Belzutifan_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belzutifan perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belzutifan_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.136157
KYNU kynureninase 0.071193
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0671896
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.059478
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0587756
RPS2 ribosomal protein S2 0.058367
COL8A1 collagen, type VIII, alpha 1 0.0544919
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0538597
PDLIM5 PDZ and LIM domain 5 0.0508157
GRAMD1B GRAM domain containing 1B 0.0464949
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0429022
MYOF myoferlin 0.0426321
RPS12 ribosomal protein S12 0.0424048
PM20D1 peptidase M20 domain containing 1 0.0417745
PCBP2 poly(rC) binding protein 2 0.0404416
RPL3 ribosomal protein L3 0.0400946
RACK1 receptor for activated C kinase 1 0.0393954
FTL ferritin, light polypeptide 0.0393622
RPL4 ribosomal protein L4 0.0381647
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0378586
TPM3 tropomyosin 3 0.0375115
EEF2 eukaryotic translation elongation factor 2 0.0371302
FTH1 ferritin, heavy polypeptide 1 0.0370722
SH3KBP1 SH3-domain kinase binding protein 1 0.0363391
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0352719
FMNL2 formin-like 2 0.0343163
ESYT2 extended synaptotagmin-like protein 2 0.0340004
RPS3 ribosomal protein S3 0.0339376
NAMPT nicotinamide phosphoribosyltransferase 0.0338602
HSPA8 heat shock 70kDa protein 8 0.032901
ANXA2 annexin A2 0.0314718
TXNRD1 thioredoxin reductase 1 0.0300405
CXCL8 chemokine (C-X-C motif) ligand 8 0.0299713
ENO1 enolase 1, (alpha) 0.0293625
FLNB filamin B, beta 0.0284047
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0274727
TRIO trio Rho guanine nucleotide exchange factor 0.027463
SET SET nuclear proto-oncogene 0.0269209
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0265102
RPL12 ribosomal protein L12 0.0261471
MT2A metallothionein 2A 0.0260671
NEK7 NIMA-related kinase 7 0.0257401
RGS2 regulator of G-protein signaling 2 0.0248431
RPS4X ribosomal protein S4, X-linked 0.0245344
KTN1 kinectin 1 (kinesin receptor) 0.0243544
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0238742
MSN moesin 0.023593
ANXA1 annexin A1 0.0228075
LDHA lactate dehydrogenase A 0.0226901
TGFBR1 transforming growth factor, beta receptor 1 0.0225722
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0225412
CLTC clathrin, heavy chain (Hc) 0.0218733
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0217136
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0216153
RAB3B RAB3B, member RAS oncogene family 0.0214801
ZMIZ1 zinc finger, MIZ-type containing 1 0.0214402
MGST1 microsomal glutathione S-transferase 1 0.0210446
BDNF brain-derived neurotrophic factor 0.020861
CTIF CBP80/20-dependent translation initiation factor 0.0207899
ENAH enabled homolog (Drosophila) 0.0207464
EIF4A1 eukaryotic translation initiation factor 4A1 0.020698
NCKAP1 NCK-associated protein 1 0.0206718
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0205146
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0204577
NAP1L1 nucleosome assembly protein 1-like 1 0.020437
MCTP1 multiple C2 domains, transmembrane 1 0.0200402
CLU clusterin 0.0200086
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0198873
APLP2 amyloid beta (A4) precursor-like protein 2 0.0194719
CD109 CD109 molecule 0.0191532
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0191502
PRRC2C proline-rich coiled-coil 2C 0.0191193
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0190492
ATP5F1B ATP synthase F1 subunit beta 0.0189906
ZEB2 zinc finger E-box binding homeobox 2 0.0187343
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0187252
CTSC cathepsin C 0.018475
ARHGAP29 Rho GTPase activating protein 29 0.0183494
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0182708
CHD1 chromodomain helicase DNA binding protein 1 0.0182047
ERRFI1 ERBB receptor feedback inhibitor 1 0.0181856
COL4A5 collagen, type IV, alpha 5 0.0179745
TNIP1 TNFAIP3 interacting protein 1 0.0179679
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0178214
EZR ezrin 0.0177898
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0177102
POTEF POTE ankyrin domain family, member F 0.0175385
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0173566
SOX9 SRY (sex determining region Y)-box 9 0.0172049
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0171683
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0170441
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0168725
FNIP1 folliculin interacting protein 1 0.0168546
IPO7 importin 7 0.0167827
NRIP1 nuclear receptor interacting protein 1 0.0167149
CD44 CD44 molecule (Indian blood group) 0.0167142
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0165886
RPL18 ribosomal protein L18 0.0165125
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0164389
TGFBI transforming growth factor, beta-induced, 68kDa 0.016438

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.26395
FN1 fibronectin 1 -0.228129
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.202641
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.139842
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.122176
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.117429
TMSB10 thymosin beta 10 -0.102955
NALF1 NALCN channel auxiliary factor 1 -0.0993531
PTMA prothymosin, alpha -0.0917613
TPT1 tumor protein, translationally-controlled 1 -0.0906313
SMYD3 SET and MYND domain containing 3 -0.088209
CDH13 cadherin 13 -0.0872157
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0713295
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0676659
EFNA5 ephrin-A5 -0.0663673
RPL35A ribosomal protein L35a -0.0638338
HLA-B major histocompatibility complex, class I, B -0.0636792
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0629383
MAML3 mastermind-like 3 (Drosophila) -0.0623242
VIM vimentin -0.0619403
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0618127
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0606012
PCBP3 poly(rC) binding protein 3 -0.0597701
RPS24 ribosomal protein S24 -0.0582328
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0560179
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0559827
GDA guanine deaminase -0.0528974
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0527027
PDE10A phosphodiesterase 10A -0.0516651
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.048767
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0486307
ADGRD1 adhesion G protein-coupled receptor D1 -0.04832
PSD3 pleckstrin and Sec7 domain containing 3 -0.0473278
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0439347
WARS1 tryptophanyl-tRNA synthetase 1 -0.0407091
IGF1R insulin-like growth factor 1 receptor -0.0401636
WSB1 WD repeat and SOCS box containing 1 -0.0401095
CANX calnexin -0.0397928
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0388185
VCL vinculin -0.0384463
NCKAP5 NCK-associated protein 5 -0.0363106
RPL38 ribosomal protein L38 -0.0356009
RPLP1 ribosomal protein, large, P1 -0.0354984
BCAS3 breast carcinoma amplified sequence 3 -0.0352788
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0344114
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0340574
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0334489
PBX1 pre-B-cell leukemia homeobox 1 -0.0328803
RPH3AL rabphilin 3A-like (without C2 domains) -0.0325789
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0318661
RPL34 ribosomal protein L34 -0.0313159
CALR calreticulin -0.0309826
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0307965
RIGI RNA sensor RIG-I -0.0305482
GNAS GNAS complex locus -0.0302605
NRCAM neuronal cell adhesion molecule -0.0299877
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0298141
ZMYND8 zinc finger, MYND-type containing 8 -0.0296544
CUX1 cut-like homeobox 1 -0.0291624
S100A6 S100 calcium binding protein A6 -0.0287652
RTN1 reticulon 1 -0.0284791
RAB31 RAB31, member RAS oncogene family -0.0284734
FNDC3B fibronectin type III domain containing 3B -0.0282812
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0278273
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.027538
IGFBP3 insulin-like growth factor binding protein 3 -0.0274227
IFIH1 interferon induced with helicase C domain 1 -0.0271087
SOX6 SRY (sex determining region Y)-box 6 -0.0270119
KIAA0825 KIAA0825 -0.0263515
NCOA7 nuclear receptor coactivator 7 -0.0261718
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0258723
MCL1 myeloid cell leukemia 1 -0.0258372
OASL 2'-5'-oligoadenylate synthetase-like -0.0257234
PTGR1 prostaglandin reductase 1 -0.0256914
STEAP1B STEAP family member 1B -0.0254168
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0253697
ZBTB20 zinc finger and BTB domain containing 20 -0.0253022
CTSL cathepsin L -0.0252065
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0248513
MAML2 mastermind-like 2 (Drosophila) -0.0245114
THSD4 thrombospondin, type I, domain containing 4 -0.0244843
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0240822
RPS13 ribosomal protein S13 -0.0236925
NPAS2 neuronal PAS domain protein 2 -0.023422
TPM4 tropomyosin 4 -0.0232517
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0232091
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.023172
SOD2 superoxide dismutase 2, mitochondrial -0.0230663
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0229931
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0225112
RPS21 ribosomal protein S21 -0.0224522
RPL36A ribosomal protein L36a -0.0222753
PRKN parkin RBR E3 ubiquitin protein ligase -0.0221268
ADGRB3 adhesion G protein-coupled receptor B3 -0.0218607
BMERB1 bMERB domain containing 1 -0.0215247
DST dystonin -0.021498
ESM1 endothelial cell-specific molecule 1 -0.0214785
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0214298
TENM3 teneurin transmembrane protein 3 -0.0211811
SRPK2 SRSF protein kinase 2 -0.0208335