Belzutifan_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belzutifan perturbation in NCI-H596 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Belzutifan_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.233498
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.18573
RPL23 ribosomal protein L23 0.126433
RPS3 ribosomal protein S3 0.123266
PTMA prothymosin, alpha 0.112333
RPS19 ribosomal protein S19 0.100719
TPT1 tumor protein, translationally-controlled 1 0.100663
FRMD5 FERM domain containing 5 0.0989804
FTL ferritin, light polypeptide 0.0933009
RPL37A ribosomal protein L37a 0.0920617
MYO9A myosin IXA 0.0889854
TMSB10 thymosin beta 10 0.088648
RPS6 ribosomal protein S6 0.0880548
ASPH aspartate beta-hydroxylase 0.0871786
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0861986
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0784277
ANXA2 annexin A2 0.0782194
RPL26 ribosomal protein L26 0.075048
AP3D1 adaptor-related protein complex 3, delta 1 subunit 0.0733126
PRELID2 PRELI domain containing 2 0.0710051
RPL9 ribosomal protein L9 0.0660387
RPLP2 ribosomal protein, large, P2 0.0643296
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0623383
RPL19 ribosomal protein L19 0.0606562
TTC17 tetratricopeptide repeat domain 17 0.0589267
RPS27 ribosomal protein S27 0.0588583
PITPNB phosphatidylinositol transfer protein, beta 0.0570033
RPS8 ribosomal protein S8 0.0569245
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0564907
UBC ubiquitin C 0.0540435
RPL13A ribosomal protein L13a 0.0506153
MYO1E myosin IE 0.0495005
MBNL1 muscleblind-like splicing regulator 1 0.0436026
MCL1 myeloid cell leukemia 1 0.0416873
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0416143
BRD2 bromodomain containing 2 0.0414364
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0399718
USP34 ubiquitin specific peptidase 34 0.039816
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0396105
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0393764
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0392633
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0384156
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0383803
RPL31 ribosomal protein L31 0.038298
MED13 mediator complex subunit 13 0.0380362
SEPTIN9 septin 9 0.0378218
OGA O-GlcNAcase 0.0357638
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0331449
DSCAM Down syndrome cell adhesion molecule 0.0331102
ARHGAP12 Rho GTPase activating protein 12 0.0331059
RAD51B RAD51 paralog B 0.0319635
NPTN neuroplastin 0.0316606
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0311283
FAF1 Fas (TNFRSF6) associated factor 1 0.0307579
RACK1 receptor for activated C kinase 1 0.0304917
CTBP2 C-terminal binding protein 2 0.0300888
RPL7A ribosomal protein L7a 0.0298826
RND3 Rho family GTPase 3 0.0297349
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0295701
GPHN gephyrin 0.0292451
EZR ezrin 0.0281738
RAB7A RAB7A, member RAS oncogene family 0.0280565
SRRM2 serine/arginine repetitive matrix 2 0.0273013
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0271848
PDLIM5 PDZ and LIM domain 5 0.0267625
EGFR epidermal growth factor receptor 0.02673
AFF1 AF4/FMR2 family, member 1 0.0264805
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0257198
TPD52 tumor protein D52 0.0253231
DSTN destrin (actin depolymerizing factor) 0.0250818
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0245398
PGK1 phosphoglycerate kinase 1 0.0242201
RPS17 ribosomal protein S17 0.023948
ZCCHC7 zinc finger, CCHC domain containing 7 0.0230819
TNPO1 transportin 1 0.0219758
LMO7 LIM domain 7 0.0218249
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0212985
PRRC2C proline-rich coiled-coil 2C 0.0212511
EEF2 eukaryotic translation elongation factor 2 0.0209665
PKM pyruvate kinase, muscle 0.0209131
HDLBP high density lipoprotein binding protein 0.0196148
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0195403
RPL4 ribosomal protein L4 0.0184886
FNIP1 folliculin interacting protein 1 0.0181653
KRT18 keratin 18, type I 0.01813
PTPRK protein tyrosine phosphatase, receptor type, K 0.0176017
AKAP13 A kinase (PRKA) anchor protein 13 0.0173764
TAS2R14 taste receptor, type 2, member 14 0.0173121
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0169392
FLNA filamin A, alpha 0.0161524
S100A10 S100 calcium binding protein A10 0.0158185
MYOF myoferlin 0.0153642
RPS12 ribosomal protein S12 0.0152787
H3-3B H3.3 histone B 0.0149578
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0144241
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0142582
ARHGAP32 Rho GTPase activating protein 32 0.0135122
CCDC91 coiled-coil domain containing 91 0.013358
SLC38A1 solute carrier family 38, member 1 0.0130797
DIAPH1 diaphanous-related formin 1 0.0128454

decreased expression

Symbol Name Standardized Value
GPC6 glypican 6 -0.123648
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.11701
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.110589
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0832045
MAML2 mastermind-like 2 (Drosophila) -0.0799568
AKAP12 A kinase (PRKA) anchor protein 12 -0.0726978
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0718181
DOCK5 dedicator of cytokinesis 5 -0.0700525
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0687717
CDH13 cadherin 13 -0.067631
VMP1 vacuole membrane protein 1 -0.065697
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0646602
FNDC3B fibronectin type III domain containing 3B -0.063135
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0629206
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0620902
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0609552
SETD5 SET domain containing 5 -0.0588741
LPP LIM domain containing preferred translocation partner in lipoma -0.0583655
MACF1 microtubule-actin crosslinking factor 1 -0.0580105
WDFY3 WD repeat and FYVE domain containing 3 -0.0579832
TENM3 teneurin transmembrane protein 3 -0.0576185
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0539935
PSD3 pleckstrin and Sec7 domain containing 3 -0.0533262
RBM39 RNA binding motif protein 39 -0.0531788
RPLP0 ribosomal protein, large, P0 -0.0514429
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0513394
COL6A3 collagen, type VI, alpha 3 -0.0508157
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0507153
AHNAK AHNAK nucleoprotein -0.0501886
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0495382
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0494442
MED13L mediator complex subunit 13-like -0.0482434
MYO1D myosin ID -0.0476336
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0474246
JMJD1C jumonji domain containing 1C -0.0456827
VIM vimentin -0.04539
FN1 fibronectin 1 -0.0439335
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0437684
SNX9 sorting nexin 9 -0.0413575
MAML3 mastermind-like 3 (Drosophila) -0.0411126
SBF2 SET binding factor 2 -0.040962
NCOR1 nuclear receptor corepressor 1 -0.0403688
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0403463
DST dystonin -0.0398484
ATP13A3 ATPase type 13A3 -0.0394791
ACTN4 actinin, alpha 4 -0.0369626
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0368954
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0368602
FOXO3 forkhead box O3 -0.0366639
KMT2A lysine (K)-specific methyltransferase 2A -0.0366585
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0362753
CALU calumenin -0.0360373
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0355678
TAOK1 TAO kinase 1 -0.0352784
ZBTB20 zinc finger and BTB domain containing 20 -0.0350992
MEF2A myocyte enhancer factor 2A -0.0350971
NAP1L1 nucleosome assembly protein 1-like 1 -0.0344479
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0343405
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0339568
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0332675
BIRC6 baculoviral IAP repeat containing 6 -0.0328831
NDRG1 N-myc downstream regulated 1 -0.0326489
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0322938
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0317319
DLG1 discs, large homolog 1 (Drosophila) -0.0314255
ZNF292 zinc finger protein 292 -0.0310803
PDE4D phosphodiesterase 4D, cAMP-specific -0.0306739
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0306537
NKD1 naked cuticle homolog 1 (Drosophila) -0.0303106
CDK17 cyclin-dependent kinase 17 -0.0302954
MATR3 matrin 3 -0.0302612
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0301642
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0298896
KLF12 Kruppel-like factor 12 -0.0290051
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0289019
CERS6 ceramide synthase 6 -0.0284091
CEP95 centrosomal protein 95kDa -0.0277148
MYH9 myosin, heavy chain 9, non-muscle -0.0273257
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0272828
EFNA5 ephrin-A5 -0.0271228
PPP4R3A protein phosphatase 4 regulatory subunit 3A -0.0269702
PHF21A PHD finger protein 21A -0.0265366
EXT1 exostosin glycosyltransferase 1 -0.0262423
NEK7 NIMA-related kinase 7 -0.0261534
CD44 CD44 molecule (Indian blood group) -0.0250683
KMT2C lysine (K)-specific methyltransferase 2C -0.0242859
CLTC clathrin, heavy chain (Hc) -0.0242696
USP53 ubiquitin specific peptidase 53 -0.0240816
NEBL nebulette -0.0237439
DENND1A DENN/MADD domain containing 1A -0.0236824
SAMD4A sterile alpha motif domain containing 4A -0.0232877
KMT2E lysine (K)-specific methyltransferase 2E -0.0228482
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0217423
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0214272
CDK13 cyclin-dependent kinase 13 -0.0213445
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0208569
TNRC6A trinucleotide repeat containing 6A -0.0205715
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0204689
CUX1 cut-like homeobox 1 -0.0204637
TSC22D1 TSC22 domain family, member 1 -0.020291