Belzutifan_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belzutifan perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belzutifan_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MACC1 metastasis associated in colon cancer 1 0.0959958
RPS3 ribosomal protein S3 0.0790721
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0742433
RPS12 ribosomal protein S12 0.0717009
HDAC9 histone deacetylase 9 0.0693819
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.063593
B2M beta-2-microglobulin 0.062419
RPS25 ribosomal protein S25 0.0607472
RPL37A ribosomal protein L37a 0.0605521
RPL19 ribosomal protein L19 0.0579011
TM4SF1 transmembrane 4 L six family member 1 0.0561292
RPS6 ribosomal protein S6 0.0540283
RPS19 ribosomal protein S19 0.0529771
AREG amphiregulin 0.0515157
FRMD5 FERM domain containing 5 0.0499211
RPL26 ribosomal protein L26 0.0474008
RPL23 ribosomal protein L23 0.0465357
RPS17 ribosomal protein S17 0.0463665
RPL13A ribosomal protein L13a 0.045732
TMC5 transmembrane channel-like 5 0.0438374
RPL12 ribosomal protein L12 0.0420178
CLDN4 claudin 4 0.0411689
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0406156
ANXA2 annexin A2 0.0384131
RPS8 ribosomal protein S8 0.0375618
IFI6 interferon, alpha-inducible protein 6 0.0373923
MYOF myoferlin 0.0367212
RPS29 ribosomal protein S29 0.0364942
RPL31 ribosomal protein L31 0.0361424
FTL ferritin, light polypeptide 0.0341864
RPL27 ribosomal protein L27 0.0336084
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0332091
RPS27A ribosomal protein S27a 0.0320481
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0319524
LOC102724023 ES1 protein homolog, mitochondrial 0.0311883
GOLGB1 golgin B1 0.0306937
RPL36 ribosomal protein L36 0.0305888
RPS27 ribosomal protein S27 0.0305724
RPL28 ribosomal protein L28 0.0305615
MBNL1 muscleblind-like splicing regulator 1 0.0302287
RACK1 receptor for activated C kinase 1 0.0300719
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0291819
VMP1 vacuole membrane protein 1 0.0288069
RUNX1 runt-related transcription factor 1 0.02843
MBNL2 muscleblind-like splicing regulator 2 0.0283376
LMO7 LIM domain 7 0.0281332
APLP2 amyloid beta (A4) precursor-like protein 2 0.0277367
RPS5 ribosomal protein S5 0.0276727
LURAP1L leucine rich adaptor protein 1-like 0.0274632
EEF2 eukaryotic translation elongation factor 2 0.0272485
RPL11 ribosomal protein L11 0.0269252
KLF6 Kruppel-like factor 6 0.0264428
RPS23 ribosomal protein S23 0.0259377
RPL18 ribosomal protein L18 0.0258102
ITGB8 integrin, beta 8 0.0256072
CDK6 cyclin-dependent kinase 6 0.0255077
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0253195
DSPP dentin sialophosphoprotein 0.0251386
MGAM2 maltase-glucoamylase 2 (putative) 0.024979
NCEH1 neutral cholesterol ester hydrolase 1 0.024816
ALCAM activated leukocyte cell adhesion molecule 0.0247871
RPL4 ribosomal protein L4 0.0246094
YAP1 Yes-associated protein 1 0.0243978
RPS14 ribosomal protein S14 0.024368
HLA-A major histocompatibility complex, class I, A 0.0236843
RPL10A ribosomal protein L10a 0.0236711
RPS11 ribosomal protein S11 0.0234568
PTPRK protein tyrosine phosphatase, receptor type, K 0.0233294
RPS10 ribosomal protein S10 0.0228698
SQSTM1 sequestosome 1 0.0228675
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.022833
RPL9 ribosomal protein L9 0.0227692
EXT1 exostosin glycosyltransferase 1 0.0227267
RPL7 ribosomal protein L7 0.0221251
AKAP13 A kinase (PRKA) anchor protein 13 0.0220903
FNIP1 folliculin interacting protein 1 0.0218348
UBB ubiquitin B 0.0217548
RPS2 ribosomal protein S2 0.0214485
FAM135A family with sequence similarity 135, member A 0.0213653
EIF1 eukaryotic translation initiation factor 1 0.0213176
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0209871
ZSWIM6 zinc finger, SWIM-type containing 6 0.0208757
CLDN1 claudin 1 0.0207328
SLC38A2 solute carrier family 38, member 2 0.0204763
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0204288
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0201268
RPL30 ribosomal protein L30 0.020092
KLF5 Kruppel-like factor 5 (intestinal) 0.0200388
RPL32 ribosomal protein L32 0.0199672
GOLGA4 golgin A4 0.0198924
RPL7A ribosomal protein L7a 0.0197082
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0196674
DST dystonin 0.0194331
RESF1 retroelement silencing factor 1 0.0186952
JMJD1C jumonji domain containing 1C 0.0181277
IFI27 interferon, alpha-inducible protein 27 0.0181096
CXCL8 chemokine (C-X-C motif) ligand 8 0.0180476
RPL37 ribosomal protein L37 0.0179239
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0178144
SOX4 SRY (sex determining region Y)-box 4 0.017706

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.223619
PTMA prothymosin, alpha -0.130289
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0934729
S100A6 S100 calcium binding protein A6 -0.08471
GMDS GDP-mannose 4,6-dehydratase -0.0747995
TMSB10 thymosin beta 10 -0.0705841
MAML2 mastermind-like 2 (Drosophila) -0.0689097
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.065072
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0630032
FLNB filamin B, beta -0.0598596
KRT18 keratin 18, type I -0.0598051
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.058457
ANLN anillin, actin binding protein -0.0571227
EZR ezrin -0.0564646
EHBP1 EH domain binding protein 1 -0.0530164
KRT8 keratin 8, type II -0.0529861
DEK DEK proto-oncogene -0.0493959
CALR calreticulin -0.0492032
MKI67 marker of proliferation Ki-67 -0.0450358
H1-0 H1.0 linker histone -0.0442956
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0434459
PDIA3 protein disulfide isomerase family A, member 3 -0.0428827
ITGA6 integrin, alpha 6 -0.0428825
SMC4 structural maintenance of chromosomes 4 -0.0422161
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0405402
POTEF POTE ankyrin domain family, member F -0.0401625
TMSB4X thymosin beta 4, X-linked -0.039207
ATF5 activating transcription factor 5 -0.038447
TMEM123 transmembrane protein 123 -0.0377698
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0360631
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0352184
S100A10 S100 calcium binding protein A10 -0.0346077
PRKCA protein kinase C, alpha -0.0335871
PDIA4 protein disulfide isomerase family A, member 4 -0.0332797
KLK10 kallikrein-related peptidase 10 -0.0332489
HMGB1 high mobility group box 1 -0.0320566
RRM2 ribonucleotide reductase M2 -0.0315604
KRT7 keratin 7, type II -0.0314346
FGFR2 fibroblast growth factor receptor 2 -0.0306535
ACTN4 actinin, alpha 4 -0.030557
DIAPH3 diaphanous-related formin 3 -0.0300648
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0299962
CBX3 chromobox homolog 3 -0.0297127
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.029691
WWC1 WW and C2 domain containing 1 -0.0288135
LMNA lamin A/C -0.0286078
S100A9 S100 calcium binding protein A9 -0.0285404
INSIG1 insulin induced gene 1 -0.0284441
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0284296
PRSS3 protease, serine, 3 -0.0281684
MECOM MDS1 and EVI1 complex locus -0.0281016
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0279099
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.02773
RAD21 RAD21 homolog (S. pombe) -0.0273144
AHNAK AHNAK nucleoprotein -0.027292
ACACA acetyl-CoA carboxylase alpha -0.0272682
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0268824
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0268088
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0265309
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0262283
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0260588
KPNB1 karyopherin (importin) beta 1 -0.025895
WARS1 tryptophanyl-tRNA synthetase 1 -0.0255648
TNIK TRAF2 and NCK interacting kinase -0.0255517
DLG1 discs, large homolog 1 (Drosophila) -0.0254223
MSI2 musashi RNA-binding protein 2 -0.0253096
SAMD12 sterile alpha motif domain containing 12 -0.0251832
TPM4 tropomyosin 4 -0.0247843
ANO1 anoctamin 1, calcium activated chloride channel -0.0246759
ANKRD11 ankyrin repeat domain 11 -0.0243113
DENND1A DENN/MADD domain containing 1A -0.0239225
XPO1 exportin 1 -0.0239125
PDIA6 protein disulfide isomerase family A, member 6 -0.0235002
TFRC transferrin receptor -0.0234442
EMP1 epithelial membrane protein 1 -0.0233192
HMGA1 high mobility group AT-hook 1 -0.0231936
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0231532
ACTG1 actin gamma 1 -0.0230297
TUBA1B tubulin, alpha 1b -0.0229161
HMGB2 high mobility group box 2 -0.0226086
GARS1 glycyl-tRNA synthetase 1 -0.0223859
COTL1 coactosin-like F-actin binding protein 1 -0.0220862
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0220416
ATAD2 ATPase family, AAA domain containing 2 -0.0219903
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0219364
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0218806
RPL35A ribosomal protein L35a -0.0218469
FAF1 Fas (TNFRSF6) associated factor 1 -0.0216848
IARS1 isoleucyl-tRNA synthetase 1 -0.0216657
NFIA nuclear factor I/A -0.0216505
MYL12B myosin, light chain 12B, regulatory -0.0212373
ECT2 epithelial cell transforming 2 -0.0210222
RAB6A RAB6A, member RAS oncogene family -0.0209563
BRCA1 breast cancer 1, early onset -0.0206645
BIRC6 baculoviral IAP repeat containing 6 -0.0205391
PPARG peroxisome proliferator-activated receptor gamma -0.0204219
LOC112694756 uncharaterized LOC112694756 -0.0200223
ZMYND8 zinc finger, MYND-type containing 8 -0.0199698
CENPF centromere protein F, 350/400kDa -0.0195829
TPX2 TPX2, microtubule-associated -0.019452