| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belzutifan perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belzutifan_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.230456 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.188329 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.10873 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.103535 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.101083 |
| ENO1 | enolase 1, (alpha) | 0.099507 |
| APOB | apolipoprotein B | 0.0950697 |
| EHBP1 | EH domain binding protein 1 | 0.0788345 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.075804 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0564758 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0564364 |
| KLF6 | Kruppel-like factor 6 | 0.0554141 |
| BCL2L1 | BCL2-like 1 | 0.0546951 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0503188 |
| PTCHD4 | patched domain containing 4 | 0.049152 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0476792 |
| FOXP1 | forkhead box P1 | 0.0435095 |
| KYNU | kynureninase | 0.0421145 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0420814 |
| ATXN1 | ataxin 1 | 0.0418464 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0417355 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.041635 |
| RACK1 | receptor for activated C kinase 1 | 0.0410678 |
| RPS12 | ribosomal protein S12 | 0.0407317 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0400154 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0395887 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0380554 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.037688 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0374777 |
| DSPP | dentin sialophosphoprotein | 0.0371042 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0370281 |
| PEG3 | paternally expressed 3 | 0.0370194 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0366119 |
| GPC3 | glypican 3 | 0.0355916 |
| FAM107B | family with sequence similarity 107, member B | 0.0348602 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.034139 |
| RPL12 | ribosomal protein L12 | 0.0341074 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0336973 |
| RPS3 | ribosomal protein S3 | 0.0335644 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0334244 |
| DST | dystonin | 0.0333855 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0330758 |
| HPCAL1 | hippocalcin-like 1 | 0.0323636 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0321924 |
| ACTG1 | actin gamma 1 | 0.0321018 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0315671 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0315636 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0312554 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0310705 |
| SVIL | supervillin | 0.0307503 |
| H1-0 | H1.0 linker histone | 0.0305282 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0297743 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0295153 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0294546 |
| TRIM26 | tripartite motif containing 26 | 0.0292781 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0289814 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0286342 |
| FRMD5 | FERM domain containing 5 | 0.0280161 |
| RSU1 | Ras suppressor protein 1 | 0.0276802 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0274275 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0273879 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | 0.0273669 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0271214 |
| RTN4 | reticulon 4 | 0.0271018 |
| RPLP0 | ribosomal protein, large, P0 | 0.0268054 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.026571 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0265457 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0262904 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.026143 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0260431 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0258595 |
| VCL | vinculin | 0.0252912 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0252702 |
| RPL18 | ribosomal protein L18 | 0.025063 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0248944 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0243342 |
| DUSP6 | dual specificity phosphatase 6 | 0.0242447 |
| RRBP1 | ribosome binding protein 1 | 0.024232 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0242291 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0242171 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0241406 |
| GLIPR1 | GLI pathogenesis-related 1 | 0.0240321 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0238897 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0238173 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0237304 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0235655 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0233927 |
| CNKSR3 | CNKSR family member 3 | 0.023156 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0231279 |
| RAI14 | retinoic acid induced 14 | 0.0231189 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0231074 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0231024 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0229326 |
| RPL26 | ribosomal protein L26 | 0.0227649 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0226136 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0223994 |
| DSG2 | desmoglein 2 | 0.0223977 |
| MAP1B | microtubule-associated protein 1B | 0.0218051 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0217854 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | 0.0215365 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.257502 |
| APOA2 | apolipoprotein A-II | -0.0871584 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0863043 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0773369 |
| NDRG1 | N-myc downstream regulated 1 | -0.0662366 |
| C3 | complement component 3 | -0.0569241 |
| RPL35A | ribosomal protein L35a | -0.0479301 |
| AHSG | alpha-2-HS-glycoprotein | -0.0439707 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0436094 |
| MT2A | metallothionein 2A | -0.0430761 |
| HMGA1 | high mobility group AT-hook 1 | -0.0423882 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0422567 |
| VEGFA | vascular endothelial growth factor A | -0.0375931 |
| INSIG2 | insulin induced gene 2 | -0.0348254 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0331949 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0330674 |
| DTNA | dystrobrevin, alpha | -0.0330324 |
| TNS1 | tensin 1 | -0.0322232 |
| PLIN2 | perilipin 2 | -0.0307792 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.0269003 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0268066 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0267285 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.026505 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0264987 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0262024 |
| RPS13 | ribosomal protein S13 | -0.0255238 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -0.0254069 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0253717 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0247554 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | -0.024622 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0243144 |
| PCGF5 | polycomb group ring finger 5 | -0.0242449 |
| RPL31 | ribosomal protein L31 | -0.0238348 |
| RPL7A | ribosomal protein L7a | -0.0237813 |
| MT1G | metallothionein 1G | -0.0228894 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0225485 |
| CALR | calreticulin | -0.0223529 |
| DENND4A | DENN/MADD domain containing 4A | -0.0223213 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0222722 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0219319 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | -0.0218252 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | -0.0214448 |
| FBXO42 | F-box protein 42 | -0.0203504 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0202989 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0202172 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | -0.0196578 |
| THRB | thyroid hormone receptor, beta | -0.0195811 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0193949 |
| IL32 | interleukin 32 | -0.0192897 |
| STC2 | stanniocalcin 2 | -0.0192118 |
| RPS24 | ribosomal protein S24 | -0.0191646 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | -0.0190927 |
| KIF1B | kinesin family member 1B | -0.0189445 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0186932 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0186199 |
| RPL34 | ribosomal protein L34 | -0.0184989 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0184374 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0184098 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0183206 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0182336 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0182021 |
| VIM | vimentin | -0.0181966 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0178249 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0177802 |
| GSE1 | Gse1 coiled-coil protein | -0.0175483 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0175223 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.017411 |
| GNAS | GNAS complex locus | -0.0174029 |
| MT1E | metallothionein 1E | -0.0173364 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.0173277 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0172513 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0171791 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0171409 |
| ABHD3 | abhydrolase domain containing 3 | -0.0171339 |
| PTMA | prothymosin, alpha | -0.0171014 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0168174 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | -0.0167713 |
| FBXO11 | F-box protein 11 | -0.0166526 |
| CHKA | choline kinase alpha | -0.0165705 |
| INTS6 | integrator complex subunit 6 | -0.0163847 |
| PKM | pyruvate kinase, muscle | -0.0163395 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0163265 |
| KIZ | kizuna centrosomal protein | -0.0162347 |
| SCARB1 | scavenger receptor class B, member 1 | -0.0161061 |
| LYZ | lysozyme | -0.0160218 |
| FOXN3 | forkhead box N3 | -0.0159031 |
| EFNA1 | ephrin-A1 | -0.0158973 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0157549 |
| PDE8A | phosphodiesterase 8A | -0.015677 |
| RPL38 | ribosomal protein L38 | -0.0156585 |
| SUCO | SUN domain containing ossification factor | -0.0155826 |
| RAB6A | RAB6A, member RAS oncogene family | -0.015493 |
| GDI2 | GDP dissociation inhibitor 2 | -0.0154771 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0154443 |
| RPL23 | ribosomal protein L23 | -0.0153619 |
| NUP58 | nucleoporin 58 | -0.0152278 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0150869 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0150543 |
| NGLY1 | N-glycanase 1 | -0.0150505 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0149091 |
