| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Belumosudil_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.215239 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0999415 |
| TOP1 | topoisomerase (DNA) I | 0.0966237 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0921177 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0876781 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0857589 |
| SMAD3 | SMAD family member 3 | 0.0830858 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.08187 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0797106 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0792271 |
| CES1 | carboxylesterase 1 | 0.0759702 |
| TXNRD1 | thioredoxin reductase 1 | 0.0724001 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.072386 |
| RPL7 | ribosomal protein L7 | 0.070624 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0692691 |
| PLEC | plectin | 0.069232 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0661911 |
| PTMA | prothymosin, alpha | 0.0655762 |
| RPS3 | ribosomal protein S3 | 0.0633493 |
| MKI67 | marker of proliferation Ki-67 | 0.0629504 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0627666 |
| MCL1 | myeloid cell leukemia 1 | 0.0577698 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0577621 |
| RNF145 | ring finger protein 145 | 0.0572165 |
| LAMB3 | laminin, beta 3 | 0.0561886 |
| DSPP | dentin sialophosphoprotein | 0.0561418 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0560155 |
| GRAMD1B | GRAM domain containing 1B | 0.0549238 |
| MT2A | metallothionein 2A | 0.0542468 |
| ARRDC3 | arrestin domain containing 3 | 0.053795 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0530021 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.052748 |
| PCBP2 | poly(rC) binding protein 2 | 0.0526462 |
| FAM13A | family with sequence similarity 13, member A | 0.0508196 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0506605 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0504495 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0501005 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0483488 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0469197 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.046335 |
| RPL19 | ribosomal protein L19 | 0.0462652 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0451895 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0431929 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.042929 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0428781 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0420964 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0420677 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0420227 |
| MSN | moesin | 0.0419751 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0415785 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0414953 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0404403 |
| ATP13A3 | ATPase type 13A3 | 0.0402445 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0398662 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0387798 |
| ENO1 | enolase 1, (alpha) | 0.0379685 |
| SLMAP | sarcolemma associated protein | 0.0377105 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0374755 |
| RPL3 | ribosomal protein L3 | 0.036996 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0369514 |
| HYOU1 | hypoxia up-regulated 1 | 0.0365512 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0362854 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0362385 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0357644 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0356495 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0354499 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0343298 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0337005 |
| RPL37A | ribosomal protein L37a | 0.0336035 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0330498 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0322688 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0321995 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0318465 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0317595 |
| CPE | carboxypeptidase E | 0.0316987 |
| NDE1 | nudE neurodevelopment protein 1 | 0.0316708 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0315346 |
| ZNF292 | zinc finger protein 292 | 0.0312783 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0309502 |
| RPL4 | ribosomal protein L4 | 0.0308521 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0303708 |
| YTHDC1 | YTH domain containing 1 | 0.0303535 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0300972 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0300306 |
| CD163L1 | CD163 molecule-like 1 | 0.0299656 |
| TPM3 | tropomyosin 3 | 0.0298995 |
| NCKAP1 | NCK-associated protein 1 | 0.0298892 |
| ANXA5 | annexin A5 | 0.0296755 |
| RPS12 | ribosomal protein S12 | 0.0296751 |
| CLU | clusterin | 0.0295857 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0294388 |
| RPS8 | ribosomal protein S8 | 0.0292504 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0290927 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0289694 |
| RPL11 | ribosomal protein L11 | 0.0287466 |
| RPS25 | ribosomal protein S25 | 0.0286524 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0285074 |
| MATR3 | matrin 3 | 0.028461 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0283876 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0283482 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.336179 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.128974 |
| EGR1 | early growth response 1 | -0.0829608 |
| OSMR | oncostatin M receptor | -0.0769459 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0752275 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0717289 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0628103 |
| LMO7 | LIM domain 7 | -0.0586495 |
| NABP1 | nucleic acid binding protein 1 | -0.0578935 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0550103 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0538953 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0504638 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0504169 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0486175 |
| TMSB10 | thymosin beta 10 | -0.0477127 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0396528 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0384449 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0358026 |
| INTS6 | integrator complex subunit 6 | -0.0354504 |
| NBEAL1 | neurobeachin-like 1 | -0.0338251 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0330173 |
| SLC38A2 | solute carrier family 38, member 2 | -0.032057 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0301723 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0298529 |
| MORF4L2 | mortality factor 4 like 2 | -0.0291493 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0287293 |
| DSCAM | Down syndrome cell adhesion molecule | -0.028713 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0285147 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0281303 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0277837 |
| ACTG1 | actin gamma 1 | -0.0264838 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0262553 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0260595 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0259179 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0256628 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0255598 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0253542 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0244749 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0243362 |
| EFNA5 | ephrin-A5 | -0.0242132 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.023231 |
| FAAH2 | fatty acid amide hydrolase 2 | -0.0232169 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0230683 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0227011 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.022598 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.022473 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0223977 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0222797 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0222021 |
| MGAT4C | MGAT4 family, member C | -0.022159 |
| GM2A | GM2 ganglioside activator | -0.0218642 |
| FOXP1 | forkhead box P1 | -0.0217319 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0217307 |
| AGR2 | anterior gradient 2 | -0.0216981 |
| TJP1 | tight junction protein 1 | -0.0216791 |
| VCL | vinculin | -0.0216367 |
| MT1X | metallothionein 1X | -0.0214518 |
| LAMA4 | laminin, alpha 4 | -0.0214353 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0209023 |
| ABLIM1 | actin binding LIM protein 1 | -0.0206786 |
| SEC24A | SEC24 family member A | -0.0205386 |
| HLA-B | major histocompatibility complex, class I, B | -0.0202338 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0201344 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0199092 |
| TRIM56 | tripartite motif containing 56 | -0.0199032 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | -0.0196878 |
| CCND1 | cyclin D1 | -0.0195683 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0194801 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0192784 |
| OXSR1 | oxidative stress responsive 1 | -0.0186694 |
| SP100 | SP100 nuclear antigen | -0.0185789 |
| MYO1E | myosin IE | -0.01857 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0185618 |
| PKM | pyruvate kinase, muscle | -0.0181922 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0176853 |
| ARF1 | ADP-ribosylation factor 1 | -0.0176377 |
| ZBTB25 | zinc finger and BTB domain containing 25 | -0.0175083 |
| MYO9A | myosin IXA | -0.0174405 |
| SYAP1 | synapse associated protein 1 | -0.0173087 |
| EHBP1 | EH domain binding protein 1 | -0.0170121 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.016921 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0168649 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0168457 |
| SIK3 | SIK family kinase 3 | -0.0168309 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0168211 |
| FBXO11 | F-box protein 11 | -0.0167002 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.016411 |
| TMEM263 | transmembrane protein 263 | -0.0161524 |
| NTN4 | netrin 4 | -0.016112 |
| TAOK1 | TAO kinase 1 | -0.0160215 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.015911 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0158474 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0156594 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0156477 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0155067 |
| BPTF | bromodomain PHD finger transcription factor | -0.0153565 |
| COPA | coatomer protein complex, subunit alpha | -0.0153255 |
| PCED1B | PC-esterase domain containing 1B | -0.0153244 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0152819 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.0152289 |
