| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Belumosudil_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.163795 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.140101 |
| PTMA | prothymosin, alpha | 0.117275 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.114123 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.110322 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.104331 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.101755 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0940626 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0921896 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.083244 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0767776 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0741621 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0704539 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0696588 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0666586 |
| SET | SET nuclear proto-oncogene | 0.064673 |
| CANX | calnexin | 0.0646372 |
| RPL19 | ribosomal protein L19 | 0.0604443 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0563508 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0556992 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0552026 |
| CTSL | cathepsin L | 0.0543246 |
| OGA | O-GlcNAcase | 0.0533527 |
| COL5A2 | collagen, type V, alpha 2 | 0.0523619 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.05176 |
| ASPH | aspartate beta-hydroxylase | 0.0493897 |
| TPM3 | tropomyosin 3 | 0.0491169 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0490974 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0473726 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.045022 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0449531 |
| MATR3 | matrin 3 | 0.0443458 |
| RGS2 | regulator of G-protein signaling 2 | 0.0440603 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.043009 |
| TBXT | T-box transcription factor T | 0.04255 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0417398 |
| FMNL2 | formin-like 2 | 0.0416883 |
| AHNAK | AHNAK nucleoprotein | 0.0414912 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0406242 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0389666 |
| MYOF | myoferlin | 0.0384396 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0382397 |
| VIM | vimentin | 0.0380916 |
| RPL3 | ribosomal protein L3 | 0.0380521 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0376899 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0376301 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0369452 |
| FLNB | filamin B, beta | 0.0367148 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0366751 |
| GRAMD1B | GRAM domain containing 1B | 0.0366273 |
| TXNRD1 | thioredoxin reductase 1 | 0.0364572 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0351193 |
| CTBP2 | C-terminal binding protein 2 | 0.0343441 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.034257 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0333695 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0330207 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.032563 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0324667 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0324641 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0316551 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0313348 |
| ENO1 | enolase 1, (alpha) | 0.0312586 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0312047 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.03103 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0309008 |
| PCBP2 | poly(rC) binding protein 2 | 0.0307589 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0307423 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0307238 |
| EZR | ezrin | 0.0305388 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0305252 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0300123 |
| PDE10A | phosphodiesterase 10A | 0.0295881 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0291591 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0284422 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0283224 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0276157 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0276061 |
| MCL1 | myeloid cell leukemia 1 | 0.0274222 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0273109 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0268816 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0268547 |
| CENPF | centromere protein F, 350/400kDa | 0.0266645 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0266602 |
| PGK1 | phosphoglycerate kinase 1 | 0.0265243 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0264032 |
| NCKAP1 | NCK-associated protein 1 | 0.026177 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0261123 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0261058 |
| RNF145 | ring finger protein 145 | 0.0257379 |
| RPL14 | ribosomal protein L14 | 0.0251967 |
| XPO1 | exportin 1 | 0.025142 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0250749 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0248916 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0247728 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0247081 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0243953 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0243544 |
| LAMB1 | laminin, beta 1 | 0.0243534 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0243043 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0242996 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.321066 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.272207 |
| EFNA5 | ephrin-A5 | -0.0931162 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0869783 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0720242 |
| PCBP3 | poly(rC) binding protein 3 | -0.0699225 |
| MT2A | metallothionein 2A | -0.0686959 |
| TMSB10 | thymosin beta 10 | -0.0675789 |
| FTL | ferritin, light polypeptide | -0.0643258 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0620277 |
| VCL | vinculin | -0.0598467 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0562776 |
| STC1 | stanniocalcin 1 | -0.0488776 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0481527 |
| EGR1 | early growth response 1 | -0.0476236 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0453737 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0432759 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0429338 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0426233 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0425679 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.041953 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0412906 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0409066 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.038161 |
| NBEAL1 | neurobeachin-like 1 | -0.0373136 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0367794 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0365478 |
| RPL35A | ribosomal protein L35a | -0.0356635 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0347225 |
| NF1 | neurofibromin 1 | -0.0338416 |
| RPLP1 | ribosomal protein, large, P1 | -0.0327474 |
| VDAC1 | voltage-dependent anion channel 1 | -0.032688 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0320723 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0309425 |
| MT1X | metallothionein 1X | -0.0305008 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0303462 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0298023 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0292886 |
| TXNIP | thioredoxin interacting protein | -0.0291974 |
| INTS6 | integrator complex subunit 6 | -0.0290448 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0288127 |
| NRCAM | neuronal cell adhesion molecule | -0.0275883 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.027534 |
| HLA-B | major histocompatibility complex, class I, B | -0.0274772 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0274215 |
| HDAC8 | histone deacetylase 8 | -0.0273005 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0272761 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0270316 |
| MORF4L2 | mortality factor 4 like 2 | -0.0264701 |
| RPLP0 | ribosomal protein, large, P0 | -0.026258 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0259242 |
| RPS24 | ribosomal protein S24 | -0.0257912 |
| GNAS | GNAS complex locus | -0.02555 |
| ACTG1 | actin gamma 1 | -0.0253928 |
| DST | dystonin | -0.0253591 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.025226 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0249512 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0249244 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0247785 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0246603 |
| RPS13 | ribosomal protein S13 | -0.0240153 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0237777 |
| GLIS3 | GLIS family zinc finger 3 | -0.023772 |
| CCDC88A | coiled-coil domain containing 88A | -0.0229429 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0219437 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0217536 |
| PFN1 | profilin 1 | -0.0215672 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0215078 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.021233 |
| BSG | basigin (Ok blood group) | -0.0211918 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0209903 |
| POTEF | POTE ankyrin domain family, member F | -0.0209871 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0209009 |
| RPS21 | ribosomal protein S21 | -0.0207617 |
| USP53 | ubiquitin specific peptidase 53 | -0.0207043 |
| BPTF | bromodomain PHD finger transcription factor | -0.0206812 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0203502 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0201356 |
| CTSC | cathepsin C | -0.0200982 |
| NCKAP5 | NCK-associated protein 5 | -0.0199781 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0199413 |
| SRGN | serglycin | -0.0196525 |
| ATXN1 | ataxin 1 | -0.0191045 |
| GLRX | glutaredoxin (thioltransferase) | -0.018937 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.0189349 |
| RPS19 | ribosomal protein S19 | -0.0185744 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0183519 |
| RTN1 | reticulon 1 | -0.0183027 |
| IL6 | interleukin 6 | -0.018218 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0182017 |
| TBCA | tubulin folding cofactor A | -0.018074 |
| ARF1 | ADP-ribosylation factor 1 | -0.0178963 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0178785 |
| OSMR | oncostatin M receptor | -0.0178569 |
| RPS16 | ribosomal protein S16 | -0.0177687 |
| RACK1 | receptor for activated C kinase 1 | -0.0175975 |
| RPL13A | ribosomal protein L13a | -0.0175923 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0175876 |
| PTEN | phosphatase and tensin homolog | -0.0175531 |
| SMAD2 | SMAD family member 2 | -0.0174529 |
