Belumosudil (mesylate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belumosudil (mesylate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belumosudil (mesylate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SYT1 synaptotagmin I 0.027766
TNS3 tensin 3 0.0256315
LMO7 LIM domain 7 0.0251067
DST dystonin 0.0244168
RPL4 ribosomal protein L4 0.0236437
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0227636
ATXN1 ataxin 1 0.0188137
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0184999
INTS6 integrator complex subunit 6 0.0176416
PCLO piccolo presynaptic cytomatrix protein 0.0168345
MBNL2 muscleblind-like splicing regulator 2 0.0158795
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0149724
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0149411
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0149305
SVIL supervillin 0.0144872
UBC ubiquitin C 0.0136748
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0136726
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0131269
WNK1 WNK lysine deficient protein kinase 1 0.0130341
SMAD3 SMAD family member 3 0.0128175
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0125158
KIZ kizuna centrosomal protein 0.0123839
ANO6 anoctamin 6 0.0123491
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.012146
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0120918
TTC3 tetratricopeptide repeat domain 3 0.0119695
SERINC5 serine incorporator 5 0.0118085
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0117531
YAP1 Yes-associated protein 1 0.0117222
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0115546
TRIO trio Rho guanine nucleotide exchange factor 0.0115259
GOLGB1 golgin B1 0.011485
CEMIP2 cell migration inducing hyaluronidase 2 0.0112127
AHNAK AHNAK nucleoprotein 0.0110549
HDAC4 histone deacetylase 4 0.0108628
ARL15 ADP-ribosylation factor-like 15 0.0108201
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0104866
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0103749
UTRN utrophin 0.0103409
AFF1 AF4/FMR2 family, member 1 0.00985792
KDM4C lysine (K)-specific demethylase 4C 0.00985398
PDLIM5 PDZ and LIM domain 5 0.00967228
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.00966494
RERE arginine-glutamic acid dipeptide (RE) repeats 0.00959852
EXOC4 exocyst complex component 4 0.00953273
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.00946933
PEAK1 pseudopodium-enriched atypical kinase 1 0.00941581
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.00927277
SAMD4A sterile alpha motif domain containing 4A 0.00910534
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.00906824
ZEB1 zinc finger E-box binding homeobox 1 0.00889831
DSPP dentin sialophosphoprotein 0.0088791
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.00877972
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.00873833
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.00867075
FNIP1 folliculin interacting protein 1 0.00853139
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.00844443
ZNF638 zinc finger protein 638 0.0083689
HELZ helicase with zinc finger 0.00835811
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.00835756
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.00830774
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00810951
UBN2 ubinuclein 2 0.00802626
H1-0 H1.0 linker histone 0.00792534
USP9X ubiquitin specific peptidase 9, X-linked 0.00791587
BMP5 bone morphogenetic protein 5 0.0077992
LPP LIM domain containing preferred translocation partner in lipoma 0.00773335
MBD5 methyl-CpG binding domain protein 5 0.00769298
OGA O-GlcNAcase 0.00767451
KLF12 Kruppel-like factor 12 0.00757459
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.00752884
WWOX WW domain containing oxidoreductase 0.00748556
KDM6A lysine (K)-specific demethylase 6A 0.00745604
PIBF1 progesterone immunomodulatory binding factor 1 0.00743235
FMNL2 formin-like 2 0.00740548
PRKCA protein kinase C, alpha 0.00740137
USP47 ubiquitin specific peptidase 47 0.00736845
MCC mutated in colorectal cancers 0.00736728
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.00727935
SBF2 SET binding factor 2 0.00727172
STK38L serine/threonine kinase 38 like 0.00723954
PHF21A PHD finger protein 21A 0.00717628
ARHGAP42 Rho GTPase activating protein 42 0.00710861
CNOT1 CCR4-NOT transcription complex, subunit 1 0.00703986
CHD9 chromodomain helicase DNA binding protein 9 0.0070159
RNF43 ring finger protein 43 0.00695392
FTO fat mass and obesity associated 0.00693016
LRP6 low density lipoprotein receptor-related protein 6 0.0069047
RIMBP2 RIMS binding protein 2 0.00689874
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0068968
ETNK1 ethanolamine kinase 1 0.00673676
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.00673652
MACC1 metastasis associated in colon cancer 1 0.00666751
RUNX1 runt-related transcription factor 1 0.0066646
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.00660635
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.00660291
NEBL nebulette 0.00656363
TOX3 TOX high mobility group box family member 3 0.00648575
NBAS neuroblastoma amplified sequence 0.00648013
SIK3 SIK family kinase 3 0.00647636

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.172676
TMSB10 thymosin beta 10 -0.147456
RPL35A ribosomal protein L35a -0.14723
TPT1 tumor protein, translationally-controlled 1 -0.142799
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.100703
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0973681
KRT18 keratin 18, type I -0.0940313
CCND1 cyclin D1 -0.0727675
ACTG1 actin gamma 1 -0.0676913
RPL23 ribosomal protein L23 -0.0671118
RPS24 ribosomal protein S24 -0.0667884
RPS6 ribosomal protein S6 -0.0652942
KRT8 keratin 8, type II -0.0632978
RPS19 ribosomal protein S19 -0.0595422
VIM vimentin -0.055986
RPLP1 ribosomal protein, large, P1 -0.0558231
HMGA1 high mobility group AT-hook 1 -0.0542285
RPL26 ribosomal protein L26 -0.0511425
RPS21 ribosomal protein S21 -0.0499694
SDK1 sidekick cell adhesion molecule 1 -0.044638
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0438807
RBP1 retinol binding protein 1, cellular -0.0437199
RPL11 ribosomal protein L11 -0.0433741
ACTN4 actinin, alpha 4 -0.0431841
CBX3 chromobox homolog 3 -0.0424192
FTL ferritin, light polypeptide -0.0423611
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0420366
RPL36A ribosomal protein L36a -0.0414848
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0406097
MT2A metallothionein 2A -0.0405012
RPLP2 ribosomal protein, large, P2 -0.0400745
KPNB1 karyopherin (importin) beta 1 -0.0395676
RPL9 ribosomal protein L9 -0.0392007
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0390628
RPS13 ribosomal protein S13 -0.0384321
RPL31 ribosomal protein L31 -0.0380076
RPLP0 ribosomal protein, large, P0 -0.0375497
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0375055
PFN1 profilin 1 -0.0373923
TUBA1B tubulin, alpha 1b -0.0366737
RPL34 ribosomal protein L34 -0.0365793
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0356234
RPL12 ribosomal protein L12 -0.0353602
TMSB4X thymosin beta 4, X-linked -0.0343236
LOC102724023 ES1 protein homolog, mitochondrial -0.0335283
RPS3 ribosomal protein S3 -0.0332746
TPI1 triosephosphate isomerase 1 -0.0329147
RPL27A ribosomal protein L27a -0.0327713
RPS14 ribosomal protein S14 -0.0326797
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0324382
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0323473
RPL37A ribosomal protein L37a -0.0322403
MKI67 marker of proliferation Ki-67 -0.0317203
HMGB1 high mobility group box 1 -0.0312615
RPS5 ribosomal protein S5 -0.0311646
RPL19 ribosomal protein L19 -0.0307479
LDHA lactate dehydrogenase A -0.0307299
S100A10 S100 calcium binding protein A10 -0.0304289
RPS27A ribosomal protein S27a -0.0303859
RPL7A ribosomal protein L7a -0.0301503
DEK DEK proto-oncogene -0.0300988
EGR1 early growth response 1 -0.0299237
RPS25 ribosomal protein S25 -0.0298458
RPS8 ribosomal protein S8 -0.0297489
S100A6 S100 calcium binding protein A6 -0.0296268
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0295641
MYL12B myosin, light chain 12B, regulatory -0.0291425
S100A9 S100 calcium binding protein A9 -0.0287868
NAP1L1 nucleosome assembly protein 1-like 1 -0.028754
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0286605
TUBB4B tubulin, beta 4B class IVb -0.0286087
KRT19 keratin 19, type I -0.0283613
POTEF POTE ankyrin domain family, member F -0.0283407
RPL5 ribosomal protein L5 -0.0283003
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0278897
RPL35 ribosomal protein L35 -0.0278702
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0277836
RPL37 ribosomal protein L37 -0.0277094
AKAP12 A kinase (PRKA) anchor protein 12 -0.0274253
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0271153
ITGA6 integrin, alpha 6 -0.0271057
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0267844
RPS11 ribosomal protein S11 -0.0264352
PGK1 phosphoglycerate kinase 1 -0.0261879
EIF1 eukaryotic translation initiation factor 1 -0.0261245
GNAS GNAS complex locus -0.0259141
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0257692
ANLN anillin, actin binding protein -0.0253587
TPM4 tropomyosin 4 -0.0252443
RPS4X ribosomal protein S4, X-linked -0.0251958
LMNA lamin A/C -0.0250309
PDGFA platelet-derived growth factor alpha polypeptide -0.0247297
RPL38 ribosomal protein L38 -0.0247252
EIF5B eukaryotic translation initiation factor 5B -0.0244665
SMC4 structural maintenance of chromosomes 4 -0.0243463
RPS16 ribosomal protein S16 -0.0240162
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0237932
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0229003
TUBB tubulin, beta class I -0.022882
NOP56 NOP56 ribonucleoprotein -0.0228672