Belzutifan_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belzutifan perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belzutifan_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.107829
RPS12 ribosomal protein S12 0.087973
RPS3 ribosomal protein S3 0.0718968
HDAC9 histone deacetylase 9 0.0703293
VIM vimentin 0.0689709
ENO1 enolase 1, (alpha) 0.0683177
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0649265
RPS16 ribosomal protein S16 0.0604318
RPL37A ribosomal protein L37a 0.0599402
FOXP2 forkhead box P2 0.0561324
RPL11 ribosomal protein L11 0.0545304
RPL37 ribosomal protein L37 0.0527501
TMSB10 thymosin beta 10 0.0519487
RPS6 ribosomal protein S6 0.0479296
RACK1 receptor for activated C kinase 1 0.0478181
RPS8 ribosomal protein S8 0.0477127
RPL12 ribosomal protein L12 0.0469272
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0452653
RPS27A ribosomal protein S27a 0.0452481
RPL19 ribosomal protein L19 0.0444191
LYST lysosomal trafficking regulator 0.0444157
RPL31 ribosomal protein L31 0.0425179
MBD5 methyl-CpG binding domain protein 5 0.0417049
IGF2 insulin-like growth factor 2 0.0404207
JMJD1C jumonji domain containing 1C 0.0391688
RPL23 ribosomal protein L23 0.0381237
RPS23 ribosomal protein S23 0.0379726
RPS17 ribosomal protein S17 0.037755
MDK midkine (neurite growth-promoting factor 2) 0.0376633
ZFP36L1 ZFP36 ring finger protein-like 1 0.0375285
RPS13 ribosomal protein S13 0.0366501
FTL ferritin, light polypeptide 0.0364596
PCDH7 protocadherin 7 0.035706
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0355262
HMGA2 high mobility group AT-hook 2 0.0349444
PTMA prothymosin, alpha 0.0346946
LOC102724023 ES1 protein homolog, mitochondrial 0.0337991
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.033667
RPS29 ribosomal protein S29 0.0335192
RPLP1 ribosomal protein, large, P1 0.0335158
RPLP2 ribosomal protein, large, P2 0.033358
RPL36A ribosomal protein L36a 0.0330597
MT2A metallothionein 2A 0.0328302
PCLO piccolo presynaptic cytomatrix protein 0.0327081
AKAP12 A kinase (PRKA) anchor protein 12 0.0326997
RPS25 ribosomal protein S25 0.0317574
CDH19 cadherin 19, type 2 0.0316369
RPS2 ribosomal protein S2 0.031522
RPL30 ribosomal protein L30 0.0312033
RPL4 ribosomal protein L4 0.0307234
RPL9 ribosomal protein L9 0.0303153
EIF1 eukaryotic translation initiation factor 1 0.0290643
NDRG1 N-myc downstream regulated 1 0.0289101
RPL7 ribosomal protein L7 0.0286591
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0286017
RPL27 ribosomal protein L27 0.028575
RPL36 ribosomal protein L36 0.0285587
DMD dystrophin 0.0278784
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.0275533
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0268809
INTS6 integrator complex subunit 6 0.026512
TENM3 teneurin transmembrane protein 3 0.0262475
NEBL nebulette 0.026097
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0258563
RPL28 ribosomal protein L28 0.0257574
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0254567
RPL26 ribosomal protein L26 0.0253828
RPL10A ribosomal protein L10a 0.0244875
FSCN1 fascin actin-bundling protein 1 0.0243225
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.0242778
DENND5B DENN/MADD domain containing 5B 0.0240139
TPT1 tumor protein, translationally-controlled 1 0.0239992
RPL5 ribosomal protein L5 0.0239898
RPS19 ribosomal protein S19 0.023529
RPS14 ribosomal protein S14 0.0227719
ASPH aspartate beta-hydroxylase 0.0224667
DRC8 dynein regulatory complex subunit 8 0.0224071
STC1 stanniocalcin 1 0.0223489
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0222077
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0221551
MYOF myoferlin 0.0218278
RPL32 ribosomal protein L32 0.0218221
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0214413
SNX6 sorting nexin 6 0.0209519
SPTSSA serine palmitoyltransferase, small subunit A 0.0207747
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0205948
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0204149
RPL18 ribosomal protein L18 0.0203238
DDIT4 DNA-damage-inducible transcript 4 0.0202865
BBS9 Bardet-Biedl syndrome 9 0.0201253
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0200548
PRKD1 protein kinase D1 0.0200516
NCOR2 nuclear receptor corepressor 2 0.020045
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.0200443
MRPS6 mitochondrial ribosomal protein S6 0.0199922
RPS10 ribosomal protein S10 0.019896
ARHGAP32 Rho GTPase activating protein 32 0.0198658
CSNK1A1 casein kinase 1, alpha 1 0.0198296
ZSWIM6 zinc finger, SWIM-type containing 6 0.0196864
LDHA lactate dehydrogenase A 0.0195622

decreased expression

Symbol Name Standardized Value
PEG10 paternally expressed 10 -0.0946866
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0721546
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0719911
MKI67 marker of proliferation Ki-67 -0.0696573
ZNF292 zinc finger protein 292 -0.0695659
TSC22D2 TSC22 domain family, member 2 -0.0691728
GPC3 glypican 3 -0.068039
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0680284
ZFAND3 zinc finger, AN1-type domain 3 -0.0677485
PCDH9 protocadherin 9 -0.0671893
ITGAV integrin, alpha V -0.0661448
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0647273
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0633999
ADAM9 ADAM metallopeptidase domain 9 -0.0605989
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0592964
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0571057
METAP2 methionyl aminopeptidase 2 -0.0533659
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0532818
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0530693
MAP4 microtubule-associated protein 4 -0.0517744
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0498448
PGAP1 post-GPI attachment to proteins 1 -0.0486006
APP amyloid beta (A4) precursor protein -0.0484569
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0481413
SPAG9 sperm associated antigen 9 -0.048066
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0479759
CENPF centromere protein F, 350/400kDa -0.0466074
ECT2 epithelial cell transforming 2 -0.0460123
NRG1 neuregulin 1 -0.0432594
TXNRD1 thioredoxin reductase 1 -0.0432434
MPG N-methylpurine-DNA glycosylase -0.0424698
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0423081
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0422427
POTEF POTE ankyrin domain family, member F -0.0420734
PDE4D phosphodiesterase 4D, cAMP-specific -0.0414975
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0411047
RTN4 reticulon 4 -0.0407276
CKAP2 cytoskeleton associated protein 2 -0.0407108
COL1A2 collagen, type I, alpha 2 -0.0406502
RBM39 RNA binding motif protein 39 -0.0403164
HMGB2 high mobility group box 2 -0.0385865
RAD21 RAD21 homolog (S. pombe) -0.0383744
OLA1 Obg-like ATPase 1 -0.0382122
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0354362
FUBP1 far upstream element (FUSE) binding protein 1 -0.0354002
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0351463
STRN3 striatin, calmodulin binding protein 3 -0.0342884
PRRC2C proline-rich coiled-coil 2C -0.0342302
NUP58 nucleoporin 58 -0.034146
NTM neurotrimin -0.0341443
PFN1 profilin 1 -0.0340061
THBS1 thrombospondin 1 -0.0335326
USP3 ubiquitin specific peptidase 3 -0.0333594
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0332979
NAMPT nicotinamide phosphoribosyltransferase -0.0328281
WDR43 WD repeat domain 43 -0.0324695
SHROOM3 shroom family member 3 -0.0322306
TPX2 TPX2, microtubule-associated -0.0322241
CDC73 cell division cycle 73 -0.0321794
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0320854
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0317812
MARCHF6 membrane associated ring-CH-type finger 6 -0.0316914
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0315973
EMP1 epithelial membrane protein 1 -0.0311599
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0308972
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.0307177
CAPNS1 calpain, small subunit 1 -0.030655
NAP1L1 nucleosome assembly protein 1-like 1 -0.0297587
TRIO trio Rho guanine nucleotide exchange factor -0.0297552
ENAH enabled homolog (Drosophila) -0.0293202
RLF rearranged L-myc fusion -0.0291092
AKAP9 A kinase (PRKA) anchor protein 9 -0.0290109
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.028721
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0284296
ADGRV1 adhesion G protein-coupled receptor V1 -0.0283425
ARHGAP21 Rho GTPase activating protein 21 -0.0282893
UBE2K ubiquitin-conjugating enzyme E2K -0.0280763
RHEB Ras homolog enriched in brain -0.0280558
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0279448
KDM5B lysine (K)-specific demethylase 5B -0.0275212
ADGRL3 adhesion G protein-coupled receptor L3 -0.0273319
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0273155
MTF2 metal response element binding transcription factor 2 -0.0271737
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.0270373
FAM171B family with sequence similarity 171, member B -0.0269011
CCNA2 cyclin A2 -0.0268533
OSBPL9 oxysterol binding protein-like 9 -0.0267455
TMSB4X thymosin beta 4, X-linked -0.0263851
KPNB1 karyopherin (importin) beta 1 -0.0260822
QKI QKI, KH domain containing, RNA binding -0.0257753
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0257297
MRPS30 mitochondrial ribosomal protein S30 -0.0256764
TBC1D12 TBC1 domain family, member 12 -0.0255774
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0254166
XPO1 exportin 1 -0.0253173
CBX3 chromobox homolog 3 -0.0252547
SEPTIN7 septin 7 -0.0251446
NUP153 nucleoporin 153kDa -0.0249503
TJP1 tight junction protein 1 -0.0248665
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0245807