| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.157806 |
| APOB | apolipoprotein B | 0.156732 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.144587 |
| TF | transferrin | 0.120822 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.11431 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.10814 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0947587 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0943186 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0938103 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0845022 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0840233 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0804569 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0788643 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0777451 |
| DSPP | dentin sialophosphoprotein | 0.0771177 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0754903 |
| FN1 | fibronectin 1 | 0.070575 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0695569 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0677574 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0672462 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0662446 |
| SVIL | supervillin | 0.0656885 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0650112 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0648501 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.064136 |
| VEGFA | vascular endothelial growth factor A | 0.0630845 |
| CANX | calnexin | 0.0616865 |
| RPL3 | ribosomal protein L3 | 0.0603189 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0596297 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0569423 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0569364 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0566123 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0550156 |
| PTMA | prothymosin, alpha | 0.0534794 |
| RPL7 | ribosomal protein L7 | 0.0524965 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0516543 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0505421 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0504901 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0497494 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0487879 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0479059 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0475953 |
| FAT1 | FAT atypical cadherin 1 | 0.0469265 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0463401 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0461737 |
| CCNY | cyclin Y | 0.044817 |
| RPS12 | ribosomal protein S12 | 0.0434184 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.043308 |
| CPE | carboxypeptidase E | 0.0428366 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0426936 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0425677 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0423973 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0418075 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0403714 |
| CFB | complement factor B | 0.0396057 |
| WDR43 | WD repeat domain 43 | 0.0394134 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0388697 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0388176 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0382448 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0381683 |
| YAP1 | Yes-associated protein 1 | 0.0380039 |
| BCL2L1 | BCL2-like 1 | 0.0379746 |
| AHSG | alpha-2-HS-glycoprotein | 0.0374157 |
| NCKAP1 | NCK-associated protein 1 | 0.0373089 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0371771 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0371229 |
| JAK1 | Janus kinase 1 | 0.0369539 |
| PTK2 | protein tyrosine kinase 2 | 0.0365651 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0364831 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0363289 |
| PLEC | plectin | 0.0360124 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0355642 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0354786 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0354616 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0352771 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0349977 |
| RBM39 | RNA binding motif protein 39 | 0.0349002 |
| PLIN2 | perilipin 2 | 0.0348627 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0348172 |
| AFDN | afadin, adherens junction formation factor | 0.0346042 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0343661 |
| ANXA5 | annexin A5 | 0.0339011 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0335187 |
| TNS1 | tensin 1 | 0.0327238 |
| XPO1 | exportin 1 | 0.0326577 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0323769 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0315346 |
| PCBP2 | poly(rC) binding protein 2 | 0.031271 |
| PAPOLA | poly(A) polymerase alpha | 0.0310984 |
| DIAPH1 | diaphanous-related formin 1 | 0.0310534 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0309537 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0309382 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0308643 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0307342 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0306027 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0305106 |
| IFNGR1 | interferon gamma receptor 1 | 0.0302532 |
| MYO1B | myosin IB | 0.0300543 |
| MRTFA | myocardin related transcription factor A | 0.029822 |
| SPAG9 | sperm associated antigen 9 | 0.0297376 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.145153 |
| GPC6 | glypican 6 | -0.137646 |
| SLC38A2 | solute carrier family 38, member 2 | -0.102789 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0985689 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0957466 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0878098 |
| RUNX1 | runt-related transcription factor 1 | -0.0877901 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0863599 |
| H1-0 | H1.0 linker histone | -0.0808437 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0752882 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0686041 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0658325 |
| FTL | ferritin, light polypeptide | -0.0617958 |
| IGF2 | insulin-like growth factor 2 | -0.0613299 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0583191 |
| PTCHD4 | patched domain containing 4 | -0.0564054 |
| INTS6 | integrator complex subunit 6 | -0.054848 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0547831 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0538385 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0501263 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.048788 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0474228 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0473218 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0466309 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0464013 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.046152 |
| CP | ceruloplasmin (ferroxidase) | -0.0458183 |
| APOA2 | apolipoprotein A-II | -0.0449544 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0445366 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.041585 |
| RPS24 | ribosomal protein S24 | -0.0415725 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0408658 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0405756 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0403418 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0403138 |
| DST | dystonin | -0.0397168 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.038967 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0383598 |
| STK17A | serine/threonine kinase 17a | -0.037509 |
| OSMR | oncostatin M receptor | -0.0374678 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0374634 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0369608 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0368936 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0365585 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0360475 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0353112 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0340229 |
| RPS16 | ribosomal protein S16 | -0.0334787 |
| SBF2 | SET binding factor 2 | -0.0326141 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0325814 |
| RPS19 | ribosomal protein S19 | -0.0324343 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0321444 |
| RPL32 | ribosomal protein L32 | -0.0316789 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0311113 |
| GPC3 | glypican 3 | -0.0308571 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0305748 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.030301 |
| EGR1 | early growth response 1 | -0.0297441 |
| RPL37 | ribosomal protein L37 | -0.0297123 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.0293169 |
| GDF15 | growth differentiation factor 15 | -0.0292467 |
| GLIS3 | GLIS family zinc finger 3 | -0.0286424 |
| TXNIP | thioredoxin interacting protein | -0.0284778 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0283867 |
| RPL12 | ribosomal protein L12 | -0.0283255 |
| WDR45B | WD repeat domain 45B | -0.0282517 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0281795 |
| NF1 | neurofibromin 1 | -0.0280652 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0278252 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0276423 |
| ATXN1 | ataxin 1 | -0.0274189 |
| RPS27A | ribosomal protein S27a | -0.0271513 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0267167 |
| NPR2 | natriuretic peptide receptor 2 | -0.0266886 |
| RPLP1 | ribosomal protein, large, P1 | -0.0265454 |
| IER3 | immediate early response 3 | -0.0261155 |
| RPLP2 | ribosomal protein, large, P2 | -0.0260378 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | -0.0256566 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0256386 |
| RPL28 | ribosomal protein L28 | -0.0255858 |
| PHF21A | PHD finger protein 21A | -0.0255636 |
| NABP1 | nucleic acid binding protein 1 | -0.0255294 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0253575 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0252024 |
| RPS29 | ribosomal protein S29 | -0.0251775 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0248948 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0248137 |
| FILIP1L | filamin A interacting protein 1-like | -0.0245414 |
| RPS15 | ribosomal protein S15 | -0.0245091 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.0244354 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0243154 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0241009 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0240744 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0240472 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.0240324 |
| ATP11A | ATPase, class VI, type 11A | -0.0240288 |
| TMEM123 | transmembrane protein 123 | -0.0240287 |
| RPL35A | ribosomal protein L35a | -0.0240024 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0237851 |
| NSD3 | nuclear receptor binding SET domain protein 3 | -0.0236041 |
