| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belzutifan perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belzutifan_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.237982 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.219378 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.102171 |
| ASPH | aspartate beta-hydroxylase | 0.100115 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0973039 |
| LMO7 | LIM domain 7 | 0.0937004 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.092131 |
| TXNRD1 | thioredoxin reductase 1 | 0.0909441 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0900526 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0819986 |
| ACTG1 | actin gamma 1 | 0.0748976 |
| LDHA | lactate dehydrogenase A | 0.0733101 |
| ENO1 | enolase 1, (alpha) | 0.0701026 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0694832 |
| STC1 | stanniocalcin 1 | 0.0694222 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0665871 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0660547 |
| GRAMD1B | GRAM domain containing 1B | 0.0660236 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0652991 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0646761 |
| TMSB10 | thymosin beta 10 | 0.0620097 |
| MYOF | myoferlin | 0.0555582 |
| S100A10 | S100 calcium binding protein A10 | 0.0551883 |
| EFNA5 | ephrin-A5 | 0.0548096 |
| LAMC2 | laminin, gamma 2 | 0.0546404 |
| MT2A | metallothionein 2A | 0.0535617 |
| PTMA | prothymosin, alpha | 0.0528555 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.049739 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0495342 |
| DSPP | dentin sialophosphoprotein | 0.0488502 |
| ANXA2 | annexin A2 | 0.0487709 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0486016 |
| DOCK5 | dedicator of cytokinesis 5 | 0.048048 |
| RNF213 | ring finger protein 213 | 0.0451322 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0448246 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0437152 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0429223 |
| CPE | carboxypeptidase E | 0.0426158 |
| KRT18 | keratin 18, type I | 0.0407158 |
| AHNAK | AHNAK nucleoprotein | 0.0402098 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0396279 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0396077 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0393102 |
| SLTM | SAFB-like, transcription modulator | 0.0387419 |
| KRT7 | keratin 7, type II | 0.0381687 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0371866 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0369318 |
| H1-0 | H1.0 linker histone | 0.0365157 |
| CST3 | cystatin C | 0.0360458 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0355894 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0353476 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0349402 |
| LAMA4 | laminin, alpha 4 | 0.0344464 |
| FOXP1 | forkhead box P1 | 0.0340553 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0340322 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0339558 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0337328 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0337226 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0336357 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0335506 |
| SMYD3 | SET and MYND domain containing 3 | 0.0334229 |
| FTL | ferritin, light polypeptide | 0.0330228 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0329474 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0326712 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0322781 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0321294 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0320708 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0320185 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0320123 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0319754 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0319294 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0314933 |
| B2M | beta-2-microglobulin | 0.0312788 |
| MYO1E | myosin IE | 0.0309741 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0309506 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0309041 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0305145 |
| PGK1 | phosphoglycerate kinase 1 | 0.0304322 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0302767 |
| SP100 | SP100 nuclear antigen | 0.0302335 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0299913 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0296917 |
| SCEL | sciellin | 0.029325 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0289779 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0286021 |
| RAB10 | RAB10, member RAS oncogene family | 0.0283927 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0281119 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0279796 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0276358 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.02758 |
| LAMB3 | laminin, beta 3 | 0.0275638 |
| AREG | amphiregulin | 0.027345 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0273324 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0269685 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0268236 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0255224 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0254239 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0253113 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0252246 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0250558 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0555801 |
| TMEM165 | transmembrane protein 165 | -0.0375457 |
| NDRG1 | N-myc downstream regulated 1 | -0.0351993 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0304811 |
| EGR1 | early growth response 1 | -0.0275245 |
| CCNL1 | cyclin L1 | -0.0268475 |
| RUNX1 | runt-related transcription factor 1 | -0.0239057 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0215193 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0190239 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0178489 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0172562 |
| SPAG9 | sperm associated antigen 9 | -0.0157484 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0157275 |
| NABP1 | nucleic acid binding protein 1 | -0.0155741 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0152683 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0148934 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0148861 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0143719 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0136171 |
| OGA | O-GlcNAcase | -0.0134426 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.012969 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0128889 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0128129 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0126316 |
| PTEN | phosphatase and tensin homolog | -0.012484 |
| MCL1 | myeloid cell leukemia 1 | -0.012418 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0123178 |
| YEATS2 | YEATS domain containing 2 | -0.0122699 |
| ARF4 | ADP-ribosylation factor 4 | -0.0122584 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0120406 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -0.0119565 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.0116525 |
| ARGLU1 | arginine and glutamate rich 1 | -0.0112054 |
| SPCS2 | signal peptidase complex subunit 2 homolog (S. cerevisiae) | -0.0110051 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0108642 |
| FBRS | fibrosin | -0.0106535 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.010535 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | -0.0104211 |
| NGLY1 | N-glycanase 1 | -0.0103869 |
| HYOU1 | hypoxia up-regulated 1 | -0.010304 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | -0.0102003 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0101834 |
| HELZ | helicase with zinc finger | -0.0101739 |
| SEC23B | Sec23 homolog B (S. cerevisiae) | -0.0100922 |
| DHFR | dihydrofolate reductase | -0.00994015 |
| SRP54 | signal recognition particle 54kDa | -0.00992584 |
| GRB10 | growth factor receptor-bound protein 10 | -0.00985831 |
| NUP58 | nucleoporin 58 | -0.00966886 |
| SUCO | SUN domain containing ossification factor | -0.00965548 |
| LAMA5 | laminin, alpha 5 | -0.0096199 |
| VEGFA | vascular endothelial growth factor A | -0.00946156 |
| YTHDC1 | YTH domain containing 1 | -0.009267 |
| SLC35F5 | solute carrier family 35, member F5 | -0.00924536 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.00922987 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.00911059 |
| GPATCH2L | G patch domain containing 2-like | -0.00898468 |
| RTN4 | reticulon 4 | -0.00862188 |
| PER1 | period circadian clock 1 | -0.00859076 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.00847434 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.00832893 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.00832557 |
| EP300 | E1A binding protein p300 | -0.0083242 |
| TXNDC11 | thioredoxin domain containing 11 | -0.00831918 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.00822401 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.00820739 |
| ARRDC3 | arrestin domain containing 3 | -0.00815329 |
| HAPSTR1 | HUWE1 associated protein modifying stress responses | -0.00815055 |
| KMT2D | lysine (K)-specific methyltransferase 2D | -0.00809984 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.00795961 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | -0.00790604 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | -0.00788328 |
| WDR45B | WD repeat domain 45B | -0.00783554 |
| ECD | ecdysoneless homolog (Drosophila) | -0.00780927 |
| MEF2D | myocyte enhancer factor 2D | -0.00771425 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | -0.00766779 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | -0.00765164 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.007625 |
| GSK3B | glycogen synthase kinase 3 beta | -0.00759822 |
| GAK | cyclin G associated kinase | -0.00745555 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | -0.00744315 |
| STT3A | STT3A, subunit of the oligosaccharyltransferase complex (catalytic) | -0.00740715 |
| WDR49 | WD repeat domain 49 | -0.00738411 |
| DGUOK | deoxyguanosine kinase | -0.00732761 |
| NPC1 | Niemann-Pick disease, type C1 | -0.00732059 |
| ZBTB25 | zinc finger and BTB domain containing 25 | -0.00719663 |
| OTUD5 | OTU deubiquitinase 5 | -0.0071901 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.00718456 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.00717315 |
| CABIN1 | calcineurin binding protein 1 | -0.00709865 |
| NPTN | neuroplastin | -0.00704914 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.00702467 |
| TUFT1 | tuftelin 1 | -0.00701898 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.00700972 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.00696611 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -0.0069236 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.00687949 |
| CASC3 | cancer susceptibility candidate 3 | -0.00681418 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | -0.00679898 |
| OCLN | occludin | -0.00673341 |
| DTNA | dystrobrevin, alpha | -0.00671984 |
