| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.168363 |
| TXNRD1 | thioredoxin reductase 1 | 0.132955 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.121203 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.114535 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0952534 |
| VIM | vimentin | 0.0934289 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0928137 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0898905 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0853709 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0687407 |
| FGB | fibrinogen beta chain | 0.0665823 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.065644 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.064574 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0616591 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0589379 |
| CALR | calreticulin | 0.0589305 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0568076 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0549499 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0529244 |
| RPL19 | ribosomal protein L19 | 0.0520386 |
| S100A6 | S100 calcium binding protein A6 | 0.0511454 |
| ASPH | aspartate beta-hydroxylase | 0.0504611 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0485605 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0460003 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0456265 |
| CANX | calnexin | 0.0452514 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0445935 |
| RPL7 | ribosomal protein L7 | 0.0440281 |
| JAK1 | Janus kinase 1 | 0.0436268 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0421627 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0421364 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.041714 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0413797 |
| RPL4 | ribosomal protein L4 | 0.0405463 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0394519 |
| HDGF | hepatoma-derived growth factor | 0.0393433 |
| RPL3 | ribosomal protein L3 | 0.0385694 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0382045 |
| RPS7 | ribosomal protein S7 | 0.0380654 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0371343 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0363487 |
| PFKP | phosphofructokinase, platelet | 0.0361324 |
| LAMB1 | laminin, beta 1 | 0.0357098 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0347213 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0344658 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0341528 |
| SVIL | supervillin | 0.0341283 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.033923 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0332997 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0330113 |
| TPM3 | tropomyosin 3 | 0.0325953 |
| OLA1 | Obg-like ATPase 1 | 0.0325095 |
| SDC4 | syndecan 4 | 0.0322747 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.0322363 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0320531 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0304393 |
| RPL26 | ribosomal protein L26 | 0.030005 |
| TPM4 | tropomyosin 4 | 0.0299761 |
| FLNA | filamin A, alpha | 0.0293788 |
| ANXA5 | annexin A5 | 0.029229 |
| RSPO3 | R-spondin 3 | 0.0286084 |
| OSMR | oncostatin M receptor | 0.028185 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0279573 |
| INHBA | inhibin, beta A | 0.0276657 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0264427 |
| HYOU1 | hypoxia up-regulated 1 | 0.0264417 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0261544 |
| IL6 | interleukin 6 | 0.0255553 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0245962 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0243774 |
| B2M | beta-2-microglobulin | 0.0237219 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0236549 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0232025 |
| NUDT21 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | 0.0231446 |
| FAM168A | family with sequence similarity 168, member A | 0.022893 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | 0.0228123 |
| RPL41 | ribosomal protein L41 | 0.0227159 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0224388 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.022297 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0222923 |
| PLEC | plectin | 0.0222889 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.022251 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0221999 |
| CD44 | CD44 molecule (Indian blood group) | 0.0220293 |
| ENO1 | enolase 1, (alpha) | 0.0219182 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0219083 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0218226 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0217707 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0217631 |
| HLA-A | major histocompatibility complex, class I, A | 0.0217501 |
| SSRP1 | structure specific recognition protein 1 | 0.0212886 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0211944 |
| RPL11 | ribosomal protein L11 | 0.0211851 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0211331 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.021034 |
| CTSL | cathepsin L | 0.0209644 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0203591 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0202822 |
| IL6ST | interleukin 6 signal transducer | 0.0202627 |
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 0.0202255 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.253906 |
| TMSB10 | thymosin beta 10 | -0.151436 |
| FTL | ferritin, light polypeptide | -0.140548 |
| ERBIN | erbb2 interacting protein | -0.0931503 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0775706 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0704567 |
| CMIP | c-Maf inducing protein | -0.0651862 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.062236 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0576798 |
| PARD3 | par-3 family cell polarity regulator | -0.0571439 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0566789 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0564559 |
| USP34 | ubiquitin specific peptidase 34 | -0.0563695 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0554498 |
| RBM39 | RNA binding motif protein 39 | -0.0536263 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0529398 |
| COPA | coatomer protein complex, subunit alpha | -0.0524913 |
| RBM25 | RNA binding motif protein 25 | -0.0513685 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0506863 |
| STC1 | stanniocalcin 1 | -0.0496869 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0495988 |
| FBXO11 | F-box protein 11 | -0.047678 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0471318 |
| EGR1 | early growth response 1 | -0.0446168 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0437266 |
| RPL8 | ribosomal protein L8 | -0.0437165 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.043385 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0432042 |
| PRR16 | proline rich 16 | -0.043166 |
| GLG1 | golgi glycoprotein 1 | -0.0421264 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0415127 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.040532 |
| ECT2 | epithelial cell transforming 2 | -0.0392984 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0391275 |
| UTRN | utrophin | -0.0390786 |
| NF1 | neurofibromin 1 | -0.0386473 |
| RPS21 | ribosomal protein S21 | -0.038045 |
| TMEM87A | transmembrane protein 87A | -0.0378149 |
| RCC1 | regulator of chromosome condensation 1 | -0.037757 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0377161 |
| ZFHX3 | zinc finger homeobox 3 | -0.0375405 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0370964 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0370754 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0367619 |
| FLNB | filamin B, beta | -0.0365875 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0355264 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0354983 |
| HMGA1 | high mobility group AT-hook 1 | -0.0354658 |
| ACTG1 | actin gamma 1 | -0.0351339 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0350973 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0350515 |
| ZNF207 | zinc finger protein 207 | -0.0347893 |
| ANKRD28 | ankyrin repeat domain 28 | -0.034415 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0343459 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0338103 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0334794 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0333731 |
| FOXO3 | forkhead box O3 | -0.0332407 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | -0.0330164 |
| RPLP0 | ribosomal protein, large, P0 | -0.0330008 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0329119 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.032599 |
| RPS29 | ribosomal protein S29 | -0.0325447 |
| NEGR1 | neuronal growth regulator 1 | -0.0320911 |
| AK1 | adenylate kinase 1 | -0.0320189 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0319574 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0318667 |
| ZNF644 | zinc finger protein 644 | -0.0317885 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.031597 |
| RAD51B | RAD51 paralog B | -0.0315596 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0315548 |
| NEBL | nebulette | -0.0313144 |
| RPS15 | ribosomal protein S15 | -0.0311878 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0310008 |
| PCNX1 | pecanex 1 | -0.0309453 |
| HMGB1 | high mobility group box 1 | -0.0309257 |
| JMJD1C | jumonji domain containing 1C | -0.0308192 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0306789 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0303443 |
| SNX14 | sorting nexin 14 | -0.0302658 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0302528 |
| NFIA | nuclear factor I/A | -0.0302358 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0302151 |
| PFN1 | profilin 1 | -0.0301507 |
| CTBP2 | C-terminal binding protein 2 | -0.0301416 |
| NUP98 | nucleoporin 98kDa | -0.0301303 |
| ARF4 | ADP-ribosylation factor 4 | -0.0300208 |
| SETD5 | SET domain containing 5 | -0.0296594 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0296559 |
| PKM | pyruvate kinase, muscle | -0.0296155 |
| TLK1 | tousled-like kinase 1 | -0.0293279 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0292594 |
| IER3 | immediate early response 3 | -0.0289111 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0287363 |
| FMNL2 | formin-like 2 | -0.0283968 |
| NOP58 | NOP58 ribonucleoprotein | -0.0281947 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0280892 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.027799 |
| EGFR | epidermal growth factor receptor | -0.0277014 |
| YY1 | YY1 transcription factor | -0.0274586 |
