| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil (mesylate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| INHBA | inhibin, beta A | 0.146012 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.118372 |
| STC1 | stanniocalcin 1 | 0.113893 |
| HLA-B | major histocompatibility complex, class I, B | 0.0928111 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0843419 |
| B2M | beta-2-microglobulin | 0.0772109 |
| MYO10 | myosin X | 0.0754745 |
| HMGA2 | high mobility group AT-hook 2 | 0.0646107 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0605762 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0559157 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0500068 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0494069 |
| NPTX1 | neuronal pentraxin I | 0.0482149 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.045044 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0436295 |
| HLA-A | major histocompatibility complex, class I, A | 0.0434155 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0411253 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0409654 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0405314 |
| MT2A | metallothionein 2A | 0.0400959 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0385388 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0380505 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.035063 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0341864 |
| GLIS3 | GLIS family zinc finger 3 | 0.0331234 |
| FMNL2 | formin-like 2 | 0.0330964 |
| COL1A2 | collagen, type I, alpha 2 | 0.0328279 |
| CD44 | CD44 molecule (Indian blood group) | 0.0326458 |
| INTS6 | integrator complex subunit 6 | 0.0325687 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0322388 |
| RPS8 | ribosomal protein S8 | 0.0317255 |
| ADM | adrenomedullin | 0.0314796 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0309401 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0307098 |
| NAV1 | neuron navigator 1 | 0.0306333 |
| EMP1 | epithelial membrane protein 1 | 0.0305148 |
| UBC | ubiquitin C | 0.0300851 |
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.0286281 |
| RPS6 | ribosomal protein S6 | 0.0280319 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0278662 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0278313 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0278144 |
| MED13L | mediator complex subunit 13-like | 0.0272655 |
| PRELID2 | PRELI domain containing 2 | 0.0271648 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0266381 |
| ENO1 | enolase 1, (alpha) | 0.0265337 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0264411 |
| CALR | calreticulin | 0.0261085 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0260191 |
| AHNAK | AHNAK nucleoprotein | 0.0256274 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0254531 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0249184 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0235697 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0235481 |
| NOTCH2 | notch 2 | 0.0232925 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0231774 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0231001 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0230012 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0229229 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0226564 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0226155 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0222427 |
| SAMD3 | sterile alpha motif domain containing 3 | 0.0222076 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0220262 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0218601 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0216725 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0214467 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0213952 |
| SNX9 | sorting nexin 9 | 0.0212828 |
| PTK2 | protein tyrosine kinase 2 | 0.0212563 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.021013 |
| GOLGA4 | golgin A4 | 0.020796 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0207704 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0206106 |
| GOLGB1 | golgin B1 | 0.0203078 |
| RPL4 | ribosomal protein L4 | 0.0202011 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0201434 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0198544 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0195814 |
| FNDC3A | fibronectin type III domain containing 3A | 0.019395 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0192144 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0190554 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0190224 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0190117 |
| CLMP | CXADR-like membrane protein | 0.0186458 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0183234 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0182094 |
| DCN | decorin | 0.0180658 |
| RPS12 | ribosomal protein S12 | 0.0179465 |
| NCKAP5 | NCK-associated protein 5 | 0.0178039 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0176167 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0175479 |
| DGKI | diacylglycerol kinase, iota | 0.0175172 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0174646 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0173034 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0173023 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0172932 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0169953 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0169776 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0169403 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | -0.128644 |
| MMP1 | matrix metallopeptidase 1 | -0.0640011 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0608212 |
| FN1 | fibronectin 1 | -0.0593951 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0550131 |
| TMSB10 | thymosin beta 10 | -0.0463481 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0431732 |
| LOXL2 | lysyl oxidase-like 2 | -0.0396604 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0313575 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0309503 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0305155 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0282179 |
| ATP13A3 | ATPase type 13A3 | -0.0281616 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0250949 |
| COL1A1 | collagen, type I, alpha 1 | -0.0245835 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0244135 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0240865 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0238975 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0223158 |
| ANXA2 | annexin A2 | -0.0222233 |
| SMAD3 | SMAD family member 3 | -0.021534 |
| PLPP3 | phospholipid phosphatase 3 | -0.0211406 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0206119 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0201594 |
| RTN4 | reticulon 4 | -0.0200144 |
| MSI2 | musashi RNA-binding protein 2 | -0.019784 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0194522 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0193564 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0191915 |
| OSMR | oncostatin M receptor | -0.017692 |
| PGK1 | phosphoglycerate kinase 1 | -0.0175068 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0173668 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0169511 |
| SEPTIN11 | septin 11 | -0.01544 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0153337 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0152325 |
| VIM | vimentin | -0.0144186 |
| HAS2 | hyaluronan synthase 2 | -0.0140795 |
| CDK17 | cyclin-dependent kinase 17 | -0.0139773 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0139157 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.013896 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0138441 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.013678 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0136192 |
| CHSY1 | chondroitin sulfate synthase 1 | -0.0133769 |
| ACTG1 | actin gamma 1 | -0.0132744 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0131797 |
| CLTC | clathrin, heavy chain (Hc) | -0.0130426 |
| SMOX | spermine oxidase | -0.0129389 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0127607 |
| HLA-C | major histocompatibility complex, class I, C | -0.0127425 |
| XPO1 | exportin 1 | -0.0127332 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0127152 |
| THBS2 | thrombospondin 2 | -0.012645 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0126411 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0125253 |
| NDRG1 | N-myc downstream regulated 1 | -0.0123194 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0120372 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0119854 |
| EHD2 | EH-domain containing 2 | -0.0118917 |
| RPL35A | ribosomal protein L35a | -0.0118608 |
| RPL38 | ribosomal protein L38 | -0.0116625 |
| DUSP10 | dual specificity phosphatase 10 | -0.0116469 |
| KCNE4 | potassium channel, voltage gated subfamily E regulatory beta subunit 4 | -0.0115677 |
| SYAP1 | synapse associated protein 1 | -0.011445 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0114201 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0112162 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.0112029 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0110604 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0110571 |
| CEP95 | centrosomal protein 95kDa | -0.0109477 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.010914 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.01085 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | -0.0108185 |
| NLGN1 | neuroligin 1 | -0.0108145 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0107397 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0106384 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0106086 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.010511 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0104122 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0103831 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0103747 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0103651 |
| TNPO1 | transportin 1 | -0.0103406 |
| AFAP1 | actin filament associated protein 1 | -0.0103014 |
| FBXO28 | F-box protein 28 | -0.010293 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0102135 |
| GRB2 | growth factor receptor-bound protein 2 | -0.0101688 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0101678 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0101338 |
| ADAMTS4 | ADAM metallopeptidase with thrombospondin type 1 motif, 4 | -0.0100704 |
| SNAI2 | snail family zinc finger 2 | -0.0100412 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.00994688 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.00985719 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.00985182 |
| FBXO34 | F-box protein 34 | -0.00979494 |
| SOCS5 | suppressor of cytokine signaling 5 | -0.00974766 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.00968236 |
| ARF4 | ADP-ribosylation factor 4 | -0.0096027 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.00958697 |
