Belzutifan_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belzutifan perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belzutifan_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.181755
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0922316
TFPI2 tissue factor pathway inhibitor 2 0.075345
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0631009
VIM vimentin 0.0580716
YBX3 Y box binding protein 3 0.0568812
TXNRD1 thioredoxin reductase 1 0.0560633
PTMA prothymosin, alpha 0.0549833
TM4SF1 transmembrane 4 L six family member 1 0.0514333
KTN1 kinectin 1 (kinesin receptor) 0.0494501
RPS3 ribosomal protein S3 0.0482698
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0449746
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0441584
TMSB10 thymosin beta 10 0.0421203
RPS8 ribosomal protein S8 0.0408055
ELL2 elongation factor, RNA polymerase II, 2 0.0392742
STC1 stanniocalcin 1 0.0367929
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0359154
ACTG1 actin gamma 1 0.0358332
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0341069
NIPBL Nipped-B homolog (Drosophila) 0.0329013
NAP1L1 nucleosome assembly protein 1-like 1 0.0315856
MT2A metallothionein 2A 0.031217
RPS12 ribosomal protein S12 0.0312149
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0307797
FTL ferritin, light polypeptide 0.0296852
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0281789
RPL4 ribosomal protein L4 0.028066
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0269116
RPL37A ribosomal protein L37a 0.026045
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0259911
TPI1 triosephosphate isomerase 1 0.0258087
ENO1 enolase 1, (alpha) 0.0257352
CAVIN1 caveolae associated protein 1 0.0256851
MYL12B myosin, light chain 12B, regulatory 0.0255569
NFE2L2 nuclear factor, erythroid 2-like 2 0.0250852
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0249841
EIF4A1 eukaryotic translation initiation factor 4A1 0.0244963
EIF5B eukaryotic translation initiation factor 5B 0.0237459
RPLP1 ribosomal protein, large, P1 0.0234706
HSPH1 heat shock 105kDa/110kDa protein 1 0.0224181
CTTN cortactin 0.0217516
RPL8 ribosomal protein L8 0.0215805
TPT1 tumor protein, translationally-controlled 1 0.0215021
RPL12 ribosomal protein L12 0.0212224
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.02069
RPS19 ribosomal protein S19 0.0206686
LOC102724023 ES1 protein homolog, mitochondrial 0.0206533
HOMER1 homer scaffolding protein 1 0.0206213
RPS29 ribosomal protein S29 0.0203799
TPM3 tropomyosin 3 0.0200529
RPL23 ribosomal protein L23 0.0200443
EIF1 eukaryotic translation initiation factor 1 0.0199455
UBB ubiquitin B 0.0197167
SNAP25 synaptosomal-associated protein, 25kDa 0.0192911
RPS10 ribosomal protein S10 0.0191484
PRDX1 peroxiredoxin 1 0.0188515
RPL19 ribosomal protein L19 0.0188391
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0187322
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0182182
HSPA8 heat shock 70kDa protein 8 0.0178817
RACK1 receptor for activated C kinase 1 0.0178358
GSTP1 glutathione S-transferase pi 1 0.0177472
RPS6 ribosomal protein S6 0.0177469
PRRC2C proline-rich coiled-coil 2C 0.0177406
RPLP2 ribosomal protein, large, P2 0.0176449
RPL26 ribosomal protein L26 0.0174946
SET SET nuclear proto-oncogene 0.0174322
RPL5 ribosomal protein L5 0.0174125
RNF145 ring finger protein 145 0.017405
RPL31 ribosomal protein L31 0.0172779
RPS27A ribosomal protein S27a 0.0171442
S100A11 S100 calcium binding protein A11 0.0171314
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0170604
BIRC2 baculoviral IAP repeat containing 2 0.0167425
RPS27 ribosomal protein S27 0.0163961
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0160907
RPS17 ribosomal protein S17 0.0160511
RPL6 ribosomal protein L6 0.0159237
RPS2 ribosomal protein S2 0.0159206
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0159039
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 0.0158659
SSB Sjogren syndrome antigen B (autoantigen La) 0.0157659
VCP valosin containing protein 0.0157487
BZW1 basic leucine zipper and W2 domains 1 0.0155225
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0155083
RPLP0 ribosomal protein, large, P0 0.0152647
RPL37 ribosomal protein L37 0.0152553
ATP5F1E ATP synthase F1 subunit epsilon 0.0151588
ATP11A ATPase, class VI, type 11A 0.0151335
RAB7A RAB7A, member RAS oncogene family 0.0151209
EREG epiregulin 0.0150385
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0149889
PA2G4 proliferation-associated 2G4, 38kDa 0.0148862
MYO10 myosin X 0.0148152
RPS4X ribosomal protein S4, X-linked 0.0147808
PDE4B phosphodiesterase 4B, cAMP-specific 0.0146155
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0146075
RPL11 ribosomal protein L11 0.014554
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0144656

decreased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B -0.0849609
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0728994
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0690377
THSD4 thrombospondin, type I, domain containing 4 -0.0596099
MCL1 myeloid cell leukemia 1 -0.0488508
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0473159
EGR1 early growth response 1 -0.0466223
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0462796
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0452512
ATXN1 ataxin 1 -0.0449957
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0388198
EXOC4 exocyst complex component 4 -0.0377402
HMGA2 high mobility group AT-hook 2 -0.0373272
IGF1R insulin-like growth factor 1 receptor -0.0361869
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0349212
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0340235
USP34 ubiquitin specific peptidase 34 -0.0335643
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0326032
EGFR epidermal growth factor receptor -0.0312679
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0307721
AFF3 AF4/FMR2 family, member 3 -0.0302252
ZBTB20 zinc finger and BTB domain containing 20 -0.0294151
PYGL phosphorylase, glycogen, liver -0.0289889
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0288852
TAS2R14 taste receptor, type 2, member 14 -0.0277627
RYR3 ryanodine receptor 3 -0.0255078
AEBP2 AE binding protein 2 -0.0251915
NCOA7 nuclear receptor coactivator 7 -0.025179
BIRC6 baculoviral IAP repeat containing 6 -0.0245109
OSMR oncostatin M receptor -0.0243932
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0239805
VCL vinculin -0.0237848
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0235477
KDM4B lysine (K)-specific demethylase 4B -0.0229136
PRELID2 PRELI domain containing 2 -0.022876
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0224264
PRKCE protein kinase C, epsilon -0.0221134
GPATCH2L G patch domain containing 2-like -0.0220051
PTK2 protein tyrosine kinase 2 -0.0219893
NABP1 nucleic acid binding protein 1 -0.0215084
PHF21A PHD finger protein 21A -0.0213036
RNF213 ring finger protein 213 -0.0209951
TAPBP TAP binding protein (tapasin) -0.0208215
POTEF POTE ankyrin domain family, member F -0.0207279
ZNF207 zinc finger protein 207 -0.0205053
DENND1A DENN/MADD domain containing 1A -0.0204486
TRIO trio Rho guanine nucleotide exchange factor -0.0203782
RSF1 remodeling and spacing factor 1 -0.0202616
TMEM165 transmembrane protein 165 -0.0202441
ZFAND3 zinc finger, AN1-type domain 3 -0.0200893
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0195527
NLGN1 neuroligin 1 -0.0193912
PDE10A phosphodiesterase 10A -0.0193554
NBAS neuroblastoma amplified sequence -0.0191303
FMN1 formin 1 -0.0190056
SND1 staphylococcal nuclease and tudor domain containing 1 -0.018965
TRIP12 thyroid hormone receptor interactor 12 -0.0187771
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0187078
EML4 echinoderm microtubule associated protein like 4 -0.0183916
TBC1D22A TBC1 domain family, member 22A -0.018128
PRH1 proline-rich protein HaeIII subfamily 1 -0.0180965
SP3 Sp3 transcription factor -0.0180929
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0179371
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0179139
ZNF609 zinc finger protein 609 -0.0176749
SBF2 SET binding factor 2 -0.0176593
TBC1D5 TBC1 domain family, member 5 -0.017621
SMAD3 SMAD family member 3 -0.0174413
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0173076
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0169839
KIAA1328 KIAA1328 -0.0168931
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0167429
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0166602
SAMD4A sterile alpha motif domain containing 4A -0.0166565
SMYD3 SET and MYND domain containing 3 -0.0166558
SENP6 SUMO1/sentrin specific peptidase 6 -0.016578
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0161847
TPM4 tropomyosin 4 -0.0161311
ZNF407 zinc finger protein 407 -0.0161262
METTL15 methyltransferase like 15 -0.0160184
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.015814
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0157885
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0156932
RBM39 RNA binding motif protein 39 -0.0156417
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0156095
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0156057
NTSR1 neurotensin receptor 1 (high affinity) -0.0155976
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0155766
MED13L mediator complex subunit 13-like -0.0154706
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0154089
MACF1 microtubule-actin crosslinking factor 1 -0.0153662
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0152767
DIAPH2 diaphanous-related formin 2 -0.0152397
BABAM2 BRISC and BRCA1 A complex member 2 -0.014818
GATAD2B GATA zinc finger domain containing 2B -0.0147887
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -0.014442
CUX1 cut-like homeobox 1 -0.0144353
PPP4R3B protein phosphatase 4 regulatory subunit 3B -0.0143559
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0143291
DENND5B DENN/MADD domain containing 5B -0.0143136