Belzutifan_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belzutifan perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belzutifan_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PODXL podocalyxin-like 0.193787
CDH13 cadherin 13 0.101491
S100A10 S100 calcium binding protein A10 0.0969969
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0967033
FSTL1 follistatin-like 1 0.0773129
ASPH aspartate beta-hydroxylase 0.0743463
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0729827
AHNAK AHNAK nucleoprotein 0.0675816
CD44 CD44 molecule (Indian blood group) 0.0666452
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0623296
CSTB cystatin B (stefin B) 0.0619328
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0602082
HDAC9 histone deacetylase 9 0.0599586
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0585084
MAP1B microtubule-associated protein 1B 0.0553587
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0526581
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0507482
NAV1 neuron navigator 1 0.0491264
EFNA5 ephrin-A5 0.047834
ANXA2 annexin A2 0.0467882
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0452674
SAMD9 sterile alpha motif domain containing 9 0.0452266
AHNAK2 AHNAK nucleoprotein 2 0.0448973
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.043892
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0428272
MT2A metallothionein 2A 0.0423128
ALCAM activated leukocyte cell adhesion molecule 0.0407869
MACF1 microtubule-actin crosslinking factor 1 0.0398098
ENO1 enolase 1, (alpha) 0.0395839
ANKRD11 ankyrin repeat domain 11 0.0389421
RHOBTB3 Rho-related BTB domain containing 3 0.0381225
SP100 SP100 nuclear antigen 0.0377474
STAT1 signal transducer and activator of transcription 1, 91kDa 0.037634
CENPF centromere protein F, 350/400kDa 0.0366131
EXT1 exostosin glycosyltransferase 1 0.0361292
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0359049
SLC39A11 solute carrier family 39, member 11 0.0356125
LRRC17 leucine rich repeat containing 17 0.0354992
FN1 fibronectin 1 0.0340655
ACTG1 actin gamma 1 0.0332288
FLNA filamin A, alpha 0.0332133
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0331831
SPDL1 spindle apparatus coiled-coil protein 1 0.033017
CDK6 cyclin-dependent kinase 6 0.0327859
CAVIN1 caveolae associated protein 1 0.0320604
COL5A1 collagen, type V, alpha 1 0.0317231
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0316556
IFI6 interferon, alpha-inducible protein 6 0.0316269
SEPTIN7 septin 7 0.0313758
S100A11 S100 calcium binding protein A11 0.0311156
MBNL1 muscleblind-like splicing regulator 1 0.0309786
RPL37A ribosomal protein L37a 0.0304619
ZSWIM6 zinc finger, SWIM-type containing 6 0.0300156
PLXNA2 plexin A2 0.0297942
POTEF POTE ankyrin domain family, member F 0.0294642
TUBB4B tubulin, beta 4B class IVb 0.0293161
TLE4 transducin-like enhancer of split 4 0.028419
KIAA1549L KIAA1549-like 0.0283822
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0283702
IFITM3 interferon induced transmembrane protein 3 0.0279159
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.026989
TPM3 tropomyosin 3 0.0267264
FMN2 formin 2 0.026726
RIGI RNA sensor RIG-I 0.0266298
PCDH7 protocadherin 7 0.0266202
VCL vinculin 0.0264781
SMAD3 SMAD family member 3 0.0263604
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0261967
SQSTM1 sequestosome 1 0.0261883
CYTH3 cytohesin 3 0.0259065
RPL12 ribosomal protein L12 0.0254692
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0252591
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0247373
PMP22 peripheral myelin protein 22 0.0244358
SDCCAG8 serologically defined colon cancer antigen 8 0.0241055
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0238349
MKI67 marker of proliferation Ki-67 0.0237288
RPS3 ribosomal protein S3 0.0234695
DGKG diacylglycerol kinase, gamma 90kDa 0.0231801
PRSS23 protease, serine, 23 0.0227335
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0224419
INTS6 integrator complex subunit 6 0.0222852
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0221337
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0220768
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0218634
PDLIM5 PDZ and LIM domain 5 0.0216574
DSPP dentin sialophosphoprotein 0.0216022
RPL36 ribosomal protein L36 0.0211825
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0210749
RPS12 ribosomal protein S12 0.0210591
NAV3 neuron navigator 3 0.0207799
DIAPH3 diaphanous-related formin 3 0.0205661
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.0204213
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0203917
SMC4 structural maintenance of chromosomes 4 0.020157
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0201424
NALF1 NALCN channel auxiliary factor 1 0.020069
RRM2 ribonucleotide reductase M2 0.0194842
RACK1 receptor for activated C kinase 1 0.019453
RPLP2 ribosomal protein, large, P2 0.0193339

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.225875
FBN1 fibrillin 1 -0.153398
LOX lysyl oxidase -0.143179
AKAP12 A kinase (PRKA) anchor protein 12 -0.142197
DLG1 discs, large homolog 1 (Drosophila) -0.124431
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.119568
NDRG1 N-myc downstream regulated 1 -0.113822
LOXL2 lysyl oxidase-like 2 -0.106385
COL1A2 collagen, type I, alpha 2 -0.104079
SOD2 superoxide dismutase 2, mitochondrial -0.0982073
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0955463
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0946566
COL8A1 collagen, type VIII, alpha 1 -0.0939604
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0838782
MYADM myeloid-associated differentiation marker -0.0766926
UBC ubiquitin C -0.0762679
ZBTB20 zinc finger and BTB domain containing 20 -0.0682275
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0626036
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0585097
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0559485
MRPS6 mitochondrial ribosomal protein S6 -0.0543341
FNDC3B fibronectin type III domain containing 3B -0.0540413
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0537577
AUTS2 autism susceptibility candidate 2 -0.0513407
ARL15 ADP-ribosylation factor-like 15 -0.0512285
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0511564
SBF2 SET binding factor 2 -0.0506198
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0502352
PSD3 pleckstrin and Sec7 domain containing 3 -0.0478704
TMSB10 thymosin beta 10 -0.0452765
CD109 CD109 molecule -0.0450279
DPYSL3 dihydropyrimidinase-like 3 -0.044708
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0440926
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0417618
COPA coatomer protein complex, subunit alpha -0.0415433
OGA O-GlcNAcase -0.0407667
ATP13A3 ATPase type 13A3 -0.0404692
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0401371
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0395193
SPAG9 sperm associated antigen 9 -0.0392896
MMP12 matrix metallopeptidase 12 -0.0390214
INSIG1 insulin induced gene 1 -0.0386837
ELL2 elongation factor, RNA polymerase II, 2 -0.0381292
FTH1 ferritin, heavy polypeptide 1 -0.0372285
GPC6 glypican 6 -0.0369496
GARS1 glycyl-tRNA synthetase 1 -0.0364878
ZEB1 zinc finger E-box binding homeobox 1 -0.0358809
GOLGA4 golgin A4 -0.0357978
COL5A2 collagen, type V, alpha 2 -0.0357171
VEGFA vascular endothelial growth factor A -0.0353291
MEIS2 Meis homeobox 2 -0.034339
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0343206
FLNB filamin B, beta -0.0341584
ESYT2 extended synaptotagmin-like protein 2 -0.0331151
DPYSL2 dihydropyrimidinase-like 2 -0.0329404
MAP4 microtubule-associated protein 4 -0.0327407
ADAM17 ADAM metallopeptidase domain 17 -0.0325077
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0324525
JAZF1 JAZF zinc finger 1 -0.0324275
OPTN optineurin -0.0322827
TTC3 tetratricopeptide repeat domain 3 -0.0318858
KCTD9 potassium channel tetramerization domain containing 9 -0.0318697
CYLD cylindromatosis (turban tumor syndrome) -0.0304482
BIRC6 baculoviral IAP repeat containing 6 -0.0303804
USP34 ubiquitin specific peptidase 34 -0.0303016
GOLGA2 golgin A2 -0.0300014
ZNF207 zinc finger protein 207 -0.0292059
STC1 stanniocalcin 1 -0.0291968
KDM5B lysine (K)-specific demethylase 5B -0.0291832
COL6A1 collagen, type VI, alpha 1 -0.0291075
FNBP4 formin binding protein 4 -0.0287401
NKTR natural killer cell triggering receptor -0.0283843
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0283667
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0282819
KMT2E lysine (K)-specific methyltransferase 2E -0.027796
C1D C1D nuclear receptor corepressor -0.0277493
WTAP Wilms tumor 1 associated protein -0.0276302
AVL9 AVL9 homolog (S. cerevisiase) -0.0275667
ZEB2 zinc finger E-box binding homeobox 2 -0.027465
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0273054
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.026886
ACBD3 acyl-CoA binding domain containing 3 -0.0267312
TAPBP TAP binding protein (tapasin) -0.0266718
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0265282
EPAS1 endothelial PAS domain protein 1 -0.0264464
TMOD1 tropomodulin 1 -0.026139
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0259394
WDFY1 WD repeat and FYVE domain containing 1 -0.0257337
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.0256657
BHLHE40 basic helix-loop-helix family, member e40 -0.0256038
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0255179
INSIG2 insulin induced gene 2 -0.0254903
KIFAP3 kinesin-associated protein 3 -0.0254893
LMAN1 lectin, mannose-binding, 1 -0.0253551
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0250705
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0250376
KLHL24 kelch-like family member 24 -0.0250008
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0249467
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0248442
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0248032