Belumosudil_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belumosudil perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belumosudil_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.181726
SPAG9 sperm associated antigen 9 0.177548
PRRC2C proline-rich coiled-coil 2C 0.145343
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.111225
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.110249
RORA RAR-related orphan receptor A 0.108189
TRIO trio Rho guanine nucleotide exchange factor 0.101772
NCOA3 nuclear receptor coactivator 3 0.0959147
ELL2 elongation factor, RNA polymerase II, 2 0.0927843
APLP2 amyloid beta (A4) precursor-like protein 2 0.0902605
HELZ helicase with zinc finger 0.0899173
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0886289
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0864305
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0833982
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0825829
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0807936
FNDC3A fibronectin type III domain containing 3A 0.0785806
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0782443
EZR ezrin 0.0767985
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.073014
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0699531
NCOR1 nuclear receptor corepressor 1 0.0692328
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0675398
B2M beta-2-microglobulin 0.0673148
BIRC6 baculoviral IAP repeat containing 6 0.0672536
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0660561
AKAP13 A kinase (PRKA) anchor protein 13 0.0651444
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0643429
RPL5 ribosomal protein L5 0.0634911
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0629354
KDM2A lysine (K)-specific demethylase 2A 0.0614337
RBM33 RNA binding motif protein 33 0.059677
EFNA5 ephrin-A5 0.0592593
PICALM phosphatidylinositol binding clathrin assembly protein 0.058528
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0582033
TBC1D22A TBC1 domain family, member 22A 0.0580097
FTH1 ferritin, heavy polypeptide 1 0.0570233
PRELID2 PRELI domain containing 2 0.0570042
EPS8 epidermal growth factor receptor pathway substrate 8 0.0568181
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0560266
FNDC3B fibronectin type III domain containing 3B 0.055072
KIF5B kinesin family member 5B 0.0541637
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0530714
TM4SF1 transmembrane 4 L six family member 1 0.0527184
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0523095
CELF1 CUGBP, Elav-like family member 1 0.0522679
FLNB filamin B, beta 0.0521736
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.050928
PTK2 protein tyrosine kinase 2 0.0507498
RPL36 ribosomal protein L36 0.0502749
MEMO1 mediator of cell motility 1 0.0500323
PDIA3 protein disulfide isomerase family A, member 3 0.048883
USP34 ubiquitin specific peptidase 34 0.0481831
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0481374
UBA6 ubiquitin-like modifier activating enzyme 6 0.0478775
PGK1 phosphoglycerate kinase 1 0.0475902
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0465546
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0464794
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0456212
COL5A2 collagen, type V, alpha 2 0.0448826
AFF4 AF4/FMR2 family, member 4 0.042544
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0421647
SND1 staphylococcal nuclease and tudor domain containing 1 0.0412796
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0391294
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0388135
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.038801
PARD3 par-3 family cell polarity regulator 0.0385244
THOC2 THO complex 2 0.0382794
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0377432
ZNF292 zinc finger protein 292 0.0376527
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0376492
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0362697
TXNRD1 thioredoxin reductase 1 0.0359234
EGFR epidermal growth factor receptor 0.0355549
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0353431
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0348112
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0343744
NALF1 NALCN channel auxiliary factor 1 0.0336872
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0336725
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0332463
GARS1 glycyl-tRNA synthetase 1 0.0332072
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0317967
CUX1 cut-like homeobox 1 0.0315238
EXT1 exostosin glycosyltransferase 1 0.0314497
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.031412
OGA O-GlcNAcase 0.0306926
IER3 immediate early response 3 0.030486
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0301211
DSCAM Down syndrome cell adhesion molecule 0.0298431
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0290043
RICTOR RPTOR independent companion of MTOR, complex 2 0.0287646
ESYT2 extended synaptotagmin-like protein 2 0.0286752
YAP1 Yes-associated protein 1 0.028561
LOXL2 lysyl oxidase-like 2 0.0285492
EIF1 eukaryotic translation initiation factor 1 0.0281766
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0273092
TPD52 tumor protein D52 0.0264196
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0263264
LIMA1 LIM domain and actin binding 1 0.026318
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0254147

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.265235
TMSB10 thymosin beta 10 -0.20254
MACF1 microtubule-actin crosslinking factor 1 -0.134891
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.10048
RPS8 ribosomal protein S8 -0.0989035
SMYD3 SET and MYND domain containing 3 -0.0965966
ZBTB20 zinc finger and BTB domain containing 20 -0.0916238
FN1 fibronectin 1 -0.0895736
FMNL2 formin-like 2 -0.0888989
MT2A metallothionein 2A -0.0827595
SNX9 sorting nexin 9 -0.0758365
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0749448
NKD1 naked cuticle homolog 1 (Drosophila) -0.0726017
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0724507
ACTG1 actin gamma 1 -0.0714933
RPL26 ribosomal protein L26 -0.0707089
MAML2 mastermind-like 2 (Drosophila) -0.0684664
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.067836
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0675382
VIM vimentin -0.0667182
HMGA2 high mobility group AT-hook 2 -0.0631383
RPS6 ribosomal protein S6 -0.0625542
MCL1 myeloid cell leukemia 1 -0.0601037
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0595055
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0592927
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0591811
EEF2 eukaryotic translation elongation factor 2 -0.057926
MED13L mediator complex subunit 13-like -0.0573404
PSD3 pleckstrin and Sec7 domain containing 3 -0.057065
NF1 neurofibromin 1 -0.0558846
SRRM2 serine/arginine repetitive matrix 2 -0.0557055
MYO1E myosin IE -0.0555685
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0551826
RPLP2 ribosomal protein, large, P2 -0.0542966
EGR1 early growth response 1 -0.0526012
BACE2 beta-site APP-cleaving enzyme 2 -0.0517972
GMDS GDP-mannose 4,6-dehydratase -0.0517064
RPS16 ribosomal protein S16 -0.0502117
JMJD1C jumonji domain containing 1C -0.0487481
KLF5 Kruppel-like factor 5 (intestinal) -0.0487107
HDAC8 histone deacetylase 8 -0.0466508
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0466159
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0459838
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0456392
ANKRD12 ankyrin repeat domain 12 -0.0446881
CARD16 caspase recruitment domain family, member 16 -0.0439935
GLG1 golgi glycoprotein 1 -0.0434342
FOXP1 forkhead box P1 -0.0432449
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0427125
INHBA inhibin, beta A -0.0423695
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.042241
ITGA6 integrin, alpha 6 -0.0421694
NAV1 neuron navigator 1 -0.0417005
RAD51B RAD51 paralog B -0.0414207
KRT8 keratin 8, type II -0.0411963
RPL13A ribosomal protein L13a -0.0411167
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0405601
WASF2 WAS protein family, member 2 -0.0402151
ENO1 enolase 1, (alpha) -0.0401867
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0397206
MAP4 microtubule-associated protein 4 -0.0396145
SPATA13 spermatogenesis associated 13 -0.0392705
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0389151
CEMIP cell migration inducing protein, hyaluronan binding -0.0380475
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0376349
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0372362
THSD4 thrombospondin, type I, domain containing 4 -0.0370825
H3-3B H3.3 histone B -0.0366063
GOLGA4 golgin A4 -0.0359228
KTN1 kinectin 1 (kinesin receptor) -0.0356798
LOC112694756 uncharaterized LOC112694756 -0.0356164
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0354899
ZFAND3 zinc finger, AN1-type domain 3 -0.0354783
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0352102
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0351419
PTMA prothymosin, alpha -0.0342227
NDRG1 N-myc downstream regulated 1 -0.0338012
RPL37A ribosomal protein L37a -0.0335042
ZNF609 zinc finger protein 609 -0.0333284
S100A6 S100 calcium binding protein A6 -0.0329376
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0324864
MAML3 mastermind-like 3 (Drosophila) -0.0319623
TOR1AIP2 torsin A interacting protein 2 -0.031843
CD44 CD44 molecule (Indian blood group) -0.0309839
AKAP12 A kinase (PRKA) anchor protein 12 -0.0305531
CNKSR3 CNKSR family member 3 -0.0303864
RBM25 RNA binding motif protein 25 -0.0303621
TTC3 tetratricopeptide repeat domain 3 -0.0302642
S100A9 S100 calcium binding protein A9 -0.0301165
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0299687
RPLP1 ribosomal protein, large, P1 -0.029827
SNX14 sorting nexin 14 -0.0296437
WSB1 WD repeat and SOCS box containing 1 -0.0295292
FAF1 Fas (TNFRSF6) associated factor 1 -0.0293868
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0293612
FRMD5 FERM domain containing 5 -0.0293193
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0292251
COL6A1 collagen, type VI, alpha 1 -0.0287256
SPIDR scaffolding protein involved in DNA repair -0.0284161
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.027855