Belumosudil_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belumosudil perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belumosudil_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.128801
MYH9 myosin, heavy chain 9, non-muscle 0.116664
NAMPT nicotinamide phosphoribosyltransferase 0.105479
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0995026
APLP2 amyloid beta (A4) precursor-like protein 2 0.0946062
TRIO trio Rho guanine nucleotide exchange factor 0.0932731
VIM vimentin 0.0914635
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0759582
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0714957
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0714568
CANX calnexin 0.0679476
RPL19 ribosomal protein L19 0.0675488
TPM3 tropomyosin 3 0.0672681
FLNA filamin A, alpha 0.0664955
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0654574
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0633605
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0633433
SFTPA2 surfactant protein A2 0.0588799
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0579293
FAT1 FAT atypical cadherin 1 0.0565692
NAP1L1 nucleosome assembly protein 1-like 1 0.0537814
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0531877
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0512327
HDGF hepatoma-derived growth factor 0.0510093
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0481712
STC2 stanniocalcin 2 0.0481184
RPL7 ribosomal protein L7 0.047775
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0477181
CALR calreticulin 0.047571
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0472851
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0443737
PRRC2C proline-rich coiled-coil 2C 0.0442897
SHB Src homology 2 domain containing adaptor protein B 0.0438536
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0429963
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0426717
RPS12 ribosomal protein S12 0.0421909
SRRM2 serine/arginine repetitive matrix 2 0.0418447
CENPF centromere protein F, 350/400kDa 0.040085
EEF2 eukaryotic translation elongation factor 2 0.0395046
PLEC plectin 0.0389488
TMEM165 transmembrane protein 165 0.0388535
PRELID2 PRELI domain containing 2 0.0386147
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0383968
LOXL2 lysyl oxidase-like 2 0.0380711
TNIP1 TNFAIP3 interacting protein 1 0.0378343
PDIA3 protein disulfide isomerase family A, member 3 0.0377126
EEF1G eukaryotic translation elongation factor 1 gamma 0.0368279
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0366036
FNDC3B fibronectin type III domain containing 3B 0.0365169
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0363009
PNN pinin, desmosome associated protein 0.0359338
BIRC3 baculoviral IAP repeat containing 3 0.0353814
RPS3 ribosomal protein S3 0.0353135
GOLGA4 golgin A4 0.0352771
BHLHE40 basic helix-loop-helix family, member e40 0.0349097
RPL3 ribosomal protein L3 0.0348815
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0344419
MACF1 microtubule-actin crosslinking factor 1 0.0342688
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0338441
CXCL3 chemokine (C-X-C motif) ligand 3 0.0334745
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0332044
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0331841
FTH1 ferritin, heavy polypeptide 1 0.0331285
GOLGB1 golgin B1 0.0328982
PLIN2 perilipin 2 0.0327729
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0325711
TLN1 talin 1 0.0323098
SET SET nuclear proto-oncogene 0.0321833
NFE2L1 nuclear factor, erythroid 2-like 1 0.0316798
SDC4 syndecan 4 0.0314842
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0313509
FRY furry homolog (Drosophila) 0.0312637
APP amyloid beta (A4) precursor protein 0.0311571
GANAB glucosidase, alpha; neutral AB 0.030776
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0304784
ANO6 anoctamin 6 0.0304753
EIF1 eukaryotic translation initiation factor 1 0.0301748
SMAD3 SMAD family member 3 0.0300557
ADAR adenosine deaminase, RNA-specific 0.0299598
VEGFA vascular endothelial growth factor A 0.0298621
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0296569
MKI67 marker of proliferation Ki-67 0.0288249
SLTM SAFB-like, transcription modulator 0.0283362
CD109 CD109 molecule 0.0281695
RPL11 ribosomal protein L11 0.0278841
ARRDC3 arrestin domain containing 3 0.0278601
AKAP9 A kinase (PRKA) anchor protein 9 0.0276469
RPL13A ribosomal protein L13a 0.027644
SOD2 superoxide dismutase 2, mitochondrial 0.0275278
KTN1 kinectin 1 (kinesin receptor) 0.0272675
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0271534
ETV6 ets variant 6 0.0266164
RPL9 ribosomal protein L9 0.0261025
DST dystonin 0.026014
EGFR epidermal growth factor receptor 0.025728
XPO1 exportin 1 0.0256889
GPC6 glypican 6 0.025206
RPL21 ribosomal protein L21 0.0251715
CD44 CD44 molecule (Indian blood group) 0.0248666
AKAP12 A kinase (PRKA) anchor protein 12 0.0244203

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.297092
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.169127
NRG1 neuregulin 1 -0.14135
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.11883
TXNIP thioredoxin interacting protein -0.100111
TMSB10 thymosin beta 10 -0.0958198
FTL ferritin, light polypeptide -0.0952755
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0788392
TMEM156 transmembrane protein 156 -0.0787257
HLA-B major histocompatibility complex, class I, B -0.0720352
ASPH aspartate beta-hydroxylase -0.0697154
RPL35A ribosomal protein L35a -0.0675554
FN1 fibronectin 1 -0.0670599
HMGA2 high mobility group AT-hook 2 -0.0654552
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0605979
IER3 immediate early response 3 -0.0541281
EXT1 exostosin glycosyltransferase 1 -0.0525477
EGR1 early growth response 1 -0.0510408
SOX4 SRY (sex determining region Y)-box 4 -0.0509899
LOC102724023 ES1 protein homolog, mitochondrial -0.0494558
VCL vinculin -0.0480155
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0456108
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0446106
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0440263
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0439307
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0432924
ZFP36L1 ZFP36 ring finger protein-like 1 -0.043257
NRP1 neuropilin 1 -0.043205
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0430541
IFI27 interferon, alpha-inducible protein 27 -0.0426794
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0426128
ETV1 ets variant 1 -0.0419928
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0417538
BIRC6 baculoviral IAP repeat containing 6 -0.0416839
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.041367
FBXO11 F-box protein 11 -0.0412149
NPEPPS aminopeptidase puromycin sensitive -0.0411024
WDR45B WD repeat domain 45B -0.041011
SYT1 synaptotagmin I -0.0409019
WSB1 WD repeat and SOCS box containing 1 -0.0407451
ARF1 ADP-ribosylation factor 1 -0.0405865
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0405258
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0401169
NTN4 netrin 4 -0.0398498
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0387018
PARD3 par-3 family cell polarity regulator -0.0383984
S100A6 S100 calcium binding protein A6 -0.038252
GNAS GNAS complex locus -0.0376904
FOXP1 forkhead box P1 -0.0373661
LCORL ligand dependent nuclear receptor corepressor-like -0.0364026
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0363409
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0362975
RAB1A RAB1A, member RAS oncogene family -0.0360927
MBNL1 muscleblind-like splicing regulator 1 -0.0360405
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0358244
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0354826
GLIS3 GLIS family zinc finger 3 -0.0353232
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.035253
TGFB1 transforming growth factor, beta 1 -0.0351762
RPLP1 ribosomal protein, large, P1 -0.0350017
RHEB Ras homolog enriched in brain -0.0347699
EML4 echinoderm microtubule associated protein like 4 -0.0334296
OSMR oncostatin M receptor -0.0331316
ELL2 elongation factor, RNA polymerase II, 2 -0.0330904
NCOA7 nuclear receptor coactivator 7 -0.0330585
RPS24 ribosomal protein S24 -0.0328449
NT5C2 5'-nucleotidase, cytosolic II -0.0326904
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.032637
RPS21 ribosomal protein S21 -0.0322152
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0316749
EFNA5 ephrin-A5 -0.0314707
MT2A metallothionein 2A -0.0309851
ANKRD28 ankyrin repeat domain 28 -0.0306465
MT1X metallothionein 1X -0.0306173
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0305566
BLZF1 basic leucine zipper nuclear factor 1 -0.0294433
SPRED2 sprouty-related, EVH1 domain containing 2 -0.029183
PALLD palladin, cytoskeletal associated protein -0.0290466
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0290155
KLHL5 kelch-like family member 5 -0.0289582
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0289284
LOC112694756 uncharaterized LOC112694756 -0.0288936
SEC24A SEC24 family member A -0.0282428
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0282397
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0279648
RAB31 RAB31, member RAS oncogene family -0.0276803
RAB7A RAB7A, member RAS oncogene family -0.0275654
TTC28 tetratricopeptide repeat domain 28 -0.0275578
SIK3 SIK family kinase 3 -0.027233
MRPS6 mitochondrial ribosomal protein S6 -0.0269338
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0267449
ENAH enabled homolog (Drosophila) -0.0260953
FBXW11 F-box and WD repeat domain containing 11 -0.0260842
MARCHF6 membrane associated ring-CH-type finger 6 -0.0259197
RTN4 reticulon 4 -0.0259155
TMEM131 transmembrane protein 131 -0.0257
ITGA1 integrin, alpha 1 -0.0255454
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0255055
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0253331
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.025279