Belumosudil_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belumosudil perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belumosudil_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.143799
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.111709
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.107365
ERBB4 erb-b2 receptor tyrosine kinase 4 0.106101
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0955134
COL5A2 collagen, type V, alpha 2 0.0886757
PDE4D phosphodiesterase 4D, cAMP-specific 0.083055
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0790325
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0601115
METAP2 methionyl aminopeptidase 2 0.0579667
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.055918
FNDC3B fibronectin type III domain containing 3B 0.0555279
PARD3B par-3 family cell polarity regulator beta 0.0534393
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0520554
PGAP1 post-GPI attachment to proteins 1 0.0517625
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0498319
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0489384
SRRM2 serine/arginine repetitive matrix 2 0.0454689
NTM neurotrimin 0.0410616
CORO1C coronin, actin binding protein, 1C 0.0410387
U2SURP U2 snRNP-associated SURP domain containing 0.0393725
CSMD3 CUB and Sushi multiple domains 3 0.0392968
GANAB glucosidase, alpha; neutral AB 0.0391893
SERBP1 SERPINE1 mRNA binding protein 1 0.0384922
NAP1L1 nucleosome assembly protein 1-like 1 0.0379942
KIF5B kinesin family member 5B 0.0368752
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0365796
APLP2 amyloid beta (A4) precursor-like protein 2 0.0355876
THBS1 thrombospondin 1 0.0349564
PTK2 protein tyrosine kinase 2 0.034107
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0338691
AHNAK AHNAK nucleoprotein 0.0338272
MB21D2 Mab-21 domain containing 2 0.0336913
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0321554
MYH9 myosin, heavy chain 9, non-muscle 0.0319199
KAT6A K(lysine) acetyltransferase 6A 0.0314315
HSPH1 heat shock 105kDa/110kDa protein 1 0.0313214
RREB1 ras responsive element binding protein 1 0.0306914
ENAH enabled homolog (Drosophila) 0.0298657
USP12 ubiquitin specific peptidase 12 0.0294907
GRM1 glutamate receptor, metabotropic 1 0.0287719
SOX5 SRY (sex determining region Y)-box 5 0.0286857
ZNF462 zinc finger protein 462 0.028405
KPNB1 karyopherin (importin) beta 1 0.0283843
MED12L mediator complex subunit 12-like 0.0283393
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0283215
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.028301
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0282556
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.0282398
SHROOM3 shroom family member 3 0.0281974
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0281072
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0280859
RNF216 ring finger protein 216 0.0277606
DNAH14 dynein, axonemal, heavy chain 14 0.0275215
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0273796
ANKRD12 ankyrin repeat domain 12 0.0266534
PM20D1 peptidase M20 domain containing 1 0.0262302
AKAP13 A kinase (PRKA) anchor protein 13 0.0261504
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0260183
TM9SF3 transmembrane 9 superfamily member 3 0.0258876
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0255791
CBX3 chromobox homolog 3 0.0254902
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0254587
KIF20B kinesin family member 20B 0.0254045
CALR calreticulin 0.02528
SSB Sjogren syndrome antigen B (autoantigen La) 0.0251745
CANX calnexin 0.0251376
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0250648
MTCL1 microtubule crosslinking factor 1 0.025025
FAT1 FAT atypical cadherin 1 0.0250043
FER fer (fps/fes related) tyrosine kinase 0.0250016
ANKRD36 ankyrin repeat domain 36 0.0247027
TFPI2 tissue factor pathway inhibitor 2 0.0246707
MDFIC MyoD family inhibitor domain containing 0.0245224
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.0244776
RAD23B RAD23 homolog B (S. cerevisiae) 0.0244036
PRKCSH protein kinase C substrate 80K-H 0.0243242
NCAM2 neural cell adhesion molecule 2 0.0242265
CALCR calcitonin receptor 0.0240604
LHFPL6 LHFPL tetraspan subfamily member 6 0.0240188
INA internexin neuronal intermediate filament protein, alpha 0.0236943
LARP4 La ribonucleoprotein domain family, member 4 0.0236374
MTDH metadherin 0.0233901
BTBD3 BTB (POZ) domain containing 3 0.0233444
PRPF4B pre-mRNA processing factor 4B 0.0231895
ATP5F1A ATP synthase F1 subunit alpha 0.023094
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.0228156
ERRFI1 ERBB receptor feedback inhibitor 1 0.0227885
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0227852
PTCD3 pentatricopeptide repeat domain 3 0.0225986
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0225898
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0225421
MBNL1 muscleblind-like splicing regulator 1 0.0225093
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0224551
BPTF bromodomain PHD finger transcription factor 0.022388
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0222948
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0222804
ADGRV1 adhesion G protein-coupled receptor V1 0.0220468
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 0.0220288
EXOC1 exocyst complex component 1 0.0219719

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.155316
H1-0 H1.0 linker histone -0.106316
POTEF POTE ankyrin domain family, member F -0.101564
TMSB10 thymosin beta 10 -0.0972439
TSC22D2 TSC22 domain family, member 2 -0.0836524
ADGRL2 adhesion G protein-coupled receptor L2 -0.081745
RPS16 ribosomal protein S16 -0.0816958
SRP54 signal recognition particle 54kDa -0.0808725
HDAC9 histone deacetylase 9 -0.0764336
RPS6 ribosomal protein S6 -0.0748783
RPS2 ribosomal protein S2 -0.073956
TMSB4X thymosin beta 4, X-linked -0.0679346
SNX6 sorting nexin 6 -0.0675263
WSB1 WD repeat and SOCS box containing 1 -0.0648636
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0629662
ZNF292 zinc finger protein 292 -0.0621146
PCDH9 protocadherin 9 -0.0613533
CLTC clathrin, heavy chain (Hc) -0.0613368
TFRC transferrin receptor -0.0603468
CENPF centromere protein F, 350/400kDa -0.0559811
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0547723
COTL1 coactosin-like F-actin binding protein 1 -0.0544898
ATP5F1B ATP synthase F1 subunit beta -0.0534664
AKAP9 A kinase (PRKA) anchor protein 9 -0.0492841
H1-4 H1.4 linker histone, cluster member -0.0490912
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0487653
UBC ubiquitin C -0.0481688
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0478086
SRPK2 SRSF protein kinase 2 -0.0474597
TPX2 TPX2, microtubule-associated -0.0468669
RHEB Ras homolog enriched in brain -0.0456922
GPC3 glypican 3 -0.0453008
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0449824
NIPBL Nipped-B homolog (Drosophila) -0.0436312
CEP192 centrosomal protein 192kDa -0.0431256
LDHA lactate dehydrogenase A -0.0420675
CAMKMT calmodulin-lysine N-methyltransferase -0.0419473
CADM2 cell adhesion molecule 2 -0.0414513
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.040137
TEX11 testis expressed 11 -0.0393351
RAB31 RAB31, member RAS oncogene family -0.0390361
UBE2H ubiquitin-conjugating enzyme E2H -0.0379319
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0378954
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0377765
TARS1 threonyl-tRNA synthetase 1 -0.0371649
TUBA1B tubulin, alpha 1b -0.036698
CEP350 centrosomal protein 350kDa -0.0366239
CUL4B cullin 4B -0.0365293
FAM177A1 family with sequence similarity 177, member A1 -0.0351324
PDCD5 programmed cell death 5 -0.0351272
RLF rearranged L-myc fusion -0.034984
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0349571
RPL37 ribosomal protein L37 -0.0348981
ENO1 enolase 1, (alpha) -0.0348236
LOC112694756 uncharaterized LOC112694756 -0.0344036
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0343723
GLG1 golgi glycoprotein 1 -0.034334
NCOR1 nuclear receptor corepressor 1 -0.0338757
PRKD1 protein kinase D1 -0.0338158
SOX2 SRY (sex determining region Y)-box 2 -0.0337901
WNK1 WNK lysine deficient protein kinase 1 -0.0337645
FTL ferritin, light polypeptide -0.0335102
TLK1 tousled-like kinase 1 -0.0334546
SFTPA2 surfactant protein A2 -0.0332038
GARS1 glycyl-tRNA synthetase 1 -0.0329714
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0328254
PGK1 phosphoglycerate kinase 1 -0.0324603
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0323957
GNAS GNAS complex locus -0.0323829
CAMTA1 calmodulin binding transcription activator 1 -0.0322305
HIP1 huntingtin interacting protein 1 -0.0318994
FBXO17 F-box protein 17 -0.0317621
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0313756
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0312891
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0312841
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0312783
SMC3 structural maintenance of chromosomes 3 -0.0311857
PARP1 poly (ADP-ribose) polymerase 1 -0.0309934
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0309889
CCNA2 cyclin A2 -0.0308184
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0307215
CAPNS1 calpain, small subunit 1 -0.0305563
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.030543
NBEAL1 neurobeachin-like 1 -0.0303964
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0302778
GOLT1B golgi transport 1B -0.0301884
PFN1 profilin 1 -0.0300751
ITGAV integrin, alpha V -0.0296218
VDAC1 voltage-dependent anion channel 1 -0.0294286
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0294213
DSTN destrin (actin depolymerizing factor) -0.0290301
SRP72 signal recognition particle 72kDa -0.0289322
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0289059
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0288293
RPS19 ribosomal protein S19 -0.0287837
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.028747
RAB7A RAB7A, member RAS oncogene family -0.028722
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0286282
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.028493
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0283817