Belzutifan_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belzutifan perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belzutifan_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.078954
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.067904
RPL37A ribosomal protein L37a 0.0628324
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0612365
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0520845
RPS12 ribosomal protein S12 0.0519112
RPL31 ribosomal protein L31 0.0511684
RPS19 ribosomal protein S19 0.04941
NAP1L1 nucleosome assembly protein 1-like 1 0.0475015
AADAC arylacetamide deacetylase 0.0470407
RPS29 ribosomal protein S29 0.0470027
RPS8 ribosomal protein S8 0.0468432
RPS3 ribosomal protein S3 0.0437231
NRG1 neuregulin 1 0.0433161
RPL4 ribosomal protein L4 0.0426489
RPL12 ribosomal protein L12 0.0411606
RPL32 ribosomal protein L32 0.0404217
VIM vimentin 0.0399034
RPL36 ribosomal protein L36 0.0391746
RPLP1 ribosomal protein, large, P1 0.0389265
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0384426
TPT1 tumor protein, translationally-controlled 1 0.0380209
ANTXR2 anthrax toxin receptor 2 0.0376545
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0376122
RPS11 ribosomal protein S11 0.0370454
RPL37 ribosomal protein L37 0.035984
TMSB10 thymosin beta 10 0.0356237
RPLP2 ribosomal protein, large, P2 0.0353351
ENO1 enolase 1, (alpha) 0.0351102
RPS23 ribosomal protein S23 0.0347758
HDAC9 histone deacetylase 9 0.0346004
RACK1 receptor for activated C kinase 1 0.0345368
RPL26 ribosomal protein L26 0.0338564
RPS17 ribosomal protein S17 0.0336966
FTL ferritin, light polypeptide 0.0336047
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0322991
RPL5 ribosomal protein L5 0.0312397
TFPI2 tissue factor pathway inhibitor 2 0.0310507
CD44 CD44 molecule (Indian blood group) 0.0310065
RPS6 ribosomal protein S6 0.0304397
RPS27 ribosomal protein S27 0.0303477
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0301088
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0299031
RPL13A ribosomal protein L13a 0.0297512
RPL19 ribosomal protein L19 0.02972
RPLP0 ribosomal protein, large, P0 0.029627
RPL11 ribosomal protein L11 0.029475
ZSWIM6 zinc finger, SWIM-type containing 6 0.028929
RPL23 ribosomal protein L23 0.0282067
RASAL2 RAS protein activator like 2 0.0271286
PARP14 poly (ADP-ribose) polymerase family, member 14 0.026856
MSRB3 methionine sulfoxide reductase B3 0.026631
EIF1 eukaryotic translation initiation factor 1 0.0263735
B2M beta-2-microglobulin 0.0262732
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0262045
OSBPL8 oxysterol binding protein-like 8 0.0259031
MYO10 myosin X 0.0255238
EXT1 exostosin glycosyltransferase 1 0.0249963
SQSTM1 sequestosome 1 0.0246635
ENO2 enolase 2 (gamma, neuronal) 0.0243339
SUMF1 sulfatase modifying factor 1 0.0240173
AHNAK AHNAK nucleoprotein 0.0240048
RPS13 ribosomal protein S13 0.023715
TRPS1 trichorhinophalangeal syndrome I 0.0236792
PKM pyruvate kinase, muscle 0.0234684
S100A10 S100 calcium binding protein A10 0.0230956
FAM20C family with sequence similarity 20, member C 0.0227864
NLK nemo-like kinase 0.0227553
MAML3 mastermind-like 3 (Drosophila) 0.0223708
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0223067
HIPK2 homeodomain interacting protein kinase 2 0.0222554
HMGA2 high mobility group AT-hook 2 0.0220201
RPL28 ribosomal protein L28 0.0219844
RPS5 ribosomal protein S5 0.0218462
RPL27 ribosomal protein L27 0.0218236
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.021502
TM4SF1 transmembrane 4 L six family member 1 0.0211029
ACTG1 actin gamma 1 0.0209348
NAV3 neuron navigator 3 0.0208501
LDHA lactate dehydrogenase A 0.0205162
RPS16 ribosomal protein S16 0.0203875
RPS15 ribosomal protein S15 0.0201019
RPL38 ribosomal protein L38 0.0200823
RPS25 ribosomal protein S25 0.0200661
RPL35A ribosomal protein L35a 0.0199936
RPS24 ribosomal protein S24 0.0199833
RSL1D1 ribosomal L1 domain containing 1 0.0198733
ARHGAP5 Rho GTPase activating protein 5 0.0198518
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0193951
LRMDA leucine rich melanocyte differentiation associated 0.0193617
RPL9 ribosomal protein L9 0.0192573
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.018959
RPL34 ribosomal protein L34 0.0189301
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0188783
RIMS2 regulating synaptic membrane exocytosis 2 0.0187772
PIBF1 progesterone immunomodulatory binding factor 1 0.0187456
RPL7A ribosomal protein L7a 0.0185848
TIMP1 TIMP metallopeptidase inhibitor 1 0.0185212
RPL18 ribosomal protein L18 0.0183997
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.018045

decreased expression

Symbol Name Standardized Value
KDM2A lysine (K)-specific demethylase 2A -0.131675
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.102515
FNDC3B fibronectin type III domain containing 3B -0.099739
NAMPT nicotinamide phosphoribosyltransferase -0.0920011
PDE4D phosphodiesterase 4D, cAMP-specific -0.0799021
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0755997
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0674044
RICTOR RPTOR independent companion of MTOR, complex 2 -0.067165
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0664696
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0659962
PCBP2 poly(rC) binding protein 2 -0.0617669
ELL2 elongation factor, RNA polymerase II, 2 -0.0606437
NDRG1 N-myc downstream regulated 1 -0.0596435
PDIA3 protein disulfide isomerase family A, member 3 -0.0579438
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0556654
P4HB prolyl 4-hydroxylase, beta polypeptide -0.054891
USP34 ubiquitin specific peptidase 34 -0.0545842
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0524563
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0502744
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0493809
SDK1 sidekick cell adhesion molecule 1 -0.0485919
GOLGA4 golgin A4 -0.0473192
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0467426
KMT2C lysine (K)-specific methyltransferase 2C -0.0423635
LOX lysyl oxidase -0.0419091
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0407371
SRP54 signal recognition particle 54kDa -0.0405991
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0403409
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0389332
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0373723
FTH1 ferritin, heavy polypeptide 1 -0.0369135
SETD5 SET domain containing 5 -0.0365234
ZNF292 zinc finger protein 292 -0.0359171
UGCG UDP-glucose ceramide glucosyltransferase -0.0358428
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0358107
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0357017
ITCH itchy E3 ubiquitin protein ligase -0.0353884
SOD2 superoxide dismutase 2, mitochondrial -0.0351735
RNF24 ring finger protein 24 -0.0345105
MRPS6 mitochondrial ribosomal protein S6 -0.0344825
ETV6 ets variant 6 -0.0341756
RIOK3 RIO kinase 3 -0.034129
PHIP pleckstrin homology domain interacting protein -0.0335167
NGLY1 N-glycanase 1 -0.032648
NPC1 Niemann-Pick disease, type C1 -0.0322909
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0317336
ESYT2 extended synaptotagmin-like protein 2 -0.0315474
DPYSL3 dihydropyrimidinase-like 3 -0.0312956
ARF4 ADP-ribosylation factor 4 -0.0310121
RBM39 RNA binding motif protein 39 -0.0306212
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0305972
MEF2A myocyte enhancer factor 2A -0.0303985
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0298028
FAM13A family with sequence similarity 13, member A -0.0296419
HILPDA hypoxia inducible lipid droplet-associated -0.0294016
FOXO3 forkhead box O3 -0.0291213
HELZ helicase with zinc finger -0.0284893
CHD1L chromodomain helicase DNA binding protein 1-like -0.0282863
SEC23A Sec23 homolog A (S. cerevisiae) -0.0282466
RUNX2 runt-related transcription factor 2 -0.0281958
SEC31A SEC31 homolog A (S. cerevisiae) -0.0279234
EGFR epidermal growth factor receptor -0.0277994
ZMYND8 zinc finger, MYND-type containing 8 -0.027794
PIAS2 protein inhibitor of activated STAT, 2 -0.0276133
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0275531
RAB1A RAB1A, member RAS oncogene family -0.027295
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0268648
TBC1D5 TBC1 domain family, member 5 -0.0267099
KMT2E lysine (K)-specific methyltransferase 2E -0.0266768
SPAG9 sperm associated antigen 9 -0.0265877
DLG1 discs, large homolog 1 (Drosophila) -0.0265771
CABIN1 calcineurin binding protein 1 -0.026048
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0260179
SUCO SUN domain containing ossification factor -0.0259892
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.0258589
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0249289
RAB6A RAB6A, member RAS oncogene family -0.0247192
RUNX1 runt-related transcription factor 1 -0.024712
ADAM9 ADAM metallopeptidase domain 9 -0.0245629
MYOF myoferlin -0.0245384
RB1CC1 RB1-inducible coiled-coil 1 -0.0245008
PTBP2 polypyrimidine tract binding protein 2 -0.0243114
HMGA1 high mobility group AT-hook 1 -0.0237549
CCNL1 cyclin L1 -0.0236302
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0235813
BIRC6 baculoviral IAP repeat containing 6 -0.0232664
TBC1D15 TBC1 domain family, member 15 -0.0232463
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0230523
CLEC1B C-type lectin domain family 1, member B -0.0230288
MYO1B myosin IB -0.0229679
DDIT3 DNA-damage-inducible transcript 3 -0.0229597
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0228716
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0228557
BASP1 brain abundant, membrane attached signal protein 1 -0.0226717
SEC24A SEC24 family member A -0.0225918
AFTPH aftiphilin -0.0224555
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0224336
SS18 synovial sarcoma translocation, chromosome 18 -0.0224332
CDK19 cyclin-dependent kinase 19 -0.0221051
PTEN phosphatase and tensin homolog -0.0220659