Belzutifan_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belzutifan perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belzutifan_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.325706
HLA-B major histocompatibility complex, class I, B 0.134832
FTL ferritin, light polypeptide 0.119991
KYNU kynureninase 0.111015
TMSB10 thymosin beta 10 0.109082
MYO1E myosin IE 0.102532
VIM vimentin 0.0949603
FN1 fibronectin 1 0.0947305
LAMA4 laminin, alpha 4 0.087402
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0867484
RSAD2 radical S-adenosyl methionine domain containing 2 0.083641
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0762182
TGFBI transforming growth factor, beta-induced, 68kDa 0.0702556
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0692377
ACTG1 actin gamma 1 0.068816
EGFR epidermal growth factor receptor 0.0678761
OSMR oncostatin M receptor 0.0645349
RPS12 ribosomal protein S12 0.0639772
TJP1 tight junction protein 1 0.0630616
STC1 stanniocalcin 1 0.0607822
JARID2 jumonji, AT rich interactive domain 2 0.0603515
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0598249
IGFBP3 insulin-like growth factor binding protein 3 0.058183
SLC38A1 solute carrier family 38, member 1 0.0566293
RPS23 ribosomal protein S23 0.0547299
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0537057
B2M beta-2-microglobulin 0.0530724
PKM pyruvate kinase, muscle 0.0518502
MT2A metallothionein 2A 0.0512389
DOCK5 dedicator of cytokinesis 5 0.0508046
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0496591
NPEPPS aminopeptidase puromycin sensitive 0.0488923
S100A10 S100 calcium binding protein A10 0.0475731
WAC WW domain containing adaptor with coiled-coil 0.0462564
PARD3 par-3 family cell polarity regulator 0.0448335
ENO1 enolase 1, (alpha) 0.0432725
BPTF bromodomain PHD finger transcription factor 0.041793
GATAD2B GATA zinc finger domain containing 2B 0.0415113
GNAS GNAS complex locus 0.0412334
BBX bobby sox homolog (Drosophila) 0.0412066
TM4SF1 transmembrane 4 L six family member 1 0.0407318
RPL9 ribosomal protein L9 0.0402566
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0398285
MYOF myoferlin 0.0397326
TXNRD1 thioredoxin reductase 1 0.0394815
FTH1 ferritin, heavy polypeptide 1 0.0390171
RPS27 ribosomal protein S27 0.038582
ZBTB38 zinc finger and BTB domain containing 38 0.0384875
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 0.0376494
PDLIM5 PDZ and LIM domain 5 0.0369911
NALF1 NALCN channel auxiliary factor 1 0.0369089
BZW1 basic leucine zipper and W2 domains 1 0.0367816
POTEF POTE ankyrin domain family, member F 0.0363867
EIF1 eukaryotic translation initiation factor 1 0.0363523
TPT1 tumor protein, translationally-controlled 1 0.035667
PLAUR plasminogen activator, urokinase receptor 0.0353618
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0350751
ALCAM activated leukocyte cell adhesion molecule 0.0349488
ESYT2 extended synaptotagmin-like protein 2 0.0346151
SMAD2 SMAD family member 2 0.0336531
RBM47 RNA binding motif protein 47 0.0336025
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0333828
RPS8 ribosomal protein S8 0.0333756
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0330007
RPS3 ribosomal protein S3 0.032938
MEIS2 Meis homeobox 2 0.0326213
SLTM SAFB-like, transcription modulator 0.0324193
CLDN4 claudin 4 0.0322482
MACC1 metastasis associated in colon cancer 1 0.031951
AKAP12 A kinase (PRKA) anchor protein 12 0.0318979
RPLP2 ribosomal protein, large, P2 0.0318041
RIMKLB ribosomal modification protein rimK-like family member B 0.0317556
MUC13 mucin 13, cell surface associated 0.0316278
PRKCA protein kinase C, alpha 0.031001
BIRC6 baculoviral IAP repeat containing 6 0.0309844
CALU calumenin 0.0306905
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0305096
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0296785
RPL37 ribosomal protein L37 0.0295501
RPL32 ribosomal protein L32 0.0293814
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0290083
BTG1 B-cell translocation gene 1, anti-proliferative 0.028379
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0281733
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0276117
CTNND1 catenin (cadherin-associated protein), delta 1 0.027105
BABAM2 BRISC and BRCA1 A complex member 2 0.0269914
ZBTB43 zinc finger and BTB domain containing 43 0.026847
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0265531
RPL35A ribosomal protein L35a 0.0264655
TRIM56 tripartite motif containing 56 0.0263576
RPL36 ribosomal protein L36 0.0260873
ELL2 elongation factor, RNA polymerase II, 2 0.0258879
MED13L mediator complex subunit 13-like 0.0258879
PCBP2 poly(rC) binding protein 2 0.0257826
RAB7A RAB7A, member RAS oncogene family 0.0255046
LOC112694756 uncharaterized LOC112694756 0.0247685
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0247623
PRRC2C proline-rich coiled-coil 2C 0.0243621
RPS6 ribosomal protein S6 0.0243155
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0241138

decreased expression

Symbol Name Standardized Value
CEMIP cell migration inducing protein, hyaluronan binding -0.152439
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.132445
PDE4D phosphodiesterase 4D, cAMP-specific -0.121665
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.118774
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0903642
SQSTM1 sequestosome 1 -0.0829058
PTMA prothymosin, alpha -0.0823943
GRB10 growth factor receptor-bound protein 10 -0.0812789
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0725634
LMO7 LIM domain 7 -0.0703074
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.069448
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0689979
LAMB3 laminin, beta 3 -0.0646453
IGF1R insulin-like growth factor 1 receptor -0.0636824
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0619521
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0617863
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0602605
MUC16 mucin 16, cell surface associated -0.0601817
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.0564883
ATOSA atos homolog A -0.0551698
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0545322
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0533629
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0529484
CMIP c-Maf inducing protein -0.0527924
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0500018
MXD1 MAX dimerization protein 1 -0.0489015
SPAG9 sperm associated antigen 9 -0.0477611
RORA RAR-related orphan receptor A -0.0474148
IER3 immediate early response 3 -0.0466457
CA12 carbonic anhydrase XII -0.0464699
LIMCH1 LIM and calponin homology domains 1 -0.0464662
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0464202
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0448963
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0447142
HOOK2 hook microtubule-tethering protein 2 -0.0439527
GLG1 golgi glycoprotein 1 -0.0437157
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0432448
OGA O-GlcNAcase -0.0425025
MAP4 microtubule-associated protein 4 -0.0424736
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0423593
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0401309
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0390249
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0384097
KMT2C lysine (K)-specific methyltransferase 2C -0.0371154
BCAS3 breast carcinoma amplified sequence 3 -0.0371006
CLASP1 cytoplasmic linker associated protein 1 -0.0360873
FAM107B family with sequence similarity 107, member B -0.0360739
AHNAK AHNAK nucleoprotein -0.0352819
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0352158
KIAA0319L KIAA0319-like -0.0348785
JUN jun proto-oncogene -0.034839
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0346773
UBC ubiquitin C -0.0345447
MIER1 mesoderm induction early response 1, transcriptional regulator -0.0345003
NIPBL Nipped-B homolog (Drosophila) -0.0341311
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0338474
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0333005
F3 coagulation factor III (thromboplastin, tissue factor) -0.033282
EIF4A3 eukaryotic translation initiation factor 4A3 -0.0332321
WDR26 WD repeat domain 26 -0.0330168
CAPN2 calpain 2, (m/II) large subunit -0.03299
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.032875
ZNF638 zinc finger protein 638 -0.0327537
MATR3 matrin 3 -0.0323064
ADM adrenomedullin -0.0322463
VCL vinculin -0.03212
RAB10 RAB10, member RAS oncogene family -0.031504
RPL37A ribosomal protein L37a -0.031336
GPATCH2L G patch domain containing 2-like -0.0310791
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0305597
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0303585
GOLGA4 golgin A4 -0.0303451
PNN pinin, desmosome associated protein -0.030221
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0301081
PDS5B PDS5 cohesin associated factor B -0.0299105
BACE2 beta-site APP-cleaving enzyme 2 -0.0293833
TJP2 tight junction protein 2 -0.0291892
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0287031
ZMYND8 zinc finger, MYND-type containing 8 -0.0274944
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0271831
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0271379
FOXO1 forkhead box O1 -0.0268534
AFDN afadin, adherens junction formation factor -0.0268132
RUNX1 runt-related transcription factor 1 -0.0267871
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0266913
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0266765
RPL4 ribosomal protein L4 -0.0262114
CSDE1 cold shock domain containing E1, RNA-binding -0.0259617
CD2AP CD2-associated protein -0.025793
CALR calreticulin -0.0256913
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0255994
BHLHE40 basic helix-loop-helix family, member e40 -0.0247062
ZFAND3 zinc finger, AN1-type domain 3 -0.0244782
S100A6 S100 calcium binding protein A6 -0.0244558
KTN1 kinectin 1 (kinesin receptor) -0.0243109
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.024066
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0235575
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0232151
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0229729
CFDP1 craniofacial development protein 1 -0.021782