| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belzutifan perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Belzutifan_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.270525 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.204305 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.146005 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.142865 |
| HMGA2 | high mobility group AT-hook 2 | 0.112672 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.112054 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.104939 |
| PCDH7 | protocadherin 7 | 0.093194 |
| RPS3 | ribosomal protein S3 | 0.0927478 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0907609 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0821992 |
| AREG | amphiregulin | 0.0778237 |
| RPS12 | ribosomal protein S12 | 0.0774636 |
| RPL37A | ribosomal protein L37a | 0.0632425 |
| RACK1 | receptor for activated C kinase 1 | 0.0616992 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0571464 |
| RPS8 | ribosomal protein S8 | 0.0523418 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0488788 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0486744 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0434391 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0431618 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0430694 |
| RPS29 | ribosomal protein S29 | 0.0429322 |
| RPL12 | ribosomal protein L12 | 0.0424802 |
| EHBP1 | EH domain binding protein 1 | 0.0401978 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0400727 |
| RPL31 | ribosomal protein L31 | 0.0400535 |
| HDAC9 | histone deacetylase 9 | 0.0397155 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0393492 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0377773 |
| ZNF804A | zinc finger protein 804A | 0.0377482 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0370121 |
| RPL19 | ribosomal protein L19 | 0.0368181 |
| RPS2 | ribosomal protein S2 | 0.0359852 |
| ASPH | aspartate beta-hydroxylase | 0.0356126 |
| RPS23 | ribosomal protein S23 | 0.0348037 |
| JMJD1C | jumonji domain containing 1C | 0.0338378 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0338131 |
| INTS6 | integrator complex subunit 6 | 0.0337763 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0336429 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0335939 |
| YAP1 | Yes-associated protein 1 | 0.0331537 |
| RPL4 | ribosomal protein L4 | 0.0331189 |
| MMP12 | matrix metallopeptidase 12 | 0.0330129 |
| RPL36 | ribosomal protein L36 | 0.0325181 |
| IPO7 | importin 7 | 0.0321069 |
| RPL37 | ribosomal protein L37 | 0.032026 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0313542 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0306055 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0299542 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0291127 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0268854 |
| MPG | N-methylpurine-DNA glycosylase | 0.0268384 |
| MYPN | myopalladin | 0.0262914 |
| ENO1 | enolase 1, (alpha) | 0.0261572 |
| RPL13A | ribosomal protein L13a | 0.0259638 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0258547 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0257579 |
| RPS27A | ribosomal protein S27a | 0.0254366 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0253966 |
| RPL26 | ribosomal protein L26 | 0.0252916 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0250766 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0245972 |
| NRXN3 | neurexin 3 | 0.0245672 |
| RPS19 | ribosomal protein S19 | 0.0238725 |
| CANX | calnexin | 0.0234611 |
| VMP1 | vacuole membrane protein 1 | 0.0233117 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0231954 |
| FNIP1 | folliculin interacting protein 1 | 0.0229536 |
| DENND5A | DENN/MADD domain containing 5A | 0.0229499 |
| DST | dystonin | 0.0229092 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0225111 |
| RPL10A | ribosomal protein L10a | 0.0224066 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0222597 |
| RPS14 | ribosomal protein S14 | 0.022179 |
| RPS17 | ribosomal protein S17 | 0.0221599 |
| SETD5 | SET domain containing 5 | 0.0221225 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0220047 |
| RPL27 | ribosomal protein L27 | 0.0216835 |
| GOLGB1 | golgin B1 | 0.0216452 |
| RPS27 | ribosomal protein S27 | 0.0216079 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0216026 |
| CDK6 | cyclin-dependent kinase 6 | 0.0212196 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0209125 |
| CEP112 | centrosomal protein 112kDa | 0.0205855 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | 0.0204621 |
| ACTG1 | actin gamma 1 | 0.0203782 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0203686 |
| RPS25 | ribosomal protein S25 | 0.0201883 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0199436 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | 0.0197451 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0195839 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.019567 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0195349 |
| S100A11 | S100 calcium binding protein A11 | 0.019317 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0192377 |
| ANK2 | ankyrin 2, neuronal | 0.019202 |
| CLTC | clathrin, heavy chain (Hc) | 0.0192003 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | 0.0190632 |
| RPS10 | ribosomal protein S10 | 0.019034 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SMC4 | structural maintenance of chromosomes 4 | -0.0706654 |
| TMSB10 | thymosin beta 10 | -0.0684864 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0611399 |
| NLGN1 | neuroligin 1 | -0.0545459 |
| PTMA | prothymosin, alpha | -0.0422981 |
| HMGA1 | high mobility group AT-hook 1 | -0.0405814 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0403425 |
| TUBA1B | tubulin, alpha 1b | -0.0375454 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0355169 |
| MKI67 | marker of proliferation Ki-67 | -0.0338059 |
| PFN1 | profilin 1 | -0.0338032 |
| CENPF | centromere protein F, 350/400kDa | -0.033093 |
| CBX3 | chromobox homolog 3 | -0.0325914 |
| EGR1 | early growth response 1 | -0.0316559 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0308765 |
| YBX3 | Y box binding protein 3 | -0.0303027 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.029949 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0298356 |
| PTMS | parathymosin | -0.0280529 |
| RRM2 | ribonucleotide reductase M2 | -0.0271026 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0266005 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0259478 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0254165 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0249584 |
| GCG | glucagon | -0.0246135 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0243281 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0240844 |
| XPO1 | exportin 1 | -0.022899 |
| FUS | FUS RNA binding protein | -0.0227946 |
| POTEF | POTE ankyrin domain family, member F | -0.0226547 |
| TPX2 | TPX2, microtubule-associated | -0.0225444 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0224314 |
| YBX1 | Y box binding protein 1 | -0.0224059 |
| KIF18B | kinesin family member 18B | -0.0223263 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0222996 |
| RPS21 | ribosomal protein S21 | -0.021969 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0212344 |
| RPS24 | ribosomal protein S24 | -0.0211686 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0211256 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0207789 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.020722 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0205272 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0203052 |
| ZNF207 | zinc finger protein 207 | -0.0202567 |
| STIL | SCL/TAL1 interrupting locus | -0.0199964 |
| DIAPH3 | diaphanous-related formin 3 | -0.0199891 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0198334 |
| RBMX | RNA binding motif protein, X-linked | -0.0196922 |
| PRR11 | proline rich 11 | -0.0196627 |
| ECT2 | epithelial cell transforming 2 | -0.0195958 |
| RPL35A | ribosomal protein L35a | -0.0195676 |
| CENPE | centromere protein E, 312kDa | -0.0190041 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | -0.0188761 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0187304 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -0.0185933 |
| DEK | DEK proto-oncogene | -0.0185414 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0182485 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0182006 |
| TSPAN5 | tetraspanin 5 | -0.0178529 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0177137 |
| MSH2 | mutS homolog 2 | -0.0176089 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0171005 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.017085 |
| HMGB1 | high mobility group box 1 | -0.0170465 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0167644 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | -0.0167065 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0166802 |
| EDN1 | endothelin 1 | -0.0165846 |
| CEP192 | centrosomal protein 192kDa | -0.0164852 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0162724 |
| SRSF3 | serine/arginine-rich splicing factor 3 | -0.0160804 |
| TUBA1C | tubulin, alpha 1c | -0.0160628 |
| PNN | pinin, desmosome associated protein | -0.0158999 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0158614 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0157962 |
| MATR3 | matrin 3 | -0.015706 |
| TUBB | tubulin, beta class I | -0.0156951 |
| LMO7 | LIM domain 7 | -0.0155928 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0155402 |
| FANCL | Fanconi anemia, complementation group L | -0.0153976 |
| GRB2 | growth factor receptor-bound protein 2 | -0.0153003 |
| FAM169A | family with sequence similarity 169, member A | -0.0151761 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0150731 |
| USP1 | ubiquitin specific peptidase 1 | -0.0149994 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0148803 |
| AHCY | adenosylhomocysteinase | -0.0148789 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0148715 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0148692 |
| RBM39 | RNA binding motif protein 39 | -0.014844 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0147869 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0146159 |
| NDST4 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 | -0.0145788 |
| NDC80 | NDC80 kinetochore complex component | -0.0144995 |
| KIF5B | kinesin family member 5B | -0.0144987 |
| RAD51B | RAD51 paralog B | -0.0144875 |
| CAPNS1 | calpain, small subunit 1 | -0.0142316 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0141806 |
| NUP58 | nucleoporin 58 | -0.0139985 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0139763 |
| ARF4 | ADP-ribosylation factor 4 | -0.0137203 |
