| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belzutifan perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belzutifan_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.218735 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.108257 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0899463 |
| EREG | epiregulin | 0.0785633 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0669673 |
| RPS12 | ribosomal protein S12 | 0.0579822 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.051241 |
| POTEF | POTE ankyrin domain family, member F | 0.0493041 |
| RUNX1 | runt-related transcription factor 1 | 0.0491592 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0426298 |
| CD44 | CD44 molecule (Indian blood group) | 0.0425621 |
| RACK1 | receptor for activated C kinase 1 | 0.0422907 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0413549 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0409766 |
| RPS2 | ribosomal protein S2 | 0.0387696 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0379153 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0374498 |
| SVIL | supervillin | 0.037141 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0359143 |
| RTN4 | reticulon 4 | 0.0350646 |
| ANGPTL4 | angiopoietin-like 4 | 0.0344685 |
| DST | dystonin | 0.0334713 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0317027 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0313072 |
| PODXL | podocalyxin-like | 0.0313045 |
| TGM2 | transglutaminase 2 | 0.0312747 |
| FOSL1 | FOS-like antigen 1 | 0.0311026 |
| TXNRD1 | thioredoxin reductase 1 | 0.0305002 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.029284 |
| SON | SON DNA binding protein | 0.0292597 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0291232 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0290387 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.028695 |
| TPM3 | tropomyosin 3 | 0.0284328 |
| S100A11 | S100 calcium binding protein A11 | 0.0284143 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.027132 |
| KLF6 | Kruppel-like factor 6 | 0.0265839 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0265473 |
| RPL3 | ribosomal protein L3 | 0.0264336 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0259425 |
| BRD2 | bromodomain containing 2 | 0.0258664 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0255184 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0251374 |
| RPL4 | ribosomal protein L4 | 0.0250431 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0250045 |
| PLK2 | polo-like kinase 2 | 0.0246806 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0244129 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0242743 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0242402 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0242085 |
| HOMER1 | homer scaffolding protein 1 | 0.0232149 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0231897 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0231656 |
| ADAR | adenosine deaminase, RNA-specific | 0.0231603 |
| TPI1 | triosephosphate isomerase 1 | 0.0230602 |
| WDR43 | WD repeat domain 43 | 0.0229599 |
| PAPOLA | poly(A) polymerase alpha | 0.0229342 |
| PKM | pyruvate kinase, muscle | 0.0219498 |
| HDAC9 | histone deacetylase 9 | 0.0219429 |
| RPL36 | ribosomal protein L36 | 0.0219391 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.021867 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0215263 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0214468 |
| TRIM55 | tripartite motif containing 55 | 0.0213799 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0209979 |
| JUN | jun proto-oncogene | 0.0207962 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0205126 |
| RPL18 | ribosomal protein L18 | 0.0204459 |
| CAPRIN2 | caprin family member 2 | 0.0202844 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0201305 |
| ANXA1 | annexin A1 | 0.0201207 |
| LDHA | lactate dehydrogenase A | 0.0198261 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0196805 |
| VEGFC | vascular endothelial growth factor C | 0.0195449 |
| RPL12 | ribosomal protein L12 | 0.0194336 |
| PCDH1 | protocadherin 1 | 0.0193423 |
| RPS19 | ribosomal protein S19 | 0.0192159 |
| CDCP1 | CUB domain containing protein 1 | 0.0186004 |
| HLA-A | major histocompatibility complex, class I, A | 0.0185852 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0185723 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0181516 |
| LIMA1 | LIM domain and actin binding 1 | 0.0181494 |
| CCNL1 | cyclin L1 | 0.0181057 |
| ENO1 | enolase 1, (alpha) | 0.0179737 |
| EMP1 | epithelial membrane protein 1 | 0.0179546 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0178796 |
| SEC24A | SEC24 family member A | 0.0178682 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0177418 |
| TRIM14 | tripartite motif containing 14 | 0.017634 |
| SET | SET nuclear proto-oncogene | 0.0175635 |
| NCKAP1 | NCK-associated protein 1 | 0.0174468 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0170582 |
| CHURC1 | churchill domain containing 1 | 0.0169727 |
| SPAG9 | sperm associated antigen 9 | 0.0168954 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.0167805 |
| AREG | amphiregulin | 0.0163017 |
| MB21D2 | Mab-21 domain containing 2 | 0.016285 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.016215 |
| RPL37A | ribosomal protein L37a | 0.0161878 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.0160599 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.249283 |
| RPL35A | ribosomal protein L35a | -0.139889 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.110006 |
| TMSB10 | thymosin beta 10 | -0.0949152 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0929647 |
| TP63 | tumor protein p63 | -0.091765 |
| TMSB4X | thymosin beta 4, X-linked | -0.0856101 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0804744 |
| HLA-B | major histocompatibility complex, class I, B | -0.0803997 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0763951 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0688011 |
| EHBP1 | EH domain binding protein 1 | -0.0665788 |
| RPS24 | ribosomal protein S24 | -0.0592728 |
| CADM2 | cell adhesion molecule 2 | -0.0573369 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0566521 |
| RIGI | RNA sensor RIG-I | -0.055964 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0558574 |
| RPS6 | ribosomal protein S6 | -0.055558 |
| RPL38 | ribosomal protein L38 | -0.0554392 |
| TNS3 | tensin 3 | -0.0552812 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0540105 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0500557 |
| RNF213 | ring finger protein 213 | -0.0495403 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0488807 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0481135 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0471219 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0471097 |
| MT2A | metallothionein 2A | -0.0467514 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0449129 |
| RPL36A | ribosomal protein L36a | -0.043033 |
| RPL34 | ribosomal protein L34 | -0.0409938 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0408293 |
| EFNA5 | ephrin-A5 | -0.0402856 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0399451 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.039046 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0390109 |
| EGR1 | early growth response 1 | -0.0383277 |
| RPLP1 | ribosomal protein, large, P1 | -0.037291 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.035879 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0352914 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0336043 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.032909 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0327778 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0321222 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0312199 |
| RPS28 | ribosomal protein S28 | -0.0304243 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0304194 |
| RPL23 | ribosomal protein L23 | -0.0302263 |
| PARD3 | par-3 family cell polarity regulator | -0.0299887 |
| FOXK1 | forkhead box K1 | -0.0299507 |
| VIM | vimentin | -0.0299355 |
| CUX1 | cut-like homeobox 1 | -0.0297412 |
| RPS8 | ribosomal protein S8 | -0.0294016 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0292728 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0291642 |
| OGA | O-GlcNAcase | -0.0291382 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0286032 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0285376 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0285004 |
| ZNF217 | zinc finger protein 217 | -0.0284288 |
| EPHA4 | EPH receptor A4 | -0.0281945 |
| DENND1A | DENN/MADD domain containing 1A | -0.0278325 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.027771 |
| CCDC91 | coiled-coil domain containing 91 | -0.0274885 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0274317 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0273768 |
| INTS6 | integrator complex subunit 6 | -0.0270453 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0269788 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0269086 |
| RSF1 | remodeling and spacing factor 1 | -0.0269043 |
| PRELID2 | PRELI domain containing 2 | -0.0268723 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0262154 |
| TBCA | tubulin folding cofactor A | -0.0260609 |
| RPL27A | ribosomal protein L27a | -0.0259869 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0259699 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0256604 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0255874 |
| FOXN3 | forkhead box N3 | -0.0254772 |
| LRRC49 | leucine rich repeat containing 49 | -0.0251302 |
| RAD51B | RAD51 paralog B | -0.0250986 |
| PDE10A | phosphodiesterase 10A | -0.0249764 |
| CFDP1 | craniofacial development protein 1 | -0.0248474 |
| S100A9 | S100 calcium binding protein A9 | -0.0246554 |
| RPL7A | ribosomal protein L7a | -0.0245541 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0245452 |
| ECE1 | endothelin converting enzyme 1 | -0.0242733 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0242591 |
| FLNB | filamin B, beta | -0.0241575 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.024128 |
| FBXO11 | F-box protein 11 | -0.0238915 |
| SBF2 | SET binding factor 2 | -0.0238329 |
| RPL39 | ribosomal protein L39 | -0.0237125 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0236808 |
| PTK2 | protein tyrosine kinase 2 | -0.0236015 |
| FUS | FUS RNA binding protein | -0.0235299 |
| GLG1 | golgi glycoprotein 1 | -0.0234395 |
| MT1E | metallothionein 1E | -0.0233719 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0233196 |
| TP53 | tumor protein p53 | -0.0232231 |
| DOCK11 | dedicator of cytokinesis 11 | -0.0231691 |
