Belzutifan_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belzutifan perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belzutifan_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.380986
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.110137
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.101348
CSTB cystatin B (stefin B) 0.0701099
ENO1 enolase 1, (alpha) 0.0637422
SAMD4A sterile alpha motif domain containing 4A 0.0605016
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0598852
RPS3 ribosomal protein S3 0.0565846
IFI6 interferon, alpha-inducible protein 6 0.0550362
DSG2 desmoglein 2 0.0533248
LAMB3 laminin, beta 3 0.05192
LAMC2 laminin, gamma 2 0.0516198
MACC1 metastasis associated in colon cancer 1 0.0512415
TACSTD2 tumor-associated calcium signal transducer 2 0.0474227
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0474196
ALCAM activated leukocyte cell adhesion molecule 0.0447129
RPS12 ribosomal protein S12 0.0438839
HDAC9 histone deacetylase 9 0.0433672
LMO7 LIM domain 7 0.042721
RPL12 ribosomal protein L12 0.0420713
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0413525
ANXA2 annexin A2 0.041247
RPL4 ribosomal protein L4 0.0411145
RACK1 receptor for activated C kinase 1 0.0410265
ASPH aspartate beta-hydroxylase 0.0394386
CD44 CD44 molecule (Indian blood group) 0.0394034
IFI27 interferon, alpha-inducible protein 27 0.0377174
TRIO trio Rho guanine nucleotide exchange factor 0.0367757
S100A6 S100 calcium binding protein A6 0.0365072
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.036122
RPL37A ribosomal protein L37a 0.0359673
EFNA5 ephrin-A5 0.0354792
CAPN2 calpain 2, (m/II) large subunit 0.0352881
PLAUR plasminogen activator, urokinase receptor 0.0341153
IFITM3 interferon induced transmembrane protein 3 0.0336267
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0333175
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.033204
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0327305
VGLL3 vestigial-like family member 3 0.0324165
SGMS2 sphingomyelin synthase 2 0.0322468
RPL19 ribosomal protein L19 0.0313246
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0302534
RPS19 ribosomal protein S19 0.0295235
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0287152
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0282632
RPS17 ribosomal protein S17 0.0280371
ZBTB38 zinc finger and BTB domain containing 38 0.0279455
KLF6 Kruppel-like factor 6 0.0277996
RPL32 ribosomal protein L32 0.0276525
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0273399
EXT1 exostosin glycosyltransferase 1 0.0266416
NAV2 neuron navigator 2 0.0247328
MACF1 microtubule-actin crosslinking factor 1 0.0244745
SQSTM1 sequestosome 1 0.024457
ERRFI1 ERBB receptor feedback inhibitor 1 0.0242215
S100A10 S100 calcium binding protein A10 0.0241101
ANO6 anoctamin 6 0.023698
DUSP6 dual specificity phosphatase 6 0.0236375
RPL18 ribosomal protein L18 0.02335
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0232755
IFI44L interferon-induced protein 44-like 0.0229986
OSMR oncostatin M receptor 0.022692
DSPP dentin sialophosphoprotein 0.0226609
ARRDC3 arrestin domain containing 3 0.0222494
MAP1B microtubule-associated protein 1B 0.0222277
DST dystonin 0.021985
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0219464
MYO5B myosin VB 0.0217367
C15ORF48 chromosome 15 open reading frame 48 0.0215479
AHNAK AHNAK nucleoprotein 0.0213915
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0213383
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0213106
RPL26 ribosomal protein L26 0.0212592
CLDN1 claudin 1 0.020851
RPL36 ribosomal protein L36 0.0208448
RPL9 ribosomal protein L9 0.0207304
SDC4 syndecan 4 0.0206389
FER fer (fps/fes related) tyrosine kinase 0.0205434
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0204367
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0203021
NABP1 nucleic acid binding protein 1 0.0202908
RASAL2 RAS protein activator like 2 0.0199954
CTSS cathepsin S 0.0199432
RPL37 ribosomal protein L37 0.0198525
EGFR epidermal growth factor receptor 0.0197179
KIAA1217 KIAA1217 0.0196849
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0195518
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0193472
FHIT fragile histidine triad 0.0191406
CD63 CD63 molecule 0.0191269
SEPTIN9 septin 9 0.0189497
SMIM14 small integral membrane protein 14 0.0184312
CLDN4 claudin 4 0.018362
ARHGAP5 Rho GTPase activating protein 5 0.0183147
S100A11 S100 calcium binding protein A11 0.0182672
GLRX glutaredoxin (thioltransferase) 0.0182488
SVIL supervillin 0.0180911
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0180674
TUBB4B tubulin, beta 4B class IVb 0.0177809
RPL27 ribosomal protein L27 0.0176722

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.181567
POTEF POTE ankyrin domain family, member F -0.133328
TSC22D2 TSC22 domain family, member 2 -0.0782515
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0639347
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0600806
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0596345
RPL35A ribosomal protein L35a -0.0566295
FNDC3B fibronectin type III domain containing 3B -0.0522095
GRB10 growth factor receptor-bound protein 10 -0.0484415
KMT2E lysine (K)-specific methyltransferase 2E -0.0429342
RBM39 RNA binding motif protein 39 -0.0428608
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0409414
RNF145 ring finger protein 145 -0.0394171
TMSB10 thymosin beta 10 -0.0393441
FTL ferritin, light polypeptide -0.0381046
RBM25 RNA binding motif protein 25 -0.0375378
VEGFA vascular endothelial growth factor A -0.0370121
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0358769
CALR calreticulin -0.0346733
ZNF207 zinc finger protein 207 -0.0345635
SPAG9 sperm associated antigen 9 -0.0343165
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0322113
HMGA1 high mobility group AT-hook 1 -0.0320155
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0315952
KDM5B lysine (K)-specific demethylase 5B -0.0313966
TOP1 topoisomerase (DNA) I -0.030874
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0305987
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0303082
KLHL24 kelch-like family member 24 -0.0293896
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0290715
ZFAND3 zinc finger, AN1-type domain 3 -0.0281235
RHOA ras homolog family member A -0.0275961
SLMAP sarcolemma associated protein -0.027548
TFG TRK-fused gene -0.0275373
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0272955
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.026518
FN1 fibronectin 1 -0.02635
MSI2 musashi RNA-binding protein 2 -0.0262219
ADAM9 ADAM metallopeptidase domain 9 -0.0262057
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0260474
GOLGA4 golgin A4 -0.0259646
FXR1 fragile X mental retardation, autosomal homolog 1 -0.025836
CERT1 ceramide transporter 1 -0.0249843
USP3 ubiquitin specific peptidase 3 -0.0248163
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0247039
FAM13A family with sequence similarity 13, member A -0.0245585
MARCHF6 membrane associated ring-CH-type finger 6 -0.024538
CCNL1 cyclin L1 -0.0237482
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0235856
COPA coatomer protein complex, subunit alpha -0.0235628
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0234974
WSB1 WD repeat and SOCS box containing 1 -0.0234081
RNASE3 ribonuclease, RNase A family, 3 -0.0233371
STRN3 striatin, calmodulin binding protein 3 -0.0230966
SRPK2 SRSF protein kinase 2 -0.0230474
PRRC2C proline-rich coiled-coil 2C -0.0229306
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0228306
OGA O-GlcNAcase -0.0226853
KDM6A lysine (K)-specific demethylase 6A -0.0222344
TPM4 tropomyosin 4 -0.0218746
DEK DEK proto-oncogene -0.0217594
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0217575
ACBD3 acyl-CoA binding domain containing 3 -0.0213872
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0213016
GARS1 glycyl-tRNA synthetase 1 -0.0212467
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0211239
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0207773
WAC WW domain containing adaptor with coiled-coil -0.0206735
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0202671
SEC23A Sec23 homolog A (S. cerevisiae) -0.0202273
YY1 YY1 transcription factor -0.0202231
MYO6 myosin VI -0.0201015
PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.0199398
SSBP2 single-stranded DNA binding protein 2 -0.0198636
LIMCH1 LIM and calponin homology domains 1 -0.0198438
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0198118
ANKRD11 ankyrin repeat domain 11 -0.0197394
FBXO11 F-box protein 11 -0.0197181
CD109 CD109 molecule -0.0196882
RHEB Ras homolog enriched in brain -0.0196853
CHD1 chromodomain helicase DNA binding protein 1 -0.0196235
NAMPT nicotinamide phosphoribosyltransferase -0.019474
KMT2C lysine (K)-specific methyltransferase 2C -0.0194048
RLF rearranged L-myc fusion -0.0193186
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0192383
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0192074
MATR3 matrin 3 -0.0191405
SETD5 SET domain containing 5 -0.0191092
ITCH itchy E3 ubiquitin protein ligase -0.0190309
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0187197
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0186809
KDM3A lysine (K)-specific demethylase 3A -0.0186264
TRAF3 TNF receptor-associated factor 3 -0.0186264
TRA2B transformer 2 beta homolog (Drosophila) -0.0185888
RAB6A RAB6A, member RAS oncogene family -0.0183551
HSPB1 heat shock 27kDa protein 1 -0.0182536
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0181527
TRA2A transformer 2 alpha homolog (Drosophila) -0.0180428
ZNF292 zinc finger protein 292 -0.0179272
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.017887