibronectin 1 | -0.104278 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.102368 |
| CDH13 | cadherin 13 | -0.099044 |
| TMSB10 | thymosin beta 10 | -0.0908393 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0777334 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.072306 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0701153 |
| IER3 | immediate early response 3 | -0.06615 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0637012 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.063262 |
| COL5A1 | collagen, type V, alpha 1 | -0.0631064 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0621262 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0612707 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0562142 |
| INTS6 | integrator complex subunit 6 | -0.0530236 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0524022 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0511424 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0506782 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0503203 |
| DIAPH2 | diaphanous-related formin 2 | -0.0481527 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0470033 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0465997 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.044984 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0436069 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0432235 |
| DST | dystonin | -0.0432174 |
| TMEM132D | transmembrane protein 132D | -0.043028 |
| RPS24 | ribosomal protein S24 | -0.0428205 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0420629 |
| OGA | O-GlcNAcase | -0.0418113 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0408517 |
| RPL37A | ribosomal protein L37a | -0.0403943 |
| PDE10A | phosphodiesterase 10A | -0.0400656 |
| RPL35A | ribosomal protein L35a | -0.0398234 |
| PGK1 | phosphoglycerate kinase 1 | -0.0395234 |
| RBM39 | RNA binding motif protein 39 | -0.0393265 |
| FAM20C | family with sequence similarity 20, member C | -0.0392184 |
| CANX | calnexin | -0.0390181 |
| SMYD3 | SET and MYND domain containing 3 | -0.038811 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0384634 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0382245 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0376176 |
| RAI14 | retinoic acid induced 14 | -0.0373265 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0372498 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0367321 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0362294 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0362133 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0359261 |
| EFNA5 | ephrin-A5 | -0.0354609 |
| EGFR | epidermal growth factor receptor | -0.0354272 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0351091 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0350825 |
| FTL | ferritin, light polypeptide | -0.0350692 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.034665 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0342717 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0341994 |
| NAV1 | neuron navigator 1 | -0.0341788 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.033663 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0332492 |
| MAP4 | microtubule-associated protein 4 | -0.032986 |
| RAD51B | RAD51 paralog B | -0.0328037 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0320967 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.031782 |
| MAP1B | microtubule-associated protein 1B | -0.0316731 |
| RPLP2 | ribosomal protein, large, P2 | -0.0313453 |
| COL6A2 | collagen, type VI, alpha 2 | -0.031222 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0312144 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0312002 |
| RPL23 | ribosomal protein L23 | -0.0311366 |
| TENM2 | teneurin transmembrane protein 2 | -0.0309834 |
| COL4A2 | collagen, type IV, alpha 2 | -0.030672 |
| GNAS | GNAS complex locus | -0.0306495 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0303007 |
| COL1A1 | collagen, type I, alpha 1 | -0.0302343 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0301887 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0301051 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.029994 |
| THBS2 | thrombospondin 2 | -0.029857 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0293612 |
| TMSB4X | thymosin beta 4, X-linked | -0.0286144 |
| FBXO11 | F-box protein 11 | -0.0281759 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0280719 |
| RPS6 | ribosomal protein S6 | -0.0275335 |
| FMNL2 | formin-like 2 | -0.0272162 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0265162 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0263972 |
| RRBP1 | ribosome binding protein 1 | -0.0263927 |
| PARD3 | par-3 family cell polarity regulator | -0.0263686 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0261739 |
| NCKAP5 | NCK-associated protein 5 | -0.0259104 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0258872 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.0258678 |
