| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belzutifan perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Belzutifan_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.20323 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.172723 |
| COL1A1 | collagen, type I, alpha 1 | 0.153485 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.12977 |
| MT2A | metallothionein 2A | 0.125799 |
| EXT1 | exostosin glycosyltransferase 1 | 0.107219 |
| CD44 | CD44 molecule (Indian blood group) | 0.0888432 |
| CDH13 | cadherin 13 | 0.0844132 |
| ACTG1 | actin gamma 1 | 0.0742808 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0728957 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0678326 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0657118 |
| GOLGB1 | golgin B1 | 0.0579374 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0575161 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0572625 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0571551 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0570565 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0565916 |
| SQSTM1 | sequestosome 1 | 0.0533233 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0528089 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0506666 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0497241 |
| STC1 | stanniocalcin 1 | 0.0492842 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0456822 |
| INHBA | inhibin, beta A | 0.0449305 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0438975 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0437779 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0432769 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0418585 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0414079 |
| SP100 | SP100 nuclear antigen | 0.0394508 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0384753 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0383126 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0376136 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0374628 |
| ANXA2 | annexin A2 | 0.0364579 |
| GLIS3 | GLIS family zinc finger 3 | 0.0363455 |
| RSU1 | Ras suppressor protein 1 | 0.0356056 |
| DST | dystonin | 0.0355958 |
| FAM107B | family with sequence similarity 107, member B | 0.035141 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0351386 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0346952 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0336679 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.033551 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.032432 |
| CALU | calumenin | 0.0321653 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0320203 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0317845 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0317237 |
| NEK10 | NIMA-related kinase 10 | 0.0315269 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0300212 |
| INTS6 | integrator complex subunit 6 | 0.0296534 |
| CALD1 | caldesmon 1 | 0.0296183 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0295812 |
| CSPP1 | centrosome and spindle pole associated protein 1 | 0.0294217 |
| ATXN1 | ataxin 1 | 0.0288796 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 0.0284806 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0283733 |
| TLE4 | transducin-like enhancer of split 4 | 0.0282519 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0279173 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0278997 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0276583 |
| FTL | ferritin, light polypeptide | 0.0276004 |
| LOX | lysyl oxidase | 0.0274594 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0274498 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0271115 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0270195 |
| MTDH | metadherin | 0.026925 |
| KIAA1328 | KIAA1328 | 0.026866 |
| ZNF644 | zinc finger protein 644 | 0.0268645 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0261844 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0260802 |
| FNIP1 | folliculin interacting protein 1 | 0.0260152 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0256849 |
| NAV2 | neuron navigator 2 | 0.0255217 |
| AHNAK | AHNAK nucleoprotein | 0.0253512 |
| ASPH | aspartate beta-hydroxylase | 0.0249769 |
| HDAC9 | histone deacetylase 9 | 0.0246114 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | 0.0245138 |
| CLTC | clathrin, heavy chain (Hc) | 0.0243385 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0238481 |
| PALLD | palladin, cytoskeletal associated protein | 0.0237443 |
| VCL | vinculin | 0.023663 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0236498 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.023475 |
| SIK3 | SIK family kinase 3 | 0.0234062 |
| COL3A1 | collagen, type III, alpha 1 | 0.023214 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.0230632 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0229891 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0228834 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0227946 |
| HDLBP | high density lipoprotein binding protein | 0.0226976 |
| CUX1 | cut-like homeobox 1 | 0.0224943 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0223877 |
| CAVIN1 | caveolae associated protein 1 | 0.022075 |
| WRN | Werner syndrome, RecQ helicase-like | 0.0219359 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0218791 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0217321 |
| RPS2 | ribosomal protein S2 | 0.0216264 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0215574 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.317028 |
| NDRG1 | N-myc downstream regulated 1 | -0.152776 |
| ATP13A3 | ATPase type 13A3 | -0.121648 |
| VEGFA | vascular endothelial growth factor A | -0.113249 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0943335 |
| COL1A2 | collagen, type I, alpha 2 | -0.0866036 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0744305 |
| TMSB10 | thymosin beta 10 | -0.073476 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0718257 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0654031 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0637135 |
| SPAG9 | sperm associated antigen 9 | -0.0574969 |
| TPM4 | tropomyosin 4 | -0.05715 |
| CALR | calreticulin | -0.0566588 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0544846 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0485105 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0466829 |
| LOXL2 | lysyl oxidase-like 2 | -0.045712 |
| PTMA | prothymosin, alpha | -0.0457067 |
| RTN4 | reticulon 4 | -0.0445733 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0439048 |
| SMAD3 | SMAD family member 3 | -0.0432337 |
| CADM1 | cell adhesion molecule 1 | -0.041996 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.040971 |
| PKM | pyruvate kinase, muscle | -0.0406708 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0392669 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0390134 |
| COL5A1 | collagen, type V, alpha 1 | -0.0381347 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.037608 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0367466 |
| RPL35A | ribosomal protein L35a | -0.0364241 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0359189 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0357622 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0351979 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0349337 |
| S100A9 | S100 calcium binding protein A9 | -0.0344286 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0341634 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0337247 |
| TAPBP | TAP binding protein (tapasin) | -0.0331607 |
| TMEM165 | transmembrane protein 165 | -0.0322208 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0320004 |
| ECE1 | endothelin converting enzyme 1 | -0.0318244 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0316464 |
| CLIC4 | chloride intracellular channel 4 | -0.0314439 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0311639 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0307936 |
| USP3 | ubiquitin specific peptidase 3 | -0.0306126 |
| ZNF292 | zinc finger protein 292 | -0.0305912 |
| S100A6 | S100 calcium binding protein A6 | -0.0291159 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0274198 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0271039 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0269266 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0269088 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0267687 |
| PTK2 | protein tyrosine kinase 2 | -0.02657 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.026557 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0260922 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0260383 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0259405 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.02593 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0258531 |
| YBX1 | Y box binding protein 1 | -0.025698 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0255947 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0253705 |
| HAS2 | hyaluronan synthase 2 | -0.0253519 |
| NRP1 | neuropilin 1 | -0.0253212 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0253001 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0251762 |
| ARRDC3 | arrestin domain containing 3 | -0.0250104 |
| MATR3 | matrin 3 | -0.024879 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0248709 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | -0.0247363 |
| PDE10A | phosphodiesterase 10A | -0.0246542 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0245228 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.02425 |
| HMGA1 | high mobility group AT-hook 1 | -0.0240075 |
| TFG | TRK-fused gene | -0.0239781 |
| EHD2 | EH-domain containing 2 | -0.0239084 |
| KIAA1217 | KIAA1217 | -0.0237965 |
| SEPTIN7 | septin 7 | -0.0237262 |
| GSK3B | glycogen synthase kinase 3 beta | -0.023212 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0229905 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.022811 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0224006 |
| YEATS2 | YEATS domain containing 2 | -0.0223379 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0222009 |
| PFN1 | profilin 1 | -0.0219653 |
| GNAS | GNAS complex locus | -0.0218585 |
| CANX | calnexin | -0.0218367 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0216939 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | -0.0216833 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | -0.0213788 |
| RPS20 | ribosomal protein S20 | -0.0213215 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.021163 |
| RPL28 | ribosomal protein L28 | -0.0211598 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0210964 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.020763 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0207463 |
| IL6 | interleukin 6 | -0.0207165 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0204056 |
