Belzutifan_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belzutifan perturbation in COLO 205 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Belzutifan_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin 0.15787
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.103708
FTL ferritin, light polypeptide 0.0903043
RPS6 ribosomal protein S6 0.0717467
MACC1 metastasis associated in colon cancer 1 0.0715609
GCLC glutamate-cysteine ligase, catalytic subunit 0.0709993
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0679184
LMO7 LIM domain 7 0.0670305
LCN2 lipocalin 2 0.0616743
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0614788
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0592474
RPL37A ribosomal protein L37a 0.0541497
RPL12 ribosomal protein L12 0.0540548
AKAP13 A kinase (PRKA) anchor protein 13 0.0520883
AREG amphiregulin 0.0518548
SMAD3 SMAD family member 3 0.0517538
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0491455
TPT1 tumor protein, translationally-controlled 1 0.0488716
RPL23 ribosomal protein L23 0.0488002
RPS3 ribosomal protein S3 0.0484913
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.047349
EFNB2 ephrin-B2 0.0472139
RPL19 ribosomal protein L19 0.0463818
RPS8 ribosomal protein S8 0.0460327
DST dystonin 0.0459402
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0440984
RPS12 ribosomal protein S12 0.0438207
RPS19 ribosomal protein S19 0.0422105
RPL31 ribosomal protein L31 0.0410961
ASPH aspartate beta-hydroxylase 0.0391919
MT2A metallothionein 2A 0.0378078
RPS17 ribosomal protein S17 0.0376942
ZFP36L1 ZFP36 ring finger protein-like 1 0.0376863
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0376141
MCTP1 multiple C2 domains, transmembrane 1 0.0375742
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0371496
FTH1 ferritin, heavy polypeptide 1 0.0363553
RPLP0 ribosomal protein, large, P0 0.0350333
ZNF292 zinc finger protein 292 0.0349359
RPL11 ribosomal protein L11 0.0342222
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0340405
RPS27 ribosomal protein S27 0.0339095
RACK1 receptor for activated C kinase 1 0.0338591
RPS23 ribosomal protein S23 0.0333464
EXT1 exostosin glycosyltransferase 1 0.0332053
RPL9 ribosomal protein L9 0.0330259
PKM pyruvate kinase, muscle 0.0324604
RPL35A ribosomal protein L35a 0.0321662
RPL26 ribosomal protein L26 0.0310404
HLA-A major histocompatibility complex, class I, A 0.0309567
TRIB1 tribbles pseudokinase 1 0.0308707
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.030867
ENO1 enolase 1, (alpha) 0.0307351
FRMD5 FERM domain containing 5 0.0303525
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0302627
RPL7L1 ribosomal protein L7-like 1 0.0302328
TSC22D1 TSC22 domain family, member 1 0.0296325
LOC102724023 ES1 protein homolog, mitochondrial 0.0294311
RPLP1 ribosomal protein, large, P1 0.0290524
HKDC1 hexokinase domain containing 1 0.0285666
RPL37 ribosomal protein L37 0.0285413
RPS29 ribosomal protein S29 0.0279105
LURAP1L leucine rich adaptor protein 1-like 0.0279077
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0275375
TMSB10 thymosin beta 10 0.0275115
SRRM2 serine/arginine repetitive matrix 2 0.0258007
PDIA3 protein disulfide isomerase family A, member 3 0.0255113
RPL7A ribosomal protein L7a 0.0253704
RPS14 ribosomal protein S14 0.0252292
RPS25 ribosomal protein S25 0.0244382
GK glycerol kinase 0.0244213
RND3 Rho family GTPase 3 0.0242865
RPL13A ribosomal protein L13a 0.0240294
DSTN destrin (actin depolymerizing factor) 0.0240109
RPL34 ribosomal protein L34 0.0239602
EIF1 eukaryotic translation initiation factor 1 0.0239371
EEF2 eukaryotic translation elongation factor 2 0.0239189
KYNU kynureninase 0.023745
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0234364
XDH xanthine dehydrogenase 0.023389
KLF6 Kruppel-like factor 6 0.0233517
EREG epiregulin 0.0232342
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0231865
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0230628
KLF5 Kruppel-like factor 5 (intestinal) 0.0225214
NAP1L1 nucleosome assembly protein 1-like 1 0.0224628
ZBTB43 zinc finger and BTB domain containing 43 0.0223975
RPLP2 ribosomal protein, large, P2 0.0223572
RPL28 ribosomal protein L28 0.0221781
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0218754
ACTG1 actin gamma 1 0.0217668
SAMD4A sterile alpha motif domain containing 4A 0.0217309
IFI6 interferon, alpha-inducible protein 6 0.0216048
CXCL8 chemokine (C-X-C motif) ligand 8 0.0214866
SOX9 SRY (sex determining region Y)-box 9 0.0214767
PRRC2C proline-rich coiled-coil 2C 0.0213639
YAP1 Yes-associated protein 1 0.02126
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0212124
RPL30 ribosomal protein L30 0.0210352
RPL35 ribosomal protein L35 0.0209637

decreased expression

Symbol Name Standardized Value
EPSTI1 epithelial stromal interaction 1 (breast) -0.146628
GMDS GDP-mannose 4,6-dehydratase -0.126122
ARHGAP26 Rho GTPase activating protein 26 -0.111542
BTBD9 BTB (POZ) domain containing 9 -0.110454
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0963253
LYZ lysozyme -0.0962666
RIGI RNA sensor RIG-I -0.089647
ZMYND8 zinc finger, MYND-type containing 8 -0.0868813
PRKCA protein kinase C, alpha -0.0818788
STS steroid sulfatase (microsomal), isozyme S -0.0796271
MX1 MX dynamin-like GTPase 1 -0.0766026
NPSR1 neuropeptide S receptor 1 -0.0754529
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0734904
PLSCR1 phospholipid scramblase 1 -0.071248
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0684929
RABGAP1L RAB GTPase activating protein 1-like -0.0640996
TSHZ2 teashirt zinc finger homeobox 2 -0.0621321
ZBTB20 zinc finger and BTB domain containing 20 -0.0616447
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0552435
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0547028
PHF3 PHD finger protein 3 -0.0539385
ITGA6 integrin, alpha 6 -0.0535462
RNF213 ring finger protein 213 -0.0527961
XAF1 XIAP associated factor 1 -0.0527097
IGF1R insulin-like growth factor 1 receptor -0.050036
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0490117
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0489911
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0472958
SPATA13 spermatogenesis associated 13 -0.0472788
MX2 MX dynamin-like GTPase 2 -0.0465982
SP100 SP100 nuclear antigen -0.0460676
EPHB2 EPH receptor B2 -0.0459892
RAD51B RAD51 paralog B -0.0449464
SSH2 slingshot protein phosphatase 2 -0.0448983
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0438638
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.042662
SAMD12 sterile alpha motif domain containing 12 -0.0426354
MECOM MDS1 and EVI1 complex locus -0.0415401
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.041213
ATP10B ATPase, class V, type 10B -0.0399468
PATJ PATJ crumbs cell polarity complex component -0.0396626
SORBS1 sorbin and SH3 domain containing 1 -0.0395266
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0394264
MAML2 mastermind-like 2 (Drosophila) -0.0368384
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0365017
MSI2 musashi RNA-binding protein 2 -0.0362562
NCOA7 nuclear receptor coactivator 7 -0.0358623
NKD1 naked cuticle homolog 1 (Drosophila) -0.0356151
LPP LIM domain containing preferred translocation partner in lipoma -0.0355532
EZR ezrin -0.0354234
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0342266
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0339312
PRKCE protein kinase C, epsilon -0.0332339
VCL vinculin -0.0331953
CATSPERB catsper channel auxiliary subunit beta -0.032692
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0318886
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0317705
NT5C2 5'-nucleotidase, cytosolic II -0.0314056
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0313691
SQSTM1 sequestosome 1 -0.0307915
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0304841
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0304035
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0303964
TRIO trio Rho guanine nucleotide exchange factor -0.0300906
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0293008
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.029132
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0290024
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0288
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0284221
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -0.0283101
IGFBP3 insulin-like growth factor binding protein 3 -0.0281958
TFRC transferrin receptor -0.028002
NF1 neurofibromin 1 -0.0278447
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -0.0278408
TMEM62 transmembrane protein 62 -0.0277426
PTGR1 prostaglandin reductase 1 -0.0276435
ATP11A ATPase, class VI, type 11A -0.0274154
PTK2 protein tyrosine kinase 2 -0.0271917
TNS4 tensin 4 -0.0271716
DOCK1 dedicator of cytokinesis 1 -0.0268841
ERBIN erbb2 interacting protein -0.0264963
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0264226
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0259719
BICRAL BICRA like chromatin remodeling complex associated protein -0.0258783
AHNAK AHNAK nucleoprotein -0.0257478
ANKRD10 ankyrin repeat domain 10 -0.0257299
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0254152
LAMA4 laminin, alpha 4 -0.0252631
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0251094
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0250905
OASL 2'-5'-oligoadenylate synthetase-like -0.0248771
SH3PXD2A SH3 and PX domains 2A -0.0242911
H1-0 H1.0 linker histone -0.0240578
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0240321
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked -0.0239794
RBM39 RNA binding motif protein 39 -0.0238192
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0237454
ITGA1 integrin, alpha 1 -0.0236977
UBAC2 UBA domain containing 2 -0.0236475
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 -0.0233621