| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Belumosudil_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.2157 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.153471 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.133497 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.133299 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.132935 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.10643 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.104576 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.100628 |
| ASPH | aspartate beta-hydroxylase | 0.0918005 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0873443 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0871062 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0807455 |
| AHNAK | AHNAK nucleoprotein | 0.0727994 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0714669 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0713897 |
| CANX | calnexin | 0.070639 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0699948 |
| CALR | calreticulin | 0.0634756 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.060695 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0601029 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0578491 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0578267 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0558915 |
| DSPP | dentin sialophosphoprotein | 0.0548429 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0533081 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0526622 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0521196 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0515921 |
| TPM3 | tropomyosin 3 | 0.0500304 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0488736 |
| MSN | moesin | 0.0468005 |
| HMGB2 | high mobility group box 2 | 0.044813 |
| SET | SET nuclear proto-oncogene | 0.0441238 |
| MKI67 | marker of proliferation Ki-67 | 0.0439936 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0437313 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0411099 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0400985 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0400613 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0395107 |
| TXNRD1 | thioredoxin reductase 1 | 0.0394777 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0393871 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0391637 |
| KRT7 | keratin 7, type II | 0.0387231 |
| PLEC | plectin | 0.0379526 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0375114 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0372336 |
| ENO1 | enolase 1, (alpha) | 0.0371792 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0367301 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0365135 |
| RPL19 | ribosomal protein L19 | 0.0360352 |
| RPLP0 | ribosomal protein, large, P0 | 0.0357735 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0355473 |
| CENPF | centromere protein F, 350/400kDa | 0.0355074 |
| PEG10 | paternally expressed 10 | 0.0352403 |
| ARRDC3 | arrestin domain containing 3 | 0.0348655 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0346396 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0344589 |
| RPL7 | ribosomal protein L7 | 0.0341179 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0339525 |
| MATR3 | matrin 3 | 0.0334335 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0329312 |
| PLAU | plasminogen activator, urokinase | 0.0321591 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0316684 |
| RPL23 | ribosomal protein L23 | 0.0315547 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0309374 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0308689 |
| RPL3 | ribosomal protein L3 | 0.0307831 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0298543 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0296406 |
| FHIT | fragile histidine triad | 0.0295593 |
| DST | dystonin | 0.0294708 |
| LAMC2 | laminin, gamma 2 | 0.0284969 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0282051 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0278607 |
| ANXA2 | annexin A2 | 0.0276997 |
| HDGF | hepatoma-derived growth factor | 0.0276094 |
| KRT18 | keratin 18, type I | 0.0275644 |
| CBX3 | chromobox homolog 3 | 0.0272642 |
| RPL14 | ribosomal protein L14 | 0.0271538 |
| DEK | DEK proto-oncogene | 0.0269165 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0265009 |
| AREG | amphiregulin | 0.0261207 |
| SQSTM1 | sequestosome 1 | 0.0260949 |
| TOP1 | topoisomerase (DNA) I | 0.0260065 |
| LDHB | lactate dehydrogenase B | 0.026006 |
| EREG | epiregulin | 0.025872 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0256454 |
| RPL4 | ribosomal protein L4 | 0.0254846 |
| CD47 | CD47 molecule | 0.0254381 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0250773 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0249503 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0249219 |
| SMAD3 | SMAD family member 3 | 0.0249007 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0247838 |
| RPL12 | ribosomal protein L12 | 0.0247596 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0247407 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0244935 |
| YBX1 | Y box binding protein 1 | 0.0244155 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0242661 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0242316 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.151989 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.14201 |
| ACTG1 | actin gamma 1 | -0.13772 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.107149 |
| TMSB10 | thymosin beta 10 | -0.0964636 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0819856 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0805831 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0667656 |
| FBXO32 | F-box protein 32 | -0.0619521 |
| RCOR1 | REST corepressor 1 | -0.0613689 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0603763 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0585905 |
| DTNA | dystrobrevin, alpha | -0.0579194 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0573981 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0554954 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0546296 |
| UBC | ubiquitin C | -0.0518389 |
| MYO1E | myosin IE | -0.0508147 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0506256 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0497719 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.04859 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0484499 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0478372 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0474573 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0473433 |
| HLA-B | major histocompatibility complex, class I, B | -0.0448306 |
| ERBIN | erbb2 interacting protein | -0.0444324 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0438251 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0425005 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0413375 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0412034 |
| COPA | coatomer protein complex, subunit alpha | -0.0407156 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0404313 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0396406 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0395059 |
| POTEF | POTE ankyrin domain family, member F | -0.0391759 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0391515 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0390883 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0389721 |
| MYO6 | myosin VI | -0.0388821 |
| LOC112694756 | uncharaterized LOC112694756 | -0.038083 |
| FBXO11 | F-box protein 11 | -0.0380183 |
| MCU | mitochondrial calcium uniporter | -0.0379559 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0378232 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.037635 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0373342 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0369901 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0369466 |
| GOLGA4 | golgin A4 | -0.0363608 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0357814 |
| TMEM263 | transmembrane protein 263 | -0.0357719 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0355643 |
| WASF2 | WAS protein family, member 2 | -0.0354298 |
| JMJD1C | jumonji domain containing 1C | -0.0351517 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0351196 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0351088 |
| CSTB | cystatin B (stefin B) | -0.0350982 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0344724 |
| ARF4 | ADP-ribosylation factor 4 | -0.0344267 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0343666 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0334334 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0330826 |
| FBXO34 | F-box protein 34 | -0.0329868 |
| FNIP1 | folliculin interacting protein 1 | -0.0329796 |
| RPL35A | ribosomal protein L35a | -0.0322893 |
| NDRG1 | N-myc downstream regulated 1 | -0.0322759 |
| CLDN4 | claudin 4 | -0.0322275 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0322099 |
| HLA-A | major histocompatibility complex, class I, A | -0.0321461 |
| ATOSA | atos homolog A | -0.0320952 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0320625 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.031593 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.031343 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0311377 |
| TXNIP | thioredoxin interacting protein | -0.0308719 |
| FAM3C | family with sequence similarity 3, member C | -0.0304827 |
| CERT1 | ceramide transporter 1 | -0.0298009 |
| USP53 | ubiquitin specific peptidase 53 | -0.0297257 |
| EFNA5 | ephrin-A5 | -0.0296572 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0295087 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0292564 |
| TMEM165 | transmembrane protein 165 | -0.0291102 |
| JUP | junction plakoglobin | -0.028921 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0283719 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0282733 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0280809 |
| NF1 | neurofibromin 1 | -0.0280183 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0275833 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0274069 |
| GNAS | GNAS complex locus | -0.0273942 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0272986 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.027127 |
| TMF1 | TATA element modulatory factor 1 | -0.0268418 |
| SEC24A | SEC24 family member A | -0.0262554 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0261724 |
| VGLL3 | vestigial-like family member 3 | -0.0261068 |
| NUMB | numb homolog (Drosophila) | -0.0260386 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | -0.0258961 |
| RBM39 | RNA binding motif protein 39 | -0.0258493 |
| KLHL24 | kelch-like family member 24 | -0.0258426 |
