| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Belumosudil_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.150196 |
| PTMA | prothymosin, alpha | 0.104482 |
| FMNL2 | formin-like 2 | 0.102715 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0888342 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0871819 |
| PDE10A | phosphodiesterase 10A | 0.0866846 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0731484 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0715591 |
| MT2A | metallothionein 2A | 0.0703199 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0701921 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.06829 |
| CENPF | centromere protein F, 350/400kDa | 0.0650515 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0640807 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0640506 |
| FAT1 | FAT atypical cadherin 1 | 0.0611759 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0608869 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0593643 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0582764 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.057069 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0568035 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0562295 |
| SMAD3 | SMAD family member 3 | 0.0548831 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0541805 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0536541 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0523103 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0510565 |
| EGFR | epidermal growth factor receptor | 0.0509751 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0508597 |
| RPS16 | ribosomal protein S16 | 0.0501066 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0488616 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0488079 |
| RASA2 | RAS p21 protein activator 2 | 0.0487191 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0485199 |
| HMGA2 | high mobility group AT-hook 2 | 0.0482785 |
| MYOF | myoferlin | 0.0477341 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0475635 |
| PTK2 | protein tyrosine kinase 2 | 0.0475531 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0472501 |
| FAM13A | family with sequence similarity 13, member A | 0.0467965 |
| TMEM123 | transmembrane protein 123 | 0.0452628 |
| RBM6 | RNA binding motif protein 6 | 0.0449916 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0445653 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0440422 |
| RPL11 | ribosomal protein L11 | 0.0438153 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0431096 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0425375 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0424875 |
| RIOK3 | RIO kinase 3 | 0.0420786 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0414592 |
| NKTR | natural killer cell triggering receptor | 0.0412129 |
| RPS25 | ribosomal protein S25 | 0.0405381 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.040159 |
| CCND1 | cyclin D1 | 0.0399686 |
| RPL8 | ribosomal protein L8 | 0.0399614 |
| CUL3 | cullin 3 | 0.0398694 |
| COG5 | component of oligomeric golgi complex 5 | 0.0397376 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0397375 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0394029 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0391762 |
| CDC27 | cell division cycle 27 | 0.0391716 |
| RPS27 | ribosomal protein S27 | 0.0391292 |
| ATF4 | activating transcription factor 4 | 0.0391188 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0390854 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0390616 |
| YME1L1 | YME1-like 1 ATPase | 0.0390099 |
| FN1 | fibronectin 1 | 0.038786 |
| ZC3H15 | zinc finger CCCH-type containing 15 | 0.0386497 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0384045 |
| PGK1 | phosphoglycerate kinase 1 | 0.0382195 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0382082 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0380401 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0380109 |
| NCOA3 | nuclear receptor coactivator 3 | 0.03795 |
| RPL32 | ribosomal protein L32 | 0.0377714 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.037717 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0375662 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0374542 |
| S100A6 | S100 calcium binding protein A6 | 0.0373921 |
| RPL7A | ribosomal protein L7a | 0.0373288 |
| RPL9 | ribosomal protein L9 | 0.0372684 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0369104 |
| RO60 | Ro60, Y RNA binding protein | 0.0356703 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0356363 |
| CTBP2 | C-terminal binding protein 2 | 0.0354875 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0354204 |
| YTHDC1 | YTH domain containing 1 | 0.0352387 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0351859 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0351426 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.035051 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0348408 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0347677 |
| TMF1 | TATA element modulatory factor 1 | 0.0347087 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.034553 |
| PDGFC | platelet derived growth factor C | 0.0344937 |
| RPS17 | ribosomal protein S17 | 0.0343186 |
| CCNL1 | cyclin L1 | 0.0343035 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0341218 |
| WDR43 | WD repeat domain 43 | 0.0340129 |
| MRTFA | myocardin related transcription factor A | 0.0329117 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.032803 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MYO1E | myosin IE | -0.124328 |
| LAMB3 | laminin, beta 3 | -0.122872 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.110835 |
| IGF2 | insulin-like growth factor 2 | -0.105655 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0989892 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0963167 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0799269 |
| TJP1 | tight junction protein 1 | -0.0734822 |
| ATOSA | atos homolog A | -0.0714443 |
| MXD1 | MAX dimerization protein 1 | -0.0694501 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0661881 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0601294 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0600794 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.059944 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0591582 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0589686 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0584725 |
| MED13L | mediator complex subunit 13-like | -0.0583227 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0582649 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0573422 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0560252 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0560153 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0557335 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0553542 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0531371 |
| EGR1 | early growth response 1 | -0.0527709 |
| KYNU | kynureninase | -0.0526536 |
| NDRG1 | N-myc downstream regulated 1 | -0.051739 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.0513855 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0513386 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0502268 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0499763 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0497177 |
| CLMP | CXADR-like membrane protein | -0.0496771 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0493433 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0480058 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0477514 |
| TMEM87A | transmembrane protein 87A | -0.0473537 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.046957 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0460403 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0443934 |
| ABI1 | abl-interactor 1 | -0.0440129 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0439712 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0434959 |
| MMP1 | matrix metallopeptidase 1 | -0.0432627 |
| FBXO11 | F-box protein 11 | -0.0430812 |
| FOXP1 | forkhead box P1 | -0.0427234 |
| FMN1 | formin 1 | -0.0426882 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0420977 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0419596 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0417803 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0417719 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.041675 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0415961 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0415648 |
| USP3 | ubiquitin specific peptidase 3 | -0.0413234 |
| PEG10 | paternally expressed 10 | -0.0409649 |
| KIF13B | kinesin family member 13B | -0.0409206 |
| KRT17 | keratin 17, type I | -0.0407223 |
| IER3 | immediate early response 3 | -0.040592 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0404968 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0404931 |
| GPATCH2L | G patch domain containing 2-like | -0.0402756 |
| NF1 | neurofibromin 1 | -0.0400527 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0396785 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0395963 |
| RUNX1 | runt-related transcription factor 1 | -0.0395782 |
| CA12 | carbonic anhydrase XII | -0.0394989 |
| C1D | C1D nuclear receptor corepressor | -0.0390878 |
| FTL | ferritin, light polypeptide | -0.0389659 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0389592 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0389149 |
| ETNK1 | ethanolamine kinase 1 | -0.0389008 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0388452 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.0385948 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.037961 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0377551 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0376968 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.0371887 |
| ZBTB43 | zinc finger and BTB domain containing 43 | -0.037179 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0369698 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0365814 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.036275 |
| S100A10 | S100 calcium binding protein A10 | -0.0362739 |
| UBC | ubiquitin C | -0.0362605 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0359087 |
| LSAMP | limbic system-associated membrane protein | -0.0358356 |
| WASF2 | WAS protein family, member 2 | -0.0357843 |
| OFD1 | oral-facial-digital syndrome 1 | -0.0350863 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0347697 |
| SH3D19 | SH3 domain containing 19 | -0.0346495 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.03455 |
| TUFT1 | tuftelin 1 | -0.0342949 |
| CSTB | cystatin B (stefin B) | -0.0340824 |
| ANXA1 | annexin A1 | -0.0339422 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0333932 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0333092 |
| CCDC91 | coiled-coil domain containing 91 | -0.0333042 |
| SLC12A6 | solute carrier family 12 (potassium/chloride transporter), member 6 | -0.0332992 |
| EHBP1 | EH domain binding protein 1 | -0.0332969 |
