| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Belumosudil_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.105583 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.102302 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.100447 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0916922 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0777428 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0765082 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0745758 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | 0.0670814 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0649541 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0635829 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0611228 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0607791 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0604019 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0598617 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0597524 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0594846 |
| WWOX | WW domain containing oxidoreductase | 0.0580185 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0572233 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0566093 |
| SMYD3 | SET and MYND domain containing 3 | 0.0562942 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0561999 |
| SET | SET nuclear proto-oncogene | 0.0512155 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0500397 |
| RPL11 | ribosomal protein L11 | 0.0488314 |
| TPM3 | tropomyosin 3 | 0.048133 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0481053 |
| GRAMD1B | GRAM domain containing 1B | 0.0455297 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0451296 |
| ENO1 | enolase 1, (alpha) | 0.0437352 |
| RAD51B | RAD51 paralog B | 0.0430087 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0394608 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0392749 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0382007 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0380904 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0375752 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.036987 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0369153 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0364054 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0363248 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0358844 |
| PLEC | plectin | 0.0354081 |
| EXOC4 | exocyst complex component 4 | 0.0348754 |
| MSH6 | mutS homolog 6 | 0.0345934 |
| THADA | thyroid adenoma associated | 0.0337777 |
| SMAD3 | SMAD family member 3 | 0.0328548 |
| MDN1 | MDN1, midasin homolog (yeast) | 0.0326447 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0325635 |
| TPM2 | tropomyosin 2 (beta) | 0.0324981 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0324008 |
| RPL3 | ribosomal protein L3 | 0.0322048 |
| CEP250 | centrosomal protein 250kDa | 0.0320657 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0318772 |
| CEP192 | centrosomal protein 192kDa | 0.031555 |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) | 0.0310202 |
| NRDC | nardilysin convertase | 0.0305685 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.030188 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0292338 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0292198 |
| ANKRD36B | ankyrin repeat domain 36B | 0.0290172 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0289474 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0278181 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0275502 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0271415 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0270648 |
| XPO1 | exportin 1 | 0.0268757 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0268229 |
| PPP1R21 | protein phosphatase 1, regulatory subunit 21 | 0.0267342 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.026721 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0264934 |
| PCBP2 | poly(rC) binding protein 2 | 0.0263543 |
| THOC1 | THO complex 1 | 0.0263073 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0258732 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0257518 |
| CENPP | centromere protein P | 0.0256004 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | 0.0255289 |
| TSR1 | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.0252339 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0250774 |
| SERPINA2 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) | 0.024928 |
| WDR70 | WD repeat domain 70 | 0.0242456 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.024194 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0239936 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0239406 |
| PNN | pinin, desmosome associated protein | 0.0238007 |
| CENPF | centromere protein F, 350/400kDa | 0.023566 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0232045 |
| DNAJC10 | DnaJ (Hsp40) homolog, subfamily C, member 10 | 0.022633 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0224814 |
| AHCYL2 | adenosylhomocysteinase-like 2 | 0.022474 |
| DENND5B | DENN/MADD domain containing 5B | 0.0222836 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0220936 |
| CTNNBL1 | catenin, beta like 1 | 0.0220425 |
| HTATSF1 | HIV-1 Tat specific factor 1 | 0.02201 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0219731 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.0218841 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0218625 |
| PDE10A | phosphodiesterase 10A | 0.0218269 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0215749 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0215505 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0215047 |
| FTO | fat mass and obesity associated | 0.0213959 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.204983 |
| YBX3 | Y box binding protein 3 | -0.155048 |
| EGR1 | early growth response 1 | -0.148497 |
| OSMR | oncostatin M receptor | -0.101971 |
| TXNRD1 | thioredoxin reductase 1 | -0.100628 |
| TMSB10 | thymosin beta 10 | -0.0893717 |
| RAB7A | RAB7A, member RAS oncogene family | -0.084267 |
| NABP1 | nucleic acid binding protein 1 | -0.0808408 |
| TPI1 | triosephosphate isomerase 1 | -0.0807346 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0749467 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0743007 |
| NF1 | neurofibromin 1 | -0.067935 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.066154 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0637806 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0617878 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0617856 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0595721 |
| VCL | vinculin | -0.0580128 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0548176 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0506176 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0495621 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0481104 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0479556 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0473442 |
| FBXO11 | F-box protein 11 | -0.0473066 |
| RPLP1 | ribosomal protein, large, P1 | -0.0468826 |
| CDK17 | cyclin-dependent kinase 17 | -0.0468066 |
| ACTN1 | actinin, alpha 1 | -0.0465938 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0460647 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0441323 |
| BBX | bobby sox homolog (Drosophila) | -0.0439773 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0436288 |
| POTEF | POTE ankyrin domain family, member F | -0.0435372 |
| HLA-B | major histocompatibility complex, class I, B | -0.0432268 |
| MCL1 | myeloid cell leukemia 1 | -0.0431751 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0431432 |
| CCNL1 | cyclin L1 | -0.0426185 |
| VMP1 | vacuole membrane protein 1 | -0.0410128 |
| RRM2 | ribonucleotide reductase M2 | -0.0409145 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0408445 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.040533 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0393895 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0391246 |
| FTL | ferritin, light polypeptide | -0.0387463 |
| ACTG1 | actin gamma 1 | -0.0383635 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0377713 |
| CLTC | clathrin, heavy chain (Hc) | -0.0376213 |
| MORF4L2 | mortality factor 4 like 2 | -0.0374921 |
| RTN4 | reticulon 4 | -0.036381 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0361191 |
| CALD1 | caldesmon 1 | -0.0352171 |
| TUBA1B | tubulin, alpha 1b | -0.0336229 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0335439 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | -0.0333932 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.032961 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.032923 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0328327 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0327913 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0324863 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0321996 |
| IGF2 | insulin-like growth factor 2 | -0.0321572 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0319394 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0317476 |
| STC1 | stanniocalcin 1 | -0.0316398 |
| YAP1 | Yes-associated protein 1 | -0.0316308 |
| RPL35A | ribosomal protein L35a | -0.0313432 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0310385 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0309309 |
| BRD2 | bromodomain containing 2 | -0.0307232 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0303723 |
| NBEAL1 | neurobeachin-like 1 | -0.0303621 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0302535 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0301852 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0301382 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0300653 |
| MT1X | metallothionein 1X | -0.0299458 |
| TPM4 | tropomyosin 4 | -0.0299101 |
| CCND2 | cyclin D2 | -0.0297706 |
| TAPBP | TAP binding protein (tapasin) | -0.0292381 |
| RPS21 | ribosomal protein S21 | -0.0291107 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.029031 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0289739 |
| CAVIN1 | caveolae associated protein 1 | -0.0288828 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0286381 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0285056 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0284974 |
| CDK12 | cyclin-dependent kinase 12 | -0.0274978 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0274392 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0273176 |
| PFN1 | profilin 1 | -0.0272375 |
| PLSCR1 | phospholipid scramblase 1 | -0.027226 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0270016 |
| TUBA1C | tubulin, alpha 1c | -0.0268004 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0265508 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0264924 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0264338 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0263827 |
| ARF4 | ADP-ribosylation factor 4 | -0.0263501 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.026151 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0261072 |
