Belzutifan_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belzutifan perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Belzutifan_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.384198
PDE4D phosphodiesterase 4D, cAMP-specific 0.233606
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.120483
AKAP12 A kinase (PRKA) anchor protein 12 0.112469
IGFBP3 insulin-like growth factor binding protein 3 0.0958622
SAMD4A sterile alpha motif domain containing 4A 0.0856108
VIM vimentin 0.0810953
STC1 stanniocalcin 1 0.0779876
FNDC3B fibronectin type III domain containing 3B 0.0754213
EIF1 eukaryotic translation initiation factor 1 0.0744549
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0718872
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0704647
FMNL2 formin-like 2 0.0625964
SMOC1 SPARC related modular calcium binding 1 0.0625259
DOCK5 dedicator of cytokinesis 5 0.0618533
KTN1 kinectin 1 (kinesin receptor) 0.0610707
TM4SF1 transmembrane 4 L six family member 1 0.0583143
FAM107B family with sequence similarity 107, member B 0.058125
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0578118
ARHGAP26 Rho GTPase activating protein 26 0.0575449
ATXN1 ataxin 1 0.056237
BASP1 brain abundant, membrane attached signal protein 1 0.0543651
DOCK4 dedicator of cytokinesis 4 0.0527126
HLA-A major histocompatibility complex, class I, A 0.0516175
SVIL supervillin 0.051164
MACF1 microtubule-actin crosslinking factor 1 0.050884
GRAMD1B GRAM domain containing 1B 0.0505855
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.049072
PYGL phosphorylase, glycogen, liver 0.0490087
TPM3 tropomyosin 3 0.0482671
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0450477
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0450104
RPS2 ribosomal protein S2 0.0445536
HLA-B major histocompatibility complex, class I, B 0.0444756
CCL5 chemokine (C-C motif) ligand 5 0.0442036
LPP LIM domain containing preferred translocation partner in lipoma 0.0433147
PM20D1 peptidase M20 domain containing 1 0.0415268
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0413192
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0407964
EGFR epidermal growth factor receptor 0.0406717
CMIP c-Maf inducing protein 0.0400331
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.039941
KIF5B kinesin family member 5B 0.0398427
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0393582
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.038772
TRIO trio Rho guanine nucleotide exchange factor 0.0386665
NIPBL Nipped-B homolog (Drosophila) 0.0382009
ZSWIM6 zinc finger, SWIM-type containing 6 0.0373874
HSPA8 heat shock 70kDa protein 8 0.0373576
WWOX WW domain containing oxidoreductase 0.0364838
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.035379
MYOF myoferlin 0.0350943
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0350138
CFLAR CASP8 and FADD-like apoptosis regulator 0.0342609
NDRG1 N-myc downstream regulated 1 0.034041
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0337465
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0336861
ZFHX3 zinc finger homeobox 3 0.0335431
B2M beta-2-microglobulin 0.033433
EPAS1 endothelial PAS domain protein 1 0.0334173
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0333646
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0332432
EHBP1 EH domain binding protein 1 0.0325445
NUMB numb homolog (Drosophila) 0.0325273
GOLGB1 golgin B1 0.0321951
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0321616
USP34 ubiquitin specific peptidase 34 0.0320693
UTRN utrophin 0.031796
EXT1 exostosin glycosyltransferase 1 0.0317289
GLG1 golgi glycoprotein 1 0.0316914
PTPRM protein tyrosine phosphatase, receptor type, M 0.0312892
ACTG1 actin gamma 1 0.0312863
AKAP13 A kinase (PRKA) anchor protein 13 0.0310028
DST dystonin 0.0309588
ALCAM activated leukocyte cell adhesion molecule 0.0308689
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0306509
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0303677
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.030338
CSNK1A1 casein kinase 1, alpha 1 0.0301237
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0296274
WAC WW domain containing adaptor with coiled-coil 0.0295891
FLNB filamin B, beta 0.0295121
MYO1E myosin IE 0.0294184
SNX14 sorting nexin 14 0.0290109
FTH1 ferritin, heavy polypeptide 1 0.028946
CDCP1 CUB domain containing protein 1 0.0285158
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0283829
APP amyloid beta (A4) precursor protein 0.0279227
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0278832
THSD4 thrombospondin, type I, domain containing 4 0.0278485
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0277039
GOLGA4 golgin A4 0.0275892
SMAD3 SMAD family member 3 0.0274966
MYH9 myosin, heavy chain 9, non-muscle 0.0274378
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0274307
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0273941
NCKAP1 NCK-associated protein 1 0.0273506
NBEAL1 neurobeachin-like 1 0.0272815
NEBL nebulette 0.0272059
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0269938

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.117164
TMSB10 thymosin beta 10 -0.104881
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0679723
EGR1 early growth response 1 -0.0679576
SLC38A2 solute carrier family 38, member 2 -0.0499638
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0451393
FTL ferritin, light polypeptide -0.0428787
WDR43 WD repeat domain 43 -0.0401916
RPL35A ribosomal protein L35a -0.0376834
RPL23 ribosomal protein L23 -0.0374031
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0364436
YBX1 Y box binding protein 1 -0.0353232
RHOA ras homolog family member A -0.0325535
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0315239
ANKRD28 ankyrin repeat domain 28 -0.0302239
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0298594
USP3 ubiquitin specific peptidase 3 -0.0298366
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0295073
HMGA1 high mobility group AT-hook 1 -0.0294602
PFN1 profilin 1 -0.0283477
HDAC9 histone deacetylase 9 -0.0256431
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0246017
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0245934
IGF2 insulin-like growth factor 2 -0.0245284
AK1 adenylate kinase 1 -0.0244692
POTEF POTE ankyrin domain family, member F -0.0234359
ECT2 epithelial cell transforming 2 -0.0232363
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0229875
EEF1G eukaryotic translation elongation factor 1 gamma -0.0228028
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0228002
NUP58 nucleoporin 58 -0.0226557
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0220011
EIF3H eukaryotic translation initiation factor 3, subunit H -0.02193
CYRIB CYFIP related Rac1 interactor B -0.0216259
RPS21 ribosomal protein S21 -0.0214378
RPS24 ribosomal protein S24 -0.0210253
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0207739
BMPR1B bone morphogenetic protein receptor, type IB -0.0201453
HMGB1 high mobility group box 1 -0.019888
ATP5F1B ATP synthase F1 subunit beta -0.0198018
EEF2 eukaryotic translation elongation factor 2 -0.0194758
MYL12B myosin, light chain 12B, regulatory -0.0191335
ZNF207 zinc finger protein 207 -0.019082
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0189011
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0188281
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0187743
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0184369
VMP1 vacuole membrane protein 1 -0.0181696
ADGRG6 adhesion G protein-coupled receptor G6 -0.0181209
TFPI2 tissue factor pathway inhibitor 2 -0.0180089
FAM168A family with sequence similarity 168, member A -0.0176632
CHN1 chimerin 1 -0.0176234
KLF6 Kruppel-like factor 6 -0.0175457
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0172149
MORF4L1 mortality factor 4 like 1 -0.0171563
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0170889
RPS20 ribosomal protein S20 -0.0170694
RTN4 reticulon 4 -0.016791
LOC112694756 uncharaterized LOC112694756 -0.0166976
ADAM9 ADAM metallopeptidase domain 9 -0.016396
RBM25 RNA binding motif protein 25 -0.0163891
PAWR PRKC, apoptosis, WT1, regulator -0.0163738
MTF2 metal response element binding transcription factor 2 -0.0163235
NSUN6 NOP2/Sun domain family, member 6 -0.0161374
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0160871
RPL34 ribosomal protein L34 -0.0160111
NCOA7 nuclear receptor coactivator 7 -0.0157406
OLA1 Obg-like ATPase 1 -0.01552
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0154647
PTK2 protein tyrosine kinase 2 -0.0152095
VDAC1 voltage-dependent anion channel 1 -0.0150363
NABP1 nucleic acid binding protein 1 -0.0150284
TUBB tubulin, beta class I -0.0149527
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0148896
OSBPL9 oxysterol binding protein-like 9 -0.0147582
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0146331
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0145905
RPS23 ribosomal protein S23 -0.0145596
TFG TRK-fused gene -0.0145077
ENAH enabled homolog (Drosophila) -0.014475
PKM pyruvate kinase, muscle -0.0144698
ERBIN erbb2 interacting protein -0.0144095
RPS5 ribosomal protein S5 -0.0142904
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0142626
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0142092
MARCHF6 membrane associated ring-CH-type finger 6 -0.0140177
ZNF804A zinc finger protein 804A -0.0139934
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0139558
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0138675
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0137067
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -0.0136991
RHEB Ras homolog enriched in brain -0.0136914
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -0.0135516
TMEM87A transmembrane protein 87A -0.0135112
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0134885
TMEM123 transmembrane protein 123 -0.0134084
RPS15 ribosomal protein S15 -0.0133413
MDN1 MDN1, midasin homolog (yeast) -0.0133319
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0132977
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0132492