Belumosudil (mesylate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belumosudil (mesylate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belumosudil (mesylate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0399873
CXCL8 chemokine (C-X-C motif) ligand 8 0.0358625
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0347516
INTS6 integrator complex subunit 6 0.0343317
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0338118
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0327096
ZSWIM6 zinc finger, SWIM-type containing 6 0.0319127
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0278439
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0268599
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0227791
GOLGA4 golgin A4 0.0220842
CTBP2 C-terminal binding protein 2 0.0187532
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.018366
ANKRD28 ankyrin repeat domain 28 0.0183208
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0179434
SUCO SUN domain containing ossification factor 0.0178018
FAM13A family with sequence similarity 13, member A 0.0173843
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0166299
UBC ubiquitin C 0.015886
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0155649
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0154838
FAT1 FAT atypical cadherin 1 0.0152033
ESYT2 extended synaptotagmin-like protein 2 0.0151514
SIRT1 sirtuin 1 0.0150308
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0144076
PDIA4 protein disulfide isomerase family A, member 4 0.0143338
FGF18 fibroblast growth factor 18 0.0134558
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0133911
DOCK5 dedicator of cytokinesis 5 0.0132643
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.012757
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0125539
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0122131
CD109 CD109 molecule 0.0120417
LRRC23 leucine rich repeat containing 23 0.0120294
SGMS2 sphingomyelin synthase 2 0.01189
COG6 component of oligomeric golgi complex 6 0.0117198
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.011557
ANKRD17 ankyrin repeat domain 17 0.0115412
TRIO trio Rho guanine nucleotide exchange factor 0.0115227
ATF6 activating transcription factor 6 0.0114606
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0114274
TTC3 tetratricopeptide repeat domain 3 0.0111485
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0109814
HSPH1 heat shock 105kDa/110kDa protein 1 0.0109263
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.010749
PAPOLA poly(A) polymerase alpha 0.0106952
POU2F2 POU class 2 homeobox 2 0.0104901
SRP54 signal recognition particle 54kDa 0.0103901
PEAK1 pseudopodium-enriched atypical kinase 1 0.0103889
FAM107B family with sequence similarity 107, member B 0.0103412
BIRC6 baculoviral IAP repeat containing 6 0.010335
AFF1 AF4/FMR2 family, member 1 0.0103028
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0102955
QKI QKI, KH domain containing, RNA binding 0.0101679
CDK13 cyclin-dependent kinase 13 0.0101666
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0100544
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.0100244
HSPA1A heat shock 70kDa protein 1A 0.0100036
NKTR natural killer cell triggering receptor 0.00996123
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.00989701
YTHDC1 YTH domain containing 1 0.00988188
RNF145 ring finger protein 145 0.00985886
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.00983733
MCTP1 multiple C2 domains, transmembrane 1 0.00969944
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.00968711
COG5 component of oligomeric golgi complex 5 0.00963107
SIK2 salt-inducible kinase 2 0.00951111
FNIP1 folliculin interacting protein 1 0.0094207
TBCA tubulin folding cofactor A 0.00939036
PICALM phosphatidylinositol binding clathrin assembly protein 0.00933154
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.00928514
DSCAM Down syndrome cell adhesion molecule 0.00922722
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.009173
EMP1 epithelial membrane protein 1 0.00915145
BHLHE40 basic helix-loop-helix family, member e40 0.00911007
SIK3 SIK family kinase 3 0.0091063
HOOK2 hook microtubule-tethering protein 2 0.00907567
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0090645
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.00905349
HILPDA hypoxia inducible lipid droplet-associated 0.00887577
LHFPL2 lipoma HMGIC fusion partner-like 2 0.00883964
LARP1B La ribonucleoprotein domain family, member 1B 0.00881647
ZNF638 zinc finger protein 638 0.00879901
SMOC1 SPARC related modular calcium binding 1 0.00864098
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.00860461
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.00860302
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0085719
NBAS neuroblastoma amplified sequence 0.00851192
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.00850672
RAB40C RAB40C, member RAS oncogene family 0.00850607
LGMN legumain 0.00848945
FMNL2 formin-like 2 0.00846204
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.00840284
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 0.00838223
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.00832862
CSPP1 centrosome and spindle pole associated protein 1 0.00831381
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.00829103
NOP58 NOP58 ribonucleoprotein 0.00826136
RPL4 ribosomal protein L4 0.008214
AGO3 argonaute RISC catalytic component 3 0.00816378

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.325267
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.235879
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.193222
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.144185
ASPH aspartate beta-hydroxylase -0.135761
NRG1 neuregulin 1 -0.129781
TMSB10 thymosin beta 10 -0.117525
HMGA2 high mobility group AT-hook 2 -0.10399
IFI27 interferon, alpha-inducible protein 27 -0.102998
MT2A metallothionein 2A -0.101774
S100A6 S100 calcium binding protein A6 -0.087643
VCL vinculin -0.0828594
ITGA1 integrin, alpha 1 -0.0775087
VIM vimentin -0.0754105
TMSB4X thymosin beta 4, X-linked -0.0691915
TMEM156 transmembrane protein 156 -0.0640373
B2M beta-2-microglobulin -0.0610649
SQSTM1 sequestosome 1 -0.0592771
PTMA prothymosin, alpha -0.0586603
HLA-B major histocompatibility complex, class I, B -0.0530923
NAMPT nicotinamide phosphoribosyltransferase -0.0520768
SYT1 synaptotagmin I -0.0492644
IFI16 interferon, gamma-inducible protein 16 -0.0490013
MAP1B microtubule-associated protein 1B -0.0484615
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0482792
OSMR oncostatin M receptor -0.0473298
SFTPA2 surfactant protein A2 -0.0465541
ETV1 ets variant 1 -0.0445783
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0443767
HMGA1 high mobility group AT-hook 1 -0.0430948
GLIS3 GLIS family zinc finger 3 -0.0426012
EXT1 exostosin glycosyltransferase 1 -0.0421335
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0416388
NRP1 neuropilin 1 -0.0411698
SOX4 SRY (sex determining region Y)-box 4 -0.0407486
KLHL5 kelch-like family member 5 -0.0407246
FTL ferritin, light polypeptide -0.0405938
TPI1 triosephosphate isomerase 1 -0.0398823
ENO2 enolase 2 (gamma, neuronal) -0.0396478
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0395233
NTN4 netrin 4 -0.0388387
RPL35A ribosomal protein L35a -0.0375185
LY6E lymphocyte antigen 6 complex, locus E -0.0371244
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0363725
S100A10 S100 calcium binding protein A10 -0.0358304
MKI67 marker of proliferation Ki-67 -0.0350838
ACTG1 actin gamma 1 -0.0350073
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0347584
EGR1 early growth response 1 -0.0343385
ENO1 enolase 1, (alpha) -0.0339008
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.033393
ZBTB20 zinc finger and BTB domain containing 20 -0.0325764
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0324045
CENPF centromere protein F, 350/400kDa -0.0323987
PGK1 phosphoglycerate kinase 1 -0.0316539
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0312839
IFI6 interferon, alpha-inducible protein 6 -0.0309089
HIPK2 homeodomain interacting protein kinase 2 -0.0307689
MYH9 myosin, heavy chain 9, non-muscle -0.0303318
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0303266
TXNRD1 thioredoxin reductase 1 -0.0300342
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0297501
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0295218
RTN4 reticulon 4 -0.0294764
RPS21 ribosomal protein S21 -0.0293738
CANX calnexin -0.0291024
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.028981
TSC22D1 TSC22 domain family, member 1 -0.0288814
ETV6 ets variant 6 -0.0288804
LOC102724023 ES1 protein homolog, mitochondrial -0.0286447
TXNIP thioredoxin interacting protein -0.0283318
EIF1 eukaryotic translation initiation factor 1 -0.0276737
RNF213 ring finger protein 213 -0.0275436
ZMYND8 zinc finger, MYND-type containing 8 -0.0274275
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0273534
LMNA lamin A/C -0.0273443
SFRP1 secreted frizzled-related protein 1 -0.0268162
LOC112694756 uncharaterized LOC112694756 -0.0263951
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0262609
CD44 CD44 molecule (Indian blood group) -0.0258859
TPT1 tumor protein, translationally-controlled 1 -0.0256278
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0251637
RUNX2 runt-related transcription factor 2 -0.0251434
TPM4 tropomyosin 4 -0.0248679
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0242493
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0234931
AHR aryl hydrocarbon receptor -0.0233735
TNNC1 troponin C type 1 (slow) -0.0233073
MX2 MX dynamin-like GTPase 2 -0.0232965
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0225605
POTEF POTE ankyrin domain family, member F -0.0224861
LDHA lactate dehydrogenase A -0.022162
PRRC2C proline-rich coiled-coil 2C -0.022023
RPL11 ribosomal protein L11 -0.021982
WDR1 WD repeat domain 1 -0.0218827
HLA-A major histocompatibility complex, class I, A -0.0218524
NT5E 5'-nucleotidase, ecto (CD73) -0.0218397
S100A9 S100 calcium binding protein A9 -0.0218073
CBX3 chromobox homolog 3 -0.021733
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0216438