Belzutifan_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belzutifan perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Belzutifan_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.270368
FMN1 formin 1 0.163228
RPL37A ribosomal protein L37a 0.0929304
ZSWIM6 zinc finger, SWIM-type containing 6 0.0848789
SLIT2 slit homolog 2 (Drosophila) 0.0817827
RPS12 ribosomal protein S12 0.0769079
RPL12 ribosomal protein L12 0.0715133
RPS3 ribosomal protein S3 0.0675949
VCL vinculin 0.0662222
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.065304
TLE4 transducin-like enhancer of split 4 0.0650942
RPL19 ribosomal protein L19 0.0602607
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.0550772
RPS23 ribosomal protein S23 0.053117
DST dystonin 0.051084
RPS17 ribosomal protein S17 0.0508723
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0503998
EEF2 eukaryotic translation elongation factor 2 0.0489113
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0469575
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0468682
PCDH17 protocadherin 17 0.0449818
EIF1 eukaryotic translation initiation factor 1 0.0438131
RPS27A ribosomal protein S27a 0.0394289
RACK1 receptor for activated C kinase 1 0.0392026
RPL26 ribosomal protein L26 0.0383367
SLITRK6 SLIT and NTRK-like family, member 6 0.0380335
HOMER1 homer scaffolding protein 1 0.0374939
RPL37 ribosomal protein L37 0.0374799
ZMIZ1 zinc finger, MIZ-type containing 1 0.0372937
ASPH aspartate beta-hydroxylase 0.0367552
KLF6 Kruppel-like factor 6 0.0367122
FAM107B family with sequence similarity 107, member B 0.0358944
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0349192
RPL18 ribosomal protein L18 0.0346586
RPL4 ribosomal protein L4 0.0344572
TPI1 triosephosphate isomerase 1 0.0343271
DNAH14 dynein, axonemal, heavy chain 14 0.034311
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0341762
VDAC1 voltage-dependent anion channel 1 0.0339174
RPS5 ribosomal protein S5 0.0333227
PKM pyruvate kinase, muscle 0.0330892
VIM vimentin 0.0324777
INTS6 integrator complex subunit 6 0.0324391
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0320441
PRKCA protein kinase C, alpha 0.0319945
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.031819
TPT1 tumor protein, translationally-controlled 1 0.0313509
EPHA7 EPH receptor A7 0.0313355
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0303784
JPT1 Jupiter microtubule associated homolog 1 0.0303404
SIK3 SIK family kinase 3 0.0302018
TOP2A topoisomerase (DNA) II alpha 170kDa 0.029817
CRH corticotropin releasing hormone 0.0298052
TIMP3 TIMP metallopeptidase inhibitor 3 0.029537
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.0291958
FN1 fibronectin 1 0.0289895
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0289844
DNM3 dynamin 3 0.0287993
LPP LIM domain containing preferred translocation partner in lipoma 0.0286469
ENO1 enolase 1, (alpha) 0.0283233
LONRF2 LON peptidase N-terminal domain and ring finger 2 0.0282854
STC1 stanniocalcin 1 0.0276646
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0276178
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0275371
RPL31 ribosomal protein L31 0.0274677
CRABP2 cellular retinoic acid binding protein 2 0.0273351
ITGA1 integrin, alpha 1 0.0272904
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0271805
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0271539
PDE4D phosphodiesterase 4D, cAMP-specific 0.0270931
MBNL1 muscleblind-like splicing regulator 1 0.0269835
CADM1 cell adhesion molecule 1 0.026973
BICD1 bicaudal D homolog 1 (Drosophila) 0.0264765
KAT6B K(lysine) acetyltransferase 6B 0.0260338
LIMA1 LIM domain and actin binding 1 0.0258177
BRD2 bromodomain containing 2 0.0257467
SRP72 signal recognition particle 72kDa 0.0255824
SIK2 salt-inducible kinase 2 0.0254035
RPL32 ribosomal protein L32 0.0253753
SOX9 SRY (sex determining region Y)-box 9 0.025287
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0251174
RPS2 ribosomal protein S2 0.0251049
PEAK1 pseudopodium-enriched atypical kinase 1 0.0250776
STAT1 signal transducer and activator of transcription 1, 91kDa 0.024991
RPS8 ribosomal protein S8 0.0249047
RSU1 Ras suppressor protein 1 0.0248755
VCP valosin containing protein 0.0244537
MYH9 myosin, heavy chain 9, non-muscle 0.0244022
PDLIM5 PDZ and LIM domain 5 0.024381
GLCCI1 glucocorticoid induced 1 0.0242799
PTPRM protein tyrosine phosphatase, receptor type, M 0.0241128
CCND1 cyclin D1 0.0240901
INHBA inhibin, beta A 0.0240581
PCBP2 poly(rC) binding protein 2 0.0240113
PCDH11Y protocadherin 11 Y-linked 0.0239533
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0239237
RPL30 ribosomal protein L30 0.0239078
VMP1 vacuole membrane protein 1 0.0238392
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.023681
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0235815

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.195371
NRG1 neuregulin 1 -0.139799
IGF2 insulin-like growth factor 2 -0.12227
NALF1 NALCN channel auxiliary factor 1 -0.0850281
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0720399
LSAMP limbic system-associated membrane protein -0.0712174
AKAP12 A kinase (PRKA) anchor protein 12 -0.063499
ZBTB20 zinc finger and BTB domain containing 20 -0.055702
MSI2 musashi RNA-binding protein 2 -0.051961
FNDC3B fibronectin type III domain containing 3B -0.0504274
LPIN1 lipin 1 -0.0497908
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0454308
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.042671
DPH6 diphthamine biosynthesis 6 -0.0421381
LIMCH1 LIM and calponin homology domains 1 -0.0420913
PTMA prothymosin, alpha -0.0417297
FRMD4A FERM domain containing 4A -0.0394925
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0390665
COL3A1 collagen, type III, alpha 1 -0.0385926
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.037295
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0352999
PARD3 par-3 family cell polarity regulator -0.0348957
MED13 mediator complex subunit 13 -0.0345615
PHIP pleckstrin homology domain interacting protein -0.0345531
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0345194
IER3 immediate early response 3 -0.0342837
FBXL20 F-box and leucine-rich repeat protein 20 -0.0320945
NAMPT nicotinamide phosphoribosyltransferase -0.0320714
NPEPPS aminopeptidase puromycin sensitive -0.0317616
RPTOR regulatory associated protein of MTOR, complex 1 -0.0317399
FNBP1 formin binding protein 1 -0.031703
IGF1R insulin-like growth factor 1 receptor -0.0313909
RNF213 ring finger protein 213 -0.0309925
ACBD3 acyl-CoA binding domain containing 3 -0.0309588
GOLGA4 golgin A4 -0.0307251
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0305285
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0303811
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.028994
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0289479
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0279429
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0279389
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0275058
OGA O-GlcNAcase -0.0268199
RB1CC1 RB1-inducible coiled-coil 1 -0.0267115
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0264965
BCAS3 breast carcinoma amplified sequence 3 -0.0260737
USP34 ubiquitin specific peptidase 34 -0.0258876
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0258778
SMYD3 SET and MYND domain containing 3 -0.0252853
MON2 MON2 homolog (S. cerevisiae) -0.024976
AFMID arylformamidase -0.0247267
SPAG9 sperm associated antigen 9 -0.0245822
KPNB1 karyopherin (importin) beta 1 -0.0245434
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0245273
MARCHF6 membrane associated ring-CH-type finger 6 -0.0245225
SSBP3 single stranded DNA binding protein 3 -0.0244872
RPLP1 ribosomal protein, large, P1 -0.0240513
DLC1 DLC1 Rho GTPase activating protein -0.0240216
DMXL2 Dmx-like 2 -0.0240115
S100A6 S100 calcium binding protein A6 -0.0239685
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0239597
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0238015
WDR45B WD repeat domain 45B -0.0236583
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0234908
CUX1 cut-like homeobox 1 -0.0234323
TMEM123 transmembrane protein 123 -0.0234094
SEPTIN2 septin 2 -0.0231971
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0231577
NDRG1 N-myc downstream regulated 1 -0.0229197
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0227953
TBX2 T-box 2 -0.0221279
WSB1 WD repeat and SOCS box containing 1 -0.0220783
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0219881
CEMIP cell migration inducing protein, hyaluronan binding -0.0219254
CD46 CD46 molecule, complement regulatory protein -0.0217856
CEP95 centrosomal protein 95kDa -0.0217835
RPL38 ribosomal protein L38 -0.0217596
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0217227
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0216681
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0216251
CDK19 cyclin-dependent kinase 19 -0.0216232
GSK3B glycogen synthase kinase 3 beta -0.021472
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0212564
ELP2 elongator acetyltransferase complex subunit 2 -0.0212557
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0210191
SCLT1 sodium channel and clathrin linker 1 -0.021005
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0209759
DCAF7 DDB1 and CUL4 associated factor 7 -0.0209213
HMGB1 high mobility group box 1 -0.0208885
AKAP13 A kinase (PRKA) anchor protein 13 -0.0208008
RREB1 ras responsive element binding protein 1 -0.0207637
SBF2 SET binding factor 2 -0.0207232
PPP4R3B protein phosphatase 4 regulatory subunit 3B -0.0207169
GLG1 golgi glycoprotein 1 -0.020712
HELZ helicase with zinc finger -0.020682
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0206357
PTK2 protein tyrosine kinase 2 -0.0206279
RIGI RNA sensor RIG-I -0.0205565
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0205164
MATR3 matrin 3 -0.0204739